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2024-04-26 19:28:30, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_032387 4194 bp mRNA linear PRI 12-MAY-2013
DEFINITION Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), mRNA.
ACCESSION NM_032387
VERSION NM_032387.4 GI:260166636
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4194)
AUTHORS Ohta,A., Schumacher,F.R., Mehellou,Y., Johnson,C., Knebel,A.,
Macartney,T.J., Wood,N.T., Alessi,D.R. and Kurz,T.
TITLE The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension
syndrome interacts with and ubiquitylates WNK isoforms:
disease-causing mutations in KLHL3 and WNK4 disrupt interaction
JOURNAL Biochem. J. 451 (1), 111-122 (2013)
PUBMED 23387299
REMARK GeneRIF: The CUL3-KLHL3 E3 ligase complex mutated in Gordon's
hypertension syndrome interacts with and ubiquitylates WNK
isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt
interaction.
REFERENCE 2 (bases 1 to 4194)
AUTHORS Na,T., Wu,G., Zhang,W., Dong,W.J. and Peng,J.B.
TITLE Disease-causing R1185C mutation of WNK4 disrupts a regulatory
mechanism involving calmodulin binding and SGK1 phosphorylation
sites
JOURNAL Am. J. Physiol. Renal Physiol. 304 (1), F8-F18 (2013)
PUBMED 23054253
REMARK GeneRIF: R1185C mutation disrupts a CaM binding site at the WNK4
COOH-terminal region and alters the phosphorylation of WNK4 by
SGK1.
REFERENCE 3 (bases 1 to 4194)
AUTHORS Mendes,A.I., Matos,P., Moniz,S., Luz,S., Amaral,M.D., Farinha,C.M.
and Jordan,P.
TITLE Antagonistic regulation of cystic fibrosis transmembrane
conductance regulator cell surface expression by protein kinases
WNK4 and spleen tyrosine kinase
JOURNAL Mol. Cell. Biol. 31 (19), 4076-4086 (2011)
PUBMED 21807898
REMARK GeneRIF: Results show that Tyr512 phosphorylation is a novel signal
regulating the prevalence of CFTR at the cell surface and that WNK4
and Syk perform an antagonistic role in this process.
REFERENCE 4 (bases 1 to 4194)
AUTHORS Han,Y., Fan,X., Sun,K., Wang,X., Wang,Y., Chen,J., Zhen,Y.,
Zhang,W. and Hui,R.
TITLE Hypertension associated polymorphisms in WNK1/WNK4 are not
associated with hydrochlorothiazide response
JOURNAL Clin. Biochem. 44 (13), 1045-1049 (2011)
PUBMED 21704025
REMARK GeneRIF: hypertension associated polymorphisms in WNK1 and WNK4 may
not be predictors for antihypertensive response to diuretics.
REFERENCE 5 (bases 1 to 4194)
AUTHORS Kahle,K.T., Gimenez,I., Hassan,H., Wilson,F.H., Wong,R.D.,
Forbush,B., Aronson,P.S. and Lifton,R.P.
TITLE WNK4 regulates apical and basolateral Cl- flux in extrarenal
epithelia
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (7), 2064-2069 (2004)
PUBMED 14769928
REMARK GeneRIF: general role for WNK4 in the regulation of electrolyte
flux in diverse epithelia
REFERENCE 6 (bases 1 to 4194)
AUTHORS Erlich,P.M., Cui,J., Chazaro,I., Farrer,L.A., Baldwin,C.T.,
Gavras,H. and DeStefano,A.L.
TITLE Genetic variants of WNK4 in whites and African Americans with
hypertension
JOURNAL Hypertension 41 (6), 1191-1195 (2003)
PUBMED 12719438
REMARK GeneRIF: Single-nucleotide polymorphims of WNK4 in whites and
African Americans with hypertension.
GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 7 (bases 1 to 4194)
AUTHORS Wilson,F.H., Kahle,K.T., Sabath,E., Lalioti,M.D., Rapson,A.K.,
Hoover,R.S., Hebert,S.C., Gamba,G. and Lifton,R.P.
TITLE Molecular pathogenesis of inherited hypertension with hyperkalemia:
the Na-Cl cotransporter is inhibited by wild-type but not mutant
WNK4
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (2), 680-684 (2003)
PUBMED 12515852
REFERENCE 8 (bases 1 to 4194)
AUTHORS Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
TITLE Expressed sequence tag analysis of human RPE/choroid for the
NEIBank Project: over 6000 non-redundant transcripts, novel genes
and splice variants
JOURNAL Mol. Vis. 8, 205-220 (2002)
PUBMED 12107410
REMARK Publication Status: Online-Only
REFERENCE 9 (bases 1 to 4194)
AUTHORS Verissimo,F. and Jordan,P.
TITLE WNK kinases, a novel protein kinase subfamily in multi-cellular
organisms
JOURNAL Oncogene 20 (39), 5562-5569 (2001)
PUBMED 11571656
REFERENCE 10 (bases 1 to 4194)
AUTHORS Wilson,F.H., Disse-Nicodeme,S., Choate,K.A., Ishikawa,K.,
Nelson-Williams,C., Desitter,I., Gunel,M., Milford,D.V.,
Lipkin,G.W., Achard,J.M., Feely,M.P., Dussol,B., Berland,Y.,
Unwin,R.J., Mayan,H., Simon,D.B., Farfel,Z., Jeunemaitre,X. and
Lifton,R.P.
TITLE Human hypertension caused by mutations in WNK kinases
JOURNAL Science 293 (5532), 1107-1112 (2001)
PUBMED 11498583
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CA388932.1, BC136664.1 and
BM683764.1.
This sequence is a reference standard in the RefSeqGene project.
On Oct 1, 2009 this sequence version replaced gi:58331254.
Summary: This gene encodes a member of the WNK family of
serine-threonine protein kinases. The kinase is part of the tight
junction complex in kidney cells, and regulates the balance between
NaCl reabsorption and K(+) secretion. The kinase regulates the
activities of several types of ion channels, cotransporters, and
exchangers involved in electrolyte flux in epithelial cells.
Mutations in this gene result in pseudohypoaldosteronism type
IIB.[provided by RefSeq, Sep 2009].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC136664.1, AJ316534.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025086 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-50 CA388932.1 1-50
51-4048 BC136664.1 1-3998
4049-4194 BM683764.1 1-146 c
FEATURES Location/Qualifiers
source 1..4194
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21-q22"
gene 1..4194
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/note="WNK lysine deficient protein kinase 4"
/db_xref="GeneID:65266"
/db_xref="HGNC:14544"
/db_xref="MIM:601844"
exon 1..686
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 22
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:375681809"
variation 26
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:370313183"
variation 41
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:374744005"
variation 47
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:200318202"
variation 51
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:61754323"
variation 62
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:202057094"
CDS 69..3800
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/EC_number="2.7.11.1"
/note="protein kinase with no lysine 4; protein kinase
lysine-deficient 4"
/codon_start=1
/product="serine/threonine-protein kinase WNK4"
/protein_id="NP_115763.2"
/db_xref="GI:34365793"
/db_xref="CCDS:CCDS11439.1"
/db_xref="GeneID:65266"
/db_xref="HGNC:14544"
/db_xref="MIM:601844"
/translation="
MLASPATETTVLMSQTEADLALRPPPPLGTAGQPRLGPPPRRARRFSGKAEPRPRSSRLSRRSSVDLGLLSSWSLPASPAPDPPDPPDSAGPGPARSPPPSSKEPPEGTWTEGAPVKAAEDSARPELPDSAVGPGSREPLRVPEAVALERRREQEEKEDMETQAVATSPDGRYLKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREERGVHVELAEEDDGEKPGLKLWLRMEDARRGGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRKREKLRKARELEALPPEPGPPPATVPMAPGPPSVFPPEPEEPEADQHQPFLFRHASYSSTTSDCETDGYLSSSGFLDASDPALQPPGGVPSSLAESHLCLPSAFALSIPRSGPGSDFSPGDSYASDAASGLSDVGEGMGQMRRPPGRNLRRRPRSRLRVTSVSDQNDRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFLRRIREIIQRVETLLKRDTGPMEAAEDTLSPQEEPAPLPALPVPLPDPSNEELQSSTSLEHRSWTAFSTSSSSPGTPLSPGNPFSPGTPISPGPIFPITSPPCHPSPSPFSPISSQVSSNPSPHPTSSPLPFSSSTPEFPVPLSQCPWSSLPTTSPPTFSPTCSQVTLSSPFFPPCPSTSSFPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPSPLPSLPLPPPVAPGGQESPSPHTAEVESEASPPPARPLPGEARLAPISEEGKPQLVGRFQVTSSKEPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGGPETREALAESDRAAEGLGAGVEEEGDDGKEPQVGGSPQPLSHPSPVWMNYSYSSLCLSSEESESSGEDEEFWAELQSLRQKHLSEVETLQTLQKKEIEDLYSRLGKQPPPGIVAPAAMLSSRQRRLSKGSFPTSRRNSLQRSEPPGPGIMRRNSLSGSSTGSQEQRASKGVTFAGDVGRM
"
misc_feature 603..1364
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature 606..1355
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/note="Catalytic domain of Protein Kinases; Region: PKc;
cd00180"
/db_xref="CDD:173623"
misc_feature order(606..620,630..632,669..671,675..677,768..770,
828..839,849..851,855..857,972..974,978..980,984..989,
993..995,1029..1031,1038..1040,1080..1091)
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(606..620,630..632,669..671,675..677,768..770,
828..839,849..851,972..974,978..980,984..989,993..995,
1029..1031)
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(618..620,849..851,855..857,972..974,978..980,
984..986,1038..1040,1080..1091)
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature order(1026..1046,1080..1091)
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature 1425..1535
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/note="Oxidative-stress-responsive kinase 1 C terminal;
Region: OSR1_C; pfam12202"
/db_xref="CDD:204847"
variation 84
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:61754324"
variation 115
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:61754325"
variation 135
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:368683340"
variation 138
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:371972656"
variation 160
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:370527167"
variation 193
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:374001790"
variation 231
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:201419013"
variation 250
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:375444500"
variation 272
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200209645"
variation 277
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="g"
/replace="t"
/db_xref="dbSNP:369689386"
variation 307
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:61754326"
variation 311
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="g"
/replace="t"
/db_xref="dbSNP:371379940"
variation 312
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="g"
/replace="t"
/db_xref="dbSNP:368949418"
variation 314
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:373427674"
variation 330
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:375244096"
variation 336
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="g"
/replace="t"
/db_xref="dbSNP:199712166"
variation 365
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="g"
/replace="t"
/db_xref="dbSNP:61754327"
variation 442
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:369221665"
variation 509
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:112188737"
variation 518
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:377745941"
variation 526
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:78058990"
variation 542
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:146717828"
variation 544
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:373246842"
variation 561
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="g"
/replace="t"
/db_xref="dbSNP:140344387"
variation 568
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:376782226"
variation 569
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201054911"
variation 575
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:61754328"
exon 687..859
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 690
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:201212813"
variation 691
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:375355128"
variation 718
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:374594203"
variation 719
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:146515383"
variation 747
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="g"
/replace="t"
/db_xref="dbSNP:140897013"
variation 749
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:75749468"
variation 750
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:75596106"
variation 784
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:199775692"
variation 798
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:78232600"
variation 844
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:138156012"
variation 845
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:149157215"
variation 851
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:371430478"
exon 860..1080
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 904
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:112475091"
variation 946
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:146556309"
variation 950
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201337475"
variation 1001
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200256086"
variation 1005
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:139202412"
variation 1009
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:368501387"
variation 1013
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:61754348"
variation 1053
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:142280606"
variation 1080
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:373585658"
exon 1081..1238
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 1117..1118
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace=""
/replace="a"
/db_xref="dbSNP:72024156"
variation 1119
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:375379956"
variation 1123
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:76310211"
variation 1129
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:368410238"
variation 1170
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:147522675"
variation 1218
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:369228385"
variation 1238
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="g"
/replace="t"
/db_xref="dbSNP:148161064"
exon 1239..1327
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 1265
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:183280336"
variation 1290
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="t"
/db_xref="dbSNP:369420670"
variation 1292
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:373485019"
variation 1308
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:377462363"
variation 1309
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:370300499"
variation 1322
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:373040449"
exon 1328..1544
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 1361
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:142027397"
variation 1397
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:55772936"
variation 1413
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:373109872"
variation 1420
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:61754356"
variation 1441
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:368869602"
variation 1455
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:372972035"
variation 1462
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:145499777"
variation 1469
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:375945297"
variation 1473
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:370770635"
exon 1545..1809
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 1553
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:184632930"
variation 1578
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:200593980"
variation 1590
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:201947637"
variation 1591
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:55997156"
variation 1592
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:55879206"
variation 1594
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:143222801"
variation 1599
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:146216767"
variation 1622
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:61755589"
variation 1624
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:139245311"
variation 1640
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="g"
/replace="t"
/db_xref="dbSNP:144084546"
variation 1641
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:145020225"
variation 1642
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200182836"
variation 1651
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:373742806"
variation 1666
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:112963672"
variation 1709
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:9916754"
variation 1710
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:371668464"
variation 1712
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:142230858"
variation 1721
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:55751736"
variation 1728
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="t"
/db_xref="dbSNP:201848994"
variation 1732
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:57737815"
variation 1734
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:56003090"
variation 1740
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:374889836"
variation 1747
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:193922734"
variation 1750
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:193922735"
variation 1752
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:137853093"
variation 1758
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:193922736"
variation 1759
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:137853094"
variation 1761
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:137853092"
variation 1787
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:56243382"
exon 1810..1931
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 1868
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace=""
/replace="t"
/db_xref="dbSNP:61755595"
variation 1869
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="g"
/replace="t"
/db_xref="dbSNP:55781437"
variation 1871
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:374742463"
variation 1886
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:149633706"
variation 1895
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201340788"
variation 1897
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:377697081"
variation 1921
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="g"
/replace="t"
/db_xref="dbSNP:143396070"
exon 1932..1990
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 1933
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:201356607"
variation 1953
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:61755600"
variation 1956
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:56030257"
variation 1969
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="g"
/replace="t"
/db_xref="dbSNP:368190514"
variation 1977..1978
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace=""
/replace="c"
/db_xref="dbSNP:35772851"
variation 1978
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:377536508"
variation 1982
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:368434117"
variation 1983
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:61755602"
variation 1986
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:199767685"
exon 1991..2108
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 2022
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:376641891"
variation 2034
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:374463256"
variation 2074
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:146190504"
variation 2077
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:367768336"
variation 2091
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:61755604"
variation 2092
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:202162490"
variation 2097
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:9896991"
variation 2099
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201748544"
exon 2109..2225
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 2148
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:142471423"
variation 2179
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:150554297"
variation 2204
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:372128794"
exon 2226..2363
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 2230
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:140819480"
variation 2253
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:370712588"
variation 2257
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:373527062"
variation 2274
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:376404874"
variation 2275
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:149389156"
variation 2281
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200823152"
variation 2287
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:201510716"
variation 2292
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:189584917"
variation 2296
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:139570279"
variation 2346
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200807433"
exon 2364..2418
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 2394
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200438705"
variation 2402
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:61755621"
variation 2408
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:199864937"
variation 2416
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:145613797"
exon 2419..3029
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 2432
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:56376863"
variation 2437
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:56227191"
variation 2450
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:56231972"
variation 2452
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:185780530"
variation 2460
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="t"
/db_xref="dbSNP:61755624"
variation 2473
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:35725557"
variation 2491
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:147081637"
variation 2498
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="g"
/replace="t"
/db_xref="dbSNP:369887011"
variation 2542
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:56226218"
variation 2544
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:190384194"
variation 2549
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:200744992"
variation 2570
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:372719835"
variation 2637
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:61755626"
variation 2720
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:376535315"
variation 2739
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:141615112"
variation 2740
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:56081375"
variation 2741
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:151077943"
variation 2792
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:2290042"
variation 2806
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:368043109"
variation 2820
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200057224"
variation 2833
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:201592842"
variation 2858
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:201032525"
variation 2891
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:371107660"
variation 2905
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:200187290"
variation 2907
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:368185978"
variation 2910
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:372807256"
variation 2949
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:2290041"
variation 2961
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:200640984"
variation 2972
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:138944002"
variation 2973
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:202060087"
variation 2976
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:372187677"
exon 3030..3090
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 3077
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:142279974"
exon 3091..3499
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 3100
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:61755628"
variation 3105
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:376863636"
variation 3114
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:370684411"
variation 3123
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="g"
/replace="t"
/db_xref="dbSNP:201925752"
variation 3142
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:56099549"
variation 3143
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:375116020"
variation 3147
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:377665825"
variation 3174
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:370906094"
variation 3250
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:142406282"
variation 3291
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:201421543"
variation 3292
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:200263366"
variation 3295
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:143956890"
variation 3319
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:148648427"
STS 3322..3520
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/standard_name="RH45445"
/db_xref="UniSTS:59661"
variation 3349
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:371930924"
variation 3434
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:373691033"
variation 3435
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:367565094"
variation 3451
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:371666484"
variation 3462
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:374887223"
variation 3464
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:150858674"
variation 3492
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:371972756"
variation 3493
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:369907969"
exon 3500..3699
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 3548
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="g"
/replace="t"
/db_xref="dbSNP:201060010"
variation 3558
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:141257205"
variation 3573
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:193922737"
variation 3586
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:117902541"
variation 3587
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:367834726"
variation 3621
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:137853095"
variation 3622
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:61755631"
variation 3661
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:61755632"
variation 3663
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:200519604"
variation 3678
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:56116165"
exon 3700..3797
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 3729
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:201075094"
variation 3748
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:368730175"
variation 3776
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="t"
/db_xref="dbSNP:377529825"
variation 3780
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:371087263"
exon 3798..4178
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/inference="alignment:Splign:1.39.8"
variation 3806
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:61755635"
variation 3814
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:202219527"
variation 3910
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="c"
/db_xref="dbSNP:200888932"
variation 3975
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:191035468"
STS 4051..4170
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/standard_name="RH47257"
/db_xref="UniSTS:44990"
variation 4057
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:111588847"
variation 4068
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="a"
/replace="g"
/db_xref="dbSNP:377763866"
variation 4135
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
/replace="c"
/replace="g"
/db_xref="dbSNP:61755636"
polyA_signal 4156..4161
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
polyA_site 4178
/gene="WNK4"
/gene_synonym="PHA2B; PRKWNK4"
ORIGIN
gtccgtctgtcaggccgcctcctctccggccgtctgattttctacccttcggcgccctgctcttcctcatgttggcatccccggccacggagaccaccgtcctcatgtcccagactgaggccgacctggccctgcggcccccgcctcctcttggcaccgcggggcagccccgcctcgggccccctcctcgccgagcgcgccgcttctccgggaaggctgagccccggccgcgctcttctcgtctcagccgccgtagctcagtcgacttggggctgctgagctcttggtccctgccagcctcacccgctccggacccccccgatcctccggactccgctggtcctggccccgcgaggagcccaccgcctagctccaaagaaccccccgagggcacgtggaccgagggagcccctgtgaaggctgcggaagactccgcgcgtcccgagctcccggactctgcagtgggcccggggtccagggagccgctaagggtccctgaagctgtggccctagagcggcggcgggagcaggaagaaaaggaggacatggagacccaggctgtggcaacgtcccccgatggccgatacctcaagtttgacatcgagattggacgtggctccttcaagacggtgtatcgagggctagacaccgacaccacagtggaggtggcctggtgtgagctgcagactcggaaactgtctagagctgagcggcagcgcttctcagaggaggtggagatgctcaaggggctgcagcaccccaacatcgtccgcttctatgattcgtggaagtcggtgctgaggggccaggtttgcatcgtgctggtcaccgaactcatgacctcgggcacgctcaagacgtacctgaggcggttccgggagatgaagccgcgggtccttcagcgctggagccgccaaatcctgcggggacttcatttcctacactcccgggttcctcccatcctgcaccgggatctcaagtgcgacaatgtctttatcacgggacctactggctctgtcaaaatcggggacctgggcctggccacgctcaagcgcgcctcctttgccaagagtgtcatcgggaccccggaattcatggcccccgagatgtacgaggaaaagtacgatgaggccgtggacgtgtacgcgttcggcatgtgcatgctggagatggccacctctgagtacccgtactccgagtgccagaatgccgcgcaaatctaccgcaaggtcacttcgggcagaaagccgaacagcttccacaaggtgaagatacccgaggtgaaggagatcattgaaggctgcatccgcacggataagaacgagaggttcaccatccaggacctcctggcccacgccttcttccgcgaggagcgcggtgtgcacgtggaactagcggaggaggacgacggcgagaagccgggcctcaagctctggctgcgcatggaggacgcgcggcgcggggggcgcccacgggacaaccaggccatcgagttcctgttccagctgggccgggacgcggccgaggaggtggcacaggagatggtggctctgggcttggtctgtgaagccgattaccagccagtggcccgtgcagtacgtgaacgggttgctgccatccagcgaaagcgtgagaagctgcgtaaagcaagggaattggaggcactcccaccagagccaggacctccaccagcaactgtgcccatggcccccggtccccccagtgtcttcccccctgagcctgaggagccagaggcagaccagcaccagcccttccttttccgccacgccagctactcatctaccacttcggattgcgagactgatggctacctcagctcctccggcttcctggatgcctcagaccctgcccttcagccccctgggggggtgccatccagcctggctgagtcccatctctgcctgccctcggcttttgccctatccattccacgttctggccctggaagtgacttttcccccggggacagctatgcctcagatgcagcttcaggccttagcgatgtgggagaagggatgggacaaatgaggagacccccagggaggaatctccggcgcagaccccgatcccggctgcgggtcactagtgtctcagaccagaatgacagagtggttgagtgccagctacagacccataacagcaagatggtgaccttccgatttgatctggatggggacagcccggaagagattgcagctgccatggtatataacgagttcattctgccttcggagcgagatggatttctcagacggattcgggagattatccagcgagtggagaccctgttgaagagagacactggccccatggaggctgctgaagacaccctaagcccccaggaggagccagcaccattacctgccctgcccgtccccctcccagacccatccaatgaagagctccagagcagcacctccctggagcacaggagctggacagccttctccacctcctcatcttctcctggaactcctttgtctcctggaaacccattttcccctggaacccccatttccccaggtcccatcttccccatcacttctcccccatgtcatcccagcccctccccattctcccccatttcttcccaggtctcctcaaatccctctccacaccccaccagctctccacttccattctcctccagcacacccgagtttccggtcccactctctcagtgtccctggagttctctccccacgacttctccacctacgttctctcccacttgttctcaggtcactcttagttcccctttctttcctccgtgcccctccacttcttccttcccctccaccacagcagcccctctcctttctctggctagtgccttctcactggctgtgatgactgtggcccagtccctgctgtccccctcacctgggctcctttcccagtctcctccagcccctcctagtcccctccctagcctgccccttccccctcccgttgctcctggtggccaggaaagcccttcaccccacacagctgaggtggagagtgaggcctcaccacctcctgctcggcccctcccaggggaagccaggctggcgcccatctctgaagagggaaagccgcagcttgttgggcgtttccaagtgacttcatccaaggaaccggctgagcctcttcccttgcagccaacatcccccactctctctggttctccaaaaccttcaacccctcagctcacttcagagagctcagatacagaggacagtgctggaggcgggccagagaccagggaagctctggctgagagcgaccgtgcagctgagggtctgggggctggagttgaggaggaaggagatgatgggaaggaaccccaagttgggggcagcccccaacccctgagccatcccagcccagtgtggatgaactactcctacagcagcctgtgtttgagcagcgaggagtcagaaagcagtggggaagatgaggagttctgggctgagctgcagagtcttcggcagaagcacttgtcagaggtggaaacactacagacactacagaaaaaagaaattgaagatttgtacagccggctggggaagcagcccccaccgggtattgtggccccagctgctatgctgtccagccgccagcgccgcctctccaagggcagcttccccacctcccgccgcaacagcctacagcgctctgagcccccaggccctggcatcatgcgaaggaactctctgagtggcagcagcaccggctcccaggagcagcgggcaagcaagggggtgacattcgccggggatgttggcaggatgtgaattcagaacagaagccatgtatctcccccacaccagggcccaccatggagcttgtgttctcagaatctgatgctttctgatcaacaaaactgagcaaggaagatcccaacactgaaggggtagaaggccaggggggcatggagagtgcagctccattatagtgaagagccaaacatatgtgaactgtttgctgtgtggaggtgttagttctgctgcctaccatcttcatctctagcacctcccctgccaagagtcaaccactaagcaatcccacccaagcctggatgcttctagaggggcccactcccagctgggagagtgtaggggatatgctcacaccacattagcagcaaccaataaaaatgctggaaacaagaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:65266 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: ISS
GeneID:65266 -> Molecular function: GO:0005524 [ATP binding] evidence: ISS
GeneID:65266 -> Biological process: GO:0006468 [protein phosphorylation] evidence: ISS
GeneID:65266 -> Biological process: GO:0006811 [ion transport] evidence: ISS
GeneID:65266 -> Biological process: GO:0006821 [chloride transport] evidence: IEA
GeneID:65266 -> Biological process: GO:0007243 [intracellular protein kinase cascade] evidence: ISS
GeneID:65266 -> Biological process: GO:0008104 [protein localization] evidence: IEA
GeneID:65266 -> Biological process: GO:0050794 [regulation of cellular process] evidence: ISS
GeneID:65266 -> Biological process: GO:0090188 [negative regulation of pancreatic juice secretion] evidence: IEA
GeneID:65266 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
GeneID:65266 -> Cellular component: GO:0005923 [tight junction] evidence: ISS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_115763 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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