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2024-03-29 16:05:30, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_032181               1832 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens eva-1 homolog A (C. elegans) (EVA1A), transcript
            variant 2, mRNA.
ACCESSION   NM_032181
VERSION     NM_032181.2  GI:205277350
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1832)
  AUTHORS   Kamboh,M.I., Wang,X., Kao,A.H., Barmada,M.M., Clarke,A.,
            Ramsey-Goldman,R., Manzi,S. and Demirci,F.Y.
  TITLE     Genome-wide association study of antiphospholipid antibodies
  JOURNAL   Autoimmune Dis 2013, 761046 (2013)
   PUBMED   23509613
REFERENCE   2  (bases 1 to 1832)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), E51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 1832)
  AUTHORS   Sun,W., Ma,X.M., Bai,J.P., Zhang,G.Q., Zhu,Y.J., Ma,H.M., Guo,H.,
            Chen,Y.Y. and Ding,J.B.
  TITLE     Transmembrane protein 166 expression in esophageal squamous cell
            carcinoma in Xinjiang, China
  JOURNAL   Asian Pac. J. Cancer Prev. 13 (8), 3713-3716 (2012)
   PUBMED   23098460
  REMARK    GeneRIF: Low TMEM166 mRNA and protein expression is associated with
            esophageal squamous cell carcinoma.
REFERENCE   4  (bases 1 to 1832)
  AUTHORS   Wang,L., Yu,C., Lu,Y., He,P., Guo,J., Zhang,C., Song,Q., Ma,D.,
            Shi,T. and Chen,Y.
  TITLE     TMEM166, a novel transmembrane protein, regulates cell autophagy
            and apoptosis
  JOURNAL   Apoptosis 12 (8), 1489-1502 (2007)
   PUBMED   17492404
  REMARK    GeneRIF: TMEM166 is a novel regulator involved in both autophagy
            and apoptosis.
REFERENCE   5  (bases 1 to 1832)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK023453.1 and AW016395.1.
            On Sep 19, 2008 this sequence version replaced gi:14149864.
            
            Transcript Variant: This variant (2) uses a different segment for
            its 5' UTR, compared to variant 1. Variants 1 and 2 both encode the
            same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023453.1, BI761625.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025084, ERS025085 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1721              AK023453.1         1-1721
            1722-1832           AW016395.1         1-111               c
FEATURES             Location/Qualifiers
     source          1..1832
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p12"
     gene            1..1832
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /note="eva-1 homolog A (C. elegans)"
                     /db_xref="GeneID:84141"
                     /db_xref="HGNC:25816"
                     /db_xref="HPRD:07827"
     exon            1..247
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    214..216
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /note="upstream in-frame stop codon"
     exon            248..370
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /inference="alignment:Splign:1.39.8"
     variation       314
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11538748"
     exon            371..523
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /inference="alignment:Splign:1.39.8"
     CDS             439..897
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /note="transmembrane protein 166; protein FAM176A; family
                     with sequence similarity 176, member A"
                     /codon_start=1
                     /product="protein eva-1 homolog A"
                     /protein_id="NP_115557.1"
                     /db_xref="GI:14149865"
                     /db_xref="CCDS:CCDS1959.1"
                     /db_xref="GeneID:84141"
                     /db_xref="HGNC:25816"
                     /db_xref="HPRD:07827"
                     /translation="
MRLPLSHSPEHVEMALLSNILAAYSFVSENPERAALYFVSGVCIGLVLTLAALVIRISCHTDCRRRPGKKFLQDRESSSDSSDSEDGSEDTVSDLSVRRHRRFERTLNKNVFTSAEELERAQRLEERERIIREIWMNGQPEVPGTRSLNRYY
"
     misc_feature    439..618
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H8M9.1);
                     Region: Necessary for the localization and biological
                     activity"
     misc_feature    541..603
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H8M9.1);
                     transmembrane region"
     exon            524..1815
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /inference="alignment:Splign:1.39.8"
     STS             1102..1299
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /standard_name="RH69495"
                     /db_xref="UniSTS:80382"
     variation       1773
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2215872"
ORIGIN      
agcataacctgtttgtgaaactgcaaaaaggttgacatggctgaagcagaagatgggttggtactgaatggttgggagagatatgtagcggctgaccctgaaggacgttgcagcccatgctatggagacctgattttattttgtaagaggtgggcaacccctgaagcattttagtgatgcgaacagatgtgtctgttaccaagcaaagccagttaaagaaggtcacagaggaggaatgatcacaaagagtctgagaagccaactggggccaaacaagttttagaacctctactggctgatgccaacatcatcagagatgaactgttcttaccagaaacttctctgctcctgacaccccacctctccccagaagagaagaaggagagtggccacgttgattcagccaagcacctccaggaggtcccctctggatgtcccatgaggctgcccctcagccacagcccagagcacgtggagatggctttgctcagcaacatcctagcggcctattcctttgtctcagaaaatcctgagcgagcagctctgtactttgtttctggcgtgtgcatcgggctggtgctgaccctggctgctctggtgataaggatctcttgccacacagactgcaggcggcgtcccgggaagaagttcctgcaggacagagagagcagcagcgacagcagcgacagcgaggatggcagtgaggacaccgtgtccgatctctccgtgcggagacaccgccgcttcgagaggactttgaacaagaatgtgttcacctctgcggaggagctggagcgcgcccagcggctggaggagcgcgagcgcatcatcagggagatctggatgaatggccagcctgaggtgcccgggaccaggagcctgaatcgctactattagggagcagcaggaccccggaaaccactggaggccgcctggaaaggagagcgtctgcagggacagtgggcacaaggaactgaacccagctctgctaatattgtgatttcagagaaaaagcaggacatgccccttttctagccaggaggattgctcctttttggccaaatgtatggagaagtagaaaaatcaaagcagttcatcaccctttccaggtctcggaatggtgctgaaaaatcctctccaacactgtggatggagatcggagaaacgcgactgtggtttctcttgatttctgaggatctcagaagtttcagcagacttccttgctctgtgttattcctttgcaaaaggaaagatcattatagcatgagggctgggaatagcagggtgaacttaacccaataaatgcaatttcctaaatgacttcatgctatggaggtgattctgattcaaatagcatgatccatgcttattatttaaggctgatttttaaaatcttgtgttgcaagggcaacctcgtccattttaactggcacctcagggattaaaatcctactttttagtgtagttcccacctcattcatgaaaatgaatagaactattgtattatgggagatgtgtcagtgaactagaaaatgtcaataacctcaaaggatgaagggtttttattttaaatagtttataaaatatatattgacatgcatatttgaaaatgctgcataaaaataaaagtggtgtgttttccccctctttggagacaagaaaattttattatgactctagataattgtgattttaaacactttgtttttttttttttttttaattggatttcaaagaaaagaatggaaatgagaggtaaggattaaagccaaagttaggatgggaattaaaaaaataaacattacataaaatcttaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:84141 -> Biological process: GO:0006914 [autophagy] evidence: IEA
            GeneID:84141 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:84141 -> Cellular component: GO:0005765 [lysosomal membrane] evidence: IEA
            GeneID:84141 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: IEA
            GeneID:84141 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:84141 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
            GeneID:84141 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA

by @meso_cacase at DBCLS
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