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2019-03-23 03:32:21, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_032510               3847 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens par-6 partitioning defective 6 homolog gamma (C.
            elegans) (PARD6G), mRNA.
ACCESSION   NM_032510 XM_938856
VERSION     NM_032510.3  GI:115495001
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3847)
  AUTHORS   Brajenovic,M., Joberty,G., Kuster,B., Bouwmeester,T. and Drewes,G.
  TITLE     Comprehensive proteomic analysis of human Par protein complexes
            reveals an interconnected protein network
  JOURNAL   J. Biol. Chem. 279 (13), 12804-12811 (2004)
   PUBMED   14676191
REFERENCE   2  (bases 1 to 3847)
  AUTHORS   Kohjima,M., Noda,Y., Takeya,R., Saito,N., Takeuchi,K. and
            Sumimoto,H.
  TITLE     PAR3beta, a novel homologue of the cell polarity protein PAR3,
            localizes to tight junctions
  JOURNAL   Biochem. Biophys. Res. Commun. 299 (4), 641-646 (2002)
   PUBMED   12459187
REFERENCE   3  (bases 1 to 3847)
  AUTHORS   Suzuki,A., Yamanaka,T., Hirose,T., Manabe,N., Mizuno,K.,
            Shimizu,M., Akimoto,K., Izumi,Y., Ohnishi,T. and Ohno,S.
  TITLE     Atypical protein kinase C is involved in the evolutionarily
            conserved par protein complex and plays a critical role in
            establishing epithelia-specific junctional structures
  JOURNAL   J. Cell Biol. 152 (6), 1183-1196 (2001)
   PUBMED   11257119
REFERENCE   4  (bases 1 to 3847)
  AUTHORS   Noda,Y., Takeya,R., Ohno,S., Naito,S., Ito,T. and Sumimoto,H.
  TITLE     Human homologues of the Caenorhabditis elegans cell polarity
            protein PAR6 as an adaptor that links the small GTPases Rac and
            Cdc42 to atypical protein kinase C
  JOURNAL   Genes Cells 6 (2), 107-119 (2001)
   PUBMED   11260256
REFERENCE   5  (bases 1 to 3847)
  AUTHORS   Joberty,G., Petersen,C., Gao,L. and Macara,I.G.
  TITLE     The cell-polarity protein Par6 links Par3 and atypical protein
            kinase C to Cdc42
  JOURNAL   Nat. Cell Biol. 2 (8), 531-539 (2000)
   PUBMED   10934474
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060797.1, AC139100.4 and AA502508.1.
            On Oct 3, 2006 this sequence version replaced gi:40254990.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060797.1, AB044556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1681              BC060797.1         1-1681
            1682-3831           AC139100.4         175504-177653       c
            3832-3847           AA502508.1         310-325
FEATURES             Location/Qualifiers
     source          1..3847
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q23"
     gene            1..3847
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /note="par-6 partitioning defective 6 homolog gamma (C.
                     elegans)"
                     /db_xref="GeneID:84552"
                     /db_xref="HGNC:16076"
                     /db_xref="HPRD:10138"
                     /db_xref="MIM:608976"
     exon            1..238
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    125..127
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /note="upstream in-frame stop codon"
     CDS             167..1297
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /note="PAR-6 gamma protein; PAR6D"
                     /codon_start=1
                     /product="partitioning defective 6 homolog gamma"
                     /protein_id="NP_115899.1"
                     /db_xref="GI:14210518"
                     /db_xref="CCDS:CCDS12022.1"
                     /db_xref="GeneID:84552"
                     /db_xref="HGNC:16076"
                     /db_xref="HPRD:10138"
                     /db_xref="MIM:608976"
                     /translation="
MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGALRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDNDVVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADPRHSLALPPGGVEEHGPAVTL
"
     misc_feature    221..460
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /note="The PB1 domain is an essential part of Par6 protein
                     which in complex with Par3 and aPKC proteins is crucial
                     for establishment of apical-basal polarity of animal
                     cells. The PB1 domain is a modular domain mediating
                     specific protein-protein interactions...; Region:
                     PB1_Par6; cd06403"
                     /db_xref="CDD:99724"
     misc_feature    order(224..226,230..232,251..259,263..265,308..310,
                     320..322,440..442)
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /note="PB1 interaction surface [polypeptide binding];
                     other site"
                     /db_xref="CDD:99724"
     misc_feature    545..928
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BYG4.1);
                     Region: Interaction with PARD3 and CDC42 (By similarity)"
     misc_feature    635..910
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /note="PDZ domain found in a variety of Eumetazoan
                     signaling molecules, often in tandem arrangements. May be
                     responsible for specific protein-protein interactions, as
                     most PDZ domains bind C-terminal polypeptides, and binding
                     to internal (non-C-terminal)...; Region: PDZ_signaling;
                     cd00992"
                     /db_xref="CDD:29049"
     misc_feature    order(671..682,686..688,860..865,872..877)
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /note="protein binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:29049"
     exon            239..461
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /inference="alignment:Splign:1.39.8"
     exon            462..3836
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /inference="alignment:Splign:1.39.8"
     STS             2309..2394
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     variation       2936
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12201"
     variation       3045
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3087701"
     STS             3483..3733
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /standard_name="RH11667"
                     /db_xref="UniSTS:58304"
     STS             3565..3672
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /standard_name="A004B28"
                     /db_xref="UniSTS:32587"
     variation       3568
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1132560"
ORIGIN      
gaggcgcgcggccagcccagctcgggcccgcagcaccgggagcagcccgccggccaagcgagcgcgggccggggccggggccggggcctgggggcgccgcccccgggagtctttctgcggcccctgaggagcgagggcgacggcgaggctgaccggggccgaaaccatgaaccgaagttttcacaagtctcagaccttgcgattctacgattgcagcgcagtggaagtcaagagcaagtttggggcggaattccgaaggttctctctggaccgtcataagcctgggaagtttgaagatttctacaagctggttgtgcacacccaccatatctccaacagtgatgtaactattggctatgcagatgtgcacggagacctgctgcccatcaacaatgatgacaacttctgcaaggcggtttctagtgcaaatcccctgctcagggtcttcatccagaaacgagaggaggccgagcgtggcagcctcggcgcgggctcgctgtgcaggcggaggcgggcgctgggcgcgctgcgtgatgaaggaccccggcggcgtgcacacctggacatcggcctcccgcgcgacttccgccccgtatcatccatcatcgatgtggacctggtccccgagacgcaccggcgagtgcggctgcaccggcacggctgcgagaagccgctgggcttctacatccgcgatggcgccagcgtgcgcgtgaccccgcacgggctggagaaggtgcccggcatcttcatctcgcgcatggtacccgggggcctggcggagagcaccgggctgctggctgtgaatgacgaggtcctggaggtgaacggcattgaggtggccgggaagacgctggaccaggtcacggacatgatgatcgccaacagccacaacctcatcgtcaccgtcaagcccgccaaccagcgcaacaacgtggtgcgcggcggccgcgcgttgggcagctcgggaccgccctcggacggcaccgcgggcttcgtgggtccccccgccccgcgcgtcctgcagaacttccaccccgacgaggcggagagcgatgaggacaacgacgtcgtcatcgagggcacactggagcctgcacgtcccccccagaccccgggcgcgcccgcaggcagcctctcccgggtcaatggcgcgggcctggcgcagcggctgcagcgggacctggccctggacggcggcctccagcggctgctcagctccctgcgggccgacccccgtcacagcctggcgctgccgccaggcggcgtggaggagcacgggcccgcggtcacgctctagactcccgagaggcccccaaatcctagctccagttccccggtaaggacagggacaggacctgcagactgcatccgctcattttttgttgtttttgtgaccacaaaaacaacgctgctctttgtttcaacttccggatataaaaacacaagtattgcctatttttatagaatttcgccacagaacttaaaatgaacgcctgtagagacactctataccaggcctgagtgcaggtcttggcgcctttgcaaagtgatagaaaagatctgaccaagtgcaaaaaaatgctttttaaaatttttacaaatactttgtttttaaagtgaagctttaaaattacttttttaaaatagtcaaattcatgtttttaagtaagttggcccatgcaacatatctcagcattcttgctgtgctctctgctgacttgcaggcgaggccgactgtgctgatgtacgtgacaagaggctggtttttaataacgaatgcagccaggtgcagtggctcacgtctgtaatcccagcactttgggaggcctacgtgggctgatcacgaggtcaggaggtcgagaccagcatggccaacatggtgaaaccctgtctctactaaaaatataaaaattagccaggtgtggtggcaggcgcctgtaatcccagctaccttgggaggctgaggcaggagaatcgcttgaacccgggaggcagaggttgcagtgagctgagatcgcaccactgcactccagcctgggtgacagagcaagactctgtctcgggaaaaaaaaaaaatacacccaaacctgtccatgtacaaccatggagatgaattccagattttcacactgttcatagtcataattcggttgggacaggagagctcccaccagcacacttatggcacccgcagctgtggaattgttccggggcttttttttgtttgttttgagacatagtgtcttgttctgtcatccaagctggagggatctcagctcactgcaacctccgcctcctgggttcaagcaattctcctgcctcagcctcccaaggagctgggacaggcacatgccaccatacccagctaatttttgtatttttagtagagatgggatttcaccacgttggtcaggctggtcttgaactcctgacctcaggtgatacggtcccccctcagcctccaaaaatgctaggattatagacgtgagccacagcaccagaccaggggctatttttgtgacccacataggtggcccattcagcctcaaggggaaatccagggtaggaagcagcagctctgctggactgggctcagcagtcccatttgggatgtaagcctctattgcctctaagatgacccttttcctgtgggttgactgactctgagggcgatttcggaaatgttttcagcagaaatgaaggataagcatcgcacatgtccagcaatgtctttgagaatgcagtcatttgcacgtgagttctcatctttgttttctgaaacagacgtttcttttagtaagtcacaatacatgctaattttcatttctagaatggtcactggcagttctcacttttaactataagaagtcacgtggaacttagtgatttttaacaaatactaaattcatcctcactttatgttgatcttccagcaacgtttatatatttagtaattttaaaaattcctatttgatacaattaaattttatataatgtgttttgcttgaataaaatgttacatttatactttgagaactctgaccaaatctttcatacagatacaggtaaagaaatatttttctaggttgtcggagctgcgtacctcccgctgcttctccttgtggtccagcaccacctgctggtcagtggcagaactgtcctgacttcgtgaacatggaactgctaagagggaaaactgcatctcagcattttcattttttctgaatattaagtgaaaagcaagttctatttttaagaaatagcttttgctgaggagttgtgaattcctgcacctgtgtttgatgttatttgtatgcaatggattgctggccctttgttcctaagcaagagaagaccaaagatgcttccccatgacctctccggtgaggatccgcaccccccggacttgctctctgatgaagggcatgtcgttcagtgccccagcagtcagaagcagtttttgtggaactaaaactaataatgttaccctcacaaaggaaatgttcttttactaagttattgctgattcttgaatgtctgttatataactgggtcggctatcaagaaggaaggttatatttcttatcacattttaagttgttaagcaaatgtgagtttttttttaagaaatgaggctttcactgagatttgtgtgctattcataattttaggaattactgcttagaacagctgcttgggtgtatttttctacacaggtctgtacttctgccactttctccttttaaaaaaacaaaactatgcatattatgtattaaagttttcttggttttatatatcagagaataaaaacttttttgacttttgagtaaacaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:84552 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:84552 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
            GeneID:84552 -> Biological process: GO:0034329 [cell junction assembly] evidence: TAS
            GeneID:84552 -> Biological process: GO:0045216 [cell-cell junction organization] evidence: TAS
            GeneID:84552 -> Biological process: GO:0051301 [cell division] evidence: IEA
            GeneID:84552 -> Biological process: GO:0070830 [tight junction assembly] evidence: TAS
            GeneID:84552 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:84552 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:84552 -> Cellular component: GO:0005923 [tight junction] evidence: IEA
            GeneID:84552 -> Cellular component: GO:0043234 [protein complex] evidence: IEA

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