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2024-04-27 09:53:12, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_032982 4242 bp mRNA linear PRI 22-JUN-2013
DEFINITION Homo sapiens caspase 2, apoptosis-related cysteine peptidase
(CASP2), transcript variant 1, mRNA.
ACCESSION NM_032982
VERSION NM_032982.3 GI:320461578
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4242)
AUTHORS Upton,J.P., Wang,L., Han,D., Wang,E.S., Huskey,N.E., Lim,L.,
Truitt,M., McManus,M.T., Ruggero,D., Goga,A., Papa,F.R. and
Oakes,S.A.
TITLE IRE1alpha cleaves select microRNAs during ER stress to derepress
translation of proapoptotic Caspase-2
JOURNAL Science 338 (6108), 818-822 (2012)
PUBMED 23042294
REMARK GeneRIF: IRE1alpha regulates translation of a proapoptotic protein,
Caspase-2, through terminating microRNA biogenesis, and noncoding
RNAs are part of the ER stress response
REFERENCE 2 (bases 1 to 4242)
AUTHORS Bouchier-Hayes,L.
TITLE The role of caspase-2 in stress-induced apoptosis
JOURNAL J. Cell. Mol. Med. 14 (6A), 1212-1224 (2010)
PUBMED 20158568
REMARK GeneRIF: This review discusses recent advances that have been made
to help elucidate the true role of caspase 2 and the potential
contribution of caspase-2 to the pathology of human diseases
including cancer.
Review article
REFERENCE 3 (bases 1 to 4242)
AUTHORS Majumder,P., Raychaudhuri,S., Chattopadhyay,B. and
Bhattacharyya,N.P.
TITLE Increased caspase-2, calpain activations and decreased
mitochondrial complex II activity in cells expressing exogenous
huntingtin exon 1 containing CAG repeat in the pathogenic range
JOURNAL Cell. Mol. Neurobiol. 27 (8), 1127-1145 (2007)
PUBMED 17902043
REFERENCE 4 (bases 1 to 4242)
AUTHORS Narkilahti,S., Jutila,L., Alafuzoff,I., Karkola,K., Paljarvi,L.,
Immonen,A., Vapalahti,M., Mervaala,E., Kalviainen,R. and
Pitkanen,A.
TITLE Increased expression of caspase 2 in experimental and human
temporal lobe epilepsy
JOURNAL Neuromolecular Med. 9 (2), 129-144 (2007)
PUBMED 17627033
REMARK GeneRIF: Data suggest that caspase 2-mediated programmed cell death
participates in the seizure-induced degenerative process in
experimental and human TLE.
REFERENCE 5 (bases 1 to 4242)
AUTHORS Martinet,W., Knaapen,M.W., De Meyer,G.R., Herman,A.G. and
Kockx,M.M.
TITLE Overexpression of the anti-apoptotic caspase-2 short isoform in
macrophage-derived foam cells of human atherosclerotic plaques
JOURNAL Am. J. Pathol. 162 (3), 731-736 (2003)
PUBMED 12598307
REMARK GeneRIF: The short isoform is overexpressed in macrophage-derived
foam cells of human atherosclerotic plaques
REFERENCE 6 (bases 1 to 4242)
AUTHORS Logette,E., Wotawa,A., Solier,S., Desoche,L., Solary,E. and
Corcos,L.
TITLE The human caspase-2 gene: alternative promoters, pre-mRNA splicing
and AUG usage direct isoform-specific expression
JOURNAL Oncogene 22 (6), 935-946 (2003)
PUBMED 12584573
REMARK GeneRIF: caspase-2 gene: alternative promoters, pre-mRNA splicing
and AUG usage direct isoform-specific expression
REFERENCE 7 (bases 1 to 4242)
AUTHORS Droin,N., Beauchemin,M., Solary,E. and Bertrand,R.
TITLE Identification of a caspase-2 isoform that behaves as an endogenous
inhibitor of the caspase cascade
JOURNAL Cancer Res. 60 (24), 7039-7047 (2000)
PUBMED 11156409
REFERENCE 8 (bases 1 to 4242)
AUTHORS Shimohama,S., Tanino,H. and Fujimoto,S.
TITLE Changes in caspase expression in Alzheimer's disease: comparison
with development and aging
JOURNAL Biochem. Biophys. Res. Commun. 256 (2), 381-384 (1999)
PUBMED 10079193
REFERENCE 9 (bases 1 to 4242)
AUTHORS Kumar,S., White,D.L., Takai,S., Turczynowicz,S., Juttner,C.A. and
Hughes,T.P.
TITLE Apoptosis regulatory gene NEDD2 maps to human chromosome segment
7q34-35, a region frequently affected in haematological neoplasms
JOURNAL Hum. Genet. 95 (6), 641-644 (1995)
PUBMED 7789948
REFERENCE 10 (bases 1 to 4242)
AUTHORS Wang,L., Miura,M., Bergeron,L., Zhu,H. and Yuan,J.
TITLE Ich-1, an Ice/ced-3-related gene, encodes both positive and
negative regulators of programmed cell death
JOURNAL Cell 78 (5), 739-750 (1994)
PUBMED 8087842
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA505883.1, DB455837.1,
AK291274.1, AC073342.3 and BQ447606.1.
This sequence is a reference standard in the RefSeqGene project.
On Jan 29, 2011 this sequence version replaced gi:39995058.
Summary: This gene encodes a member of the cysteine-aspartic acid
protease (caspase) family. Caspases mediate cellular apoptosis
through the proteolytic cleavage of specific protein substrates.
The encoded protein may function in stress-induced cell death
pathways, cell cycle maintenance, and the suppression of
tumorigenesis. Increased expression of this gene may play a role in
neurodegenerative disorders including Alzheimer's disease,
Huntington's disease and temporal lobe epilepsy. Alternatively
spliced transcript variants encoding multiple isoforms have been
observed for this gene. [provided by RefSeq, Jan 2011].
Transcript Variant: This variant (1) encodes the longest isoform
(1, also known as ICH-1L), which has been shown to function as a
positive regulator of apoptosis (PMID:8087842).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC002427.2, AK291274.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-35 DA505883.1 1-35
36-208 DB455837.1 1-173
209-1982 AK291274.1 1-1774
1983-3591 AC073342.3 122136-123744
3592-4242 BQ447606.1 1-651 c
FEATURES Location/Qualifiers
source 1..4242
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q34-q35"
gene 1..4242
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/note="caspase 2, apoptosis-related cysteine peptidase"
/db_xref="GeneID:835"
/db_xref="HGNC:1503"
/db_xref="HPRD:02800"
/db_xref="MIM:600639"
exon 1..315
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/inference="alignment:Splign:1.39.8"
variation 12
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="g"
/db_xref="dbSNP:186744526"
variation 126
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="c"
/db_xref="dbSNP:113268906"
variation 148
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="c"
/db_xref="dbSNP:144511554"
misc_feature 155..157
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/note="upstream in-frame stop codon"
variation 158
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="g"
/db_xref="dbSNP:11981631"
variation 188
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:112207701"
variation 201
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:371891055"
variation 217
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:374157123"
variation 220
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="g"
/replace="t"
/db_xref="dbSNP:368033765"
variation 227
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:376047462"
variation 228
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:367660182"
variation 236
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="c"
/db_xref="dbSNP:199504713"
CDS 242..1600
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/EC_number="3.4.22.55"
/note="isoform 1 preproprotein is encoded by transcript
variant 1; protease ICH-1; neural precursor cell expressed
developmentally down-regulated protein 2; protein
phosphatase 1, regulatory subunit 57"
/codon_start=1
/product="caspase-2 isoform 1 preproprotein"
/protein_id="NP_116764.2"
/db_xref="GI:39995059"
/db_xref="CCDS:CCDS5879.1"
/db_xref="GeneID:835"
/db_xref="HGNC:1503"
/db_xref="HPRD:02800"
/db_xref="MIM:600639"
/translation="
MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT
"
misc_feature 335..604
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/note="Caspase activation and recruitment domain of
Caspase-2; Region: CARD_CASP2; cd08332"
/db_xref="CDD:176744"
misc_feature 746..748
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:02800"
mat_peptide 749..1216
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/product="Caspase-2 subunit p18"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P42575.2)"
misc_feature 812..1579
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/note="Caspase, interleukin-1 beta converting enzyme (ICE)
homologues; Cysteine-dependent aspartate-directed
proteases that mediate programmed cell death (apoptosis).
Caspases are synthesized as inactive zymogens and
activated by proteolysis of the peptide...; Region: CASc;
cd00032"
/db_xref="CDD:28914"
misc_feature order(896..898,1073..1075,1193..1195,1214..1216,
1364..1381,1391..1396)
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/note="substrate pocket [chemical binding]; other site"
/db_xref="CDD:28914"
misc_feature order(1070..1072,1199..1201)
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/note="active site"
/db_xref="CDD:28914"
misc_feature order(1217..1219,1319..1324,1343..1345,1352..1354,
1361..1363,1430..1432,1454..1456,1472..1474,1529..1531,
1544..1549,1553..1555,1562..1567)
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:28914"
misc_feature order(1220..1222,1316..1318)
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/note="proteolytic cleavage site; other site"
/db_xref="CDD:28914"
mat_peptide 1241..1597
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/product="Caspase-2 subunit p13"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P42575.2)"
misc_feature 1259..1261
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P42575.2); phosphorylation site"
mat_peptide 1283..1597
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/product="Caspase-2 subunit p12"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P42575.2)"
variation 261
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:200275372"
variation 262
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:143572840"
variation 296
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:145693200"
variation 310
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:148934764"
variation 312
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:368981317"
exon 316..466
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/inference="alignment:Splign:1.39.8"
variation 318
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:143160365"
variation 328
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:192384558"
variation 376
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:61732978"
variation 390
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:374173198"
variation 403
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="g"
/db_xref="dbSNP:370888284"
variation 404
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:200501629"
variation 409
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:4647288"
variation 422
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:368191317"
exon 467..634
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/inference="alignment:Splign:1.39.8"
variation 604
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:113837507"
variation 634
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:137989079"
exon 635..716
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/inference="alignment:Splign:1.39.8"
variation 649
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:200175061"
variation 670
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:143560034"
variation 674
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:150118322"
variation 682
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="g"
/db_xref="dbSNP:372179335"
variation 694
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:4647293"
variation 704
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:149245237"
variation 705
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:144817015"
exon 717..811
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/inference="alignment:Splign:1.39.8"
variation 755
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="g"
/db_xref="dbSNP:4647297"
variation 772
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="g"
/replace="t"
/db_xref="dbSNP:200880743"
variation 773
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="g"
/db_xref="dbSNP:4647298"
exon 812..988
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/inference="alignment:Splign:1.39.8"
variation 831
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:373353027"
variation 931
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:186256855"
STS 932..1133
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/standard_name="Casp2"
/db_xref="UniSTS:259199"
variation 944
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:146134510"
variation 958
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:371326834"
variation 959
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:141615673"
exon 989..1117
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/inference="alignment:Splign:1.39.8"
variation 1003
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:143669356"
variation 1034
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="g"
/db_xref="dbSNP:150852779"
variation 1035
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:139233385"
variation 1042
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:114290247"
variation 1054
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:200779188"
variation 1055
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:370097426"
variation 1069
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:373653048"
variation 1084
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:367713957"
exon 1118..1208
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/inference="alignment:Splign:1.39.8"
variation 1152
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:200353443"
variation 1153
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:374230679"
variation 1176
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:377218240"
variation 1203
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:368449253"
exon 1209..1358
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/inference="alignment:Splign:1.39.8"
variation 1220
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:369175154"
variation 1231
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="g"
/db_xref="dbSNP:145619760"
variation 1285
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:372837731"
variation 1286
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:141466335"
variation 1302
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:145217184"
variation 1307
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="c"
/db_xref="dbSNP:75941380"
variation 1339
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:147605073"
variation 1350
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="g"
/replace="t"
/db_xref="dbSNP:11551881"
exon 1359..1468
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/inference="alignment:Splign:1.39.8"
STS 1376..1494
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/standard_name="WI-9353"
/db_xref="UniSTS:2543"
variation 1402
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:142190608"
variation 1403
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:188499115"
variation 1431
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:369524386"
variation 1443
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:201856807"
variation 1449
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="t"
/db_xref="dbSNP:376253426"
exon 1469..4225
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/inference="alignment:Splign:1.39.8"
variation 1474
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:200701125"
STS 1475..1742
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/standard_name="WI-19013"
/db_xref="UniSTS:47275"
variation 1477
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="c"
/db_xref="dbSNP:143054447"
variation 1538
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="g"
/replace="t"
/db_xref="dbSNP:3212151"
variation 1562
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:4647338"
variation 1584
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:373916487"
STS 1604..1719
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/standard_name="CASP2"
/db_xref="UniSTS:479808"
variation 1606
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:368127872"
variation 1607
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:4647339"
variation 1636
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="c"
/db_xref="dbSNP:3212152"
variation 1682
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:137974186"
variation 1700
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:71528907"
variation 1918
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:4647340"
variation 1964
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="g"
/replace="t"
/db_xref="dbSNP:186746216"
variation 2124
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:191347184"
variation 2202
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:183528359"
variation 2299
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:142900816"
variation 2426
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:4647341"
variation 2433
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:147422589"
variation 2459
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:139897181"
variation 2645
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="g"
/replace="t"
/db_xref="dbSNP:188559339"
variation 2677
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:373020827"
variation 2713
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="g"
/replace="t"
/db_xref="dbSNP:143815758"
variation 2733
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="t"
/db_xref="dbSNP:150650825"
variation 2746
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:145289077"
variation 2768
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="t"
/db_xref="dbSNP:4647342"
variation 2778..2779
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace=""
/replace="t"
/db_xref="dbSNP:11386631"
variation 2804
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace=""
/replace="ttttg"
/db_xref="dbSNP:78324220"
variation 2806
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="g"
/db_xref="dbSNP:111922510"
variation 2838
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="g"
/replace="t"
/db_xref="dbSNP:1141773"
variation 2873
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="c"
/db_xref="dbSNP:1141774"
variation 2878
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:139766832"
STS 2881..2984
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/standard_name="D8S2278"
/db_xref="UniSTS:473906"
STS 2889..2979
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 2889
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="c"
/db_xref="dbSNP:1141775"
variation 2897
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:1141776"
variation 2911
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="c"
/db_xref="dbSNP:370922614"
variation 2918
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:3200104"
variation 2969
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="g"
/replace="t"
/db_xref="dbSNP:373957104"
variation 3004
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="g"
/replace="t"
/db_xref="dbSNP:13222071"
variation 3054
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="g"
/db_xref="dbSNP:181124609"
variation 3090
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="c"
/db_xref="dbSNP:62471034"
variation 3099
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="t"
/db_xref="dbSNP:71528908"
variation 3109
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace=""
/replace="aaa"
/db_xref="dbSNP:71875187"
variation 3113..3117
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace=""
/replace="aaaaa"
/db_xref="dbSNP:77667787"
variation 3120
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="t"
/db_xref="dbSNP:62471035"
variation 3149
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:375751578"
variation 3151
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:371026231"
variation 3157
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:71528909"
variation 3200
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:149837738"
variation 3203
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="g"
/replace="t"
/db_xref="dbSNP:28436039"
variation 3235
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:71528910"
variation 3297
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:185340596"
variation 3357
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="c"
/db_xref="dbSNP:190238617"
variation 3448
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="g"
/db_xref="dbSNP:144788313"
variation 3482
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:373568549"
variation 3491
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:139657780"
variation 3492
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:144528534"
variation 3509
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="g"
/replace="t"
/db_xref="dbSNP:182236290"
variation 3511
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="g"
/replace="t"
/db_xref="dbSNP:146629101"
variation 3753
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="c"
/db_xref="dbSNP:77951251"
variation 3789
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:140252650"
variation 3806
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:142505490"
variation 3815
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="g"
/replace="t"
/db_xref="dbSNP:186396120"
variation 3817
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="c"
/db_xref="dbSNP:371214726"
variation 3846
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:79479809"
variation 3917..3918
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace=""
/replace="a"
/db_xref="dbSNP:35408368"
STS 3947..4016
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/standard_name="NEDD2"
/db_xref="UniSTS:75169"
variation 3949
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="g"
/replace="t"
/db_xref="dbSNP:150969153"
variation 3952
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:190887805"
variation 3953
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="t"
/db_xref="dbSNP:62471036"
variation 4023
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:180944601"
variation 4041
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="c"
/replace="g"
/db_xref="dbSNP:150204326"
variation 4190
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="t"
/db_xref="dbSNP:367897153"
variation 4193
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="g"
/db_xref="dbSNP:185114711"
polyA_signal 4201..4206
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
variation 4201
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
/replace="a"
/replace="c"
/db_xref="dbSNP:202090018"
polyA_site 4225
/gene="CASP2"
/gene_synonym="CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57"
ORIGIN
cttttgtctgtccgccgagcaccccacttcaccccattggaccgcgcggccgccgctagagctctgcgcctgcgcacgcaccgggccggggactgggtggcctggtgtgtgggcgcggcagggcgcaggcgcaggcgcagtgtgcgtccgcgtctgaggggagggatgtgggggaagcgacggcccccggtttgtttgggctgtgggcggtgcgcagcggagagcccgggaaaagcgggaaatggcggcgccgagcgcggggtcttggtccaccttccagcacaaggagctgatggccgctgacaggggacgcaggatattgggagtgtgtggcatgcatcctcatcatcaggaaactctaaaaaagaaccgagtggtgctagccaaacagctgttgttgagcgaattgttagaacatcttctggagaaggacatcatcaccttggaaatgagggagctcatccaggccaaagtgggcagtttcagccagaatgtggaactcctcaacttgctgcctaagaggggtccccaagcttttgatgccttctgtgaagcactgagggagaccaagcaaggccacctggaggatatgttgctcaccaccctttctgggcttcagcatgtactcccaccgttgagctgtgactacgacttgagtctcccttttccggtgtgtgagtcctgtcccctttacaagaagctccgcctgtcgacagatactgtggaacactccctagacaataaagatggtcctgtctgccttcaggtgaagccttgcactcctgaattttatcaaacacacttccagctggcatataggttgcagtctcggcctcgtggcctagcactggtgttgagcaatgtgcacttcactggagagaaagaactggaatttcgctctggaggggatgtggaccacagtactctagtcaccctcttcaagcttttgggctatgacgtccatgttctatgtgaccagactgcacaggaaatgcaagagaaactgcagaattttgcacagttacctgcacaccgagtcacggactcctgcatcgtggcactcctctcgcatggtgtggagggcgccatctatggtgtggatgggaaactgctccagctccaagaggtttttcagctctttgacaacgccaactgcccaagcctacagaacaaaccaaaaatgttcttcatccaggcctgccgtggagatgagactgatcgtggggttgaccaacaagatggaaagaaccacgcaggatcccctgggtgcgaggagagtgatgccggtaaagaaaagttgccgaagatgagactgcccacgcgctcagacatgatatgcggctatgcctgcctcaaagggactgccgccatgcggaacaccaaacgaggttcctggtacatcgaggctcttgctcaagtgttttctgagcgggcttgtgatatgcacgtggccgacatgctggttaaggtgaacgcacttatcaaggatcgggaaggttatgctcctggcacagaattccaccggtgcaaggagatgtctgaatactgcagcactctgtgccgccacctctacctgttcccaggacaccctcccacatgatgtcacctccccatcatccacgccaagtggaagccactggaccacaggaggtgtgatagagcctttgatcttcaggatgcacggtttctgttctgccccctcagggatgtgggaatctcccagacttgtttcctgtgcccatcatctctgcctttgagtgtgggactccaggccagctccttttctgtgaagccctttgcctgtagagccagccttggttggacctattgccaggaatgtttcagctgcagttgaagagcctgacaagtgaagttgtaaacacagtgtggttatggggagagggcatataaattccccatatttgtgttcagttccagcttttgtagatggcactttagtgattgcttttattacattagttaagatgtctgagagaccatctcctatcttttatttcattcatatcctccgccctttttgtcctagagtgagagtttggaaggtgtccaaatttaatgtagacattatcttttggctctgaagaagcaaacatgactagagacgcaccttgctgcagtgtccagaagcggcctgtgcgttcccttcagtactgcagcgccacccagtggaaggacactcttggctcgtttgggctcaaggcaccgcagcctgtcagccaacattgccttgcatttgtaccttattgatctttgcccatggaagtctcaaagatctttcgttggttgtttctctgagctttgttactgaaatgagcctcgtggggagcatcagagaaggccaggaagaatggtgtgtttccctagactctgtaaccacctctctgtctttttccttcctgagaaacgtccatctctctcccttactattcccactttcattcaatcaacctgcacttcatatctagatttctagaaaagcttcctagcttatctccctgcttcatatctctcccttctttaccttcatttcatcctgttggctgctgccaccaaatctgtctagaatcctgctttacaggatcatgtaaatgctcaaagatgtaatgtagttctttgttcctgctttctctttcagtattaaactctcctttgatattatgtggcttttatttcagtgccatacatgttattgttttcaacctagaaacctttatccctgcttatctgaaacttcccaacttccctgttctttaagactttttttttttttttttttttttttgagacagagtctcgctctgtcgcccaggctggagggcagtggcacgatctcagctcactgcaagctccaactcccgggttcacgccattctcctgcctcagccttccaagtagctgggactacaggtgcccgccaccgtgcccggctaatttttttgtatttttagtagagacagggtttcaccatgttagccgggatggtcttgatctcctgacctcatgatccacccacctcagcctcccaaagtgttgggattacaggcgtgagccactgcgcccgggcaagacctttttttaaaaaaaaaaaaaaaaaaacttccattctttcttcctccagtctgttctcacataacagagtagttttggtttttaattttttttggttgtttgctgttttttgttttttaaggtgagttctcactatgtttctcagactggtctcgaactcctggcctcaagccatcttcccgcctcagcctctcaaatagctgggcttacaggcatgagccaccacacctggccaggatttggttgtttaaatataaatctgatcacccccctgcttagaacccttctgctttctattacccctcatttaaaatgtaaactcttcaccttggtttatgagaactggttcttgccttccccttgaacctcattaaatggtgatttcttgctaagctccagcccgagtggtctcctctcagcttctaattttgtgctctttcctgcccttttcctgggccttctcagctctccacccccaccactcttgactcaggtggtgtccttcttcctcaagtcttgacaattcccgggcccttcagtccctgagcagtctacttctgtgtctgtcaccacatcttgtcttttcccctcattgcatttattgcagtttatatatatgctacttttacttgttcatttctgtctcccctaccaggctgtaaatgagggcagaaaccttgtttgttttattcaccatcatgtaccaagtgcttggcacatagtgggccttcattaaatgtttgttgaataaaagagggaagaaggcaagccaaccttagctacaatcctaccttttgataaaatgttccttttgacaatatacacggattattatttgtactttgtttttccatgtgttttgcttttatccactggcatttttagctccttgaagacatatcatgtgtgagataacttccttcacatctcccatggtccctagcaaaatgctaggcctgtagtagtcaaggtgctcaataaatatttgtttgggtggtttgtgagccttgctgccaagtcctgcctttgggtcgacatagtatggaagtatttgagagagagaacctttccactcccactgccaggattttgtattgccatcgggtgccaaataaatgctcatatttattactgaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:835 -> Molecular function: GO:0004197 [cysteine-type endopeptidase activity] evidence: IDA
GeneID:835 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:835 -> Molecular function: GO:0019899 [enzyme binding] evidence: ISS
GeneID:835 -> Molecular function: GO:0019904 [protein domain specific binding] evidence: IPI
GeneID:835 -> Biological process: GO:0001554 [luteolysis] evidence: IEA
GeneID:835 -> Biological process: GO:0003407 [neural retina development] evidence: IEA
GeneID:835 -> Biological process: GO:0006508 [proteolysis] evidence: IEA
GeneID:835 -> Biological process: GO:0006915 [apoptotic process] evidence: NAS
GeneID:835 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IEA
GeneID:835 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: IMP
GeneID:835 -> Biological process: GO:0007420 [brain development] evidence: IEA
GeneID:835 -> Biological process: GO:0007568 [aging] evidence: IEA
GeneID:835 -> Biological process: GO:0016485 [protein processing] evidence: IDA
GeneID:835 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IDA
GeneID:835 -> Biological process: GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: TAS
GeneID:835 -> Biological process: GO:0043525 [positive regulation of neuron apoptotic process] evidence: IEA
GeneID:835 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:835 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
GeneID:835 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
GeneID:835 -> Biological process: GO:0097194 [execution phase of apoptosis] evidence: TAS
GeneID:835 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:835 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
GeneID:835 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:835 -> Cellular component: GO:0016020 [membrane] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_116764 -> EC 3.4.22.55
by
@meso_cacase at
DBCLS
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