LOCUS       NM_032498               1297 bp    mRNA    linear   PRI 24-JUN-2013
DEFINITION  Homo sapiens Rhox homeobox family, member 2 (RHOXF2), mRNA.
ACCESSION   NM_032498
VERSION     NM_032498.1  GI:14249118
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1297)
  AUTHORS   Zou,Y. and Zhong,W.
  TITLE     A likely role for a novel PH-domain containing protein, PEPP2, in
            connecting membrane and cytoskeleton
  JOURNAL   Biocell 36 (3), 127-132 (2012)
   PUBMED   23682428
  REMARK    GeneRIF: PEPP2 has a role in regulating function of membrane and
            microtubules
REFERENCE   2  (bases 1 to 1297)
  AUTHORS   Smith,B.A. and Jackman,J.E.
  TITLE     Kinetic analysis of 3'-5' nucleotide addition catalyzed by
            eukaryotic tRNA(His) guanylyltransferase
  JOURNAL   Biochemistry 51 (1), 453-465 (2012)
   PUBMED   22136300
  REMARK    GeneRIF: The high-resolution crystal structure of human Thg1
            reveals remarkable structural similarity between canonical DNA/RNA
            polymerases and eukaryotic Thg1.
REFERENCE   3  (bases 1 to 1297)
  AUTHORS   Shibata-Minoshima,F., Oki,T., Doki,N., Nakahara,F., Kageyama,S.,
            Kitaura,J., Fukuoka,J. and Kitamura,T.
  TITLE     Identification of RHOXF2 (PEPP2) as a cancer-promoting gene by
            expression cloning
  JOURNAL   Int. J. Oncol. 40 (1), 93-98 (2012)
   PUBMED   21874235
  REMARK    GeneRIF: RHOXF2 is highly expressed in some leukemia cell lines and
            a variety of human cancers. Results indicate that RHOXF2 is
            involved in carcinogenesis.
REFERENCE   4  (bases 1 to 1297)
  AUTHORS   Niu,A.L., Wang,Y.Q., Zhang,H., Liao,C.H., Wang,J.K., Zhang,R.,
            Che,J. and Su,B.
  TITLE     Rapid evolution and copy number variation of primate RHOXF2, an
            X-linked homeobox gene involved in male reproduction and possibly
            brain function
  JOURNAL   BMC Evol. Biol. 11, 298 (2011)
   PUBMED   21988730
  REMARK    GeneRIF: In striking contrast to non-human primates, humans appear
            to have homogenized their two RHOXF2 copies by the endogenous
            retrovirus -mediated non-allelic recombination mechanism.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1297)
  AUTHORS   Xin,X., Rual,J.F., Hirozane-Kishikawa,T., Hill,D.E., Vidal,M.,
            Boone,C. and Thierry-Mieg,N.
  TITLE     Shifted Transversal Design smart-pooling for high coverage
            interactome mapping
  JOURNAL   Genome Res. 19 (7), 1262-1269 (2009)
   PUBMED   19447967
REFERENCE   6  (bases 1 to 1297)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat. Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   7  (bases 1 to 1297)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res. 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   8  (bases 1 to 1297)
  AUTHORS   Wayne,C.M., MacLean,J.A., Cornwall,G. and Wilkinson,M.F.
  TITLE     Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2,
            selectively expressed in the testis
  JOURNAL   Gene 301 (1-2), 1-11 (2002)
   PUBMED   12490318
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL590526.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL590526.1, AF317219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1297
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..1297
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /note="Rhox homeobox family, member 2"
                     /db_xref="GeneID:84528"
                     /db_xref="HGNC:30011"
                     /db_xref="HPRD:02345"
                     /db_xref="MIM:300447"
     misc_feature    1..464
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /note="matches EST AI954612 from clone IMAGE:2473139"
     misc_feature    1..455
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /note="matches EST BE046930 from clone IMAGE:2916991"
     misc_feature    1..406
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /note="matches EST AI657125 from clone IMAGE:2244151"
     misc_feature    1..396
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /note="matches EST AI209091 from clone IMAGE:1838548"
     misc_feature    1..383
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /note="matches EST AA933590 from clone IMAGE:1551106"
     exon            1..269
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    2..232
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /note="matches EST R69071 from clone IMAGE:141589"
     misc_feature    113..115
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /note="upstream in-frame stop codon"
     CDS             191..1057
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /note="homeobox protein from AL590526; PEPP subfamily gene
                     2; cancer/testis antigen 107; testis homeobox gene 1;
                     paired-like homeobox protein PEPP-2"
                     /codon_start=1
                     /product="rhox homeobox family member 2"
                     /protein_id="NP_115887.1"
                     /db_xref="GI:14249119"
                     /db_xref="CCDS:CCDS14594.1"
                     /db_xref="GeneID:84528"
                     /db_xref="HGNC:30011"
                     /db_xref="HPRD:02345"
                     /db_xref="MIM:300447"
                     /translation="

MEPPDQCSQYMTSLLSPAVDDEKELQDMNAMVLSLTEEVKEEEEDAQPEPEQGTAAGEKLKSAGAQGGEEKDGGGEEKDGGGAGVPGHLWEGDLEGTSGSDGNVEDSDQSEKEPGQQYSRPQGAVGGLEPGNAQQPNVHAFTPLQLQELERIFQREQFPSEFLRRRLARSMNVTELAVQIWFENRRAKWRRHQRALMARNMLPFMAVGQPVMVTAAEAITAPLFISGMRDDYFWDHSHSSSLCFPMPPFPPPSLPLPLMLLPPMPPAGQAEFGPFPFVIVPSFTFPNV

"
     misc_feature    611..769
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(611..613,662..664,680..682,719..721,725..730,
                     737..742,746..754,758..763)
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(728..730,737..742,749..751)
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    746..775
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BQY4.1);
                     Region: Nuclear localization signal (By similarity)"
     exon            270..681
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /inference="alignment:Splign:1.39.8"
     variation       363
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200645714"
     variation       376
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374278020"
     variation       392
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148604152"
     variation       395
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:62637695"
     variation       395
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143283202"
     variation       409
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377342685"
     variation       433
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146682591"
     variation       434
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140341265"
     variation       437
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145501005"
     variation       446
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369778742"
     variation       457
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35263081"
     variation       457
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149340601"
     variation       467
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146311958"
     variation       467
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:40786"
     variation       472
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140903249"
     variation       473
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373969876"
     variation       485
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150161751"
     variation       491
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376075919"
     variation       505
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:76849625"
     variation       505
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138734517"
     variation       511
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200866984"
     variation       563
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202000800"
     variation       589
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199940228"
     variation       601
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142963365"
     variation       607
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376079408"
     variation       619
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147065169"
     variation       641
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:40785"
     variation       642
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142899626"
     variation       653
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370729029"
     exon            682..727
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /inference="alignment:Splign:1.39.8"
     variation       682
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200574498"
     misc_feature    687..963
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /note="matches EST R69179 from clone IMAGE:141589"
     variation       716
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3764830"
     variation       716
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199871532"
     exon            728..1297
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /inference="alignment:Splign:1.39.8"
     variation       894
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:6646602"
     variation       1047
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35435371"
     variation       1047
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200893778"
     variation       1258..1259
                     /gene="RHOXF2"
                     /gene_synonym="CT107; PEPP-2; PEPP2; THG1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:35812130"
ORIGIN      

aacccacagcaaatagcgggaagcagaaaagcaagagaggaggtctctaagtggatacactgttgctgagtctagacaccagaagaacgttgcaggcggcgactcacagttctagcactgcctaggagagcgtggtggccccagctcagaatctgcagaagtgcacagctccatccacaccactcagggtatggagcctccggaccagtgtagccagtatatgaccagcttgctcagccctgcagtcgacgacgagaaagaactacaggatatgaatgctatggtgctgtcgcttactgaagaggtcaaagaggaggaagaggatgcacagcctgagcctgagcaaggcacagcagcaggagaaaagttaaagtcggcaggagcccaaggcggagaagaaaaagatggcggcggagaagaaaaagatggcggcggcgccggagttcctggccacctatgggaaggagacctcgagggcaccagcggcagcgatggcaacgttgaggacagcgaccagagcgagaaggaacctgggcagcagtattcgcgcccacagggcgccgtcggggggctggagcctggcaacgcgcagcagcccaacgtccacgccttcaccccattgcagctgcaggagctggagcgcattttccaacgcgagcagttccccagtgagttcctgcgaaggaggctggcaagaagcatgaatgtgactgaactcgcagtgcagatttggtttgagaatagaagagccaaatggaggagacatcagagggcattaatggcaagaaacatgctgcccttcatggcagtgggccagcctgtcatggtaaccgcagctgaggccataacggcacccttgttcatcagcgggatgagagatgattacttctgggaccacagccattccagcagcctgtgtttccccatgccaccctttcctcctccgtccttgccccttccactcatgcttcttccacctatgccacccgctggccaggctgaatttggcccattcccttttgttatcgtgccttctttcacattccccaatgtctaagggatagcctctgtgccactttttgccagagtgtctttgagccagattcatattttgcatagcaccccatcaaaagtagttcatcaaatgtctattaaacgttttaaagaaaagtacatcattgacccatttttagggcacttgtaaaaatgtttctataaatatgtgaagggtatgtacatttgttttgtgtgtcacatggggtcagtaagttctcaataaaaattgttaagaaatgcc

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:84528 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:84528 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:84528 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:84528 -> Cellular component: GO:0005634 [nucleus] evidence: IEA