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2024-04-20 07:30:08, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_032865 4090 bp mRNA linear PRI 09-JUN-2013
DEFINITION Homo sapiens tensin 4 (TNS4), mRNA.
ACCESSION NM_032865
VERSION NM_032865.5 GI:157738638
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4090)
AUTHORS Chen,N.T., Kuwabara,Y., Conley,C., Liao,Y.C., Hong,S.Y., Chen,M.,
Shih,Y.P., Chen,H.W., Hsieh,F. and Lo,S.H.
TITLE Phylogenetic analysis, expression patterns, and transcriptional
regulation of human CTEN gene
JOURNAL Gene 520 (2), 90-97 (2013)
PUBMED 23500447
REMARK GeneRIF: Phylogenetic analysis, expression patterns, and
transcriptional regulation of human CTEN gene.
REFERENCE 2 (bases 1 to 4090)
AUTHORS Al-Ghamdi,S., Cachat,J., Albasri,A., Ahmed,M., Jackson,D.,
Zaitoun,A., Guppy,N., Otto,W.R., Alison,M.R., Kindle,K.B. and
Ilyas,M.
TITLE C-terminal tensin-like gene functions as an oncogene and promotes
cell motility in pancreatic cancer
JOURNAL Pancreas 42 (1), 135-140 (2013)
PUBMED 22750970
REMARK GeneRIF: Show an oncogenic role for CTEN in pancreatic cancer
through promotion of colony formation and cell motility.
REFERENCE 3 (bases 1 to 4090)
AUTHORS Albasri,A., Al-Ghamdi,S., Fadhil,W., Aleskandarany,M., Liao,Y.C.,
Jackson,D., Lobo,D.N., Lo,S.H., Kumari,R., Durrant,L., Watson,S.,
Kindle,K.B. and Ilyas,M.
TITLE Cten signals through integrin-linked kinase (ILK) and may promote
metastasis in colorectal cancer
JOURNAL Oncogene 30 (26), 2997-3002 (2011)
PUBMED 21339732
REMARK GeneRIF: Cten expression is of prognostic significance in
colorectal carcinoma, and delineate a Cten-ILK pathway controlling
cell motility and possibly promoting metastasis.
REFERENCE 4 (bases 1 to 4090)
AUTHORS Al-Ghamdi,S., Albasri,A., Cachat,J., Ibrahem,S., Muhammad,B.A.,
Jackson,D., Nateri,A.S., Kindle,K.B. and Ilyas,M.
TITLE Cten is targeted by Kras signalling to regulate cell motility in
the colon and pancreas
JOURNAL PLoS ONE 6 (6), E20919 (2011)
PUBMED 21698197
REMARK GeneRIF: conclude that, in the colon and pancreas, Cten is a
downstream target of Kras and may be a mechanism through which Kras
regulates of cell motility
REFERENCE 5 (bases 1 to 4090)
AUTHORS Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
CONSRTM DREAM investigators
TITLE Variation at the NFATC2 locus increases the risk of
thiazolidinedione-induced edema in the Diabetes REduction
Assessment with ramipril and rosiglitazone Medication (DREAM) study
JOURNAL Diabetes Care 33 (10), 2250-2253 (2010)
PUBMED 20628086
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 6 (bases 1 to 4090)
AUTHORS Lo,S.S., Lo,S.H. and Lo,S.H.
TITLE Cleavage of cten by caspase-3 during apoptosis
JOURNAL Oncogene 24 (26), 4311-4314 (2005)
PUBMED 15806167
REFERENCE 7 (bases 1 to 4090)
AUTHORS Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
Gu,J.
TITLE Large-scale cDNA transfection screening for genes related to cancer
development and progression
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (44), 15724-15729 (2004)
PUBMED 15498874
REMARK Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE 8 (bases 1 to 4090)
AUTHORS Sasaki,H., Yukiue,H., Kobayashi,Y., Fukai,I. and Fujii,Y.
TITLE Cten mRNA expression is correlated with tumor progression in
thymoma
JOURNAL Tumour Biol. 24 (5), 271-274 (2003)
PUBMED 15001839
REMARK GeneRIF: Cten/GAPDH mRNA expression was correlated with evidence of
tumor progression in thymoma.
REFERENCE 9 (bases 1 to 4090)
AUTHORS Sasaki,H., Moriyama,S., Mizuno,K., Yukiue,H., Konishi,A., Yano,M.,
Kaji,M., Fukai,I., Kiriyama,M., Yamakawa,Y. and Fujii,Y.
TITLE Cten mRNA expression was correlated with tumor progression in lung
cancers
JOURNAL Lung Cancer 40 (2), 151-155 (2003)
PUBMED 12711115
REMARK GeneRIF: Increased cten mRNA expression was correlated with tumor
progression in lung cancers
REFERENCE 10 (bases 1 to 4090)
AUTHORS Lo,S.H. and Lo,T.B.
TITLE Cten, a COOH-terminal tensin-like protein with prostate restricted
expression, is down-regulated in prostate cancer
JOURNAL Cancer Res. 62 (15), 4217-4221 (2002)
PUBMED 12154022
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BM710196.1, AF417488.1, BC018706.1, AW937802.1, AW378527.1 and
BC013373.2.
On Sep 28, 2007 this sequence version replaced gi:141802567.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF370421.1, AF417488.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025087 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-39 BM710196.1 1-39
40-554 AF417488.1 2-516
555-3017 BC018706.1 1-2463
3018-3294 AW937802.1 235-511
3295-3522 AF417488.1 3256-3483
3523-3594 AW378527.1 67-138 c
3595-4066 BC018706.1 3029-3500
4067-4090 BC013373.2 2173-2196
FEATURES Location/Qualifiers
source 1..4090
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21.2"
gene 1..4090
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/note="tensin 4"
/db_xref="GeneID:84951"
/db_xref="HGNC:24352"
/db_xref="MIM:608385"
exon 1..69
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/inference="alignment:Splign:1.39.8"
exon 70..603
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/inference="alignment:Splign:1.39.8"
misc_feature 138..140
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/note="upstream in-frame stop codon"
CDS 165..2312
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/note="C terminal tensin like; tensin-4; C-terminal
tensin-like protein"
/codon_start=1
/product="tensin-4 precursor"
/protein_id="NP_116254.4"
/db_xref="GI:157738639"
/db_xref="CCDS:CCDS11368.1"
/db_xref="GeneID:84951"
/db_xref="HGNC:24352"
/db_xref="MIM:608385"
/translation="
MSQVMSSPLLAGGHAVSLAPCDEPRRTLHPAPSPSLPPQCSYYTTEGWGAQALMAPVPCMGPPGRLQQAPQVEAKATCFLPSPGEKALGTPEDLDSYIDFSLESLNQMILELDPTFQLLPPGTGGSQAELAQSTMSMRKKEESEALDIKYIEVTSARSRCHDGPQHCSSPSVTPPFGSLRSGGLLLSRDVPRETRSSSESLIFSGNQGRGHQRPLPPSEGLSPRPPNSPSISIPCMGSKASSPHGLGSPLVASPRLEKRLGGLAPQRGSRISVLSASPVSDVSYMFGSSQSLLHSSNSSHQSSSRSLESPANSSSSLHSLGSVSLCTRPSDFQAPRNPTLTMGQPRTPHSPPLAKEHASSCPPSITNSMVDIPIVLINGCPEPGSSPPQRTPGHQNSVQPGAASPSNPCPATRSNSQTLSDAPFTTCPEGPARDMQPTMKFVMDTSKYWFKPNITREQAIELLRKEEPGAFVIRDSSSYRGSFGLALKVQEVPASAQSRPGEDSNDLIRHFLIESSAKGVHLKGADEEPYFGSLSAFVCQHSIMALALPCKLTIPQRELGGADGASDSTDSPASCQKKSAGCHTLYLSSVSVETLTGALAVQKAISTTFERDILPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLTTLRFCGMDPEQRKWQKYCKPSWIFGFVAKSQTEPQENVCHLFAEYDMVQPASQVIGLVTALLQDAERM
"
sig_peptide 165..218
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/inference="non-experimental evidence, no additional
details recorded"
/note="Potential; propagated from UniProtKB/Swiss-Prot
(Q8IZW8.3)"
mat_peptide 219..2309
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/product="Tensin-4"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q8IZW8.3)"
misc_feature 408..410
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q8IZW8.3); phosphorylation site"
misc_feature 906..908
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q8IZW8.3); phosphorylation site"
misc_feature 1497..1838
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/note="Src homology 2 (SH2) domain; Region: SH2; cl15255"
/db_xref="CDD:210054"
misc_feature order(1530..1532,1584..1586,1692..1694,1698..1700)
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/note="phosphotyrosine binding pocket [polypeptide
binding]; other site"
/db_xref="CDD:198173"
misc_feature order(1695..1697,1782..1784)
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/note="hydrophobic binding pocket [polypeptide binding];
other site"
/db_xref="CDD:198173"
misc_feature 1872..1877
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/experiment="experimental evidence, no additional details
recorded"
/note="Cleavage, by caspase-3; propagated from
UniProtKB/Swiss-Prot (Q8IZW8.3); cleavage site"
misc_feature 1893..2291
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/note="Pleckstrin homology-like domain; Region: PH-like;
cl00273"
/db_xref="CDD:206947"
misc_feature order(1902..1925,2016..2036,2043..2063,2112..2126,
2172..2186,2220..2234,2253..2279)
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/note="PH-like core; other site"
/db_xref="CDD:176275"
exon 604..1027
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/inference="alignment:Splign:1.39.8"
exon 1028..1452
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/inference="alignment:Splign:1.39.8"
exon 1453..1539
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/inference="alignment:Splign:1.39.8"
exon 1540..1665
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/inference="alignment:Splign:1.39.8"
variation 1657
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/replace="a"
/replace="g"
/db_xref="dbSNP:2290207"
exon 1666..1758
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/inference="alignment:Splign:1.39.8"
exon 1759..1836
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/inference="alignment:Splign:1.39.8"
exon 1837..1905
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/inference="alignment:Splign:1.39.8"
exon 1906..2074
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/inference="alignment:Splign:1.39.8"
exon 2075..2143
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/inference="alignment:Splign:1.39.8"
exon 2144..2170
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/inference="alignment:Splign:1.39.8"
exon 2171..4072
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/inference="alignment:Splign:1.39.8"
variation 2625
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/replace="a"
/replace="c"
/db_xref="dbSNP:3169905"
variation 3391
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/replace="c"
/replace="g"
/db_xref="dbSNP:3169906"
STS 3775..3975
/gene="TNS4"
/gene_synonym="CTEN; PP14434"
/standard_name="RH69878"
/db_xref="UniSTS:75205"
ORIGIN
ggactctgagtcgtcttggtcccaggagccagtagtgaaggcaacagtctgcccacctgtggacaccagatcctgggagctcctggttagcaagtgagatctctgggatgtcagtgaggctggttgaagaccagaggtaaactgcagaggtcaccacccccaccatgtcccaggtgatgtccagcccactgctggcaggaggccatgctgtcagcttggcgccttgtgatgagcccaggaggaccctgcacccagcacccagccccagcctgccaccccagtgttcttactacaccacggaaggctggggagcccaggccctgatggcccccgtgccctgcatggggccccctggccgactccagcaagccccacaggtggaggccaaagccacctgcttcctgccgtcccctggtgagaaggccttggggaccccagaggaccttgactcctacattgacttctcactggagagcctcaatcagatgatcctggaactggaccccaccttccagctgcttcccccagggactgggggctcccaggctgagctggcccagagcaccatgtcaatgagaaagaaggaggaatctgaagccttggacataaagtacatcgaggtgacctccgccagatcaaggtgccacgatggcccccagcactgctccagcccctctgtcaccccgcccttcggctcccttcgcagtggtggcctcctcctttccagagacgtcccccgagagacacgaagcagcagtgagagcctcatcttctctgggaaccagggcagggggcaccagcgccctctgcccccctcagagggtctctcccctcgacccccaaattcccccagcatctcaatcccttgcatggggagcaaggcctcgagcccccatggtttgggctccccgctggtggcttctccaagactggagaagcggctgggaggcctggccccacagcggggcagcaggatctctgtgctgtcagccagcccagtgtctgatgtcagctatatgtttggaagcagccagtccctcctgcactccagcaactccagccatcagtcatcttccagatccttggaaagtccagccaactcttcctccagcctccacagccttggctcagtgtccctgtgtacaagacccagtgacttccaggctcccagaaaccccaccctaaccatgggccaacccagaacaccccactctccaccactggccaaagaacatgccagcagctgccccccatccatcaccaactccatggtggacatacccattgtgctgatcaacggctgcccagaaccagggtcttctccaccccagcggaccccaggacaccagaactccgttcaacctggagctgcttctcccagcaacccctgtccagccaccaggagcaacagccagaccctgtcagatgccccctttaccacatgcccagagggtcccgccagggacatgcagcccaccatgaagttcgtgatggacacatctaaatactggtttaagccaaacatcacccgagagcaagcaatcgagctgctgaggaaggaggagccaggggcttttgtcataagggacagctcttcataccgaggctccttcggcctggccctgaaggtgcaggaggttcccgcgtctgctcagagtcgaccaggtgaggacagcaatgacctcatccgacacttcctcatcgagtcgtctgccaaaggagtgcatctcaaaggagcagatgaggagccctactttgggagcctctctgccttcgtgtgccagcattccatcatggccctggccctgccctgcaaactcaccatcccacagagagaactgggaggtgcagatggggcctcggactctacagacagcccagcctcctgccagaagaaatctgcgggctgccacaccctgtacctgagctcagtgagcgtggagaccctgactggagccctggccgtgcagaaagccatctccaccacctttgagagggacatcctccccacgcccaccgtggtccacttcaaagtcacagagcagggcatcactctgactgatgtccagaggaaggtgtttttccggcgccattacccactcaccaccctccgcttctgtggtatggaccctgagcaacggaagtggcagaagtactgcaaaccctcctggatctttgggtttgtggccaagagccagacagagcctcaggagaacgtatgccacctctttgcggagtatgacatggtccagccagcctcgcaggtcatcggcctggtgactgctctgctgcaggacgcagaaaggatgtaggggagagactgcctgtgcacctaaccaacacctccaggggctcgctaaggagcccccctccaccccctgaatgggtgtggcttgtggccatattgacagaccaatctatgggactagggggattggcatcaagttgacacccttgaacctgctatggccttcagcagtcaccatcatccagaccccccgggcctcagtttcctcaatcatagaagaagaccaatagacaagatcagctgttcttagatgctggtgggcatttgaacatgctcctccatgattctgaagcatgcacacctctgaagacccctgcatgaaaataacctccaaggaccctctgaccccatcgacctgggccctgcccacacaacagtctgagcaagagacctgcagcccctgtttcgtggcagacagcaggtgcctggcggtgacccacggggctcctggcttgcagctggtgatggtcaagaactgactacaaaacaggaatggatagactctatttccttccatatctgttcctctgttccttttcccactttctgggtggctttttgggtccacccagccaggatgctgcaggccaagctgggtgtggtatttagggcagctcagcagggggaacttgtccccatggtcagaggagacccagctgtcctgcacccccttgcagatgagtatcaccccatcttttctttccacttggtttttatttttatttttttttgagacagagtctcactgtcacccaggctgaactgcagtggtgtgatctaggctcactgcaacctccacctcccaggttcaagcaattatcctgcctcaggctcccaagtagctgggattacaggcatgtgcaactcacccagctaattttgtatttttagtagagacagggtttcaccatgttggccaggctggtcttgaactcctgaccgcaggtaatccacctgcttcggcctcccaaagtgctgggattacaggcgcaagccacccagcccagcttctttccattccttgataggcgagtattccaaagctggtatcgtagctgccctaatgttgcatattaggcggcgggggcagagataagggccatctctctgtgattctgcctcagctcctgtcttgctgagccctcccccaacccacgctccaacacacacacacacacacacacacacacacacacacacacacacacacacacacacacacgcccctctactgctatgtggcttcaaccagcctcacagccacacgggggaagcagagagtcaagaatgcaaagaggccgcttccctaagaggcttggaggagctgggctctatcccacacccacccccaccccacccccacccagcctccagaagctggaaccatttctcccgcaggcctgagttcctaaggaaaccaccctaccggggtggaagggagggtcagggaagaaacccactcttgctctacgaggagcaagtgcctgccccctcccagcagccagccctgccaaagttgcattatctttggccaaggctgggcctgacggttatgatttcagccctgggcctgcaggagaggctgagaccagcccacccagccagtggtcgagcactgccccgccgccaaagtctgcagaatgtgagatgaggttctcaaggtcacaggccccagtcccagcctgggggctggcagaggcccccatatactctgctacagctcctatcatgaaaaataaaatgtttgtctttgcaaaacagtaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:84951 -> Molecular function: GO:0003779 [actin binding] evidence: IEA
GeneID:84951 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:84951 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:84951 -> Biological process: GO:0008104 [protein localization] evidence: IDA
GeneID:84951 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
GeneID:84951 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA
GeneID:84951 -> Cellular component: GO:0005925 [focal adhesion] evidence: IDA
by
@meso_cacase at
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