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2024-04-20 08:38:57, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_033027 3188 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens cysteine-serine-rich nuclear protein 1 (CSRNP1), mRNA.
ACCESSION NM_033027
VERSION NM_033027.3 GI:224593753
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3188)
AUTHORS Gingras,S., Pelletier,S., Boyd,K. and Ihle,J.N.
TITLE Characterization of a family of novel cysteine- serine-rich nuclear
proteins (CSRNP)
JOURNAL PLoS ONE 2 (8), E808 (2007)
PUBMED 17726538
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 3188)
AUTHORS Ishiguro,H., Tsunoda,T., Tanaka,T., Fujii,Y., Nakamura,Y. and
Furukawa,Y.
TITLE Identification of AXUD1, a novel human gene induced by AXIN1 and
its reduced expression in human carcinomas of the lung, liver,
colon and kidney
JOURNAL Oncogene 20 (36), 5062-5066 (2001)
PUBMED 11526492
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC092053.3.
On Mar 6, 2009 this sequence version replaced gi:17136074.
Summary: This gene encodes a protein that localizes to the nucleus
and expression of this gene is induced in response to elevated
levels of axin. The Wnt signalling pathway, which is negatively
regulated by axin, is important in axis formation in early
development and impaired regulation of this signalling pathway is
often involved in tumors. A decreased level of expression of this
gene in tumors compared to the level of expression in their
corresponding normal tissues suggests that this gene product has a
tumor suppressor function. [provided by RefSeq, Jul 2008].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: AB053121.1, BC038949.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-174 AC092053.3 141551-141724
175-419 AC092053.3 148440-148684
420-679 AC092053.3 149906-150165
680-994 AC092053.3 150711-151025
995-3188 AC092053.3 151118-153311
FEATURES Location/Qualifiers
source 1..3188
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p22"
gene 1..3188
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
/note="cysteine-serine-rich nuclear protein 1"
/db_xref="GeneID:64651"
/db_xref="HGNC:14300"
/db_xref="MIM:606458"
exon 1..174
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
/inference="alignment:Splign:1.39.8"
exon 175..419
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
/inference="alignment:Splign:1.39.8"
CDS 215..1984
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
/note="AXIN1 up-regulated 1; TGF-beta induced apoptosis
protein 3; axin-1 up-regulated gene 1 protein;
TGF-beta-induced apoptosis protein 3"
/codon_start=1
/product="cysteine/serine-rich nuclear protein 1"
/protein_id="NP_149016.2"
/db_xref="GI:224593754"
/db_xref="CCDS:CCDS2682.1"
/db_xref="GeneID:64651"
/db_xref="HGNC:14300"
/db_xref="MIM:606458"
/translation="
MTGLLKRKFDQLDEDNSSVSSSSSSSGCQSRSCSPSSSVSRAWDSEEEGPWDQMPLPDRDFCGPRSFTPLSILKRARRERPGRVAFDGITVFYFPRCQGFTSVPSRGGCTLGMALRHSACRRFSLAEFAQEQARARHEKLRQRLKEEKLEMLQWKLSAAGVPQAEAGLPPVVDAIDDASVEEDLAVAVAGGRLEEVSFLQPYPARRRRALLRASGVRRIDREEKRELQALRQSREDCGCHCDRICDPETCSCSLAGIKCQMDHTAFPCGCCREGCENPMGRVEFNQARVQTHFIHTLTRLQLEQEAESFRELEAPAQGSPPSPGEEALVPTFPLAKPPMNNELGDNSCSSDMTDSSTASSSASGTSEAPDCPTHPGLPGPGFQPGVDDDSLARILSFSDSDFGGEEEEEEEGSVGNLDNLSCFHPADIFGTSDPGGLASWTHSYSGCSFTSGVLDENANLDASCFLNGGLEGSREGSLPGTSVPPSMDAGRSSSVDLSLSSCDSFELLQALPDYSLGPHYTSQKVSDSLDNIEAPHFPLPGLSPPGDASSCFLESLMGFSEPAAEALDPFIDSQFEDTVPASLMEPVPV
"
exon 420..679
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
/inference="alignment:Splign:1.39.8"
variation 439
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:784517"
exon 680..994
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
/inference="alignment:Splign:1.39.8"
exon 995..3188
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
/inference="alignment:Splign:1.39.8"
variation 1282
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
/replace="c"
/replace="t"
/db_xref="dbSNP:784519"
variation 1453
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1274957"
variation 1571
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1274958"
variation 2177
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
/replace="a"
/replace="g"
/db_xref="dbSNP:704960"
STS 2249..2399
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
/standard_name="SHGC-76832"
/db_xref="UniSTS:76949"
variation 2635
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
/replace="c"
/replace="t"
/db_xref="dbSNP:784501"
STS 2899..3132
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
/standard_name="RH80080"
/db_xref="UniSTS:86336"
STS 2954..3166
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
/standard_name="D3S3824"
/db_xref="UniSTS:21259"
polyA_signal 3164..3169
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
polyA_site 3184
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
polyA_site 3188
/gene="CSRNP1"
/gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
ORIGIN
gggcggggctgggcgcaggcagtctcccgccgccgccgccgctgccggacgcgcagagcgaggggcggctggaccgacggctgccgggccgagcgcacagagtcgcggcgcagggggcgtccccggccgggacgcgggtcgcgtcgttgtcctccgcgagcgtccggattgcaggctgtctgtccccagaccccagagcacgtccggcaccaccatgactgggctgttgaagaggaaatttgaccagctggatgaggacaactcctcggtctcctcctcctcctcttcctctgggtgccagtctcgctcctgctccccaagctcttctgtctcccgtgcctgggactcagaggaggaaggcccctgggatcagatgcccctgcctgaccgtgacttctgcggccccagaagtttcacccccctgtctatcctgaagcgggctcgccgggagcgcccaggccgtgtagcctttgatgggatcaccgtcttctacttcccccgctgccagggcttcaccagtgtgcccagccgtggtggctgtactctgggtatggcccttcgccacagtgcttgccgtcgcttctctttggctgagtttgcgcaggagcaagcccgtgcacggcacgagaagctccgccagcgcttgaaagaggagaagttggagatgctgcagtggaagctttcggcagctggggtaccccaggcagaggcagggctgccacctgtggtggatgccattgatgacgcctctgtggaggaggacttggcagtcgctgtggcaggtggccggttggaagaagtgagcttcctacagccctacccagcccggcgacgtcgagctctgctgagggcttcaggtgtgcgaaggatcgatcgggaggagaagcgggagctgcaggcactgcgccaatcccgggaggattgtggctgtcactgcgataggatctgcgaccctgagacctgcagctgcagcctggcaggcatcaagtgccagatggaccacacagcattcccctgtggctgctgcagggagggctgtgagaaccccatgggccgtgtggaatttaatcaggcaagagttcagacccatttcatccacacactcacccgcctgcagttggaacaggaggctgagagctttagggagctggaggcccctgcccagggcagcccacccagccctggtgaggaggccctggtccctactttcccactggccaagccccccatgaacaatgagctgggagacaacagctgcagcagcgacatgactgattcttctacagcatcttcatcagcatcgggcactagtgaggctcctgactgccccacccacccaggcctgcctggccctggcttccagcctggcgttgatgatgacagcctggcacgcatcttgagtttcagtgactctgacttcggtggggaggaggaggaagaggaggaagggagcgtggggaacctggacaacctcagctgcttccatccagctgacatctttggtactagtgaccctggtggcctggccagctggacccacagctattctggctgtagcttcacatcaggcgtcctggatgagaatgccaacctggatgccagctgcttcctaaatggtggccttgaagggtcaagggaaggcagccttcctggcacctcagtgccacccagcatggacgctggccggagtagctcagtggatctcagcttgtcttcttgtgactcctttgagttactccaggctctgccagattatagtctggggcctcactacacatcacagaaggtgtctgacagcctggacaacatcgaggcacctcacttccccctgcctggcctgtctccacctggggatgccagcagttgcttcctggagtccctcatgggcttctccgagccagccgccgaagccctagatccctttattgacagccagtttgaggacactgtcccagcatctctaatggagcctgtgccggtgtgaggaccaggatgtcttttcccagccccaagagacctgttgctgctttcttgtaattatggggctccccagagtctgcgtaacagtctcccactggctggctcacccacaggtgccatgtgcacactcctggttttcaaacaattctctggatttatttatttgttttaacttttctgtgctgaagagaggactggggggagggggcttcccctttcagctgcccggccccccacacccacagcttgctcttctatctccacaacgtgagcctggaagaggagaaaatgtggctcctctggagcttggcagaccacttttcggtctttgcgtgatgttccttagcccaaagacggtgagacagggctgaaatcaggtggcttctgccaccctgagccctagacccatgggtggctaaatccactggactgtgaagactataatttatttccataatttatttggagattgaggaggctttggttgcacttctttggctggtgggtaatgccaggggtggggtgggcacaggccctcaagagccccttttgccttgtagtcctacaccttgccctgcctgggctttggtgcagactaggtgtggatttgagctctgtgatctatgtctgctgcctggctcctagatggctctgtgggcaggtgctggccaaggacatcatctaggcagggggagagcctgggctgaacagctgtgaccaaaactcccttctgccccaccctgccccctccacttcctgccctctgttccatcttcccccttcccaaaggccacagcctttattccaggcccagggatgtaggagggggaaggaggaaacaggaagcccagagagggcaaagggcctacctcggggcgcgaaccatgccccagactattatctcagggctttctgggcactgcacttcagcgtggcccacctgcccatgccctgaggccagttggcgaggggtggctcctgagggtttttataccctttgtttgctaatgtttaattttgcatcataatttctacattgtccctgagtgtcagaactataatttattccatttctctctgtgtctgtgccaagaaacgcaggctctgggcctgccccttgcccaggaggccttgccagcctgtgtgcttgtgggaacaccttgtacctgagcttacaggtaccaataaagaggctttatttttagcaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:64651 -> Molecular function: GO:0003674 [molecular_function] evidence: ND
GeneID:64651 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:64651 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: ISS
GeneID:64651 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:64651 -> Biological process: GO:0006915 [apoptotic process] evidence: NAS
GeneID:64651 -> Biological process: GO:0009791 [post-embryonic development] evidence: IEA
GeneID:64651 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: ISS
GeneID:64651 -> Biological process: GO:0048008 [platelet-derived growth factor receptor signaling pathway] evidence: IEA
GeneID:64651 -> Biological process: GO:0048705 [skeletal system morphogenesis] evidence: IEA
GeneID:64651 -> Biological process: GO:0060021 [palate development] evidence: IEA
GeneID:64651 -> Biological process: GO:0060325 [face morphogenesis] evidence: IEA
GeneID:64651 -> Cellular component: GO:0005575 [cellular_component] evidence: ND
GeneID:64651 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:64651 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
GeneID:64651 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
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