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2024-03-29 14:38:25, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_032869               3965 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens NudC domain containing 1 (NUDCD1), transcript variant
            1, mRNA.
ACCESSION   NM_032869
VERSION     NM_032869.3  GI:189571676
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3965)
  AUTHORS   Wang,Q., Li,M., Wang,Y., Zhang,Y., Jin,S., Xie,G., Liu,Z., Wang,S.,
            Zhang,H., Shen,L. and Ge,H.
  TITLE     RNA interference targeting CML66, a novel tumor antigen, inhibits
            proliferation, invasion and metastasis of HeLa cells
  JOURNAL   Cancer Lett. 269 (1), 127-138 (2008)
   PUBMED   18534745
  REMARK    GeneRIF: CML66 may play an oncogenic role in ways of favoring tumor
            cells proliferation, invasion and metastasis-associated with
            multiple pathways.
REFERENCE   2  (bases 1 to 3965)
  AUTHORS   Jin,S., Wang,Y., Zhang,Y., Zhang,H.Z., Wang,S.J., Tang,J.Q.,
            Chen,H.J. and Ge,H.L.
  TITLE     Humoral immune responses against tumor-associated antigen OVA66
            originally defined by serological analysis of recombinant cDNA
            expression libraries and its potentiality in cellular immunity
  JOURNAL   Cancer Sci. 99 (8), 1670-1678 (2008)
   PUBMED   18754882
  REMARK    GeneRIF: study identified a novel gene, OVA66, which was expressed
            significantly higher in cancer patients than normal controls; IgG
            level against OVA66 was significantly elevated in the serum of
            cancer patients from different histological types of cancer [OVA66]
REFERENCE   3  (bases 1 to 3965)
  AUTHORS   Yan,Y., Phan,L., Yang,F., Talpaz,M., Yang,Y., Xiong,Z., Ng,B.,
            Timchenko,N.A., Wu,C.J., Ritz,J., Wang,H. and Yang,X.F.
  TITLE     A novel mechanism of alternative promoter and splicing regulates
            the epitope generation of tumor antigen CML66-L
  JOURNAL   J. Immunol. 172 (1), 651-660 (2004)
   PUBMED   14688378
  REMARK    GeneRIF: An alternative promoter (CML66-S short isoform) has been
            identified in combination with alternative splicing as a novel
            mechanism for regulation of the epitope generation of a self-tumor
            antigen.
REFERENCE   4  (bases 1 to 3965)
  AUTHORS   Yang,X.F., Wu,C.J., McLaughlin,S., Chillemi,A., Wang,K.S.,
            Canning,C., Alyea,E.P., Kantoff,P., Soiffer,R.J., Dranoff,G. and
            Ritz,J.
  TITLE     CML66, a broadly immunogenic tumor antigen, elicits a humoral
            immune response associated with remission of chronic myelogenous
            leukemia
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 98 (13), 7492-7497 (2001)
   PUBMED   11416219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF283301.1, AK307663.1, AC021237.5 and BC043406.1.
            On Jun 10, 2008 this sequence version replaced gi:31377641.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043406.1, AF283301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-866               AF283301.1         122-987
            867-1857            AK307663.1         768-1758
            1858-3559           AC021237.5         136900-138601
            3560-3965           BC043406.1         3528-3933
FEATURES             Location/Qualifiers
     source          1..3965
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23"
     gene            1..3965
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /note="NudC domain containing 1"
                     /db_xref="GeneID:84955"
                     /db_xref="HGNC:24306"
                     /db_xref="MIM:606109"
     exon            1..229
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    52..54
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /note="upstream in-frame stop codon"
     CDS             112..1863
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chronic myelogenous leukemia tumor antigen 66; nudC
                     domain-containing protein 1; tumor antigen CML66"
                     /codon_start=1
                     /product="nudC domain-containing protein 1 isoform 1"
                     /protein_id="NP_116258.2"
                     /db_xref="GI:189571677"
                     /db_xref="CCDS:CCDS6312.1"
                     /db_xref="GeneID:84955"
                     /db_xref="HGNC:24306"
                     /db_xref="MIM:606109"
                     /translation="
MEVAANCSLRVKRPLLDPRFEGYKLSLEPLPCYQLELDAAVAEVKLRDDQYTLEHMHAFGMYNYLHCDSWYQDSVYYIDTLGRIMNLTVMLDTALGKPREVFRLPTDLTACDNRLCASIHFSSSTWVTLSDGTGRLYVIGTGERGNSASEKWEIMFNEELGDPFIIIHSISLLNAEEHSIATLLLRIEKEELDMKGSGFYVSLEWVTISKKNQDNKKYEIIKRDILRGKSVPHYAAIEPDGNGLMIVSYKSLTFVQAGQDLEENMDEDISEKIKEPLYYWQQTEDDLTVTIRLPEDSTKEDIQIQFLPDHINIVLKDHQFLEGKLYSSIDHESSTWIIKESNSLEISLIKKNEGLTWPELVIGDKQGELIRDSAQCAAIAERLMHLTSEELNPNPDKEKPPCNAQELEECDIFFEESSSLCRFDGNTLKTTHVVNLGSNQYLFSVIVDPKEMPCFCLRHDVDALLWQPHSSKQDDMWEHIATFNALGYVQASKRDKKFFACAPNYSYAALCECLRRVFIYRQPAPMSTVLYNRKEGRQVGQVAKQQVASLETNDPILGFQATNERLFVLTTKNLFLIKVNTEN
"
     misc_feature    943..1194
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /note="p23_NUDCD1: p23-like NUD (nuclear distribution)
                     C-like domain found in human NUD (nuclear distribution) C
                     domain-containing protein 1, NUDCD1 (also known as CML66),
                     and similar proteins. NUDCD1/CML66 is a broadly
                     immunogenic tumor associated antigen; Region:
                     p23_NUDCD1_like; cd06493"
                     /db_xref="CDD:107242"
     exon            230..384
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:1.39.8"
     exon            385..570
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:1.39.8"
     variation       407
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11550168"
     exon            571..751
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:1.39.8"
     exon            752..934
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:1.39.8"
     exon            935..1139
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:1.39.8"
     exon            1140..1284
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:1.39.8"
     exon            1285..1410
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:1.39.8"
     variation       1388
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11550169"
     exon            1411..1570
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:1.39.8"
     exon            1571..3953
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /inference="alignment:Splign:1.39.8"
     STS             1871..2073
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /standard_name="STS-AA009819"
                     /db_xref="UniSTS:11395"
     STS             2023..2153
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /standard_name="STS-N32587"
                     /db_xref="UniSTS:78028"
     variation       2149
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11550167"
     variation       2206
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1548082"
     variation       3222
                     /gene="NUDCD1"
                     /gene_synonym="CML66; OVA66"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1548083"
ORIGIN      
agtgttttctgggatgggaaccacgccgcttcccagtctctgtgcgaggcgtgaagcgcggacctttcaacaagggctttattaattctcacgctgcggccctggaaagcgatggaggtggcggctaattgctccctacgggtgaagagacctctgttggatccccgcttcgagggttacaagctctctcttgagccgctgccttgttaccagctggagcttgacgcagctgtggcagaggtaaaacttcgagatgatcaatatacactggaacacatgcatgcttttggaatgtataattacctgcactgtgattcatggtatcaagacagtgtctactatattgatacccttggaagaattatgaatttaacagtaatgctggacactgccttaggaaaaccacgagaggtgtttcgacttcctacagatttgacagcatgtgacaaccgtctttgtgcatctatccatttctcatcttctacctgggttaccttgtcagatggaactggaagattgtatgtcattggaacaggtgaacgtggaaatagcgcttctgaaaaatgggagattatgtttaatgaagaacttggggatccttttattataattcacagtatctcactgctaaatgctgaagaacattctatagctaccctacttcttcgaatagagaaagaggaattggatatgaaaggaagtggtttctatgtttctctggagtgggtcactatcagtaagaaaaatcaagataataaaaaatatgaaattattaagcgtgatattctccgtggaaagtcagtgccacattatgctgctattgagcctgatggaaatggtctaatgattgtatcctacaagtctttaacatttgttcaggctggtcaagatcttgaagaaaatatggatgaagacatatcagagaaaatcaaagaacctctgtattactggcaacagactgaagatgatttgacagtaaccatacggcttccagaagacagtactaaggaggacattcaaatacagtttttgcctgatcacatcaacattgtactgaaggatcaccagtttttagaaggaaaactctattcatctattgatcatgaaagcagtacatggataattaaagagagtaatagcttggagatttccttgattaagaagaatgaaggactgacctggccagagctagtaattggagataaacaaggggaacttataagagattcagcccagtgtgctgcaatagctgaacgtttgatgcatttgacctctgaagaactgaatccaaatccagataaagaaaaaccaccttgcaatgctcaagagttagaagaatgtgatattttctttgaagagagctccagtttatgcagatttgatggcaatacattaaaaactactcatgtggtgaatcttggaagcaaccagtaccttttctctgtcatagtggatcctaaagaaatgccctgcttctgtttgcgccatgatgttgatgccctactctggcaaccacactccagcaaacaagatgatatgtgggagcacatcgcaactttcaatgctttaggctatgtccaagcatcaaagagagacaaaaaattttttgcctgtgctccaaattactcgtatgcagccctttgtgagtgccttcgtcgagtattcatctatcgtcagcctgctcccatgtccactgtactttacaacagaaaggaaggcaggcaagtaggacaggttgctaagcagcaagtagcaagcctagaaaccaatgatcctattttaggatttcaggcaacaaatgagagattatttgttcttactaccaaaaacctctttttaataaaagtaaatacagagaattaattattctaacatattggcctctttgtactggaaaagtattcagtggtacctggaggtctggacagttatactgtaacctcttaagttttaatgtgctaaatatatcttgtatgattttttattttttaataacattggaaatatattcaagagattatgattctgtaaagctgtggaatgaagctgcagatttagagaacattggcttctgaaaaaaaaaaagagtgaagatagtactagcaagtatacttattttttaaaacaggctagaatctcatgttttatatgaaagatgtacaattcagtgtttaaaaataaaaatatttattgtgtactctgttcgttgattagttgctacaggctgtacctataagatgtacaggataatagttaaatgttgagtattgtacatatgtatttaagtggattgaataactgagtctacatggaggaggaaatgctagagaacagcaggtctaatattttttaagtttactgagagacctttattattattttcaaattaagtatagctttatgtaacttttagccagttgctctgccacagacatagacaaagagagataagatttcacattatccatcactgcataacaaaccacaccaaaactcagtggtttaaaacaaggacttttattatttttcacgattcagtgagttggctgtctctgctgtacagggcctctcagcctccagtagactagacgaatcttctttccatagtagagaaaacatcttaagagagcaagctccaatatgcaagagcttatcgatcctgtacatctatcatatttactaatgttccattggacaaagcaaatcacatggccaagtctagagtcagaatgaggggactacacaagctgacagcggatggtatgactcattgggggccattgatggaacaatcttaccacacaaggacaaattataatttatccttgtggctctctttatttttctaacaacttcaacaaaataatcctgtttatatgttatagtttcttgccacaaattttgttttttcaaacttacctttccaggtttgttttagtatgtatgtacctggaaatttttattactttttataccatttcaagatatgtatcttatataaacctcaagttggattttatattttaataaggaagttaagaccttcatttaagaggcagaagattaagataagaaatataagatagaaaagctttgttcctaacatatcttttgcctgtctgggcaagtatttgactcaactaaattttaatgaacgaatgaatgacagagaggaggaaaaaagatgaggattgcatacatgttctaaaccctttgtcagattgcagtttcctagagagtattgaggtgctaggtagaaagttaggaaaggtcctgaggactggtattgacaattggagtcctaatagtactctattcgtattaggaaagagagactagataccaaacatcacgagatcatagagatggaaaactgtatagtaaccaaaaaccaaaacagtgatatttccagaactttttagtattgttgtaaaacttcatgaaacaaaagaccatttaaatagtgaattattaaaaatctttatgatgggaaagtagatctaaattttctctaaaattttccccaaagataatatcctcttagggaacataagaaaaatgtataataaaaatgtggtgcttaattaaccatgactatgtatatattgccaattttagtaatcaatattctttgtgcatgtgatttttttgcatgattaatgttgaattgaaagctctcaggataattaatcctaaatattgtcgcatgttgacctacgttaaaagatgaataggtctagagccgtgatttcaagctattttcctgaaatgcttcagggattccataaacatttaaacaatgttctaaggtacatatacttagaacattgagatatatactacaagtgctaagaatatagtaccttgtatttttgttgatttttatcatgttttaaataggaatttataaaatatttatgatagtaataaagtagtattttatgtgttttgcaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:84955 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
            GeneID:84955 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA

by @meso_cacase at DBCLS
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