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2024-03-28 23:01:46, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_033379               1752 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens cyclin-dependent kinase 1 (CDK1), transcript variant
            2, mRNA.
ACCESSION   NM_033379
VERSION     NM_033379.4  GI:281427276
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1752)
  AUTHORS   Kabuta,T., Mitsui,T., Takahashi,M., Fujiwara,Y., Kabuta,C.,
            Konya,C., Tsuchiya,Y., Hatanaka,Y., Uchida,K., Hohjoh,H. and
            Wada,K.
  TITLE     Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel
            potentiator of cyclin-dependent kinases to enhance cell
            proliferation independently of its hydrolase activity
  JOURNAL   J. Biol. Chem. 288 (18), 12615-12626 (2013)
   PUBMED   23543736
  REMARK    GeneRIF: UCH-L1 physically interacts with CDK1, CDK4, and CDK5,
            enhancing their kinase activity.
REFERENCE   2  (bases 1 to 1752)
  AUTHORS   Schofield,A.V., Gamell,C., Suryadinata,R., Sarcevic,B. and
            Bernard,O.
  TITLE     Tubulin polymerization promoting protein 1 (Tppp1) phosphorylation
            by Rho-associated coiled-coil kinase (rock) and cyclin-dependent
            kinase 1 (Cdk1) inhibits microtubule dynamics to increase cell
            proliferation
  JOURNAL   J. Biol. Chem. 288 (11), 7907-7917 (2013)
   PUBMED   23355470
  REMARK    GeneRIF: dual Rock and Cdk phosphorylation of Tppp1 inhibits its
            regulation of the cell cycle to increase cell proliferation
REFERENCE   3  (bases 1 to 1752)
  AUTHORS   Cho,H.J., Oh,Y.J., Han,S.H., Chung,H.J., Kim,C.H., Lee,N.S.,
            Kim,W.J., Choi,J.M. and Kim,H.
  TITLE     Cdk1 protein-mediated phosphorylation of receptor-associated
            protein 80 (RAP80) serine 677 modulates DNA damage-induced G2/M
            checkpoint and cell survival
  JOURNAL   J. Biol. Chem. 288 (6), 3768-3776 (2013)
   PUBMED   23264621
  REMARK    GeneRIF: post-translational phosphorylation of RAP80 by the
            Cdk1-cyclin B(1) complex is important for RAP80 functional
            sensitivity to IR and G(2)/M checkpoint control.
REFERENCE   4  (bases 1 to 1752)
  AUTHORS   Zhao,X.F., Zhao,M.Y., Chai,L., Kukuruga,D., Tan,M. and Stass,S.A.
  TITLE     Amplified RPS6KB1 and CDC2 genes are potential biomarkers for
            aggressive HIV+/EBV+ diffuse large B-cell lymphomas
  JOURNAL   Int J Clin Exp Pathol 6 (2), 148-154 (2013)
   PUBMED   23330000
  REMARK    GeneRIF: HIV+/EBV+ aggressive diffuse large B-cell lymphoma could
            be potentially treated by targeting RPS6KB1 and CDC2 genes.
REFERENCE   5  (bases 1 to 1752)
  AUTHORS   Parker,L.L. and Piwnica-Worms,H.
  TITLE     Inactivation of the p34cdc2-cyclin B complex by the human WEE1
            tyrosine kinase
  JOURNAL   Science 257 (5078), 1955-1957 (1992)
   PUBMED   1384126
REFERENCE   6  (bases 1 to 1752)
  AUTHORS   Koff,A., Giordano,A., Desai,D., Yamashita,K., Harper,J.W.,
            Elledge,S., Nishimoto,T., Morgan,D.O., Franza,B.R. and Roberts,J.M.
  TITLE     Formation and activation of a cyclin E-cdk2 complex during the G1
            phase of the human cell cycle
  JOURNAL   Science 257 (5077), 1689-1694 (1992)
   PUBMED   1388288
REFERENCE   7  (bases 1 to 1752)
  AUTHORS   Dutta,A. and Stillman,B.
  TITLE     cdc2 family kinases phosphorylate a human cell DNA replication
            factor, RPA, and activate DNA replication
  JOURNAL   EMBO J. 11 (6), 2189-2199 (1992)
   PUBMED   1318195
REFERENCE   8  (bases 1 to 1752)
  AUTHORS   Azzi,L., Meijer,L., Reed,S.I., Pidikiti,R. and Tung,H.Y.
  TITLE     Interaction between the cell-cycle-control proteins p34cdc2 and
            p9CKShs2. Evidence for two cooperative binding domains in p9CKShs2
  JOURNAL   Eur. J. Biochem. 203 (3), 353-360 (1992)
   PUBMED   1310466
REFERENCE   9  (bases 1 to 1752)
  AUTHORS   Nazarenko,S.A., Ostroverhova,N.V. and Spurr,N.K.
  TITLE     Regional assignment of the human cell cycle control gene CDC2 to
            chromosome 10q21 by in situ hybridization
  JOURNAL   Hum. Genet. 87 (5), 621-622 (1991)
   PUBMED   1916766
REFERENCE   10 (bases 1 to 1752)
  AUTHORS   Lee,M.G. and Nurse,P.
  TITLE     Complementation used to clone a human homologue of the fission
            yeast cell cycle control gene cdc2
  JOURNAL   Nature 327 (6117), 31-35 (1987)
   PUBMED   3553962
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG723076.1, AW976143.1,
            D88357.1, AC022390.9 and BC107750.1.
            On Dec 19, 2009 this sequence version replaced gi:195927039.
            
            Summary: The protein encoded by this gene is a member of the
            Ser/Thr protein kinase family. This protein is a catalytic subunit
            of the highly conserved protein kinase complex known as M-phase
            promoting factor (MPF), which is essential for G1/S and G2/M phase
            transitions of eukaryotic cell cycle. Mitotic cyclins stably
            associate with this protein and function as regulatory subunits.
            The kinase activity of this protein is controlled by cyclin
            accumulation and destruction through the cell cycle. The
            phosphorylation and dephosphorylation of this protein also play
            important regulatory roles in cell cycle control. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (2), also known as CDC2 delta T,
            lacks an alternate in-frame exon in the middle portion of the
            coding region, compared to variant 1. This results in a shorter
            protein (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW976143.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025084, ERS025085 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                BG723076.1         6-95
            91-131              AW976143.1         6-46
            132-894             D88357.1           17-779
            895-1606            AC022390.9         127006-127717
            1607-1752           BC107750.1         1764-1909
FEATURES             Location/Qualifiers
     source          1..1752
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.1"
     gene            1..1752
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /note="cyclin-dependent kinase 1"
                     /db_xref="GeneID:983"
                     /db_xref="HGNC:1722"
                     /db_xref="HPRD:00302"
                     /db_xref="MIM:116940"
     exon            1..117
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /inference="alignment:Splign:1.39.8"
     variation       59
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3213016"
     variation       60
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138297542"
     variation       67
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185105988"
     exon            118..179
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    134..136
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /note="upstream in-frame stop codon"
     variation       134
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3213028"
     CDS             143..865
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /EC_number="2.7.11.23"
                     /EC_number="2.7.11.22"
                     /note="isoform 2 is encoded by transcript variant 2; cell
                     division cycle 2, G1 to S and G2 to M; cell division
                     control protein 2 homolog; p34 protein kinase; cell cycle
                     controller CDC2; cell division protein kinase 1"
                     /codon_start=1
                     /product="cyclin-dependent kinase 1 isoform 2"
                     /protein_id="NP_203698.1"
                     /db_xref="GI:16306492"
                     /db_xref="CCDS:CCDS7260.1"
                     /db_xref="GeneID:983"
                     /db_xref="HGNC:1722"
                     /db_xref="HPRD:00302"
                     /db_xref="MIM:116940"
                     /translation="
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
"
     misc_feature    143..850
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /note="cyclin-dependent kinase A; Provisional; Region:
                     PLN00009"
                     /db_xref="CDD:177649"
     misc_feature    149..832
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /note="Protein Kinases, catalytic domain; Region:
                     PKc_like; cl09925"
                     /db_xref="CDD:214163"
     misc_feature    order(170..184,194..196,233..235,239..241,332..334,
                     380..391,398..400,404..406,464..475)
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /note="active site"
                     /db_xref="CDD:173623"
     misc_feature    order(170..184,194..196,233..235,239..241,332..334,
                     380..391,398..400)
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173623"
     misc_feature    order(182..184,398..400,404..406,464..475)
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173623"
     misc_feature    182..184
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="dephosphorylation site; modified site"
                     /db_xref="HPRD:01146"
     misc_feature    182..184
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:02659"
     misc_feature    182..184
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:03920"
     misc_feature    185..187
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="dephosphorylation site; modified site"
                     /db_xref="HPRD:01146"
     misc_feature    185..187
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01301"
     misc_feature    185..187
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:01907"
     misc_feature    197..199
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    197..199
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    197..199
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    197..199
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00302"
     misc_feature    197..199
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    257..259
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:00277"
     variation       177..178
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:67885060"
     exon            180..336
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /inference="alignment:Splign:1.39.8"
     variation       210
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111992007"
     variation       225
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377117179"
     variation       287
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142650572"
     variation       317
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:8755"
     exon            337..460
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /inference="alignment:Splign:1.39.8"
     variation       356
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11540347"
     variation       370
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148632129"
     variation       412
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144445383"
     variation       413
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147689519"
     variation       439
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373485880"
     variation       440
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374332309"
     exon            461..624
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /inference="alignment:Splign:1.39.8"
     variation       503..504
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:67045639"
     variation       510
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45540532"
     variation       547
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371079846"
     STS             554..737
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /standard_name="ksks369"
                     /db_xref="UniSTS:514418"
     variation       613
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189255717"
     STS             618..759
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /standard_name="RH71273"
                     /db_xref="UniSTS:82900"
     exon            625..766
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /inference="alignment:Splign:1.39.8"
     variation       658
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370173780"
     variation       672
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373718394"
     variation       698..699
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:66768032"
     variation       722
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:113211927"
     variation       727
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367855803"
     variation       754
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371690253"
     exon            767..1742
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /inference="alignment:Splign:1.39.8"
     variation       794
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:202147652"
     variation       798
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142476851"
     variation       807
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35671174"
     variation       833
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11540348"
     variation       895
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1871446"
     variation       902
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372993738"
     polyA_signal    1091..1096
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
     polyA_site      1129
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
     variation       1224
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149799948"
     variation       1315
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:145740622"
     variation       1412..1414
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace=""
                     /replace="agg"
                     /db_xref="dbSNP:71908653"
     variation       1414..1416
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace=""
                     /replace="gag"
                     /db_xref="dbSNP:3213084"
     variation       1414
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200697170"
     variation       1442
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189563607"
     STS             1489..1625
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /standard_name="SHGC-57924"
                     /db_xref="UniSTS:67283"
     variation       1491
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181893967"
     variation       1606
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:10711"
     variation       1632
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1060373"
     polyA_signal    1722..1727
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
     polyA_site      1742
                     /gene="CDK1"
                     /gene_synonym="CDC2; CDC28A; P34CDC2"
ORIGIN      
agcgcggtgagtttgaaactgctcgcacttggcttcaaagctggctcttggaaattgagcggagagcgacgcggttgttgtagctgccgctgcggccgccgcggaataataagccgggatctaccatacccattgactaactatggaagattataccaaaatagagaaaattggagaaggtacctatggagttgtgtataagggtagacacaaaactacaggtcaagtggtagccatgaaaaaaatcagactagaaagtgaagaggaaggggttcctagtactgcaattcgggaaatttctctattaaaggaacttcgtcatccaaatatagtcagtcttcaggatgtgcttatgcaggattccaggttatatctcatctttgagtttctttccatggatctgaagaaatacttggattctatccctcctggtcagtacatggattcttcacttgttaaggtagtaacactctggtacagatctccagaagtattgctggggtcagctcgttactcaactccagttgacatttggagtataggcaccatatttgctgaactagcaactaagaaaccacttttccatggggattcagaaattgatcaactcttcaggattttcagagctttgggcactcccaataatgaagtgtggccagaagtggaatctttacaggactataagaatacatttcccaaatggaaaccaggaagcctagcatcccatgtcaaaaacttggatgaaaatggcttggatttgctctcgaaaatgttaatctatgatccagccaaacgaatttctggcaaaatggcactgaatcatccatattttaatgatttggacaatcagattaagaagatgtagctttctgacaaaaagtttccatatgttatatcaacagatagttgtgtttttattgttaactcttgtctatttttgtcttatatatatttctttgttatcaaacttcagctgtacttcgtcttctaatttcaaaaatataacttaaaaatgtaaatattctatatgaatttaaatataattctgtaaatgtgtgtaggtctcactgtaacaactatttgttactataataaaactataatattgatgtcaggaatcaggaaaaaatttgagttggcttaaatcatctcagtccttatggcagttttattttcctgtagttggaactactaaaatttaggaaaatgctaagttcaagtttcgtaatgctttgaagtatttttatgctctgaatgtttaaatgttctcatcagtttcttgccatgttgttaactatacaacctggctaaagatgaatatttttctactggtattttaatttttgacctaaatgtttaagcattcggaatgagaaaactatacagatttgagaaatgatgctaaatttataggagttttcagtaacttaaaaagctaacatgagagcatgccaaaatttgctaagtcttacaaagatcaagggctgtccgcaacagggaagaacagttttgaaaatttatgaactatcttatttttaggtaggttttgaaagctttttgtctaagtgaattcttatgccttggtcagagtaataactgaaggagttgcttatcttggctttcgagtctgagtttaaaactacacattttgacatagtgtttattagcagccatctaaaaaggctctaatgtatatttaactaaaattactagctttgggaattaaactgtttaacaaataaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:983 -> Molecular function: GO:0004672 [protein kinase activity] evidence: NAS
            GeneID:983 -> Molecular function: GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] evidence: IDA
            GeneID:983 -> Molecular function: GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] evidence: TAS
            GeneID:983 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:983 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:983 -> Molecular function: GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity] evidence: IDA
            GeneID:983 -> Molecular function: GO:0030332 [cyclin binding] evidence: IEA
            GeneID:983 -> Molecular function: GO:0030544 [Hsp70 protein binding] evidence: IEA
            GeneID:983 -> Molecular function: GO:0035173 [histone kinase activity] evidence: IEA
            GeneID:983 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
            GeneID:983 -> Biological process: GO:0000083 [regulation of transcription involved in G1/S phase of mitotic cell cycle] evidence: TAS
            GeneID:983 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: TAS
            GeneID:983 -> Biological process: GO:0000165 [MAPK cascade] evidence: TAS
            GeneID:983 -> Biological process: GO:0000186 [activation of MAPKK activity] evidence: TAS
            GeneID:983 -> Biological process: GO:0000187 [activation of MAPK activity] evidence: TAS
            GeneID:983 -> Biological process: GO:0000226 [microtubule cytoskeleton organization] evidence: TAS
            GeneID:983 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:983 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0006260 [DNA replication] evidence: TAS
            GeneID:983 -> Biological process: GO:0006281 [DNA repair] evidence: TAS
            GeneID:983 -> Biological process: GO:0006461 [protein complex assembly] evidence: IEA
            GeneID:983 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:983 -> Biological process: GO:0007067 [mitosis] evidence: IEA
            GeneID:983 -> Biological process: GO:0007077 [mitotic nuclear envelope disassembly] evidence: TAS
            GeneID:983 -> Biological process: GO:0007095 [mitotic G2 DNA damage checkpoint] evidence: IEA
            GeneID:983 -> Biological process: GO:0007098 [centrosome cycle] evidence: TAS
            GeneID:983 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0007264 [small GTPase mediated signal transduction] evidence: TAS
            GeneID:983 -> Biological process: GO:0007265 [Ras protein signal transduction] evidence: TAS
            GeneID:983 -> Biological process: GO:0007344 [pronuclear fusion] evidence: TAS
            GeneID:983 -> Biological process: GO:0007411 [axon guidance] evidence: TAS
            GeneID:983 -> Biological process: GO:0007569 [cell aging] evidence: IEA
            GeneID:983 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0009636 [response to toxic substance] evidence: IEA
            GeneID:983 -> Biological process: GO:0010628 [positive regulation of gene expression] evidence: IEA
            GeneID:983 -> Biological process: GO:0014038 [regulation of Schwann cell differentiation] evidence: TAS
            GeneID:983 -> Biological process: GO:0014070 [response to organic cyclic compound] evidence: IEA
            GeneID:983 -> Biological process: GO:0014075 [response to amine stimulus] evidence: IEA
            GeneID:983 -> Biological process: GO:0014823 [response to activity] evidence: IEA
            GeneID:983 -> Biological process: GO:0016477 [cell migration] evidence: TAS
            GeneID:983 -> Biological process: GO:0030261 [chromosome condensation] evidence: IEA
            GeneID:983 -> Biological process: GO:0031100 [organ regeneration] evidence: IEA
            GeneID:983 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
            GeneID:983 -> Biological process: GO:0033160 [positive regulation of protein import into nucleus, translocation] evidence: IEA
            GeneID:983 -> Biological process: GO:0034134 [toll-like receptor 2 signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0034146 [toll-like receptor 5 signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0034162 [toll-like receptor 9 signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0034166 [toll-like receptor 10 signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0034501 [protein localization to kinetochore] evidence: IDA
            GeneID:983 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0042493 [response to drug] evidence: IEA
            GeneID:983 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
            GeneID:983 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:983 -> Biological process: GO:0045471 [response to ethanol] evidence: IEA
            GeneID:983 -> Biological process: GO:0045740 [positive regulation of DNA replication] evidence: IEA
            GeneID:983 -> Biological process: GO:0045931 [positive regulation of mitotic cell cycle] evidence: IEA
            GeneID:983 -> Biological process: GO:0045995 [regulation of embryonic development] evidence: TAS
            GeneID:983 -> Biological process: GO:0046686 [response to cadmium ion] evidence: IEA
            GeneID:983 -> Biological process: GO:0046688 [response to copper ion] evidence: IEA
            GeneID:983 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
            GeneID:983 -> Biological process: GO:0048678 [response to axon injury] evidence: IEA
            GeneID:983 -> Biological process: GO:0051301 [cell division] evidence: IEA
            GeneID:983 -> Biological process: GO:0051403 [stress-activated MAPK cascade] evidence: TAS
            GeneID:983 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:983 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:983 -> Biological process: GO:0055015 [ventricular cardiac muscle cell development] evidence: IEA
            GeneID:983 -> Biological process: GO:0060045 [positive regulation of cardiac muscle cell proliferation] evidence: IEA
            GeneID:983 -> Biological process: GO:0070301 [cellular response to hydrogen peroxide] evidence: IEA
            GeneID:983 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:983 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:983 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:983 -> Cellular component: GO:0005739 [mitochondrion] evidence: TAS
            GeneID:983 -> Cellular component: GO:0005815 [microtubule organizing center] evidence: IEA
            GeneID:983 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:983 -> Cellular component: GO:0005876 [spindle microtubule] evidence: IDA
            GeneID:983 -> Cellular component: GO:0030496 [midbody] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_203698 -> EC 2.7.11.22
            NP_203698 -> EC 2.7.11.23

by @meso_cacase at DBCLS
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