2024-03-30 00:34:26, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_031483 6412 bp mRNA linear PRI 20-APR-2013 DEFINITION Homo sapiens itchy E3 ubiquitin protein ligase (ITCH), transcript variant 2, mRNA. ACCESSION NM_031483 VERSION NM_031483.5 GI:380420336 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6412) AUTHORS Sellebjerg,F., Krakauer,M., Khademi,M., Olsson,T. and Sorensen,P.S. TITLE FOXP3, CBLB and ITCH gene expression and cytotoxic T lymphocyte antigen 4 expression on CD4(+) CD25(high) T cells in multiple sclerosis JOURNAL Clin. Exp. Immunol. 170 (2), 149-155 (2012) PUBMED 23039885 REMARK GeneRIF: FOXP3 mRNA expression correlated with CBLB and ITCH in MS patients. REFERENCE 2 (bases 1 to 6412) AUTHORS Bellomaria,A., Barbato,G., Melino,G., Paci,M. and Melino,S. TITLE Recognition mechanism of p63 by the E3 ligase Itch: novel strategy in the study and inhibition of this interaction JOURNAL Cell Cycle 11 (19), 3638-3648 (2012) PUBMED 22935697 REMARK GeneRIF: The interaction of Itch-WW2 domain with p63, was investigated. Erratum:[Cell Cycle. 2013 Feb 15;12(4):705] REFERENCE 3 (bases 1 to 6412) AUTHORS Wei,W., Li,M., Wang,J., Nie,F. and Li,L. TITLE The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein JOURNAL Mol. Cell. Biol. 32 (19), 3903-3912 (2012) PUBMED 22826439 REMARK GeneRIF: Overexpression of ITCH inhibited wild-type DVL2 -induced, but not DVL2-Y568F mutant-induced, Wnt reporter activity. REFERENCE 4 (bases 1 to 6412) AUTHORS Wang,C., An,J., Zhang,P., Xu,C., Gao,K., Wu,D., Wang,D., Yu,H., Liu,J.O. and Yu,L. TITLE The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation JOURNAL Biochem. J. 444 (2), 279-289 (2012) PUBMED 22385262 REMARK GeneRIF: Knockdown of Nedd4, Nedd4-2 and Itch causes an accumulation of steady-state level of AMOT/p130. REFERENCE 5 (bases 1 to 6412) AUTHORS Lohr,N.J., Molleston,J.P., Strauss,K.A., Torres-Martinez,W., Sherman,E.A., Squires,R.H., Rider,N.L., Chikwava,K.R., Cummings,O.W., Morton,D.H. and Puffenberger,E.G. TITLE Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease JOURNAL Am. J. Hum. Genet. 86 (3), 447-453 (2010) PUBMED 20170897 REMARK GeneRIF: describe, in ten patients, identification of a mutation resulting in truncation of ITCH. These patients not only have multisystem autoimmune disease but also display morphologic and developmental abnormalities. REFERENCE 6 (bases 1 to 6412) AUTHORS Chen,X., Wen,S., Fukuda,M.N., Gavva,N.R., Hsu,D., Akama,T.O., Yang-Feng,T. and Shen,C.K. TITLE Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2 JOURNAL Genomics 73 (2), 238-241 (2001) PUBMED 11318614 REMARK GeneRIF: gene expression regulation; coregulates hematopoietic transcription factor NF-E2 REFERENCE 7 (bases 1 to 6412) AUTHORS Qiu,L., Joazeiro,C., Fang,N., Wang,H.Y., Elly,C., Altman,Y., Fang,D., Hunter,T. and Liu,Y.C. TITLE Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase JOURNAL J. Biol. Chem. 275 (46), 35734-35737 (2000) PUBMED 10940313 REFERENCE 8 (bases 1 to 6412) AUTHORS Winberg,G., Matskova,L., Chen,F., Plant,P., Rotin,D., Gish,G., Ingham,R., Ernberg,I. and Pawson,T. TITLE Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases JOURNAL Mol. Cell. Biol. 20 (22), 8526-8535 (2000) PUBMED 11046148 REFERENCE 9 (bases 1 to 6412) AUTHORS Wood,J.D., Yuan,J., Margolis,R.L., Colomer,V., Duan,K., Kushi,J., Kaminsky,Z., Kleiderlein,J.J., Sharp,A.H. and Ross,C.A. TITLE Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins JOURNAL Mol. Cell. Neurosci. 11 (3), 149-160 (1998) PUBMED 9647693 REFERENCE 10 (bases 1 to 6412) AUTHORS Perry,W.L., Hustad,C.M., Swing,D.A., O'Sullivan,T.N., Jenkins,N.A. and Copeland,N.G. TITLE The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice JOURNAL Nat. Genet. 18 (2), 143-146 (1998) PUBMED 9462742 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL356299.16, AL705688.1, AK315212.1, AL109923.29 and AA730741.1. On Mar 15, 2012 this sequence version replaced gi:169658379. Summary: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]. Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB056663.2, AK315212.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-40 AL356299.16 92612-92651 41-132 AL705688.1 42-133 133-2802 AK315212.1 92-2761 2803-6152 AL109923.29 84937-88286 6153-6412 AA730741.1 7-266 FEATURES Location/Qualifiers source 1..6412 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="20" /map="20q11.22" gene 1..6412 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /note="itchy E3 ubiquitin protein ligase" /db_xref="GeneID:83737" /db_xref="HGNC:13890" /db_xref="MIM:606409" exon 1..115 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" exon 116..192 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 132 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:3746455" variation 138 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:6059784" variation 151 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:143842156" variation 154 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:6059785" variation 163 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:112587100" misc_feature 181..183 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /note="upstream in-frame stop codon" exon 193..283 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" CDS 214..2802 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /note="isoform 2 is encoded by transcript variant 2; atrophin-1 interacting protein 4; NFE2-associated polypeptide 1; dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)); itchy E3 ubiquitin protein ligase homolog" /codon_start=1 /product="E3 ubiquitin-protein ligase Itchy homolog isoform 2" /protein_id="NP_113671.3" /db_xref="GI:27477109" /db_xref="CCDS:CCDS13234.1" /db_xref="GeneID:83737" /db_xref="HGNC:13890" /db_xref="MIM:606409" /translation="
MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTLQLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSESASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIYGNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE
" misc_feature 262..633 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /note="C2 domain present in E3 ubiquitin ligase; Region: C2_E3_ubiquitin_ligase; cd04021" /db_xref="CDD:175988" misc_feature 1075..1167 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /note="Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; Region: WW; cd00201" /db_xref="CDD:29258" misc_feature order(1117..1119,1150..1152) /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /note="binding pocket" /db_xref="CDD:29258" misc_feature 1171..1260 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /note="Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; Region: WW; cd00201" /db_xref="CDD:29258" misc_feature order(1213..1215,1246..1248) /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /note="binding pocket" /db_xref="CDD:29258" misc_feature 1411..1500 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /note="Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; Region: WW; cd00201" /db_xref="CDD:29258" misc_feature order(1453..1455,1486..1488) /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /note="binding pocket" /db_xref="CDD:29258" misc_feature 1531..1620 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /note="Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other...; Region: WW; cd00201" /db_xref="CDD:29258" misc_feature order(1573..1575,1606..1608) /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /note="binding pocket" /db_xref="CDD:29258" misc_feature 1732..2793 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /note="HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; Region: HECTc; cd00078" /db_xref="CDD:28959" misc_feature order(1750..1752,1840..1842,1873..1875,2056..2058, 2578..2580,2683..2688,2695..2709,2767..2769,2788..2790) /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /note="catalytic cleft [active]" /db_xref="CDD:28959" misc_feature 1804..2790 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /note="Domain Homologous to E6-AP Carboxyl Terminus with; Region: HECTc; smart00119" /db_xref="CDD:197523" misc_feature order(2140..2142,2149..2154,2158..2163,2170..2172, 2191..2193,2197..2199,2209..2214,2218..2220,2233..2235, 2248..2250,2299..2301,2311..2313) /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /note="E2 interaction site; other site" /db_xref="CDD:28959" variation 236 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:11552867" variation 259 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:377431173" exon 284..425 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 296 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:373940007" variation 330 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:368044001" variation 354 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:199513051" variation 366 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:141446117" variation 386 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:144293716" variation 387 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:370090459" exon 426..550 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 459 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="c" /replace="g" /db_xref="dbSNP:3761146" variation 510 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:137925915" variation 542 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:201149238" variation 549 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:140692208" variation 550 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:199947085" exon 551..688 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 598 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:183893157" variation 604 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:150122428" variation 621 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:373829127" variation 622 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:138451400" variation 637 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:188736253" variation 646 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="g" /db_xref="dbSNP:202036043" variation 680 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:149625278" exon 689..734 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 708 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:373751787" variation 734 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:112357913" exon 735..892 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 754 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="g" /db_xref="dbSNP:200506310" variation 779 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="g" /replace="t" /db_xref="dbSNP:368544131" variation 787 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="t" /db_xref="dbSNP:200246240" variation 871 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="c" /db_xref="dbSNP:371486505" variation 883 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:200896809" exon 893..1082 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 902 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:371132495" variation 912 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="c" /db_xref="dbSNP:200651161" variation 929 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="g" /replace="t" /db_xref="dbSNP:145113977" variation 940 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:372508275" variation 956 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:368353835" variation 957 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:375751829" variation 959 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:370394645" variation 1041 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:373885533" variation 1055 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="g" /db_xref="dbSNP:200085579" exon 1083..1178 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 1101 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:370665674" variation 1130 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:201610952" variation 1155 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:138920167" exon 1179..1353 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 1202 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="g" /replace="t" /db_xref="dbSNP:375212186" variation 1204 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:368511233" variation 1227 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:142268366" variation 1245 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:201221876" variation 1260 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:367592506" variation 1287 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:371860516" variation 1298 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:146383612" variation 1320 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="t" /db_xref="dbSNP:148516658" exon 1354..1423 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 1359 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:141828786" variation 1406 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:146021135" exon 1424..1508 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 1458 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:368866673" variation 1459 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:373086001" variation 1481 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:1052275" exon 1509..1637 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 1510 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="g" /db_xref="dbSNP:372589721" variation 1524 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:76412574" variation 1546 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:150653226" variation 1587 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="c" /db_xref="dbSNP:75849635" variation 1618 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:201066823" exon 1638..1710 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 1665 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="g" /replace="t" /db_xref="dbSNP:139765100" variation 1686 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:149786961" exon 1711..1782 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 1756 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:201871783" variation 1762 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:200841333" variation 1774 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:200239748" variation 1775 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:199703668" exon 1783..1871 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 1803 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:373876115" exon 1872..2031 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 1890 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:199629170" variation 1891 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:113468730" variation 1968 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:373626080" variation 1977 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:147824534" variation 2026 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="g" /replace="t" /db_xref="dbSNP:80241710" exon 2032..2165 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 2057 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="t" /db_xref="dbSNP:7268389" variation 2061 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:374135990" variation 2128 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:139633287" exon 2166..2306 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 2193 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:147636046" variation 2253 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:149046008" variation 2295 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="g" /db_xref="dbSNP:377380158" variation 2306 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:6059862" exon 2307..2427 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 2367 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:143022837" variation 2382 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:371043535" exon 2428..2532 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 2484 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:56366303" exon 2533..2629 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 2596 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:368005062" exon 2630..2702 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 2634 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:112607958" variation 2656 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:374226560" exon 2703..6401 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /inference="alignment:Splign:1.39.8" variation 2718 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:140201242" variation 2724 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="c" /db_xref="dbSNP:145318917" variation 2793 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="t" /db_xref="dbSNP:4911428" variation 2807 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="t" /db_xref="dbSNP:368637997" variation 2821 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:41290892" variation 2841 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:200138554" variation 2846 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:376617291" variation 2948 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:77883048" variation 2977 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:190970171" variation 3094 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:6088512" variation 3172 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="t" /db_xref="dbSNP:372058359" variation 3302 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="g" /replace="t" /db_xref="dbSNP:375005789" variation 3373 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="g" /replace="t" /db_xref="dbSNP:182746652" STS 3374..3537 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /standard_name="A007H06" /db_xref="UniSTS:32777" variation 3421 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:186405217" variation 3474 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:376694648" variation 3514 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="c" /db_xref="dbSNP:141320183" variation 3619 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="g" /replace="t" /db_xref="dbSNP:191310394" variation 3628 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="g" /replace="t" /db_xref="dbSNP:183046054" variation 3642 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:145451437" variation 3658 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="" /replace="t" /db_xref="dbSNP:34832553" variation 3692 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:187379795" variation 3706 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:6119502" variation 3770 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:114102657" variation 3838 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:6142187" variation 3859..3860 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="" /replace="ta" /db_xref="dbSNP:373695855" variation 3870 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="c" /db_xref="dbSNP:6059886" variation 3884 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:138059778" variation 3959 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:78110206" variation 4011 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:190591565" variation 4039 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="t" /db_xref="dbSNP:149513459" variation 4143 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:41290894" variation 4165 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:372868851" variation 4256..4257 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="" /replace="c" /db_xref="dbSNP:34533763" variation 4276 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:35568544" variation 4393 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:7509362" variation 4657 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="g" /replace="t" /db_xref="dbSNP:188957568" variation 4761 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:192446602" variation 4828..4829 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="" /replace="c" /db_xref="dbSNP:34285280" variation 4921..4922 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="" /replace="t" /db_xref="dbSNP:11167237" variation 4977 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:184323628" variation 5256 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:113307527" variation 5286 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:188075885" variation 5297 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:139117456" variation 5311 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:149905261" variation 5364 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:1569927" variation 5378 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:6058068" STS 5394..5997 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /standard_name="ITCH_3687" /db_xref="UniSTS:462281" variation 5447..5451 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="" /replace="gttaa" /db_xref="dbSNP:367900721" variation 5452..5453 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="" /replace="tt" /db_xref="dbSNP:10598635" variation 5452 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="t" /db_xref="dbSNP:1569928" variation 5463 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="" /replace="tt" /db_xref="dbSNP:11468815" variation 5478 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="" /replace="ttt" /db_xref="dbSNP:59923096" variation 5691 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:71349764" variation 5717 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:71349765" variation 5789 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:112533205" variation 5926 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="c" /db_xref="dbSNP:191499961" variation 5936 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:148618095" variation 6008 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:184374823" variation 6021 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:376212023" variation 6058 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="a" /replace="g" /db_xref="dbSNP:189101223" variation 6089 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="g" /replace="t" /db_xref="dbSNP:181549465" variation 6349 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:148273189" polyA_signal 6380..6385 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" variation 6390 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" /replace="c" /replace="t" /db_xref="dbSNP:185667767" polyA_site 6401 /gene="ITCH" /gene_synonym="AIF4; AIP4; dJ468O1.1; NAPP1" ORIGIN
gcgctcaggcgcctgcgctttagctgctaactcgctctagtagctgtggtcggggctcgggaccggctgccatcttagtctagggactgaggagtcgccgccgccccgagtcccggtaccatgcatttcacggtggccttgtggagacaacgccttaacccaaggaagtgactcaaactgtgagaacttcaggttttccaacctattggtggtatgtctgacagtggatcacaacttggttcaatgggtagcctcaccatgaaatcacagcttcagatcactgtcatctcagcaaaacttaaggaaaataagaagaattggtttggaccaagtccttacgtagaggtcacagtagatggacagtcaaagaagacagaaaaatgcaacaacacaaacagtcccaagtggaagcaaccccttacagttatcgttacccctgtgagtaaattacattttcgtgtgtggagtcaccagacactgaaatctgatgttttgttgggaactgctgcattagatatttatgaaacattaaagtcaaacaatatgaaacttgaagaagtagttgtgactttgcagcttggaggtgacaaagagccaacagagacaataggagacttgtcaatttgtcttgatgggctacagttagagtctgaagttgttaccaatggtgaaactacatgttcagaaagtgcttctcagaatgatgatggctccagatccaaggatgaaacaagagtgagcacaaatggatcagatgaccctgaagatgcaggagctggtgaaaataggagagtcagtgggaataattctccatcactctcaaatggtggttttaaaccttctagacctccaagaccttcacgaccaccaccacccaccccacgtagaccagcatctgtcaatggttcaccatctgccacttctgaaagtgatgggtctagtacaggctctctgccgccgacaaatacaaatacaaatacatctgaaggagcaacatctggattaataattcctcttactatatctggaggctcaggccctaggccattaaatcctgtaactcaagctcccttgccacctggttgggagcagagagtggaccagcacgggcgagtttactatgtagatcatgttgagaaaagaacaacatgggatagaccagaacctctacctcctggctgggaacggcgggttgacaacatgggacgtatttattatgttgaccatttcacaagaacaacaacgtggcagaggccaacactggaatccgtccggaactatgaacaatggcagctacagcgtagtcagcttcaaggagcaatgcagcagtttaaccagagattcatttatgggaatcaagatttatttgctacatcacaaagtaaagaatttgatcctcttggtccattgccacctggatgggagaagagaacagacagcaatggcagagtatatttcgtcaaccacaacacacgaattacacaatgggaagaccccagaagtcaaggtcaattaaatgaaaagcccttacctgaaggttgggaaatgagattcacagtggatggaattccatattttgtggaccacaatagaagaactaccacctatatagatccccgcacaggaaaatctgccctagacaatggacctcagatagcctatgttcgggacttcaaagcaaaggttcagtatttccggttctggtgtcagcaactggccatgccacagcacataaagattacagtgacaagaaaaacattgtttgaggattcctttcaacagataatgagcttcagtccccaagatctgcgaagacgtttgtgggtgatttttccaggagaagaaggtttagattatggaggtgtagcaagagaatggttctttcttttgtcacatgaagtgttgaacccaatgtattgcctgtttgaatatgcagggaaggataactactgcttgcagataaaccccgcttcttacatcaatccagatcacctgaaatattttcgttttattggcagatttattgccatggctctgttccatgggaaattcatagacacgggtttttctttaccattctataagcgtatcttgaacaaaccagttggactcaaggatttagaatctattgatccagaattttacaattctctcatctgggttaaggaaaacaatattgaggaatgtgatttggaaatgtacttctccgttgacaaagaaattctaggtgaaattaagagtcatgatctgaaacctaatggtggcaatattcttgtaacagaagaaaataaagaggaatacatcagaatggtagctgagtggaggttgtctcgaggtgttgaagaacagacacaagctttctttgaaggctttaatgaaattcttccccagcaatatttgcaatactttgatgcaaaggaattagaggtccttttatgtggaatgcaagagattgatttgaatgactggcaaagacatgccatctaccgtcattatgcaaggaccagcaaacaaatcatgtggttttggcagtttgttaaagaaattgataatgagaagagaatgagacttctgcagtttgttactggaacctgccgattgccagtaggaggatttgctgatctcatggggagcaatggaccacagaaattctgcattgaaaaagttgggaaagaaaattggctacccagaagtcatacctgttttaatcgcctggacctgccaccatacaagagctatgagcaactgaaggaaaagctgttgtttgccatagaagaaacagaaggatttggacaagagtaacttctgagaacttgcaccatgaatgggcaagaacttatttgcaatgtttgtccttctctgcctgttgcacatcttgtaaaattggacaatggctctttagagagttatctgagtgtaagtaaattaatgttctcatttagatttatctcccagtgatttctactcagcgtttccagaaatcaggtctgcaaatgactagtcagaaccttgcttaacatgagattttaacacaacaatgaaatttgccttgtcttattccactagtttattcctttaacaacaatattttatgtgtgtcaaaagtctcacttgggagtagtgtttttttcttttagacattctgcagacatgcagggaagtcctttggtaactgcaatatacaagattttcctattaagcctcttggtaagaggcatttgttaaaagtgcaagcttactcctgcttctggggatgtgagcaaaattcgggcttgtgttctccctctcattttagtctgacttgactattgtttttcctttctggcgcatgaatccatacatcattcctggaagtgaggcaagactcttgcatctctacaaagtagttttgtcaatttgaattcagggaaaagttggtcacagcctgcaaatgacttcatttggaagtctgattgtttcagttgcctgacaaatactacactttacaaacaatgttaacactgtgattccttcattgttttaagaagttaacctagggccgggcatggtggctcatacctgtaatcctagcactctgggaggccgaggcaggaggatccctttagcccaggagttaaagaccagcctgggcaacatagggagaccctgtcttttttttgggcagcgtggtgggggataaataaataaaaggaaaaaaaacttagcctagaattagaattaatttaattgaattcatctaaagatgtctctggtgatttttatatgttccgctatataattgatgctttatagttttatcataatccaacaacttcagttatatttaattattgttaaggagtttaagactagaaagactagagtgctttctagtccaaatagaggtcagtgaaacagcttttgacatcagattttcatttgagagggagagctgtggtactggctaaaaagaaaggaagataacatccagtaaccacaggaatatattctctgtgaattaaaagtcttcaaagttatcatttctctgacatatgttggagtagtcatttccattctttacattgtcatgaactggattgataaccctcatctgcaatattttcacccctaaaatttttaacagggtttcctttttttctcacgactatttaagtttagattgctccattattaactgattaatgcactttgaagttctctggaattaattattttaacttggcctagcttcgactgtcaaggtggctgttataaatttgacttcattggcagtggatgaagcctaagccagctgagtctctatcatagctgaaccctgaggacagcctcatagctcatgtatcagggacttttgccacatttcagaggcatagcatgaacaagtaatattaagccaagaataagcagcagaaccctgttccatatggaaaaaagaaaaacaattttttgtccctaatgttcttccttttacatcctggaacaacaataaaaacatttttttaaacttgtctactgtaagatactgccatcataaagcagagacttacatgagtgaaagggttgcctcatcaagcagctcagtgtaaatggggaggctaggctctccccagccctatggtttttttatttcatgtaccccaggaaatactgtgtggtttctaaaagccctggttgttaaaagtagggactctgcctttttgttggtagggagaaaaaacgctattgctttgtcttacagagcgaatgtctgccaactacccgttcattatataagtctgaacttggtaatatatggctaatgaagattaagccctctataaagacttcctgttgaggtgaattctcatactgaaatgtagttacctacaatatttactagagatttatgaaattaaattaagagataatgtaagaaaatacatttttttggttctatataatgcttcatgattcatttagggacctagaaatattgtgtgaaaatatataaatatcacccaaaaggctttctgccctatatttttaaaatacagaatagttatatttgaagtagccctggccctagttctatagggcttggctatttaatatttttatggaagaagtgtttagttctggaaaaggtaaatgcttgtatatatttttgcagcctgggatctccctactccattttttcctttaatttaagtggccacatgtatatgtcttccctgctgtgttaggaaaatgggggctggatatcccaagaatcagaggttatataaaaatactgcaaatagaccgcagacataaatatctaccaaatgctatcttaaattttggtccaaactgaacatatggaaatagatttattgtaagtatttacttagagctttttcttaaatctgaactaacttgcttttagaagtctttttctttgtaagcattgtaaatgctaataaatcctgttaatttttttttttttttttttttttttttactgcatgttacattgaaataaaaacaaagtaaaatgagcaattgccttattgttctgctcttttgcagggggtgggggttggggaagacagcattccacagcctggtcaggagggaaggacctcacttgtttcatcaaatggagtggtttaaaactgatcaagcagctcataataatgaattcctgctctgtcttttattatcttatgtcagagtgcagcaaaatctcatttcataagacttacaataactctatttaaaattcaggtattgtactcgggaggctgaggtgggaggatcccaggagttcaaatcctgcctgggcaacatagcaagaccctgtctcttaaaaaaacaaaaagacatattcaggtactgatttttcatcaagagattgacataccaatgatcagaaattttagtgaaacttgactcaactatacacaaagttctcatcctaaatgaactatttcagtcaagcccactctaccactttttacttatctggttaataatccgaaatgttaccggggttgactcacggaattaaatttttcctctatttttatatcctttcctgttgtggatgtaacttacctttctaaactcctttagagttaacgacttctatttagtattgttggtatctccagcccccctcctttttttgtttttcttttagttatttactttgtttgtataatttgctttcattaactaaaaatggaattggcagcactggattgtatattactgtattaagagtacctttgttttcttgatctgttacttttaatactcaggtaatgctacaaatattacagggagtcaaatgcttttataaagttccttcagtggttgcctcacttgcgttttcctacaagatgtaagactgtttataattaaacttttttggtccttcaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:83737 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IDA GeneID:83737 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: NAS GeneID:83737 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: TAS GeneID:83737 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:83737 -> Molecular function: GO:0043021 [ribonucleoprotein complex binding] evidence: IPI GeneID:83737 -> Molecular function: GO:0045236 [CXCR chemokine receptor binding] evidence: IPI GeneID:83737 -> Biological process: GO:0001558 [regulation of cell growth] evidence: NAS GeneID:83737 -> Biological process: GO:0002669 [positive regulation of T cell anergy] evidence: IEA GeneID:83737 -> Biological process: GO:0006511 [ubiquitin-dependent protein catabolic process] evidence: IDA GeneID:83737 -> Biological process: GO:0006511 [ubiquitin-dependent protein catabolic process] evidence: NAS GeneID:83737 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:83737 -> Biological process: GO:0006954 [inflammatory response] evidence: NAS GeneID:83737 -> Biological process: GO:0007219 [Notch signaling pathway] evidence: TAS GeneID:83737 -> Biological process: GO:0016567 [protein ubiquitination] evidence: IDA GeneID:83737 -> Biological process: GO:0032088 [negative regulation of NF-kappaB transcription factor activity] evidence: ISS GeneID:83737 -> Biological process: GO:0032480 [negative regulation of type I interferon production] evidence: TAS GeneID:83737 -> Biological process: GO:0035519 [protein K29-linked ubiquitination] evidence: IDA GeneID:83737 -> Biological process: GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] evidence: TAS GeneID:83737 -> Biological process: GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] evidence: IBA GeneID:83737 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP GeneID:83737 -> Biological process: GO:0045087 [innate immune response] evidence: TAS GeneID:83737 -> Biological process: GO:0045732 [positive regulation of protein catabolic process] evidence: IEA GeneID:83737 -> Biological process: GO:0046329 [negative regulation of JNK cascade] evidence: ISS GeneID:83737 -> Biological process: GO:0046642 [negative regulation of alpha-beta T cell proliferation] evidence: IEA GeneID:83737 -> Biological process: GO:0046718 [viral entry into host cell] evidence: TAS GeneID:83737 -> Biological process: GO:0050687 [negative regulation of defense response to virus] evidence: IMP GeneID:83737 -> Biological process: GO:0051607 [defense response to virus] evidence: IEA GeneID:83737 -> Biological process: GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] evidence: TAS GeneID:83737 -> Biological process: GO:0070534 [protein K63-linked ubiquitination] evidence: IDA GeneID:83737 -> Biological process: GO:0070936 [protein K48-linked ubiquitination] evidence: IDA GeneID:83737 -> Biological process: GO:0090085 [regulation of protein deubiquitination] evidence: ISS GeneID:83737 -> Cellular component: GO:0005634 [nucleus] evidence: IBA GeneID:83737 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:83737 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:83737 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA GeneID:83737 -> Cellular component: GO:0005938 [cell cortex] evidence: IEA GeneID:83737 -> Cellular component: GO:0031410 [cytoplasmic vesicle] evidence: IEA
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