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2024-04-25 20:08:15, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_033529 2620 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens cyclin-dependent kinase 11A (CDK11A), transcript
variant 4, mRNA.
ACCESSION NM_033529 XM_001125937 XM_001128005
VERSION NM_033529.2 GI:148763344
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2620)
AUTHORS Olson,J.E., Wang,X., Pankratz,V.S., Fredericksen,Z.S., Vachon,C.M.,
Vierkant,R.A., Cerhan,J.R. and Couch,F.J.
TITLE Centrosome-related genes, genetic variation, and risk of breast
cancer
JOURNAL Breast Cancer Res. Treat. 125 (1), 221-228 (2011)
PUBMED 20508983
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 2 (bases 1 to 2620)
AUTHORS Malumbres,M., Harlow,E., Hunt,T., Hunter,T., Lahti,J.M.,
Manning,G., Morgan,D.O., Tsai,L.H. and Wolgemuth,D.J.
TITLE Cyclin-dependent kinases: a family portrait
JOURNAL Nat. Cell Biol. 11 (11), 1275-1276 (2009)
PUBMED 19884882
REFERENCE 3 (bases 1 to 2620)
AUTHORS Kong,X., Gan,H., Hao,Y., Cheng,C., Jiang,J., Hong,Y., Yang,J.,
Zhu,H., Chi,Y., Yun,X. and Gu,J.
TITLE CDK11p58 phosphorylation of PAK1 Ser174 promotes DLC2 binding and
roles on cell cycle progression
JOURNAL J. Biochem. 146 (3), 417-427 (2009)
PUBMED 19520772
REMARK GeneRIF: study identified p21 activated kinase 1 (PAK1) as a new
CDK11(p58) substrate; mapped a new phosphorylation site of Ser174
on PAK1; results indicated PAK1 may serve as a downstream effector
of CDK11(p58) during mitosis progression
REFERENCE 4 (bases 1 to 2620)
AUTHORS Shi,J., Hershey,J.W. and Nelson,M.A.
TITLE Phosphorylation of the eukaryotic initiation factor 3f by
cyclin-dependent kinase 11 during apoptosis
JOURNAL FEBS Lett. 583 (6), 971-977 (2009)
PUBMED 19245811
REMARK GeneRIF: Phosphorylation of the eukaryotic initiation factor 3f by
cyclin-dependent kinase 11 during apoptosis.
REFERENCE 5 (bases 1 to 2620)
AUTHORS Wang,Y., Zong,H., Chi,Y., Hong,Y., Yang,Y., Zou,W., Yun,X. and
Gu,J.
TITLE Repression of estrogen receptor alpha by CDK11p58 through promoting
its ubiquitin-proteasome degradation
JOURNAL J. Biochem. 145 (3), 331-343 (2009)
PUBMED 19122208
REMARK GeneRIF: These data identified a new negative regulatory protein of
ERalpha and provided a new pathway by which CDK11(p58) negatively
regulated cells.
REFERENCE 6 (bases 1 to 2620)
AUTHORS White,P.S., Maris,J.M., Beltinger,C., Sulman,E., Marshall,H.N.,
Fujimori,M., Kaufman,B.A., Biegel,J.A., Allen,C., Hilliard,C.,
Valentine,M.B., Look,A.T., Enomoto,H., Sakiyama,S. and Brodeur,G.M.
TITLE A region of consistent deletion in neuroblastoma maps within human
chromosome 1p36.2-36.3
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (12), 5520-5524 (1995)
PUBMED 7777541
REFERENCE 7 (bases 1 to 2620)
AUTHORS Lahti,J.M., Valentine,M., Xiang,J., Jones,B., Amann,J., Grenet,J.,
Richmond,G., Look,A.T. and Kidd,V.J.
TITLE Alterations in the PITSLRE protein kinase gene complex on
chromosome 1p36 in childhood neuroblastoma
JOURNAL Nat. Genet. 7 (3), 370-375 (1994)
PUBMED 7920654
REFERENCE 8 (bases 1 to 2620)
AUTHORS Eipers,P.G., Lahti,J.M. and Kidd,V.J.
TITLE Structure and expression of the human p58clk-1 protein kinase
chromosomal gene
JOURNAL Genomics 13 (3), 613-621 (1992)
PUBMED 1639388
REFERENCE 9 (bases 1 to 2620)
AUTHORS Eipers,P.G., Barnoski,B.L., Han,J., Carroll,A.J. and Kidd,V.J.
TITLE Localization of the expressed human p58 protein kinase chromosomal
gene to chromosome 1p36 and a highly related sequence to chromosome
15
JOURNAL Genomics 11 (3), 621-629 (1991)
PUBMED 1774066
REFERENCE 10 (bases 1 to 2620)
AUTHORS Bunnell,B.A., Heath,L.S., Adams,D.E., Lahti,J.M. and Kidd,V.J.
TITLE Increased expression of a 58-kDa protein kinase leads to changes in
the CHO cell cycle
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (19), 7467-7471 (1990)
PUBMED 2217177
REMARK Erratum:[Proc Natl Acad Sci U S A 1991 Mar 15;88(6):2612]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC388505.1, AF067521.1,
AL043340.1 and BC094827.1.
On or before Jun 14, 2007 this sequence version replaced
gi:113402535, gi:16357483.
Summary: This gene encodes a member of the p34Cdc2 protein kinase
family. p34Cdc2 kinase family members are known to be essential for
eukaryotic cell cycle control. This gene is in close proximity to
CDC2L1, a nearly identical gene in the same chromosomal region. The
gene loci including this gene, CDC2L1, as well as metalloprotease
MMP21/22, consist of two identical, tandemly linked genomic
regions, which are thought to be a part of the larger region that
has been duplicated. This gene and CDC2L1 were shown to be deleted
or altered frequently in neuroblastoma with amplified MYCN genes.
The protein kinase encoded by this gene could be cleaved by
caspases and was demonstrated to play roles in cell apoptosis. Many
transcript variants encoding several different isoforms have been
found for this gene, but the full-length nature of only two have
been determined so far. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (4) uses an alternate in-frame
splice junction compared to variant 1. The resulting isoform (4)
has the same N- and C-termini but is shorter compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF067521.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-574 DC388505.1 1-574
575-922 AF067521.1 546-893
923-1524 AL043340.1 93-694
1525-2620 BC094827.1 532-1627
FEATURES Location/Qualifiers
source 1..2620
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p36.33"
gene 1..2620
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/note="cyclin-dependent kinase 11A"
/db_xref="GeneID:728642"
/db_xref="HGNC:1730"
/db_xref="MIM:116951"
exon 1..95
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
misc_feature 91..93
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/note="upstream in-frame stop codon"
exon 96..219
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
CDS 109..2421
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/EC_number="2.7.11.22"
/note="isoform 4 is encoded by transcript variant 4; cell
division cycle 2-like 2 (PITSLRE proteins); PITSLRE
protein kinase beta; PITSLRE B;
galactosyltransferase-associated protein kinase p58/GTA;
cell division protein kinase 11A; PITSLRE
serine/threonine-protein kinase CDC2L2; cell division
cycle 2-like protein kinase 2"
/codon_start=1
/product="cyclin-dependent kinase 11A isoform 4"
/protein_id="NP_277071.2"
/db_xref="GI:148763345"
/db_xref="CCDS:CCDS44043.1"
/db_xref="GeneID:728642"
/db_xref="HGNC:1730"
/db_xref="MIM:116951"
/translation="
MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
"
misc_feature 382..384
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 772..774
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 880..882
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 886..888
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1327..2202
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/note="Catalytic domain of the Serine/Threonine Kinase,
Cell Division Cycle 2-like 1; Region: STKc_CDC2L1;
cd07843"
/db_xref="CDD:173741"
misc_feature 1336..2208
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/note="cyclin-dependent kinase A; Provisional; Region:
PLN00009"
/db_xref="CDD:177649"
misc_feature order(1363..1374,1387..1389,1426..1428,1432..1434,
1483..1485,1525..1527,1579..1590,1597..1599,1603..1608,
1717..1719,1723..1725,1729..1734,1738..1740,1771..1773,
1780..1782,1816..1818,1822..1833,1837..1839,1951..1956)
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/note="active site"
/db_xref="CDD:173741"
misc_feature order(1363..1374,1387..1389,1426..1428,1432..1434,
1525..1527,1579..1590,1597..1599,1606..1608,1729..1734,
1738..1740,1771..1773)
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173741"
misc_feature order(1459..1467,1471..1473,1480..1485,1489..1494,
1501..1506,1540..1542,1546..1548,1567..1569,1684..1686,
1693..1704,1786..1788,1792..1803,1813..1818,2158..2160,
2170..2178)
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/note="CDK/cyclin interface [polypeptide binding]; other
site"
/db_xref="CDD:173741"
misc_feature order(1483..1485,1603..1605,1717..1719,1723..1725,
1780..1782,1816..1818,1822..1833,1837..1839,1951..1956)
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173741"
misc_feature order(1768..1803,1807..1839)
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173741"
misc_feature 1816..1818
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2284..2286
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2287..2289
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 220..335
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
variation 277
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/replace="c"
/replace="t"
/db_xref="dbSNP:17424353"
exon 336..433
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
exon 434..566
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
exon 567..703
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
exon 704..826
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
exon 827..922
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
exon 923..1081
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
STS 1029..2445
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/db_xref="UniSTS:484401"
exon 1082..1147
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
exon 1148..1323
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
exon 1324..1414
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
exon 1415..1536
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
variation 1524
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/replace="c"
/replace="t"
/db_xref="dbSNP:2377226"
exon 1537..1642
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
exon 1643..1764
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
exon 1765..1872
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
exon 1873..1989
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
exon 1990..2138
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
exon 2139..2328
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
exon 2329..2598
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
/inference="alignment:Splign:1.39.8"
polyA_signal 2569..2574
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
polyA_site 2598
/gene="CDK11A"
/gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46;
CDK11-p58; p58GTA; PITSLRE"
ORIGIN
atcattaggcgtcaacacaggaagtgaggatacttctggcgagcgccggttgctgtttcttctcaggctcagggaccggccgcggccccgtagggtgttttaactcaaatgggtgatgaaaaggactcttggaaagtgaaaactttagatgaaattcttcaggaaaagaaacgaaggaaggaacaagaggagaaagcagagataaaacgcttaaaaaattctgatgaccgggattccaagcgggattcccttgaggagggggagctgagagatcactgcatggagatcacaataaggaactccccgtatagaagagaagactcaatggaagacagaggagaagaagatgattctttggccatcaaaccaccccagcaaatgtctcggaaagaaaaagttcatcacagaaaagatgaaaagagaaaagaaaaatggaagcatgctagagtgaaagaaagagagcacgaacgtcggaaacgacatcgagaagaacaggataaagctcgccgggaatgggaaagacagaagagaagggaaatggcaagggagcattccaggagagaaagggaccgcttggagcagttagaaaggaagcgggagcgggagcgcaagatgcgggagcagcagaaggagcagcgggagcagaaggagcgcgagcggcgggcggaggagcggcgcaaggagcgggaggcccgcagggaagtgtctgcacatcaccgaacgatgagagaggactacagcgacaaagtgaaagccagccactggagtcgcagcccgcctcggccgccgcgggagcggttcgagttgggagacggccggaagccagtaaaagaagagaaaatggaagaaagggacctgctgtccgacttacaggacatcagcgacagcgagaggaagaccagctcggccgagtcctcgtcagcggaatcaggctcaggttctgaggaagaagaggaggaggaggaagaggaggaggaggaagggagcaccagtgaagaatcagaggaggaggaggaggaagaggaagaggaggaggaggagaccggcagcaactctgaggaggcatcagagcagtctgccgaagaagtaagtgaggaagaaatgagtgaagatgaagaacgagaaaatgaaaaccacctcttggttgttccagagtcacggttcgaccgagattccggggagagtgaagaagcagaggaagaagtgggtgagggaacgccgcagagcagcgccctgacagagggcgactatgtgcccgactcccctgccctgttgcccatcgagctcaagcaggagctgcccaagtacctgccggccctgcagggctgccggagcgtcgaggagttccagtgcctgaacaggatcgaggagggcacctatggagtggtctacagagcaaaagacaagaaaacagatgaaattgtggctctaaagcggctgaagatggagaaggagaaggagggcttcccgatcacgtccctgagggagatcaacaccatcctcaaggcccagcatcccaacattgtcaccgttagagagattgtggtgggcagcaacatggacaagatctacatcgtgatgaactacgtggagcacgacctcaagagcctgatggagaccatgaaacagcccttcctgccaggggaggtgaagaccctgatgatccagctgctgcggggggtgaaacacctgcacgacaactggatcctgcaccgtgacctcaagacgtccaacctgctgctgagccacgccggcatcctcaaggtgggtgattttgggctggcgcgggagtacggatcccctctgaaggcctacaccccggtcgtggtgacccagtggtaccgcgccccagagctgctgcttggtgccaaggaatactccacggccgtggacatgtggtcagtgggctgcatcttcggggagctgctgactcagaagcctctgttccccgggaattcggaaatcgatcagatcaacaaagtgttcaaggagctggggacccccagtgagaaaatctggcccggctacagtgagctcccagtagtcaaaaagatgaccttcagcgagcacccctacaacaacctccgcaagcgcttcggggctctgctctcagaccagggcttcgacctcatgaacaagttcctgacctacttccccgggaggaggatcagcgctgaggacggcctcaagcatgagtatttccgcgagacccccctccccatcgacccctccatgttccccacgtggcccgccaagagcgagcagcagcgtgtgaagcggggcaccagcccgaggccccctgagggaggcctgggctacagccagctgggtgacgacgacctgaaggagacgggcttccaccttaccaccacgaaccagggggcctctgccgcgggccccggcttcagcctcaagttctgaaggtcagagtggaccccgtcatggggagaactcagccgggaccacaggcgtggctactgcggctggagctgcgatgagactcggaactcctcgtcttactttgtgctccatgttttgtttttgtattttggtttgtaaatttgtagaattaaatcattttccttgttgtggaggaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:728642 -> Molecular function: GO:0004672 [protein kinase activity] evidence: NAS
GeneID:728642 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:728642 -> Molecular function: GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] evidence: IEA
GeneID:728642 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
GeneID:728642 -> Biological process: GO:0001558 [regulation of cell growth] evidence: IEP
GeneID:728642 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: NAS
GeneID:728642 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:728642 -> Biological process: GO:0006915 [apoptotic process] evidence: NAS
GeneID:728642 -> Biological process: GO:0007067 [mitosis] evidence: NAS
GeneID:728642 -> Biological process: GO:0050684 [regulation of mRNA processing] evidence: IDA
GeneID:728642 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:728642 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_277071 -> EC 2.7.11.22
by
@meso_cacase at
DBCLS
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