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2024-04-20 10:30:24, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_032991 2522 bp mRNA linear PRI 07-JUL-2013
DEFINITION Homo sapiens caspase 3, apoptosis-related cysteine peptidase
(CASP3), transcript variant beta, mRNA.
ACCESSION NM_032991
VERSION NM_032991.2 GI:73622122
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2522)
AUTHORS Li,Y., Zhao,Y., Cheng,Z., Zhan,J., Sun,X., Qian,H., Zhu,W. and
Xu,W.
TITLE Mesenchymal stem cell-like cells from children foreskin inhibit the
growth of SGC-7901 gastric cancer cells
JOURNAL Exp. Mol. Pathol. 94 (3), 430-437 (2013)
PUBMED 23421973
REMARK GeneRIF: Human mesenchymal stem cell-like cells from foreskin
derived conditioned medium inhibited the expression of BCL-2 while
increased the expression of BAX and caspase-3 in gastric cancer
cells.
REFERENCE 2 (bases 1 to 2522)
AUTHORS Wu,B., Yao,H., Wang,S. and Xu,R.
TITLE DAPK1 modulates a curcumin-induced G2/M arrest and apoptosis by
regulating STAT3, NF-kappaB, and caspase-3 activation
JOURNAL Biochem. Biophys. Res. Commun. 434 (1), 75-80 (2013)
PUBMED 23545262
REMARK GeneRIF: Knockdown of DAPK1 attenuates curcumin-induced inhibition
of STAT3 and NF-kappaB. Moreover, DAPK1 suppression diminishes
curcumin-induced caspase-3 activation.
REFERENCE 3 (bases 1 to 2522)
AUTHORS Datta,D., McClendon,C.L., Jacobson,M.P. and Wells,J.A.
TITLE Substrate and inhibitor-induced dimerization and cooperativity in
caspase-1 but not caspase-3
JOURNAL J. Biol. Chem. 288 (14), 9971-9981 (2013)
PUBMED 23386603
REMARK GeneRIF: Substrate and inhibitor-induced dimerization and
cooperativity in caspase-1 but not caspase-3
REFERENCE 4 (bases 1 to 2522)
AUTHORS Guan,X., Liu,Z., Liu,H., Yu,H., Wang,L.E., Sturgis,E.M., Li,G. and
Wei,Q.
TITLE A functional variant at the miR-885-5p binding site of CASP3
confers risk of both index and second primary malignancies in
patients with head and neck cancer
JOURNAL FASEB J. 27 (4), 1404-1412 (2013)
PUBMED 23271051
REMARK GeneRIF: miR-885-5p binding site rs1049253T>C SNP in the 3'-UTR of
CASP3 modulates CASP3 expression at both mRNA and protein levels
and thus contributes to squamous cell carcinoma of the head and
neck susceptibility.
REFERENCE 5 (bases 1 to 2522)
AUTHORS Park,S.H., Kim,M.K. and Lee,C.H.
TITLE Up-regulation of p27Kip1 protects hES cells from
differentiation-associated and caspase 3-dependent apoptosis
JOURNAL J. Microbiol. Biotechnol. 22 (12), 1790-1794 (2012)
PUBMED 23221544
REMARK GeneRIF: Results show p27Kip1 and cyclin D3 are strongly associated
with cellular differentiation, and, for the first time, show that
up-regulation of p27Kip1 protects hES cells from inducing
differentiation-associated and caspase 3-dependent apoptosis.
REFERENCE 6 (bases 1 to 2522)
AUTHORS Nicholson,D.W., Ali,A., Thornberry,N.A., Vaillancourt,J.P.,
Ding,C.K., Gallant,M., Gareau,Y., Griffin,P.R., Labelle,M.,
Lazebnik,Y.A. et al.
TITLE Identification and inhibition of the ICE/CED-3 protease necessary
for mammalian apoptosis
JOURNAL Nature 376 (6535), 37-43 (1995)
PUBMED 7596430
REFERENCE 7 (bases 1 to 2522)
AUTHORS Tewari,M., Quan,L.T., O'Rourke,K., Desnoyers,S., Zeng,Z.,
Beidler,D.R., Poirier,G.G., Salvesen,G.S. and Dixit,V.M.
TITLE Yama/CPP32 beta, a mammalian homolog of CED-3, is a
CrmA-inhibitable protease that cleaves the death substrate
poly(ADP-ribose) polymerase
JOURNAL Cell 81 (5), 801-809 (1995)
PUBMED 7774019
REFERENCE 8 (bases 1 to 2522)
AUTHORS Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S.
TITLE CPP32, a novel human apoptotic protein with homology to
Caenorhabditis elegans cell death protein Ced-3 and mammalian
interleukin-1 beta-converting enzyme
JOURNAL J. Biol. Chem. 269 (49), 30761-30764 (1994)
PUBMED 7983002
REFERENCE 9 (bases 1 to 2522)
AUTHORS Walker,N.P., Talanian,R.V., Brady,K.D., Dang,L.C., Bump,N.J.,
Ferenz,C.R., Franklin,S., Ghayur,T., Hackett,M.C., Hammill,L.D. et
al.
TITLE Crystal structure of the cysteine protease interleukin-1
beta-converting enzyme: a (p20/p10)2 homodimer
JOURNAL Cell 78 (2), 343-352 (1994)
PUBMED 8044845
REFERENCE 10 (bases 1 to 2522)
AUTHORS Kopp,S.
TITLE Reproducibility of response to a questionnaire on symptoms of
masticatory dysfunction
JOURNAL Community Dent Oral Epidemiol 4 (5), 205-209 (1976)
PUBMED 1067155
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AU127028.1, BC016926.2 and
BU753483.1.
On Aug 19, 2005 this sequence version replaced gi:14790114.
Summary: This gene encodes a protein which is a member of the
cysteine-aspartic acid protease (caspase) family. Sequential
activation of caspases plays a central role in the execution-phase
of cell apoptosis. Caspases exist as inactive proenzymes which
undergo proteolytic processing at conserved aspartic residues to
produce two subunits, large and small, that dimerize to form the
active enzyme. This protein cleaves and activates caspases 6, 7 and
9, and the protein itself is processed by caspases 8, 9 and 10. It
is the predominant caspase involved in the cleavage of amyloid-beta
4A precursor protein, which is associated with neuronal death in
Alzheimer's disease. Alternative splicing of this gene results in
two transcript variants that encode the same protein. [provided by
RefSeq, Jul 2008].
Transcript Variant: This variant (beta) differs in the 5' UTR,
compared to variant alpha.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AU127028.1, BM800636.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-453 AU127028.1 1-453
454-2346 BC016926.2 573-2465
2347-2522 BU753483.1 1-176 c
FEATURES Location/Qualifiers
source 1..2522
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q34"
gene 1..2522
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/note="caspase 3, apoptosis-related cysteine peptidase"
/db_xref="GeneID:836"
/db_xref="HGNC:1504"
/db_xref="HPRD:02799"
/db_xref="MIM:600636"
exon 1..81
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/inference="alignment:Splign:1.39.8"
misc_feature 76..78
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/note="upstream in-frame stop codon"
exon 82..149
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/inference="alignment:Splign:1.39.8"
CDS 97..930
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/EC_number="3.4.22.56"
/note="caspase 3, apoptosis-related cysteine protease;
PARP cleavage protease; cysteine protease CPP32; SREBP
cleavage activity 1; caspase-3; procaspase3; apopain;
CASP-3; CPP-32; protein Yama"
/codon_start=1
/product="caspase-3 preproprotein"
/protein_id="NP_116786.1"
/db_xref="GI:14790115"
/db_xref="CCDS:CCDS3836.1"
/db_xref="GeneID:836"
/db_xref="HGNC:1504"
/db_xref="HPRD:02799"
/db_xref="MIM:600636"
/translation="
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
"
misc_feature 121..123
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:03458"
misc_feature 121..123
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:04047"
misc_feature 172..174
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
mat_peptide 181..621
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/product="caspase-3 p17 subunit"
misc_feature 205..921
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/note="Caspase, interleukin-1 beta converting enzyme (ICE)
homologues; Cysteine-dependent aspartate-directed
proteases that mediate programmed cell death (apoptosis).
Caspases are synthesized as inactive zymogens and
activated by proteolysis of the peptide...; Region: CASc;
cd00032"
/db_xref="CDD:28914"
misc_feature order(286..288,460..462,577..579,598..600,706..723,
733..738)
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/note="substrate pocket [chemical binding]; other site"
/db_xref="CDD:28914"
misc_feature order(457..459,583..585)
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/note="active site"
/db_xref="CDD:28914"
misc_feature 583..585
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/experiment="experimental evidence, no additional details
recorded"
/note="S-nitrosylation site; modified site"
misc_feature 583..585
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/experiment="experimental evidence, no additional details
recorded"
/note="S-nitrosocysteine, in inhibited form; propagated
from UniProtKB/Swiss-Prot (P42574.2); nitrosylation site"
misc_feature order(601..603,661..666,685..687,694..696,703..705,
772..774,796..798,814..816,874..876,889..894,898..900,
907..912)
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:28914"
misc_feature order(604..606,658..660)
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/note="proteolytic cleavage site; other site"
/db_xref="CDD:28914"
misc_feature 619..621
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:03459"
misc_feature 619..621
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:04047"
misc_feature 619..621
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:00476"
misc_feature 619..621
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:03321"
mat_peptide 622..927
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/product="caspase-3 p12 subunit"
exon 150..274
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/inference="alignment:Splign:1.39.8"
variation 161
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35578277"
variation 168
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35566035"
exon 275..403
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/inference="alignment:Splign:1.39.8"
exon 404..579
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/inference="alignment:Splign:1.39.8"
STS 415..628
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/standard_name="Casp3"
/db_xref="UniSTS:259200"
exon 580..700
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/inference="alignment:Splign:1.39.8"
variation 666
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/replace="g"
/replace="t"
/db_xref="dbSNP:1049210"
exon 701..2506
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/inference="alignment:Splign:1.39.8"
STS 707..904
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/standard_name="SHGC-67239"
/db_xref="UniSTS:91423"
STS 1193..1302
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/standard_name="D4S3281"
/db_xref="UniSTS:28167"
variation 1210
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/replace="a"
/replace="c"
/db_xref="dbSNP:34309992"
variation 1234
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/replace="a"
/replace="c"
/db_xref="dbSNP:4647694"
variation 1267
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1049216"
variation 1404
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:4647695"
STS 1444..1635
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/standard_name="G10724"
/db_xref="UniSTS:63374"
variation 1498..1499
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/replace=""
/replace="aat"
/db_xref="dbSNP:4647696"
variation 1918
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/replace="c"
/replace="g"
/db_xref="dbSNP:4647697"
variation 2139
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:4647698"
STS 2188..2299
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/standard_name="G62021"
/db_xref="UniSTS:139104"
variation 2198
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:4647699"
variation 2226
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/replace="a"
/replace="c"
/db_xref="dbSNP:6948"
STS 2286..2387
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/standard_name="SHGC-59603"
/db_xref="UniSTS:61364"
variation 2348
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/replace="a"
/replace="g"
/db_xref="dbSNP:8549"
variation 2383
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/replace="a"
/replace="c"
/db_xref="dbSNP:1802667"
variation 2405
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
/replace="c"
/replace="t"
/db_xref="dbSNP:1049253"
polyA_site 2506
/gene="CASP3"
/gene_synonym="CPP32; CPP32B; SCA-1"
ORIGIN
acatctcccggcggcgggccgcggaagcagtgcagacgcggctcctagcggatgggtgctattgtgaggcggttgtagaagttaataaaggtatccatggagaacactgaaaactcagtggattcaaaatccattaaaaatttggaaccaaagatcatacatggaagcgaatcaatggactctggaatatccctggacaacagttataaaatggattatcctgagatgggtttatgtataataattaataataagaattttcataaaagcactggaatgacatctcggtctggtacagatgtcgatgcagcaaacctcagggaaacattcagaaacttgaaatatgaagtcaggaataaaaatgatcttacacgtgaagaaattgtggaattgatgcgtgatgtttctaaagaagatcacagcaaaaggagcagttttgtttgtgtgcttctgagccatggtgaagaaggaataatttttggaacaaatggacctgttgacctgaaaaaaataacaaactttttcagaggggatcgttgtagaagtctaactggaaaacccaaacttttcattattcaggcctgccgtggtacagaactggactgtggcattgagacagacagtggtgttgatgatgacatggcgtgtcataaaataccagtggaggccgacttcttgtatgcatactccacagcacctggttattattcttggcgaaattcaaaggatggctcctggttcatccagtcgctttgtgccatgctgaaacagtatgccgacaagcttgaatttatgcacattcttacccgggttaaccgaaaggtggcaacagaatttgagtccttttcctttgacgctacttttcatgcaaagaaacagattccatgtattgtttccatgctcacaaaagaactctatttttatcactaaagaaatggttggttggtggttttttttagtttgtatgccaagtgagaagatggtatatttggtactgtatttccctctcattttgacctactctcatgctgcagagggtactttaagacatactccttccatcaaatagaaccactatgaagctacctcaaacttccagtcaggtagttgcaattgaattaaattaggaataaataaaaatggatactggtgcagtcattatgagaggcaatgattgttaatttacagctttcatgattagcaagttacagtgatgctgtgctatgaattttcaagtaattgtgaaaaagttaaacattgaagtaatgaatttttatgatattccccccacttaagactgtgtattctagttttgtcaaactgtagaaatgatgatgtggaagaacttaggcatctgtgggcatggtcaaaggctcaaacctttattttagaattgatatacacggatgacttaactgcatttttagaccatttatctgggattatggttttgtgatgtttgtcctgaacacttttgttgtaaaaaaataataataatgtttaatattgagaaagaaactaatattttatgtgagagaaagtgtgagcaaactaacttgacttttaaggctaaaacttaacattcatagaggggtggagttttaactgtaaggtgctacaatgcccctggatctaccagcataaatatcttctgatttgtccctatgcatatcagttgagcttcatataccagcaatatatctgaagagctattatataaaaaccccaaactgttgattattagccaggtaatgtgaataaattctataggaacatatgaaaatacaacttaaataataaacagtggaatataaggaaagcaataaatgaatgggctgagctgcctgtaacttgagagtagatggtttgagcctgagcagagacatgactcagcctgttccatgaaggcagagccatggaccacgcaggaagggcctacagcccatttctccatacgcactggtatgtgtggatgatgctgccagggcgccatcgccaagtaagaaagtgaagcaaatcagaaacttgtgaagtggaaatgttctaaaggtggtgaggcaataaaaatcatagtactctttgtagcaaaattcttaagtatgttattttctgttgaagtttacaatcaaaggaaaatagtaatgttttatactgtttactgaaagaaaaagacctatgagcacataggactctagacggcatccagccggaggccagagctgagccctcagcccgggaggcaggctccaggcctcagcaggtgcggagccgtcactgcaccaagtctcactggctgtcagtatgacatttcacgggagatttcttgttgctcaaaaaatgagctcgcatttgtcaatgacagtttcttttttcttactagacctgtaacttttgtaaatacacatagcatgtaatggtatcttaaagtgtgtttctatgtgacaattttgtacaaatttgttattttccatttttatttcaaaatatacattcaaacttaaaattaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:836 -> Molecular function: GO:0004190 [aspartic-type endopeptidase activity] evidence: EXP
GeneID:836 -> Molecular function: GO:0004197 [cysteine-type endopeptidase activity] evidence: IDA
GeneID:836 -> Molecular function: GO:0004197 [cysteine-type endopeptidase activity] evidence: TAS
GeneID:836 -> Molecular function: GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] evidence: IEA
GeneID:836 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:836 -> Molecular function: GO:0008233 [peptidase activity] evidence: IDA
GeneID:836 -> Biological process: GO:0001782 [B cell homeostasis] evidence: IEA
GeneID:836 -> Biological process: GO:0001836 [release of cytochrome c from mitochondria] evidence: IEA
GeneID:836 -> Biological process: GO:0006309 [apoptotic DNA fragmentation] evidence: TAS
GeneID:836 -> Biological process: GO:0006508 [proteolysis] evidence: IDA
GeneID:836 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:836 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IEA
GeneID:836 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:836 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IEA
GeneID:836 -> Biological process: GO:0007507 [heart development] evidence: IEA
GeneID:836 -> Biological process: GO:0007605 [sensory perception of sound] evidence: IEA
GeneID:836 -> Biological process: GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] evidence: IEA
GeneID:836 -> Biological process: GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] evidence: IEA
GeneID:836 -> Biological process: GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c] evidence: TAS
GeneID:836 -> Biological process: GO:0009411 [response to UV] evidence: IEA
GeneID:836 -> Biological process: GO:0009611 [response to wounding] evidence: IEA
GeneID:836 -> Biological process: GO:0016485 [protein processing] evidence: IEA
GeneID:836 -> Biological process: GO:0030216 [keratinocyte differentiation] evidence: IEA
GeneID:836 -> Biological process: GO:0030264 [nuclear fragmentation involved in apoptotic nuclear change] evidence: IMP
GeneID:836 -> Biological process: GO:0030889 [negative regulation of B cell proliferation] evidence: IEA
GeneID:836 -> Biological process: GO:0034612 [response to tumor necrosis factor] evidence: TAS
GeneID:836 -> Biological process: GO:0035329 [hippo signaling cascade] evidence: TAS
GeneID:836 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
GeneID:836 -> Biological process: GO:0043029 [T cell homeostasis] evidence: IEA
GeneID:836 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: TAS
GeneID:836 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IGI
GeneID:836 -> Biological process: GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: TAS
GeneID:836 -> Biological process: GO:0043525 [positive regulation of neuron apoptotic process] evidence: IEA
GeneID:836 -> Biological process: GO:0045165 [cell fate commitment] evidence: IEA
GeneID:836 -> Biological process: GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] evidence: IEA
GeneID:836 -> Biological process: GO:0046007 [negative regulation of activated T cell proliferation] evidence: IEA
GeneID:836 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:836 -> Biological process: GO:0051402 [neuron apoptotic process] evidence: IEA
GeneID:836 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
GeneID:836 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS
GeneID:836 -> Biological process: GO:0097194 [execution phase of apoptosis] evidence: IDA
GeneID:836 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:836 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:836 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:836 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:836 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
GeneID:836 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
GeneID:836 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:836 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_116786 -> EC 3.4.22.56
by
@meso_cacase at
DBCLS
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