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2024-04-20 10:43:19, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_032805 2463 bp mRNA linear PRI 18-APR-2013
DEFINITION Homo sapiens zinc finger and SCAN domain containing 10 (ZSCAN10),
mRNA.
ACCESSION NM_032805
VERSION NM_032805.1 GI:14249487
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2463)
AUTHORS Sugito,K., Kawashima,H., Uekusa,S., Yoshizawa,S., Hoshi,R.,
Furuya,T., Kaneda,H., Hosoda,T., Masuko,T., Ohashi,K., Ikeda,T.,
Koshinaga,T., Fujiwara,K., Igarashi,J., Ghosh,S., Held,W.A. and
Nagase,H.
TITLE Identification of aberrant methylation regions in neuroblastoma by
screening of tissue-specific differentially methylated regions
JOURNAL Pediatr Blood Cancer 60 (3), 383-389 (2013)
PUBMED 22911660
REMARK GeneRIF: We demonstrated that SLC16A5 and ZNF206 displayed altered
methylation patterns in the neuroblastoma genome
REFERENCE 2 (bases 1 to 2463)
AUTHORS Kawashima,H., Sugito,K., Yoshizawa,S., Uekusa,S., Furuya,T.,
Ikeda,T., Koshinaga,T., Shinojima,Y., Hasegawa,R., Mishra,R.,
Igarashi,J., Kimura,M., Wang,X., Fujiwara,K., Gosh,S. and Nagase,H.
TITLE DNA hypomethylation at the ZNF206-exon 5 CpG island associated with
neuronal differentiation in mice and development of neuroblastoma
in humans
JOURNAL Int. J. Oncol. 40 (1), 31-39 (2012)
PUBMED 22011711
REMARK GeneRIF: Data indicates that changes in DNA methylation levels at
the Zfp206-exon 5 might be one of the important factors during
neuronal development in mice and the hypomethylation of the
homologous region induced ZNF206 expression in humans.
REFERENCE 3 (bases 1 to 2463)
AUTHORS Bernot,A., Heilig,R., Clepet,C., Smaoui,N., Da Silva,C.,
Petit,J.L., Devaud,C., Chiannilkulchai,N., Fizames,C., Samson,D.,
Cruaud,C., Caloustian,C., Gyapay,G., Delpech,M. and Weissenbach,J.
TITLE A transcriptional Map of the FMF region
JOURNAL Genomics 50 (2), 147-160 (1998)
PUBMED 9653642
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AK027455.1.
##Evidence-Data-START##
Transcript exon combination :: AK027455.1, DA728426.1 [ECO:0000332]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..2463
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p13.3"
gene 1..2463
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/note="zinc finger and SCAN domain containing 10"
/db_xref="GeneID:84891"
/db_xref="HGNC:12997"
/db_xref="HPRD:15747"
exon 1..319
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/inference="alignment:Splign:1.39.8"
CDS 89..2266
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/note="zinc finger protein 206"
/codon_start=1
/product="zinc finger and SCAN domain-containing protein
10"
/protein_id="NP_116194.1"
/db_xref="GI:14249488"
/db_xref="CCDS:CCDS10493.1"
/db_xref="GeneID:84891"
/db_xref="HGNC:12997"
/db_xref="HPRD:15747"
/translation="
MGPRASLSRLRELCGHWLRPALHTKKQILELLVLEQFLSVLPPHLLGRLQGQPLRDGEEVVLLLEGIHREPSHAGPLDFSCNAGKSCPRADVTLEEKGCASQVPSHSPKKELPAEEPSVLGPSDEPPRPQPRAAQPAEPGQWRLPPSSKQPLSPGPQKTFQALQESSPQGPSPWPEESSRDQELAAVLECLTFEDVPENKAWPAHPLGFGSRTPDKEEFKQEEPKGAAWPTPILAESQADSPGVPGEPCAQSLGRGAAASGPGEDGSLLGSSEILEVKVAEGVPEPNPELQFICADCGVSFPQLSRLKAHQLRSHPAGRSFLCLCCGKSFGRSSILKLHMRTHTDERPHACHLCGHRFRQSSHLSKHLLTHSSEPAFLCAECGRGFQRRASLVQHLLAHAQDQKPPCAPESKAEAPPLTDVLCSHCGQSFQRRSSLKRHLRIHARDKDRRSSEGSGSRRRDSDRRPFVCSDCGKAFRRSEHLVAHRRVHTGERPFSCQACGRSFTQSSQLVSHQRVHTGEKPYACPQCGKRFVRRASLARHLLTHGGPRPHHCTQCGKSFGQTQDLARHQRSHTGEKPCRCSECGEGFSQSAHLARHQRIHTGEKPHACDTCGHRFRNSSNLARHRRSHTGERPYSCQTCGRSFRRNAHLRRHLATHAEPGQEQAEPPQECVECGKSFSRSCNLLRHLLVHTGARPYSCTQCGRSFSRNSHLLRHLRTHARETLY
"
misc_feature 89..295
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/note="SCAN oligomerization domain; Region: SCAN; cd07936"
/db_xref="CDD:153421"
misc_feature order(92..100,104..109,116..121,128..133,137..148,
158..163,170..175,182..190,194..199,203..214,269..271,
278..283,287..295)
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:153421"
misc_feature 407..409
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96SZ4.1); phosphorylation site"
misc_feature 545..547
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96SZ4.1); phosphorylation site"
misc_feature 725..727
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q96SZ4.1); phosphorylation site"
misc_feature 1094..1168
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 1484..>2242
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/note="FOG: Zn-finger [General function prediction only];
Region: COG5048"
/db_xref="CDD:34653"
misc_feature 1529..1606
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 1616..1690
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 1697..1768
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 1781..1858
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 1865..1942
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 1949..2026
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 2135..2212
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
exon 320..587
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/inference="alignment:Splign:1.39.8"
exon 588..652
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/inference="alignment:Splign:1.39.8"
exon 653..710
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/inference="alignment:Splign:1.39.8"
exon 711..2463
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/inference="alignment:Splign:1.39.8"
variation 742
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/replace="a"
/replace="g"
/db_xref="dbSNP:3810808"
STS 2259..2395
/gene="ZSCAN10"
/gene_synonym="ZNF206"
/standard_name="RH91869"
/db_xref="UniSTS:89322"
ORIGIN
cagcccagaggaccccaggcgaccagagtccaggctgaggcccgaggtggctcaccagctgttcagatgcttccagtatcaggaggacatggggccacgggcgtccctgagccggctccgggagctctgcggccactggctgcggccggctctgcacaccaagaaacagatcctggagctgctggtgctggagcagttcctgagtgtgctgcctccgcacctcctgggccgcctgcaggggcagccgctcagggatggggaggaggtggtgctgctgctcgagggcatccaccgggagcccagccacgcggggccgctggattttagttgtaatgctggcaagagttgtccccgtgcagacgtcaccttggaggaaaaggggtgtgcttcccaggtccccagccacagccccaagaaggaattgcctgcggaagagccttcagtgctgggcccatcggatgagcctccccgaccccagccaagggctgcccagcctgctgagccgggacagtggaggcttcccccaagttcaaagcagccgctgagcccggggccccagaagacattccaggccctgcaagaaagcagtccccagggcccctcaccatggccagaggagagttcccgagatcaggagctggcggctgtgctggagtgcctgacctttgaggatgtgccagagaataaggcgtggcctgcacaccccctgggattcggaagcagaaccccagacaaggaggaatttaaacaagaagagcccaaaggggctgcctggcccactcccatcttagcagagtcccaggcagatagtcctggggtgccgggagagccttgcgcccagtcgctcggacggggcgctgcggctagcggccctggcgaagatgggtcccttcttggcagcagtgaaattttggaggtcaaagtggctgagggcgtccccgagcccaatccggagttgcagttcatctgcgcggactgcggggtgagcttcccgcagctgtctcgcctgaaggcgcaccagctgcgctcgcacccggctgggcgctccttcctgtgcctttgctgcgggaagagcttcggccgcagctccattctcaagctgcacatgcgcactcacacggacgagcggccgcacgcctgccacctgtgcggccaccgcttccgccagagctcgcacctgagcaagcacctgctgacccactcctccgaacccgccttcctgtgcgcagagtgcggccgcggcttccagcgccgcgccagccttgtgcagcacctgctggcgcacgcccaggaccagaagccgccctgcgctcctgagagtaaggccgaagcgccgccactgaccgatgtcctgtgctcccactgcggccagagcttccagcgccgctccagcctcaagcgccacctgcggatccacgccagggacaaggaccgccggtcctccgaaggctccggcagccgccgccgggactccgaccggaggcccttcgtgtgcagcgactgcggcaaggccttccggcgcagcgagcacctggtggcccaccggagggtgcacacgggcgagcggcccttctcctgccaggcttgcggccgcagcttcacgcagagctcgcagctggtcagccaccaacgggtgcacacgggcgagaagccctacgcctgtccgcagtgcgggaagcgctttgtgcgccgggccagccttgcccgccacctgctgacccacggtggccctcggccccaccactgcacccagtgcgggaagagtttcggccagacccaggatctggcccgccaccagcgcagccacacgggcgagaagccctgccgctgcagcgagtgcggtgagggcttcagccagagcgcccacctggcgcgccaccagcgcatccacacaggggagaagccccacgcctgcgacacctgcggccaccgtttccgcaatagctccaacctggcccgccatcgccgcagccacacgggcgagcggccctacagctgtcagacgtgcggtcgcagcttccggcgcaacgcgcatctgcggcggcacctggctacccatgcggagcccgggcaggagcaggccgagcccccgcaggagtgcgtggagtgcgggaagagcttcagccgcagctgcaatctgctgcgacacctgctggtgcacacgggcgccaggccctactcctgcacgcagtgtggccgcagcttcagccgcaactcccacctgctgcgccacctgcgcacccacgcccgcgagacgctgtactagcttggcccgccttccgccagccgcgccctgcgccacctacccggggtcctccacagcggaggcctgcaggaatgtcccttcccaccacaccccacttccctctccttccactttcacagctgtccttccctggccgaggcattgctttctggcctcagctatgtaattaaaacgcccgaagtaaaatggccttctcc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:84891 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: ISS
GeneID:84891 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: ISS
GeneID:84891 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:84891 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:84891 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: ISS
GeneID:84891 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
by
@meso_cacase at
DBCLS
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