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2024-04-19 13:15:23, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_031892 4766 bp mRNA linear PRI 29-APR-2013
DEFINITION Homo sapiens SH3-domain kinase binding protein 1 (SH3KBP1),
transcript variant 1, mRNA.
ACCESSION NM_031892
VERSION NM_031892.2 GI:215490004
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4766)
AUTHORS Minegishi,Y., Shibagaki,Y., Mizutani,A., Fujita,K., Tezuka,T.,
Kinoshita,M., Kuroda,M., Hattori,S. and Gotoh,N.
TITLE Adaptor protein complex of FRS2beta and CIN85/CD2AP provides a
novel mechanism for ErbB2/HER2 protein downregulation
JOURNAL Cancer Sci. 104 (3), 345-352 (2013)
PUBMED 23279575
REMARK GeneRIF: an FRS2beta-CIN85/CD2AP-Cbl axis for downregulation of
ErbB2 may regulate ErbB2 protein levels in physiological and
pathological settings
REFERENCE 2 (bases 1 to 4766)
AUTHORS Samoylenko,A., Vynnytska-Myronovska,B., Byts,N., Kozlova,N.,
Basaraba,O., Pasichnyk,G., Palyvoda,K., Bobak,Y., Barska,M.,
Mayevska,O., Rzhepetsky,Y., Shuvayeva,H., Lyzogubov,V., Usenko,V.,
Savran,V., Volodko,N., Buchman,V., Kietzmann,T. and Drobot,L.
TITLE Increased levels of the HER1 adaptor protein Rukl/CIN85 contribute
to breast cancer malignancy
JOURNAL Carcinogenesis 33 (10), 1976-1984 (2012)
PUBMED 22791810
REMARK GeneRIF: this study indicates that high levels of Ruk(l)/CIN85
contribute to the conversion of breast adenocarcinoma cells into a
more malignant phenotype via modulation of the Src/Akt pathway.
REFERENCE 3 (bases 1 to 4766)
AUTHORS Schroeder,B., Srivatsan,S., Shaw,A., Billadeau,D. and McNiven,M.A.
TITLE CIN85 phosphorylation is essential for EGFR ubiquitination and
sorting into multivesicular bodies
JOURNAL Mol. Biol. Cell 23 (18), 3602-3611 (2012)
PUBMED 22833562
REMARK GeneRIF: Data show that EGFR activation leads to a pronounced
src-mediated tyrosine phosphorylation of CIN85 that subsequently
influences EGFR ubiquitination.
REFERENCE 4 (bases 1 to 4766)
AUTHORS Niiro,H., Jabbarzadeh-Tabrizi,S., Kikushige,Y., Shima,T., Noda,K.,
Ota,S., Tsuzuki,H., Inoue,Y., Arinobu,Y., Iwasaki,H., Shimoda,S.,
Baba,E., Tsukamoto,H., Horiuchi,T., Taniyama,T. and Akashi,K.
TITLE CIN85 is required for Cbl-mediated regulation of antigen receptor
signaling in human B cells
JOURNAL Blood 119 (10), 2263-2273 (2012)
PUBMED 22262777
REMARK GeneRIF: Data show that CIN85 (c-Cbl interacting protein of 85 kDa)
is constitutively associated with c-Cbl, Cbl-b, and B-cell linker
in B cells.
REFERENCE 5 (bases 1 to 4766)
AUTHORS Soubeyran,P., Kowanetz,K., Szymkiewicz,I., Langdon,W.Y. and
Dikic,I.
TITLE Cbl-CIN85-endophilin complex mediates ligand-induced downregulation
of EGF receptors
JOURNAL Nature 416 (6877), 183-187 (2002)
PUBMED 11894095
REMARK GeneRIF: Cbl-CIN85-endophilin complex mediates ligand-induced
downregulation of EGF receptors
Erratum:[Nature 2002 May 2;417(6884):102]
REFERENCE 6 (bases 1 to 4766)
AUTHORS Narita,T., Amano,F., Yoshizaki,K., Nishimoto,N., Nishimura,T.,
Tajima,T., Namiki,H. and Taniyama,T.
TITLE Assignment of SH3KBP1 to human chromosome band Xp22.1-->p21.3 by in
situ hybridization
JOURNAL Cytogenet. Cell Genet. 93 (1-2), 133-134 (2001)
PUBMED 11474197
REFERENCE 7 (bases 1 to 4766)
AUTHORS Watanabe,S., Take,H., Takeda,K., Yu,Z.X., Iwata,N. and Kajigaya,S.
TITLE Characterization of the CIN85 adaptor protein and identification of
components involved in CIN85 complexes
JOURNAL Biochem. Biophys. Res. Commun. 278 (1), 167-174 (2000)
PUBMED 11071869
REFERENCE 8 (bases 1 to 4766)
AUTHORS Gout,I., Middleton,G., Adu,J., Ninkina,N.N., Drobot,L.B.,
Filonenko,V., Matsuka,G., Davies,A.M., Waterfield,M. and
Buchman,V.L.
TITLE Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein
JOURNAL EMBO J. 19 (15), 4015-4025 (2000)
PUBMED 10921882
REFERENCE 9 (bases 1 to 4766)
AUTHORS Take,H., Watanabe,S., Takeda,K., Yu,Z.X., Iwata,N. and Kajigaya,S.
TITLE Cloning and characterization of a novel adaptor protein, CIN85,
that interacts with c-Cbl
JOURNAL Biochem. Biophys. Res. Commun. 268 (2), 321-328 (2000)
PUBMED 10679202
REFERENCE 10 (bases 1 to 4766)
AUTHORS Salvatore,P., Hanash,C.R., Kido,Y., Imai,Y. and Accili,D.
TITLE Identification of sirm, a novel insulin-regulated SH3 binding
protein that associates with Grb-2 and FYN
JOURNAL J. Biol. Chem. 273 (12), 6989-6997 (1998)
PUBMED 9507006
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DR000949.1, AF230904.1 and
AL732423.12.
This sequence is a reference standard in the RefSeqGene project.
On Dec 3, 2008 this sequence version replaced gi:13994241.
Summary: This gene encodes an adapter protein that contains three
N-terminal Src homology domains, a proline rich region and a
C-terminal coiled-coil domain. The encoded protein facilitates
protein-protein interactions and has been implicated in numerous
cellular processes including apoptosis, cytoskeletal rearrangement,
cell adhesion and in the regulation of clathrin-dependent
endocytosis. Alternate splicing results in multiple transcript
variants.[provided by RefSeq, May 2010].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longest isoform (a).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF230904.1, BC015806.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-25 DR000949.1 28-52
26-3329 AF230904.1 1-3304
3330-4766 AL732423.12 133973-135409 c
FEATURES Location/Qualifiers
source 1..4766
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp22.1-p21.3"
gene 1..4766
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/note="SH3-domain kinase binding protein 1"
/db_xref="GeneID:30011"
/db_xref="HGNC:13867"
/db_xref="HPRD:02301"
/db_xref="MIM:300374"
misc_feature <1..>1437
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/note="annotated region of clone"
exon 1..320
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
misc_feature 176..178
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/note="upstream in-frame stop codon"
CDS 317..2314
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/note="isoform a is encoded by transcript variant 1; Src
family kinase-binding protein 1; src-related kinase
binding protein-1; SH3 domain-containing kinase-binding
protein 1; CD2-binding protein 3; migration-inducing gene
18; c-Cbl-interacting protein; cbl-interacting protein of
85 kDa; human Src family kinase-binding protein 1"
/codon_start=1
/product="SH3 domain-containing kinase-binding protein 1
isoform a"
/protein_id="NP_114098.1"
/db_xref="GI:13994242"
/db_xref="CCDS:CCDS14193.1"
/db_xref="GeneID:30011"
/db_xref="HGNC:13867"
/db_xref="HPRD:02301"
/db_xref="MIM:300374"
/translation="
MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
"
misc_feature 323..481
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/note="First Src Homology 3 domain (SH3A) of
Cbl-interacting protein of 85 kDa; Region: SH3_CIN85_1;
cd12052"
/db_xref="CDD:212985"
misc_feature order(335..355,365..367,377..382,416..424,452..457,
461..463,467..472)
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/note="putative ubiquitin interaction site [polypeptide
binding]; other site"
/db_xref="CDD:212985"
misc_feature order(338..340,344..346,353..358,362..367,416..418,
422..424,455..457,467..472,476..478)
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/note="peptide ligand binding site [polypeptide binding];
other site"
/db_xref="CDD:212985"
misc_feature 623..778
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/note="Second Src Homology 3 domain (SH3B) of
Cbl-interacting protein of 85 kDa; Region: SH3_CIN85_2;
cd12055"
/db_xref="CDD:212988"
misc_feature order(632..652,662..664,674..679,713..721,749..754,
758..760,764..769)
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/note="putative ubiquitin interaction site [polypeptide
binding]; other site"
/db_xref="CDD:212988"
misc_feature order(635..637,641..643,650..652,662..664,713..721,
752..754,758..760,764..769)
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/note="putative peptide ligand binding site [polypeptide
binding]; other site"
/db_xref="CDD:212988"
misc_feature 1004..1006
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96B97.2); phosphorylation site"
misc_feature 1004..1006
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1076..1078
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q96B97.2); phosphorylation site"
misc_feature 1127..1294
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/note="Third Src Homology 3 domain (SH3C) of
Cbl-interacting protein of 85 kDa; Region: SH3_CIN85_3;
cd12057"
/db_xref="CDD:212990"
misc_feature order(1139..1162,1166..1171,1181..1186,1223..1234,
1262..1267,1271..1273,1277..1282,1286..1288)
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/note="ubiquitin interaction site [polypeptide binding];
other site"
/db_xref="CDD:212990"
misc_feature order(1142..1144,1148..1150,1157..1159,1169..1171,
1226..1234,1265..1267,1271..1273,1277..1282)
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/note="putative peptide ligand binding site [polypeptide
binding]; other site"
/db_xref="CDD:212990"
misc_feature 1622..1624
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96B97.2); phosphorylation site"
misc_feature 1841..1843
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96B97.2); phosphorylation site"
misc_feature 1841..1843
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1847..1849
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96B97.2); phosphorylation site"
misc_feature 1847..1849
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1877..1879
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96B97.2); phosphorylation site"
misc_feature 2075..2077
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q96B97.2); phosphorylation site"
misc_feature 2075..2077
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 321..478
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
exon 479..602
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
exon 603..706
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
exon 707..836
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
exon 837..1042
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
exon 1043..1118
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
exon 1119..1213
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
variation 1119
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/replace="g"
/replace="t"
/db_xref="dbSNP:11552354"
exon 1214..1321
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
exon 1322..1373
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
exon 1374..1454
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
exon 1455..1614
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
variation 1582
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/replace="a"
/replace="g"
/db_xref="dbSNP:2290805"
exon 1615..1700
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
exon 1701..1810
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
exon 1811..1939
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
exon 1940..2208
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
variation 2140
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/replace="c"
/replace="t"
/db_xref="dbSNP:11552353"
exon 2209..2272
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
exon 2273..4766
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/inference="alignment:Splign:1.39.8"
STS 3063..3247
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/standard_name="RH18201"
/db_xref="UniSTS:41536"
variation 3266
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/replace="c"
/replace="t"
/db_xref="dbSNP:200486212"
polyA_signal 3296..3300
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
STS 4340..4509
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/standard_name="RH94355"
/db_xref="UniSTS:88071"
STS 4523..4657
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
/standard_name="G31065"
/db_xref="UniSTS:30615"
polyA_signal 4732..4737
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
polyA_site 4756
/gene="SH3KBP1"
/gene_synonym="CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18"
ORIGIN
tttttttttttttttttttttttttcgcaatttccactcgcggggagcaggaaacccggcgcagccgggcgcattgggccgcgatgcaacagcagcagcaggagtcgccccggggcagcagcggcagcagcagcagaggcagcagcgggcggcgctgagccgccgccgccgccactgaggaagaagccggcccagccgccgccgcgtccggaccctcgcgcctggatcccagcgccccgatcccggcgccccaacccccacgcccgcctccgccaactttcacgctgcctcggcggcccggcccggctcgacgccaatggtggaggccatagtggagtttgactaccaggcccagcacgatgatgagctgacgatcagcgtgggtgaaatcatcaccaacatcaggaaggaggatggaggctggtgggagggacagatcaacggcaggagaggtttgttccctgacaactttgtaagagaaataaagaaagagatgaagaaagaccctctcaccaacaaagctccagaaaagcccctgcacgaagtgcccagtggaaactctttgctgtcttctgaaacgattttaagaaccaataagagaggcgagcgacggaggcgccggtgccaggtggcattcagctacctgccccagaatgacgatgaacttgagctgaaagttggcgacatcatagaggtggtaggagaggtagaggaaggatggtgggaaggtgttctcaacgggaagactggaatgtttccttccaacttcatcaaggagctgtcaggggagtcggatgagcttggcatttcccaggatgagcagctatccaagtcaagtttaagggaaaccacaggctccgagagtgatgggggtgactcaagcagcaccaagtctgaaggtgccaacgggacagtggcaactgcagcaatccagcccaagaaagttaagggagtgggctttggagacattttcaaagacaagccaatcaaactaagaccaaggtcaattgaagtagaaaatgactttctgccggtagaaaagactattgggaagaagttacctgcaactacagcaactccagactcatcaaaaacagaaatggacagcaggacaaagagcaaggattactgcaaagtaatatttccatatgaggcacagaatgatgatgaattgacaatcaaagaaggagatatagtcactctcatcaataaggactgcatcgacgtaggctggtgggaaggagagctgaacggcagacgaggcgtgttccccgataacttcgtgaagttacttccaccggactttgaaaaggaagggaatagacccaagaagccaccgcctccatccgctcctgtcatcaaacaaggggcaggcaccactgagagaaaacatgaaattaaaaagatacctcctgaaagaccagaaatgcttccaaacagaacagaagaaaaagaaagaccagagagagagccaaaactggatttacagaagccctccgttcctgccataccgccaaaaaagcctcggccacctaagaccaattctctcagcagacctggcgcactgcccccgagaaggccggagagaccggtgggtccgctgacacacaccaggggtgacagtccaaagattgacttggccggcagttcgctatctggcatcctggacaaagatctctcggaccgcagcaatgacattgacttagaaggttttgactccgtggtatcatctactgagaaactcagtcatccgaccacaagcagaccaaaagctacagggaggcggcctccgtcccagtccctcacatcttcatccctttcaagccctgatatcttcgactccccaagtcccgaagaggataaggaggaacacatttcacttgcgcacagaggagtggacgcgtcaaagaaaacttccaagactgttaccatatcccaagtgtctgacaacaaagcatccctgccgcccaagccggggaccatggcagcaggtggcggtgggccagcccctctgtcctcagcggcgccctcccccctgtcatcctctttgggaacagctggacacagagccaactccccgtctctgttcggcacggaaggaaaaccaaagatggagcctgcggccagcagccaggcggccgtggaggagctaaggacacaggtccgcgagctgaggagcatcatcgagaccatgaaggaccagcagaaacgagagattaaacagttattgtctgagttggatgaagagaagaaaatccggcttcggttgcagatggaagtgaacgacataaagaaagctctacaatcaaaatgaatacttgatcaatgaaatgtcacattattcatcctgagtccgagactcaaattttctgccccagccaaaataatcttgtgccaaaagattaaaggtttgcctcaaaatgtccctgtttgaaagattagcacaaaagtcttgatagcacaacacaaattccatccaagaggagaatcttccccagggtttagtcctggggctggcactcgttgtgacttacacagagcaaaattgtgctaaaggcttttctactctgagatctcaatgcgaaatgaaaactcaggcagtttagtccatagtggtactattttgatgatattttccattaataaaatgtaatttcagattattcgtttacaagctttataattttatgattttttaatcgtgttttgtcacagacttccctagtgtttgtactacacgtagtcagaagcgagtgtccttttcttttgcttcaggctaagagctgcctcgctctttgtccccccattaggattctattacatatgcaattgtaggttcaacctgtccctttccctgccagcaaaccccaccaccctaagagaaattttagcttatatatgacggtatatttacaaaaagagaaagagaaaatctggtatttgcaatgatctgtgccttctttttaccaccctcttgattggagcttttgtgatgcagctaccatgattcaaaaaaattaaaaattaaaaaaaaaaaatctgccacttatccaagtccactagaggccactgtcttcaaagcttctctcaccctagccaaaggtcctaagaggagacagctgtgaagttgggcgtgctctgtggtaccagctgtgacttttctatttctcctagttttaggttgttcatgaaactagaaatgtcatcctgcttgatttttcatcagccaagttaaacccctgctttctgtcctttgcaccttttgcgtgaacagaatatgcattattaaagcaaaaataaataaaagtaaaatgcaaatgaaaacaagggagggaaagttgtattatttcctgcactgggttacccgtgtgtgttatcgtttaaactgtattcacataatgtcatttgccttgctcacttgtaaccccttcctcaggtccaagagaatgggaggagggtcatgttgaagtgtagccactggaactttcttgcatttatggagttgctttttctttcccaaggaaactgatgtttgcctgtccgctttatctttgtagtacatgaacagttcagccttagactatgtaactgttttctcatccttagctgaaaatgaggggcctactgtattgcgagactgttcaggggtaggggtggagggggtggtcccttaatggcccctgaagatgttggatgtgtttctcaaaagctgctttgtctctttcctgagtttaatagtgaaactactaaacattaatagatttgcacagccacaaagaatgagagttgataataccgaagaagtgatgcaaaaacaaaaaatcacattactgatcattgatagtattacaaataaatgtctcttcctttctcttcctcccttcctccccctgccttcctcttaacctatgtgctcatccttgctacttgaggctgttatttccctccgagtatttaaggagcccaaacaccttggtcttcctgggtgggggcataattaagggaagggagtgtataaggaaggaaacctcataccctccattcccatccctggatatattgccttttcagcagcctcgggttcagtgtgcttggggtcaggagtgccaggttcccaagagcagcgtaaaacatccctgtaccccttgacagttataagcatttctgcgttaaacttgaagattccagagattccccacgacctaatgatctaagaatgcagattggattctttgatgttcaaatttctcatttacttatgaaaatccctaattatatagttttatataatgtgtatacagagtaggattgttgatgaaattgagcggttggaacaccctcatggaacactggcaacatggaatgtagagagctgatgtcttccccctcatagaggccattggcttcctttgtataaggagagggagaagtgattctggaaggagaagttggtatgtctagcttcattgcggcccctcgggctacccagcaagaggattctgcatcaaggaactggacgagccgctacccaaactgccaccatctttactctttacaaaatggacccatcgagaatgttgaaaagcttggaagtatcacttttgaaaaaaaaaaaaattattttgcattcagcatggactcgaccaggcatctatggagattatttttttgcttcattttataaagttgtatttagaaaagtcttaagtattgtgctttgtaaagaagatgattaaaatgaaattttgtgagaatagttttgttca
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:30011 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:30011 -> Molecular function: GO:0017124 [SH3 domain binding] evidence: IEA
GeneID:30011 -> Biological process: GO:0006897 [endocytosis] evidence: IEA
GeneID:30011 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:30011 -> Biological process: GO:0007010 [cytoskeleton organization] evidence: IMP
GeneID:30011 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
GeneID:30011 -> Biological process: GO:0007267 [cell-cell signaling] evidence: NAS
GeneID:30011 -> Biological process: GO:0008360 [regulation of cell shape] evidence: IMP
GeneID:30011 -> Biological process: GO:0016477 [cell migration] evidence: IMP
GeneID:30011 -> Biological process: GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] evidence: TAS
GeneID:30011 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:30011 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA
GeneID:30011 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:30011 -> Cellular component: GO:0005925 [focal adhesion] evidence: IEA
GeneID:30011 -> Cellular component: GO:0030659 [cytoplasmic vesicle membrane] evidence: IEA
GeneID:30011 -> Cellular component: GO:0043005 [neuron projection] evidence: IEA
GeneID:30011 -> Cellular component: GO:0045202 [synapse] evidence: IEA
by
@meso_cacase at
DBCLS
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