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2024-04-19 22:29:57, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_032313 2307 bp mRNA linear PRI 31-MAY-2013
DEFINITION Homo sapiens nitric oxide associated 1 (NOA1), mRNA.
ACCESSION NM_032313
VERSION NM_032313.2 GI:34147413
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2307)
AUTHORS He,J., Cooper,H.M., Reyes,A., Di Re,M., Kazak,L., Wood,S.R.,
Mao,C.C., Fearnley,I.M., Walker,J.E. and Holt,I.J.
TITLE Human C4orf14 interacts with the mitochondrial nucleoid and is
involved in the biogenesis of the small mitochondrial ribosomal
subunit
JOURNAL Nucleic Acids Res. 40 (13), 6097-6108 (2012)
PUBMED 22447445
REMARK GeneRIF: This study indicates rhat C4orf14 is involved in 28S
subunit biogenesis and mtDNA maintenance.
REFERENCE 2 (bases 1 to 2307)
AUTHORS Arakawa,S., Takahashi,A., Ashikawa,K., Hosono,N., Aoi,T.,
Yasuda,M., Oshima,Y., Yoshida,S., Enaida,H., Tsuchihashi,T.,
Mori,K., Honda,S., Negi,A., Arakawa,A., Kadonosono,K., Kiyohara,Y.,
Kamatani,N., Nakamura,Y., Ishibashi,T. and Kubo,M.
TITLE Genome-wide association study identifies two susceptibility loci
for exudative age-related macular degeneration in the Japanese
population
JOURNAL Nat. Genet. 43 (10), 1001-1004 (2011)
PUBMED 21909106
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2307)
AUTHORS Heidler,J., Al-Furoukh,N., Kukat,C., Salwig,I., Ingelmann,M.E.,
Seibel,P., Kruger,M., Holtz,J., Wittig,I., Braun,T. and Szibor,M.
TITLE Nitric oxide-associated protein 1 (NOA1) is necessary for
oxygen-dependent regulation of mitochondrial respiratory complexes
JOURNAL J. Biol. Chem. 286 (37), 32086-32093 (2011)
PUBMED 21771794
REFERENCE 4 (bases 1 to 2307)
AUTHORS Gu,J., Ye,Y., Spitz,M.R., Lin,J., Kiemeney,L.A., Xing,J.,
Hildebrandt,M.A., Ki Hong,W., Amos,C.I. and Wu,X.
TITLE A genetic variant near the PMAIP1/Noxa gene is associated with
increased bleomycin sensitivity
JOURNAL Hum. Mol. Genet. 20 (4), 820-826 (2011)
PUBMED 21106707
REFERENCE 5 (bases 1 to 2307)
AUTHORS Kolanczyk,M., Pech,M., Zemojtel,T., Yamamoto,H., Mikula,I.,
Calvaruso,M.A., van den Brand,M., Richter,R., Fischer,B., Ritz,A.,
Kossler,N., Thurisch,B., Spoerle,R., Smeitink,J., Kornak,U.,
Chan,D., Vingron,M., Martasek,P., Lightowlers,R.N., Nijtmans,L.,
Schuelke,M., Nierhaus,K.H. and Mundlos,S.
TITLE NOA1 is an essential GTPase required for mitochondrial protein
synthesis
JOURNAL Mol. Biol. Cell 22 (1), 1-11 (2011)
PUBMED 21118999
REFERENCE 6 (bases 1 to 2307)
AUTHORS Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
TITLE Genetic variants in nuclear-encoded mitochondrial genes influence
AIDS progression
JOURNAL PLoS ONE 5 (9), E12862 (2010)
PUBMED 20877624
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Online-Only
REFERENCE 7 (bases 1 to 2307)
AUTHORS Tang,T., Zheng,B., Chen,S.H., Murphy,A.N., Kudlicka,K., Zhou,H. and
Farquhar,M.G.
TITLE hNOA1 interacts with complex I and DAP3 and regulates mitochondrial
respiration and apoptosis
JOURNAL J. Biol. Chem. 284 (8), 5414-5424 (2009)
PUBMED 19103604
REFERENCE 8 (bases 1 to 2307)
AUTHORS Parihar,A., Parihar,M.S., Chen,Z. and Ghafourifar,P.
TITLE mAtNOS1 induces apoptosis of human mammary adenocarcinoma cells
JOURNAL Life Sci. 82 (21-22), 1077-1082 (2008)
PUBMED 18456285
REMARK GeneRIF: The present study suggests a novel function for mAtNOS1 in
regulating mitochondrial nitric oxide and calcium and inducing
apoptosis of MCF-7 cells
REFERENCE 9 (bases 1 to 2307)
AUTHORS Zemojtel,T., Kolanczyk,M., Kossler,N., Stricker,S., Lurz,R.,
Mikula,I., Duchniewicz,M., Schuelke,M., Ghafourifar,P.,
Martasek,P., Vingron,M. and Mundlos,S.
TITLE Mammalian mitochondrial nitric oxide synthase: characterization of
a novel candidate
JOURNAL FEBS Lett. 580 (2), 455-462 (2006)
PUBMED 16380119
REMARK Erratum:[FEBS Lett. 2007 May 15;581(10):2072-3]
REFERENCE 10 (bases 1 to 2307)
AUTHORS Brun,C., Dang,Q. and Miassod,R.
TITLE Studies of an 800-kilobase DNA stretch of the Drosophila X
chromosome: comapping of a subclass of scaffold-attached regions
with sequences able to replicate autonomously in Saccharomyces
cerevisiae
JOURNAL Mol. Cell. Biol. 10 (10), 5455-5463 (1990)
PUBMED 2118999
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC004894.2.
On Aug 25, 2003 this sequence version replaced gi:14150077.
##Evidence-Data-START##
Transcript exon combination :: BC004894.2, AK128696.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..2307
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q12"
gene 1..2307
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/note="nitric oxide associated 1"
/db_xref="GeneID:84273"
/db_xref="HGNC:28473"
/db_xref="HPRD:12823"
/db_xref="MIM:614919"
exon 1..1219
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/inference="alignment:Splign:1.39.8"
misc_feature 28..30
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/note="upstream in-frame stop codon"
CDS 76..2172
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/note="nitric oxide associated-1; putative ortholog of
Arabidopsis mitochondrial nitric oxide synthase; nitric
oxide synthase, mitochondrial (putative); mitochondrial
GTPase 3 homolog"
/codon_start=1
/product="nitric oxide-associated protein 1"
/protein_id="NP_115689.1"
/db_xref="GI:14150078"
/db_xref="CCDS:CCDS3510.1"
/db_xref="GeneID:84273"
/db_xref="HGNC:28473"
/db_xref="HPRD:12823"
/db_xref="MIM:614919"
/translation="
MLPARLPFRLLSLFLRGSAPTAARHGLREPLLERRCAAASSFQHSSSLGRELPYDPVDTEGFGEGGDMQERFLFPEYILDPEPQPTREKQLQELQQQQEEEERQRQQRREERRQQNLRARSREHPVVGHPDPALPPSGVNCSGCGAELHCQDAGVPGYLPREKFLRTAEADGGLARTVCQRCWLLSHHRRALRLQVSREQYLELVSAALRRPGPSLVLYMVDLLDLPDALLPDLPALVGPKQLIVLGNKVDLLPQDAPGYRQRLRERLWEDCARAGLLLAPGHQGPQRPVKDEPQDGENPNPPNWSRTVVRDVRLISAKTGYGVEELISALQRSWRYRGDVYLVGATNAGKSTLFNTLLESDYCTAKGSEAIDRATISPWPGTTLNLLKFPICNPTPYRMFKRHQRLKKDSTQAEEDLSEQEQNQLNVLKKHGYVVGRVGRTFLYSEEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILNLLTEKEVNIVLPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADALYQKHAGHTLLQIPMGGKERMAGFPPLVAEDIMLKEGLGASEAVADIKFSSAGWVSVTPNFKDRLHLRGYTPEGTVLTVRPPLLPYIVNIKGQRIKKSVAYKTKKPPSLMYNVRKKKGKINV
"
misc_feature 304..306
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphotyrosine; propagated from
UniProtKB/Swiss-Prot (Q8NC60.2); phosphorylation site"
misc_feature 610..1257
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/note="Circularly permuted YqeH GTPase; Region: YqeH;
cd01855"
/db_xref="CDD:206748"
misc_feature order(817..822,826..831,1024..1032,1114..1134)
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/note="GTP/Mg2+ binding site [chemical binding]; other
site"
/db_xref="CDD:206748"
misc_feature 817..828
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/note="G4 box; other site"
/db_xref="CDD:206748"
misc_feature 1024..1032
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/note="G5 box; other site"
/db_xref="CDD:206748"
misc_feature 1108..1131
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/note="G1 box; other site"
/db_xref="CDD:206748"
misc_feature 1216..1239
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/note="Switch I region; other site"
/db_xref="CDD:206748"
misc_feature 1222..1224
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/note="G2 box; other site"
/db_xref="CDD:206748"
variation 527
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553075"
variation 536
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/replace="c"
/replace="g"
/db_xref="dbSNP:11553076"
exon 1220..1384
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/inference="alignment:Splign:1.39.8"
exon 1385..1590
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/inference="alignment:Splign:1.39.8"
variation 1424
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553077"
exon 1591..1722
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/inference="alignment:Splign:1.39.8"
exon 1723..1839
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/inference="alignment:Splign:1.39.8"
exon 1840..1960
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/inference="alignment:Splign:1.39.8"
exon 1961..2272
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/inference="alignment:Splign:1.39.8"
STS 2123..2269
/gene="NOA1"
/gene_synonym="C4orf14; hAtNOS1; hNOA1; mAtNOS1; MTG3"
/standard_name="D4S3270"
/db_xref="UniSTS:42696"
ORIGIN
ctcgggtcaaatgcgcgcctcggaccctagtgcgcgtgcgcgctggtggctccgcccctttggagctacttcctcatgctgcccgctcgcctaccgttcaggctgctgagccttttccttcgtggatccgctcccacggcagcgcgccatggcctccgggagccgctcctggagaggaggtgcgctgccgcctcctccttccagcactcatcgagtctgggacgcgagcttccttatgaccccgtggacacggagggctttggagaaggtggtgacatgcaggagcgttttctgttcccggagtacatcctggatccggagccgcaacccacccgcgaaaagcagctgcaggagctccagcaacagcaggaggaggaggagcgacagaggcagcagcggcgggaggagcggcgacagcaaaacctacgggccaggtcccgggagcacccggtcgtggggcacccggacccggcattgccgcccagcggcgtgaactgctcgggctgcggggcagagctgcactgccaggacgccggagtgcccggctacctgccccgagagaagttcctccgcacggcggaggcagacggcgggctggcacggaccgtgtgccagcgctgctggctgctgtcgcaccaccggcgcgctctacgcctgcaggtgagccgcgagcagtacctggagctggtgagcgccgcgttgcggcggcccggcccctccctggtgctctacatggtggacctgctggacctgcccgacgccctgctgcccgacttgcccgcgctggtgggccccaagcagctgatcgtgctgggaaacaaagtggacctcctgccccaggatgctcctggctaccggcagaggctgcgggagcgactgtgggaggactgtgcccgcgccgggctcctgctggcccctggccaccaagggccacagcgccccgtcaaggacgagccacaggacggggagaatccgaatccgccgaactggtcccgcacagtggtcagggacgtgcggctgatcagcgccaagaccggctatggagtggaagagttgatctctgcccttcagcgctcctggcgctaccgtggggacgtctacttagtgggcgccaccaacgccggcaaatccactctctttaacacgctcctggagtccgattactgcactgccaagggctccgaggccatcgacagagccaccatctccccttggccaggtactacattaaaccttctgaagtttcctatttgcaacccaactccttacagaatgtttaaaaggcatcaaagacttaaaaaagattcaactcaagctgaagaagatcttagtgagcaagaacaaaatcagcttaatgtcctcaaaaagcatggttatgtcgtaggaagagttggaaggacattcttgtattcagaagaacagaaggataacattccctttgagtttgatgctgattcacttgcctttgacatggaaaatgaccctgttatgggtacacacaaatccaccaaacaagtagaattgactgcacaagatgtgaaagatgcccactggttttatgacacccctggaattacaaaagaaaattgtattttaaatcttctaacagaaaaagaagtaaatattgttttgccaacacagtccattgttccaagaacttttgtgcttaaaccaggaatggttctgtttttgggtgctataggccgcatagatttcctgcagggaaatcagtcagcttggtttacagtcgtggcttccaacatcctccctgtgcatatcacctccttggacagggcagacgctctgtatcagaagcatgcaggtcatacgttactccagattccaatgggtggaaaagaacgaatggcaggatttcctcctcttgttgctgaagacattatgttaaaagaaggactgggggcatctgaagcagtggccgacatcaagttttcctctgcaggttgggtttcagtaacacctaattttaaggacagactgcatctccgaggctatacacctgaaggaacagttttgaccgtccggccccctctcttgccatatattgttaacatcaaaggacagcgcatcaagaaaagtgtggcctataaaaccaagaagcctccttcccttatgtacaacgtgaggaagaagaaaggaaagataaatgtatgagaccgaccttgttcactccagatattaactgtattgaacacaacaaaatacattgaatttgtattaaacatataacgcataaataaagctcccattcttaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:84273 -> Molecular function: GO:0003924 [GTPase activity] evidence: IBA
GeneID:84273 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:84273 -> Molecular function: GO:0005525 [GTP binding] evidence: IDA
GeneID:84273 -> Biological process: GO:0006184 [GTP catabolic process] evidence: IBA
GeneID:84273 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:84273 -> Biological process: GO:0010941 [regulation of cell death] evidence: IMP
GeneID:84273 -> Biological process: GO:0032543 [mitochondrial translation] evidence: ISS
GeneID:84273 -> Biological process: GO:0042254 [ribosome biogenesis] evidence: IBA
GeneID:84273 -> Biological process: GO:0043457 [regulation of cellular respiration] evidence: IMP
GeneID:84273 -> Cellular component: GO:0031314 [extrinsic to mitochondrial inner membrane] evidence: IDA
by
@meso_cacase at
DBCLS
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