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2024-04-26 05:54:58, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_032271 3676 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens TNF receptor-associated factor 7, E3 ubiquitin protein
ligase (TRAF7), mRNA.
ACCESSION NM_032271
VERSION NM_032271.2 GI:45594311
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3676)
AUTHORS Clark,V.E., Erson-Omay,E.Z., Serin,A., Yin,J., Cotney,J.,
Ozduman,K., Avsar,T., Li,J., Murray,P.B., Henegariu,O., Yilmaz,S.,
Gunel,J.M., Carrion-Grant,G., Yilmaz,B., Grady,C., Tanrikulu,B.,
Bakircioglu,M., Kaymakcalan,H., Caglayan,A.O., Sencar,L.,
Ceyhun,E., Atik,A.F., Bayri,Y., Bai,H., Kolb,L.E., Hebert,R.M.,
Omay,S.B., Mishra-Gorur,K., Choi,M., Overton,J.D., Holland,E.C.,
Mane,S., State,M.W., Bilguvar,K., Baehring,J.M., Gutin,P.H.,
Piepmeier,J.M., Vortmeyer,A., Brennan,C.W., Pamir,M.N., Kilic,T.,
Lifton,R.P., Noonan,J.P., Yasuno,K. and Gunel,M.
TITLE Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7,
KLF4, AKT1, and SMO
JOURNAL Science 339 (6123), 1077-1080 (2013)
PUBMED 23348505
REMARK GeneRIF: Nearly one-fourth of all meningiomas have mutations in
TRAF7.
REFERENCE 2 (bases 1 to 3676)
AUTHORS Zotti,T., Vito,P. and Stilo,R.
TITLE The seventh ring: exploring TRAF7 functions
JOURNAL J. Cell. Physiol. 227 (3), 1280-1284 (2012)
PUBMED 22105767
REMARK GeneRIF: TRAF7 is involved in signal transduction pathways that
lead either to activation or repression of NF-kappaB transcription
factor.
Review article
REFERENCE 3 (bases 1 to 3676)
AUTHORS Scudiero,I., Zotti,T., Ferravante,A., Vessichelli,M., Reale,C.,
Masone,M.C., Leonardi,A., Vito,P. and Stilo,R.
TITLE Tumor necrosis factor (TNF) receptor-associated factor 7 is
required for TNFalpha-induced Jun NH2-terminal kinase activation
and promotes cell death by regulating polyubiquitination and
lysosomal degradation of c-FLIP protein
JOURNAL J. Biol. Chem. 287 (8), 6053-6061 (2012)
PUBMED 22219201
REMARK GeneRIF: an important role for TRAF7 in the activation of JNK
following TNFalpha stimulation and involvement of this protein in
regulating the turnover of c-FLIP
REFERENCE 4 (bases 1 to 3676)
AUTHORS Zotti,T., Uva,A., Ferravante,A., Vessichelli,M., Scudiero,I.,
Ceccarelli,M., Vito,P. and Stilo,R.
TITLE TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB
kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA
protein and represses NF-kappaB activation
JOURNAL J. Biol. Chem. 286 (26), 22924-22933 (2011)
PUBMED 21518757
REMARK GeneRIF: this study identifies TRAF7 as a NEMO- and p65-interacting
molecule and brings important information on the ubiquitination
events that control NF-kappaB transcriptional activity.
REFERENCE 5 (bases 1 to 3676)
AUTHORS Joslyn,G., Ravindranathan,A., Brush,G., Schuckit,M. and White,R.L.
TITLE Human variation in alcohol response is influenced by variation in
neuronal signaling genes
JOURNAL Alcohol. Clin. Exp. Res. 34 (5), 800-812 (2010)
PUBMED 20201926
REMARK GeneRIF: Observational study and genome-wide association study of
gene-disease association. (HuGE Navigator)
REFERENCE 6 (bases 1 to 3676)
AUTHORS Xu,L.G., Li,L.Y. and Shu,H.B.
TITLE TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces
apoptosis
JOURNAL J. Biol. Chem. 279 (17), 17278-17282 (2004)
PUBMED 15001576
REMARK GeneRIF: TRAF7 potentiates MEKK3-induced AP1 and CHOP activation
and induces apoptosis
REFERENCE 7 (bases 1 to 3676)
AUTHORS Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
Superti-Furga,G.
TITLE A physical and functional map of the human TNF-alpha/NF-kappa B
signal transduction pathway
JOURNAL Nat. Cell Biol. 6 (2), 97-105 (2004)
PUBMED 14743216
REMARK Erratum:[Nat Cell Biol. 2004 May;6(5):465]
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK090624.1, AL136921.1 and AW245178.1.
On Mar 19, 2004 this sequence version replaced gi:14150010.
Summary: Tumor necrosis factor (TNF; see MIM 191160)
receptor-associated factors, such as TRAF7, are signal transducers
for members of the TNF receptor superfamily (see MIM 191190). TRAFs
are composed of an N-terminal cysteine/histidine-rich region
containing zinc RING and/or zinc finger motifs; a coiled-coil
(leucine zipper) motif; and a homologous region that defines the
TRAF family, the TRAF domain, which is involved in self-association
and receptor binding.[supplied by OMIM, Apr 2004].
##Evidence-Data-START##
Transcript exon combination :: AY569455.1, AK090624.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025083 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1627 AK090624.1 15-1641
1628-3662 AL136921.1 1524-3558
3663-3676 AW245178.1 1-14 c
FEATURES Location/Qualifiers
source 1..3676
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="16"
/map="16p13.3"
gene 1..3676
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/note="TNF receptor-associated factor 7, E3 ubiquitin
protein ligase"
/db_xref="GeneID:84231"
/db_xref="HGNC:20456"
/db_xref="MIM:606692"
exon 1..61
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 1
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="g"
/replace="t"
/db_xref="dbSNP:9936649"
variation 23
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:9936655"
exon 62..180
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 64
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:370938292"
variation 80
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="g"
/db_xref="dbSNP:374884281"
variation 88
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="c"
/db_xref="dbSNP:184752135"
misc_feature 94..96
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/note="upstream in-frame stop codon"
CDS 100..2112
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/note="ring finger and WD repeat domain 1; RING finger
protein 119; RING finger and WD repeat-containing protein
1"
/codon_start=1
/product="E3 ubiquitin-protein ligase TRAF7"
/protein_id="NP_115647.2"
/db_xref="GI:45594312"
/db_xref="CCDS:CCDS10461.1"
/db_xref="GeneID:84231"
/db_xref="HGNC:20456"
/db_xref="MIM:606692"
/translation="
MSSGKSARYNRFSGGPSNLPTPDVTTGTRMETTFGPAFSAVTTITKADGTSTYKQHCRTPSSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLVFAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNVKLTVVVNNIAVAEQIGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNPSCPPLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVWTC
"
misc_feature 361..363
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q6Q0C0.1); phosphorylation site"
misc_feature 370..372
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q6Q0C0.1); phosphorylation site"
misc_feature 481..588
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/note="Zinc finger, C3HC4 type (RING finger); Region:
zf-C3HC4_2; pfam13923"
/db_xref="CDD:206094"
misc_feature 487..588
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/note="RING-finger (Really Interesting New Gene) domain, a
specialized type of Zn-finger of 40 to 60 residues that
binds two atoms of zinc; defined by the 'cross-brace'
motif C-X2-C-X(9-39)-C-X(1-3)-
H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved
in...; Region: RING; cd00162"
/db_xref="CDD:29102"
misc_feature order(490..492,499..501,535..537,541..543,550..552,
559..561,580..582)
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/note="cross-brace motif; other site"
/db_xref="CDD:29102"
misc_feature 763..933
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/note="TRAF-type zinc finger; Region: zf-TRAF; pfam02176"
/db_xref="CDD:190233"
misc_feature 943..1065
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/note="Dimerization/Docking domain of Cyclic GMP-dependent
Protein Kinase I; Region: DD_cGKI; cl17044"
/db_xref="CDD:213151"
misc_feature order(946..951,958..960,967..972,979..984,991..993,
1000..1005,1009..1014,1021..1026,1030..1035,1042..1047,
1051..1056,1063..1065)
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:213040"
misc_feature order(994..999,1003..1005,1009..1011)
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/note="putative GKAP docking site [polypeptide binding];
other site"
/db_xref="CDD:213040"
misc_feature 1120..>2109
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/note="FOG: WD40 repeat [General function prediction
only]; Region: COG2319"
/db_xref="CDD:32473"
misc_feature 1261..2103
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; Region:
WD40; cd00200"
/db_xref="CDD:29257"
misc_feature 1279..1398
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6Q0C0.1);
Region: WD 1"
misc_feature order(1282..1284,1336..1338,1348..1350,1366..1371,
1408..1413,1459..1461,1471..1473,1489..1494,1528..1533,
1576..1578,1606..1611,1654..1656,1699..1701,1729..1734,
1768..1773,1819..1821,1831..1833,1849..1854,1888..1893,
1948..1950,1963..1965,1981..1986,2020..2025,2071..2073,
2083..2085,2101..2103)
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/note="structural tetrad; other site"
/db_xref="CDD:29257"
misc_feature 1408..1521
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6Q0C0.1);
Region: WD 2"
misc_feature 1528..1638
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6Q0C0.1);
Region: WD 3"
misc_feature 1642..1761
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6Q0C0.1);
Region: WD 4"
misc_feature 1768..1881
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6Q0C0.1);
Region: WD 5"
misc_feature 1888..2013
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6Q0C0.1);
Region: WD 6"
misc_feature 2020..2106
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6Q0C0.1);
Region: WD 7"
variation 102
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:373677359"
variation 122
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:368909792"
variation 127
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:188793383"
variation 152
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:372283115"
variation 168
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:376587431"
variation 174
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:199615844"
exon 181..238
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 183
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:376119190"
variation 184
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:77497016"
variation 193
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:147236770"
variation 194
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:370203279"
variation 202
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:201132936"
variation 207
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:185257232"
variation 216
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:149538546"
variation 232
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:201343471"
exon 239..330
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 240
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:202214562"
variation 251
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:200141222"
variation 255
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="c"
/db_xref="dbSNP:372468156"
variation 259
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="c"
/db_xref="dbSNP:200475538"
variation 299
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="g"
/db_xref="dbSNP:369733800"
variation 320
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:375968017"
variation 328
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="c"
/db_xref="dbSNP:17855504"
exon 331..447
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 336
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="g"
/db_xref="dbSNP:370516870"
variation 344
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:141444291"
variation 349
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:373277405"
variation 350
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:375735405"
variation 357
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:78086885"
variation 363
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:200035101"
variation 364
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:376429748"
variation 377
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:202208831"
variation 386
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="t"
/db_xref="dbSNP:374293398"
variation 390
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:368178476"
variation 424
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="g"
/db_xref="dbSNP:371760782"
variation 446
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:201037324"
exon 448..540
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 453
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:200306273"
variation 457
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:372494731"
variation 465
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:150850739"
variation 488
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:376879458"
variation 508
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:371097636"
variation 518
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="t"
/db_xref="dbSNP:139591663"
variation 531
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="g"
/db_xref="dbSNP:143361048"
variation 534
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:145626962"
exon 541..574
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 561
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:34752687"
variation 564
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:143997074"
variation 567
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="g"
/db_xref="dbSNP:144871289"
exon 575..758
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 595
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:375286771"
variation 642
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:367889112"
variation 645
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:371460998"
variation 658
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:149059378"
variation 665
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:375818110"
variation 669
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:11547311"
variation 690
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:35765267"
variation 695
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:191186027"
variation 726
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:141784925"
exon 759..893
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 813
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:375174789"
variation 891
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:187643207"
exon 894..1111
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 899
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:373051088"
variation 900
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:138558486"
variation 918
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:142600379"
variation 924
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:373436400"
variation 938
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:375287184"
variation 958
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:183510986"
variation 996
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:369566946"
variation 997
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:150194608"
variation 1006
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:376570339"
variation 1014
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:200088757"
variation 1017
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="g"
/db_xref="dbSNP:138752269"
variation 1068
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:377382568"
variation 1073
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:371429918"
variation 1077
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="g"
/db_xref="dbSNP:113743245"
variation 1098
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:149348053"
exon 1112..1185
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 1113
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:201641425"
variation 1114
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:144751745"
variation 1143
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:148108015"
exon 1186..1234
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 1188
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:368139413"
variation 1213
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:141769285"
variation 1225
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:374604544"
exon 1235..1362
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 1239
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:200959929"
variation 1308
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:138647853"
variation 1309
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:200505184"
variation 1335
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:199701608"
variation 1344
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:367720236"
exon 1363..1445
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 1402
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:139420193"
variation 1434
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="g"
/db_xref="dbSNP:144124704"
exon 1446..1485
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 1456
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:201318943"
variation 1476
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:377479113"
exon 1486..1602
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 1531
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:201904294"
variation 1542
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:370665973"
variation 1551
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:377124237"
variation 1570
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:139483392"
exon 1603..1725
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 1616
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:149661968"
variation 1704
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:200042334"
variation 1716
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:145525624"
exon 1726..1845
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 1767
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:117821778"
variation 1782
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:145567897"
variation 1793
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:200476393"
variation 1830
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:61739544"
exon 1846..1977
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 1878
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="g"
/replace="t"
/db_xref="dbSNP:200632998"
variation 1887
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:375832596"
variation 1926
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:147707985"
variation 1959
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:189074648"
variation 1971
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:142534945"
exon 1978..2097
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 1983
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="g"
/db_xref="dbSNP:375612617"
variation 2040
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:74573292"
variation 2043
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:371337922"
variation 2091
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="t"
/db_xref="dbSNP:11383"
exon 2098..3667
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/inference="alignment:Splign:1.39.8"
variation 2133
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:371235860"
variation 2139
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:377344718"
variation 2157
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:370672855"
variation 2167
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:367935643"
variation 2192
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:375215059"
variation 2201
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:376052319"
variation 2241
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:375408603"
variation 2262
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="t"
/db_xref="dbSNP:370666417"
variation 2286
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:113523330"
variation 2300
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="g"
/db_xref="dbSNP:184220090"
variation 2309
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="g"
/db_xref="dbSNP:373176573"
variation 2352..2364
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace=""
/replace="ccatccccaccct"
/db_xref="dbSNP:376471774"
variation 2561
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="g"
/replace="t"
/db_xref="dbSNP:149148401"
variation 2744
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:190417881"
variation 2753
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:142263447"
variation 2829
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="t"
/db_xref="dbSNP:376350214"
variation 2905
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:35199162"
variation 2966
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:374752828"
variation 3122
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:111428398"
variation 3175
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="g"
/db_xref="dbSNP:151281479"
STS 3356..3531
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/standard_name="SHGC-61344"
/db_xref="UniSTS:41562"
variation 3403
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="t"
/db_xref="dbSNP:182199125"
variation 3409
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="g"
/db_xref="dbSNP:115022524"
variation 3522
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="c"
/replace="g"
/db_xref="dbSNP:145672192"
variation 3526
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="c"
/db_xref="dbSNP:138680218"
variation 3582
/gene="TRAF7"
/gene_synonym="RFWD1; RNF119"
/replace="a"
/replace="t"
/db_xref="dbSNP:1136770"
ORIGIN
ggccgagggggcatcatgaagcgggctggcggcgctgccgctcccgggcggccgcgggcgggaggtgcttcccaaggaccgtagatgcctctctagagcatgagctcaggcaagagtgcccgctacaaccgcttctccggggggcccagcaatcttcccaccccagacgtcaccacagggaccagaatggaaacgaccttcggacccgccttttcagccgtcaccaccatcacaaaagctgacgggaccagcacctacaagcagcactgcaggacaccctcctcctccagcacccttgcctactccccgcgggacgaggaggacagcatgccccccatcagcactccccgccgctccgactccgccatctctgtccgctccctgcactcagagtccagcatgtctctgcgctccacattctcactgcccgaggaggaggaggagccggagccactggtgtttgcggagcagccctcggtgaagctgtgctgtcagctctgctgcagcgtcttcaaagaccccgtgatcaccacgtgtgggcacacgttctgtaggagatgcgccttgaagtcagagaagtgtcccgtggacaacgtcaaactgaccgtggtggtgaacaacatcgcggtggccgagcagatcggggagctcttcatccactgccggcacggctgccgggtagcgggcagcgggaagccccccatctttgaggtggacccccgagggtgccccttcaccatcaagctcagcgcccggaaggaccacgagggcagctgtgactacaggcctgtgcggtgtcccaacaaccccagctgccccccgctgctcaggatgaacctggaggcccacctcaaggagtgcgagcacatcaaatgcccccactccaagtacgggtgcacgttcatcgggaaccaggacacttacgagacccacctggagacttgccgcttcgagggcctgaaggagtttctgcagcagacggatgaccgcttccacgagatgcacgtggctctggcccagaaggaccaggagatcgccttcctgcgctccatgctgggaaagctctcggagaagatcgaccagctagagaagagcctggagctcaagtttgacgtcctggacgaaaaccagagcaagctcagcgaggacctcatggagttccggcgggacgcatccatgttaaatgacgagctgtcccacatcaacgcgcggctgaacatgggcatcctaggctcctacgaccctcagcagatcttcaagtgcaaagggacctttgtgggccaccagggccctgtgtggtgtctctgcgtctactccatgggtgacctgctcttcagtggctcctctgacaagaccatcaaggtgtgggacacatgtaccacctacaagtgtcagaagacactggagggccatgatggcatcgtgctggctctctgcatccaggggtgcaaactctacagcggctctgcagactgcaccatcattgtgtgggacatccagaacctgcagaaggtgaacaccatccgggcccatgacaacccggtgtgcacgctggtctcctcacacaacgtgctcttcagcggctccctgaaggccatcaaggtctgggacatcgtgggcactgagctgaagttgaagaaggagctcacaggcctcaaccactgggtgcgggccctggtggctgcccagagctacctgtacagcggctcctaccagacaatcaagatctgggacatccgaacccttgactgcatccacgtcctgcagacgtctggtggcagcgtctactccattgctgtgacaaatcaccacattgtctgtggcacctacgagaacctcatccacgtgtgggacattgagtccaaggagcaggtgcggaccctcacgggccacgtgggcaccgtgtatgccctggcggtcatctcgacgccagaccagaccaaagtcttcagtgcatcctacgaccggtccctcagggtctggagtatggacaacatgatctgcacgcagaccctgctgcgtcaccagggcagtgtcaccgcgctggctgtgtcccggggccgactcttctcaggggctgtggatagcactgtgaaggtttggacttgctaacaggatccaggccaggctgtggtttcccctgaaccagccctggacctttctgagccaggctggccacatggggtggtctcggggtttctgcctgccccgtgggcataggtggacaggctctggcagccgggcagtgccctccccgtcccatgctcggcgagcctccctctactcggcactgtccttgctgcccagcccctctctgggtgccaggtacgacgcttgccccggcccaccctccatccccaccctccatccccaccctagatggagcgagggcctttttactcaccttttctaccgtttttagactgtatgtagatttggttacctcctggttgaaataaatgctccacagactgtggctgtgagtggggacagctcctcgggacaagggggctgtgtgtggccttgaggttggtgtgcacaggcactggctgctgtgagtgggggggcatggggcagtttcctttggtggaccccaggacttcggcccactccggggcctcccctccctgctaggaggcaactcgtcacacccaagctgctggcctccagtcccatctcccccaacacatgtgcccccaaaaagtgagccaggcacctctgtttcctgctgtttattgacagccgacggcagcgccttgcccagacctcccctgcccacctgctggagcccagcctgtgccgccctctgaggagaggcctggggggacagctgggcacgtccactcgcagggaaacacggggtgagacagcaggaaggggccctgcacgccgggacgccacctccgccagccgcctccacccgccccacaccacaatcgctggttttcggcattttttaaattttttttttaagaaacgtcaaagttgtgcccaacactgtggatcagcaaacacgatagaggagaccagtcagtacttcttggagggggcaggaggagagaggaaaagggagggcgagaatgaccacacaacacagccttggaccatgagcagaagcgtccgtgggaactccactggggtggatgggctgcctgcacagcccctggagagggggccaggcacaccctcagaggagctgcaagcccgtggcctggcctgctacatgccctgcttccacgtggctgccacgctgacacacccacattcaccaaacccacccgcgccctgggacgcagccacgccaggaggaggacacggccgccgagagcaaggcacaacctcgagttcttggggcgcagagaacttaggagagaagcacggaggagcccccggcagagcacccgcccccgggccccagccttccacctgtgctagcagcctggggcctccactctggccggaggaaggaccgcaggcagacagcctgggcctctaacagcttttgtccggagctagacttcgtgtcctttcagttggtaaatggttttctatagaatcaataatatttctttctttaaatatatatttgttaaagttatacctttttgtttctctggggaaatccgcctcagctcattcccaataaattaatactcttgatagcttaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:84231 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IDA
GeneID:84231 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:84231 -> Molecular function: GO:0008270 [zinc ion binding] evidence: NAS
GeneID:84231 -> Biological process: GO:0000185 [activation of MAPKKK activity] evidence: IDA
GeneID:84231 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:84231 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:84231 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA
GeneID:84231 -> Biological process: GO:0016567 [protein ubiquitination] evidence: IDA
GeneID:84231 -> Biological process: GO:0043410 [positive regulation of MAPK cascade] evidence: IDA
GeneID:84231 -> Biological process: GO:0097194 [execution phase of apoptosis] evidence: IMP
GeneID:84231 -> Cellular component: GO:0000151 [ubiquitin ligase complex] evidence: IDA
GeneID:84231 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:84231 -> Cellular component: GO:0016023 [cytoplasmic membrane-bounded vesicle] evidence: IEA
GeneID:84231 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.