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2024-04-25 18:15:12, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_032515 2663 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens BCL2-related ovarian killer (BOK), mRNA.
ACCESSION NM_032515 NM_014204
VERSION NM_032515.4 GI:347658959
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2663)
AUTHORS Jaaskelainen,M., Nieminen,A., Pokkyla,R.M., Kauppinen,M.,
Liakka,A., Heikinheimo,M., Vaskivuo,T.E., Klefstrom,J. and
Tapanainen,J.S.
TITLE Regulation of cell death in human fetal and adult ovaries--role of
Bok and Bcl-X(L)
JOURNAL Mol. Cell. Endocrinol. 330 (1-2), 17-24 (2010)
PUBMED 20673843
REMARK GeneRIF: The results suggest important roles for Bok and Bcl-X(L)
in human ovarian development, follicle maturation and apoptosis.
REFERENCE 2 (bases 1 to 2663)
AUTHORS Stein,J.L., Hua,X., Lee,S., Ho,A.J., Leow,A.D., Toga,A.W.,
Saykin,A.J., Shen,L., Foroud,T., Pankratz,N., Huentelman,M.J.,
Craig,D.W., Gerber,J.D., Allen,A.N., Corneveaux,J.J.,
Dechairo,B.M., Potkin,S.G., Weiner,M.W. and Thompson,P.
CONSRTM Alzheimer's Disease Neuroimaging Initiative
TITLE Voxelwise genome-wide association study (vGWAS)
JOURNAL Neuroimage 53 (3), 1160-1174 (2010)
PUBMED 20171287
REFERENCE 3 (bases 1 to 2663)
AUTHORS Ray,J.E., Garcia,J., Jurisicova,A. and Caniggia,I.
TITLE Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast
cell proliferation during human placental development and in
preeclampsia
JOURNAL Cell Death Differ. 17 (5), 846-859 (2010)
PUBMED 19942931
REMARK GeneRIF: Data conclude that Mtd-L functions to regulate trophoblast
cell proliferation during early placentation and that the elevated
levels of Mtd found in PE may contribute to increased trophoblast
proliferation.
REFERENCE 4 (bases 1 to 2663)
AUTHORS Zhang,H., Gao,S. and De Geyter,C.
TITLE A natural antisense transcript, BOKAS, regulates the pro-apoptotic
activity of human Bok
JOURNAL Int. J. Oncol. 34 (4), 1135-1138 (2009)
PUBMED 19287972
REMARK GeneRIF: BOKAS is a natural antisense transcript that regulates the
pro-apoptotic activity of human Bok
REFERENCE 5 (bases 1 to 2663)
AUTHORS Ray,J., Jurisicova,A. and Caniggia,I.
TITLE IFPA Trophoblast Research Award Lecture: the dynamic role of Bcl-2
family members in trophoblast cell fate
JOURNAL Placenta 30 (SUPPL A), S96-S100 (2009)
PUBMED 19095301
REFERENCE 6 (bases 1 to 2663)
AUTHORS Zhang,H., Holzgreve,W. and De Geyter,C.
TITLE Evolutionarily conserved Bok proteins in the Bcl-2 family
JOURNAL FEBS Lett. 480 (2-3), 311-313 (2000)
PUBMED 11034351
REFERENCE 7 (bases 1 to 2663)
AUTHORS Zhang,H., Huang,Q., Ke,N., Matsuyama,S., Hammock,B., Godzik,A. and
Reed,J.C.
TITLE Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary
conservation of cell death mechanisms
JOURNAL J. Biol. Chem. 275 (35), 27303-27306 (2000)
PUBMED 10811653
REFERENCE 8 (bases 1 to 2663)
AUTHORS Leo,C.P., Hsu,S.Y., Chun,S.Y., Bae,H.W. and Hsueh,A.J.
TITLE Characterization of the antiapoptotic Bcl-2 family member myeloid
cell leukemia-1 (Mcl-1) and the stimulation of its message by
gonadotropins in the rat ovary
JOURNAL Endocrinology 140 (12), 5469-5477 (1999)
PUBMED 10579309
REFERENCE 9 (bases 1 to 2663)
AUTHORS Inohara,N., Ekhterae,D., Garcia,I., Carrio,R., Merino,J., Merry,A.,
Chen,S. and Nunez,G.
TITLE Mtd, a novel Bcl-2 family member activates apoptosis in the absence
of heterodimerization with Bcl-2 and Bcl-XL
JOURNAL J. Biol. Chem. 273 (15), 8705-8710 (1998)
PUBMED 9535847
REFERENCE 10 (bases 1 to 2663)
AUTHORS Hsu,S.Y., Kaipia,A., McGee,E., Lomeli,M. and Hsueh,A.J.
TITLE Bok is a pro-apoptotic Bcl-2 protein with restricted expression in
reproductive tissues and heterodimerizes with selective
anti-apoptotic Bcl-2 family members
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 94 (23), 12401-12406 (1997)
PUBMED 9356461
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BX460019.2, AF174487.1,
CN279175.1, BP332256.1, CN279174.1, BX395656.2 and CD368092.1.
This sequence is a reference standard in the RefSeqGene project.
On Sep 24, 2011 this sequence version replaced gi:34335395.
Summary: The protein encoded by this gene belongs to the BCL2
family, members of which form homo- or heterodimers, and act as
anti- or proapoptotic regulators that are involved in a wide
variety of cellular processes. Studies in rat show that this
protein has restricted expression in reproductive tissues,
interacts strongly with some antiapoptotic BCL2 proteins, not at
all with proapoptotic BCL2 proteins, and induces apoptosis in
transfected cells. Thus, this protein represents a proapoptotic
member of the BCL2 family. [provided by RefSeq, Sep 2011].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BX460019.2, BX334491.2 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-160 BX460019.2 1-160
161-1041 AF174487.1 10-890
1042-1408 CN279175.1 335-701
1409-1723 BP332256.1 227-541
1724-2136 CN279174.1 205-617
2137-2578 BX395656.2 22-463 c
2579-2663 CD368092.1 1-85 c
FEATURES Location/Qualifiers
source 1..2663
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q37.3"
gene 1..2663
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/note="BCL2-related ovarian killer"
/db_xref="GeneID:666"
/db_xref="HGNC:1087"
/db_xref="HPRD:05657"
/db_xref="MIM:605404"
exon 1..263
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/inference="alignment:Splign:1.39.8"
variation 75
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="c"
/db_xref="dbSNP:186908585"
variation 96..106
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace=""
/replace="ggaagccccgt"
/db_xref="dbSNP:201711208"
variation 120
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:112259601"
variation 130
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:375404902"
variation 215
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="g"
/replace="t"
/db_xref="dbSNP:377729850"
misc_feature 218..220
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/note="upstream in-frame stop codon"
exon 264..512
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/inference="alignment:Splign:1.39.8"
CDS 293..931
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/note="hBOK; bcl2-L-9; bcl-2-like protein 9"
/codon_start=1
/product="bcl-2-related ovarian killer protein"
/protein_id="NP_115904.1"
/db_xref="GI:14210524"
/db_xref="CCDS:CCDS2550.1"
/db_xref="GeneID:666"
/db_xref="HGNC:1087"
/db_xref="HPRD:05657"
/db_xref="MIM:605404"
/translation="
MEVLRRSSVFAAEIMDAFDRSPTDKELVAQAKALGREYVHARLLRAGLSWSAPERAAPVPGRLAEVCAVLLRLGDELEMIRPSVYRNVARQLHISLQSEPVVTDAFLAVAGHIFSAGITWGKVVSLYAVAAGLAVDCVRQAQPAMVHALVDCLGEFVRKTLATWLRRRGGWTDVLKCVVSTDPGLRSHWLVAALCSFGRFLKAAFFVLLPER
"
misc_feature 386..424
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UMX3.1);
Region: BH4"
misc_feature 401..823
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/note="Apoptosis regulator proteins of the Bcl-2 family,
named after B-cell lymphoma 2. This alignment model spans
what have been described as Bcl-2 homology regions BH1,
BH2, BH3, and BH4. Many members of this family have an
additional C-terminal transmembrane...; Region:
Bcl-2_like; cd06845"
/db_xref="CDD:132900"
misc_feature 401..445
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/note="BH4; other site"
/db_xref="CDD:132900"
misc_feature 488..538
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UMX3.1);
Region: BH3"
misc_feature 500..526
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/note="BH3; other site"
/db_xref="CDD:132900"
misc_feature order(509..514,518..523,533..535,542..547,602..607,
614..619,626..631,647..649,653..658,662..667,677..679,
689..691,821..823)
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/note="BH3-homology region binding site; other site"
/db_xref="CDD:132900"
misc_feature 626..685
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UMX3.1);
Region: BH1"
misc_feature order(626..634,644..682)
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/note="BH1; other site"
/db_xref="CDD:132900"
misc_feature 779..823
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/note="BH2; other site"
/db_xref="CDD:132900"
misc_feature 782..826
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UMX3.1);
Region: BH2"
variation 335
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:201959873"
variation 340
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="g"
/db_xref="dbSNP:148655369"
variation 378
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="g"
/db_xref="dbSNP:142158341"
variation 401
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="g"
/replace="t"
/db_xref="dbSNP:372034705"
variation 414
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="c"
/db_xref="dbSNP:200232215"
exon 513..641
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/inference="alignment:Splign:1.39.8"
STS 513..641
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/standard_name="G42020"
/db_xref="UniSTS:49343"
variation 516
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="c"
/db_xref="dbSNP:193087751"
variation 533
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:146987702"
variation 541..542
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace=""
/replace="g"
/db_xref="dbSNP:34395510"
variation 541
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:372094266"
variation 542
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:199763136"
variation 553
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:377356735"
variation 554
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:145752883"
variation 558
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:201382143"
variation 563
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="g"
/db_xref="dbSNP:148098112"
variation 578
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:145137590"
variation 585
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:142111641"
variation 595
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="g"
/db_xref="dbSNP:376688053"
variation 601
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="g"
/db_xref="dbSNP:74003741"
variation 602
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:200898291"
variation 607
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:370022649"
variation 616
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:140246126"
variation 624
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:116907701"
exon 642..805
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/inference="alignment:Splign:1.39.8"
variation 649
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:116974074"
variation 654
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:139803399"
variation 664
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:150995812"
variation 666
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:149999244"
variation 667
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:375595353"
variation 670
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:370676314"
variation 675
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:374419286"
variation 676
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:201505911"
variation 682
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="c"
/db_xref="dbSNP:367601307"
variation 683
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:141191357"
variation 685
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:200712559"
variation 694
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:371228276"
variation 695
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:371649114"
variation 733
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:375145660"
variation 738
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:368464201"
variation 739
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:140733714"
variation 740
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:148128971"
variation 760
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:141945444"
variation 761
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:371687248"
variation 765
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:375947780"
variation 789
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:138737081"
variation 795
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:147943274"
variation 797
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:199967975"
exon 806..2647
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/inference="alignment:Splign:1.39.8"
variation 845
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:147359626"
variation 863
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="g"
/replace="t"
/db_xref="dbSNP:374794185"
variation 865
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:202131864"
variation 892
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="c"
/db_xref="dbSNP:148652354"
variation 955
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:202219182"
variation 956
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="g"
/db_xref="dbSNP:373866878"
variation 976
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:376881909"
variation 1113
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:367548581"
variation 1232
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:11545680"
variation 1315
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:13010555"
variation 1329
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:112011420"
variation 1356
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:12987834"
variation 1370
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:56202143"
variation 1374
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:60163360"
variation 1375
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:79619383"
variation 1451..1452
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace=""
/replace="c"
/db_xref="dbSNP:35082415"
variation 1477
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:13010818"
variation 1518
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:79675934"
variation 1537
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:13411096"
variation 1537
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace=""
/replace="g"
/db_xref="dbSNP:367867474"
variation 1539..1540
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace=""
/replace="g"
/db_xref="dbSNP:71049586"
variation 1586
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="g"
/db_xref="dbSNP:113829133"
variation 1603
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="t"
/db_xref="dbSNP:12618714"
variation 1616
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:36191086"
variation 1617
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace=""
/replace="g"
/db_xref="dbSNP:372412864"
variation 1625
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:75917160"
variation 1637
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="g"
/db_xref="dbSNP:36156162"
variation 1639
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:372970849"
variation 1644
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="t"
/db_xref="dbSNP:12619342"
variation 1665
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:12619344"
variation 1723..1724
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace=""
/replace="aggtgaaggggcccggaacacctgctctcacctgagcccc"
/db_xref="dbSNP:71049587"
variation 1724..1729
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace=""
/replace="cggtga"
/db_xref="dbSNP:199966104"
variation 1724
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:12695003"
variation 1745
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:12695004"
variation 1754
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="g"
/db_xref="dbSNP:369661365"
variation 1764
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="c"
/db_xref="dbSNP:12993567"
variation 1785
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:12695005"
variation 1787
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="g"
/db_xref="dbSNP:13398152"
variation 1826
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="t"
/db_xref="dbSNP:114168330"
variation 1827
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="g"
/db_xref="dbSNP:62191738"
variation 1830
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="g"
/db_xref="dbSNP:3210568"
variation 1835
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:35995476"
STS 1858..1981
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/standard_name="RH91690"
/db_xref="UniSTS:92830"
variation 1858
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:114722433"
variation 1858
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace=""
/replace="g"
/db_xref="dbSNP:371708460"
STS 1911..2018
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/standard_name="D2S2142"
/db_xref="UniSTS:154274"
variation 1968
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:111823469"
variation 2041
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:57627133"
variation 2056
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="g"
/replace="t"
/db_xref="dbSNP:117659022"
variation 2064
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:1128528"
variation 2088
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:373065782"
variation 2099
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:186401380"
variation 2102
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:114015085"
variation 2104
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:190878245"
variation 2213
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:28538736"
variation 2216
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:78390238"
variation 2243
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="t"
/db_xref="dbSNP:62191739"
variation 2246
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:12618880"
variation 2247
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:114118485"
variation 2249
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="c"
/db_xref="dbSNP:115909425"
variation 2265
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="t"
/db_xref="dbSNP:191494230"
variation 2269
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:138649564"
variation 2288
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:368263648"
STS 2322..2446
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/standard_name="RH78529"
/db_xref="UniSTS:31503"
variation 2508
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="c"
/replace="t"
/db_xref="dbSNP:149302133"
STS 2523..2625
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/standard_name="RH80183"
/db_xref="UniSTS:87573"
variation 2531
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="t"
/db_xref="dbSNP:182921456"
polyA_signal 2608..2613
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
variation 2646
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
/replace="a"
/replace="g"
/db_xref="dbSNP:74673035"
polyA_site 2647
/gene="BOK"
/gene_synonym="BCL2L9; BOKL"
ORIGIN
gccccaagcccagcctctcgccagctgggagtcgcgcgctgcccacctcgctgcccaggcccccgacgccgcggcaggagccccccaagagcgcgggaagccccgtggacctggcgctcccggctcgggcgtggacggggcgggcgccggggcggggcgcgcgtcctcgcgggtctgaatggaagggtcgaggtcgtcgtcggcggcgagcagatcctgaagccagaactccaccccggcgcccgcgccatgcggcgggagaggtgcggcgccccccacccgcgtcgccgccatggaggtgctgcggcgctcctcggtcttcgccgccgagatcatggacgcctttgaccgctcgcccacagacaaggagctggtggcccaggccaaggcgctgggccgggagtacgtgcacgcgcggctgctgcgcgccggcctctcctggagcgcgcccgagcgtgccgcgccggtcccgggacgcctggctgaggtgtgcgcggtgctgctgcgcctgggcgatgagctggagatgatccggcccagcgtctaccgcaacgtggcgcgtcagctgcacatctccctgcagtctgagcctgtggtgaccgatgcgttcctggccgtggctggccacatcttctctgcaggcatcacgtggggcaaggtggtgtccctgtatgcggtggccgcggggctggccgtggactgtgtgaggcaggcccagcctgccatggtccacgccctcgtggactgcctgggggagttcgtgcgcaagaccctggcaacctggctgcggagacgcggcggatggactgatgtcctcaagtgtgtggtcagcacagaccctggcctccgctcccactggctggtggctgcactctgcagcttcggccgcttcctgaaggctgccttcttcgtgctgctgccagagagatgagctgcccacctggcagtggccgcagcctggccctctgggcccaacgcaggaggccctcagcacccgaacacatcttcctcctccccacccgagcctggagcactctaaccctcggagaccccctaagccccgttcctccgcagacccaggccctccggaaggggtgagtggggaggggctttcctgagcctggagctgggctttggggcagcctgcgaccctccccgcttgtgtcccttctcctgtgatctctgtgttttcccttttctttctggggccaggaagtcagggtcaactcccaggcctcagatgcaggggcccagaacacctgctctcacctgagccccaggtgaaggggcccgggaacacctgctctcacctgagccccaggtgaaggggcccgggaacacctgctctcacctgaaccccaggtgaaggggcccggaacacctgctctcacctgagccccaggtgaaggggcccggaacacctgctctcacctgagccccaggtgaaggggcccgggaacacctgctctcacctgagccccaggtgaaggggcccgggaacacctgctctcacctgaaccccaggtgaaggggcccagaacacctgctctcacctgagccccaggtgaaggggcccggaacacctgctctcacctgagccccaggtgaaggggcccgggaacacctgctctcacctgagcccctggtgaaggggcccggaacacttgctctcacctgagccccaggtgaaggggcccggaacacctgctctcacctgagcccccggtgaaggggcccggaacacttgctctcacctgagccccaggtgaaggggcccggaacacctcctctcacctgagccccaggtgaaggggcccggaacacctcctgtcacctgagccccaggtgaaggggcccgggaacacctctcacctgaacccgggggtcccatcccaggaagaagggccatctcaggacatgagtcctcaggggccctgcacattcaatctgaaggtgaccctggcctggctgaagctggaagagctgtggggactcagcctgtaaacagagcgtaaggttcacatgctggttgcttaatccgtttctggaggaagagtatgacacccacttgtgatggggtccttgtgcggtggggaccggggccggcgggctccaggccagcacacctaacccatggatgtggaacctacggccgagaaggaatgttgcatgagtcggatcccagtccattgtcagtggagggtgagggtgaccccatctgctatttttgtgctcatcctcatacaaccatttggggatgtgcctattagggctccgtaagaactcagatgcctgggaagcccagcccctcaggtgcccccacacacagccttcccttgacgcctacatttctaggcacatgtgaggcatctttcctggagccccgagccagccctgtccctccccagtgcagcatggcactcaggagatacaggctggacatggggcagtcgttctggggaggcctggcctagcagccacccacctgagccctcccggccaggcttcgtgctggggtgggccatgtgccaggacaggagggtcccggcggaaagccagccccggactcatcgtgacattgagatcccactggagggtaggggtggtaataaacttctccaaacgatcgttgtcattttagacagaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:666 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:666 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IEA
GeneID:666 -> Molecular function: GO:0051400 [BH domain binding] evidence: IEA
GeneID:666 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA
GeneID:666 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IEA
GeneID:666 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IMP
GeneID:666 -> Biological process: GO:0007420 [brain development] evidence: IEA
GeneID:666 -> Biological process: GO:0008283 [cell proliferation] evidence: IEP
GeneID:666 -> Biological process: GO:0008584 [male gonad development] evidence: IEA
GeneID:666 -> Biological process: GO:0048709 [oligodendrocyte differentiation] evidence: IEA
GeneID:666 -> Biological process: GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] evidence: IMP
GeneID:666 -> Biological process: GO:1900119 [positive regulation of execution phase of apoptosis] evidence: IMP
GeneID:666 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:666 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:666 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
GeneID:666 -> Cellular component: GO:0031966 [mitochondrial membrane] evidence: IDA
by
@meso_cacase at
DBCLS
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