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2024-04-23 22:15:47, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_031421 2298 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens tetratricopeptide repeat domain 25 (TTC25), mRNA.
ACCESSION NM_031421
VERSION NM_031421.2 GI:134152711
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2298)
AUTHORS Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
Wiemann,S.
TITLE Systematic subcellular localization of novel proteins identified by
large-scale cDNA sequencing
JOURNAL EMBO Rep. 1 (3), 287-292 (2000)
PUBMED 11256614
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
CF593846.1 and AL136760.1.
On Mar 28, 2007 this sequence version replaced gi:13899232.
##Evidence-Data-START##
Transcript exon combination :: AL136760.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025084, ERS025085 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-21 CF593846.1 29-49
22-2298 AL136760.1 1-2277
FEATURES Location/Qualifiers
source 1..2298
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q21.2"
gene 1..2298
/gene="TTC25"
/note="tetratricopeptide repeat domain 25"
/db_xref="GeneID:83538"
/db_xref="HGNC:25280"
/db_xref="HPRD:10888"
misc_feature 30..32
/gene="TTC25"
/note="upstream in-frame stop codon"
CDS 90..2108
/gene="TTC25"
/note="TPR repeat protein 25"
/codon_start=1
/product="tetratricopeptide repeat protein 25"
/protein_id="NP_113609.1"
/db_xref="GI:13899233"
/db_xref="GeneID:83538"
/db_xref="HGNC:25280"
/db_xref="HPRD:10888"
/translation="
MSDPEGETLRSTFPSYMAEGERLYLCGEFSKAAQSFSNALYLQDGDKNCLVARSKCFLKMGDLERSLKDAEASLQSDPAFCKGILQKAETLYTMGDFEFALVFYHRGYKLRPDREFRVGIQKAQEAINNSVGSPSSIKLENKGDLSFLSKQAENIKAQQKPQPMKHLLHPTKGEPKWKASLKSEKTVRQLLGELYVDKEYLEKLLLDEDLIKGTMKGGLTVEDLIMTGINYLDTHSNFWRQQKPIYARERDRKLMQEKWLRDHKRRPSQTAHYILKSLEDIDMLLTSGSAEGSLQKAEKVLKKVLEWNKEEVPNKDELVGNLYSCIGNAQIELGQMEAALQSHRKDLEIAKEYDLPDAKSRALDNIGRVFARVGKFQQAIDTWEEKIPLAKTTLEKTWLFHEIGRCYLELDQAWQAQNYGEKSQQCAEEEGDIEWQLNASVLVAQAQVKLRDFESAVNNFEKALERAKLVHNNEAQQAIISALDDANKGIIRELRKTNYVENLKEKSEGEASLYEDRIITREKDMRRVRDEPEKVVKQWDHSEDEKETDEDDEAFGEALQSPASGKQSVEAGKARSDLGAVAKGLSGELGTRSGETGRKLLEAGRRESREIYRRPSGELEQRLSGEFSRQEPEELKKLSEVGRREPEELGKTQFGEIGETKKTGNEMEKEYE
"
misc_feature 126..227
/gene="TTC25"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NG3.2);
Region: TPR 1"
misc_feature 135..428
/gene="TTC25"
/note="Tetratricopeptide repeat domain; typically contains
34 amino acids
[WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-
X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in
a variety of organisms including bacteria, cyanobacteria,
yeast, fungi; Region: TPR; cd00189"
/db_xref="CDD:29151"
misc_feature 135..323
/gene="TTC25"
/note="TPR repeat; Region: TPR_11; pfam13414"
/db_xref="CDD:205592"
misc_feature order(138..143,150..155,240..245,249..254,261..266,
342..347,354..359,366..371)
/gene="TTC25"
/note="binding surface"
/db_xref="CDD:29151"
misc_feature order(147..149,183..185,195..197,204..206,249..251,
285..287,297..299,306..308,351..353,387..389,399..401,
408..410)
/gene="TTC25"
/note="TPR motif; other site"
/db_xref="CDD:29151"
misc_feature 231..329
/gene="TTC25"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NG3.2);
Region: TPR 2"
misc_feature 330..431
/gene="TTC25"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NG3.2);
Region: TPR 3"
misc_feature 912..1022
/gene="TTC25"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NG3.2);
Region: TPR 4"
misc_feature 957..1265
/gene="TTC25"
/note="Tetratricopeptide repeat domain; typically contains
34 amino acids
[WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-
X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in
a variety of organisms including bacteria, cyanobacteria,
yeast, fungi; Region: TPR; cl02429"
/db_xref="CDD:207591"
misc_feature order(978..980,990..992,999..1001,1068..1070,1104..1106,
1116..1118,1125..1127,1188..1190,1224..1226,1236..1238,
1245..1247)
/gene="TTC25"
/note="TPR motif; other site"
/db_xref="CDD:29151"
misc_feature 1035..1244
/gene="TTC25"
/note="Tetratricopeptide repeat; Region: TPR_12;
pfam13424"
/db_xref="CDD:205602"
misc_feature 1047..1148
/gene="TTC25"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NG3.2);
Region: TPR 5"
misc_feature order(1059..1064,1068..1073,1080..1085,1179..1184,
1191..1196,1203..1208)
/gene="TTC25"
/note="binding surface"
/db_xref="CDD:29151"
misc_feature 1167..1268
/gene="TTC25"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NG3.2);
Region: TPR 6"
misc_feature 1170..1376
/gene="TTC25"
/note="Tetratricopeptide repeat; Region: TPR_12;
pfam13424"
/db_xref="CDD:205602"
misc_feature 1278..1379
/gene="TTC25"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NG3.2);
Region: TPR 7"
misc_feature 1284..1493
/gene="TTC25"
/note="Tetratricopeptide repeat; Region: TPR_12;
pfam13424"
/db_xref="CDD:205602"
misc_feature 1398..1499
/gene="TTC25"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q96NG3.2);
Region: TPR 8"
variation 91
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:201800581"
variation 99
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:34516580"
variation 142
/gene="TTC25"
/replace="c"
/replace="g"
/db_xref="dbSNP:35516909"
variation 144
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:201321025"
variation 151
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:190929235"
variation 154
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:377736469"
variation 160
/gene="TTC25"
/replace="a"
/replace="t"
/db_xref="dbSNP:200374561"
variation 168
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:199737978"
variation 286
/gene="TTC25"
/replace=""
/replace="c"
/db_xref="dbSNP:139256162"
variation 296
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:370318195"
variation 308
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:377117826"
variation 359
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375473709"
variation 361
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:367818261"
variation 383
/gene="TTC25"
/replace="g"
/replace="t"
/db_xref="dbSNP:201095186"
variation 399
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:75504508"
variation 430
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:34520854"
variation 498
/gene="TTC25"
/replace="a"
/replace="t"
/db_xref="dbSNP:202226204"
variation 522
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:375976105"
variation 538
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:370585734"
variation 553
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:370683881"
variation 579
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374672260"
variation 613
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:368731263"
variation 644
/gene="TTC25"
/replace="g"
/replace="t"
/db_xref="dbSNP:370238675"
variation 673
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:367688207"
variation 674
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:372198587"
variation 675
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:199823863"
variation 705
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:376776759"
variation 740
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:3809878"
variation 743
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:147969617"
variation 753
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375888994"
variation 769
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:200498473"
variation 818
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:188182718"
variation 828
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:181295455"
variation 838
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:148926603"
variation 872
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:371648458"
variation 882
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:184013464"
variation 885
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:374566388"
variation 886
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:373685258"
variation 928
/gene="TTC25"
/replace="a"
/replace="t"
/db_xref="dbSNP:370180388"
variation 1001
/gene="TTC25"
/replace="a"
/replace="t"
/db_xref="dbSNP:372893438"
variation 1091
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:369010092"
variation 1169
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:374840031"
variation 1457
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:200778987"
variation 1469
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:376342938"
variation 1498
/gene="TTC25"
/replace="a"
/replace="t"
/db_xref="dbSNP:370563740"
variation 1501
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:144272262"
variation 1508
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:374922478"
variation 1541
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:370439442"
variation 1593
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:373808757"
variation 1610
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:201461009"
variation 1671
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:368318610"
variation 1685
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:372293526"
variation 1712
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:376733724"
variation 1743
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:373880984"
variation 1782
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375089566"
variation 1817
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:368871475"
variation 1848
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:191841643"
variation 1891
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:184299114"
variation 1908
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:200610016"
variation 1936
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:188595090"
variation 1951
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375862808"
variation 1976
/gene="TTC25"
/replace="a"
/replace="t"
/db_xref="dbSNP:146613555"
variation 1978
/gene="TTC25"
/replace="a"
/replace="t"
/db_xref="dbSNP:373037467"
variation 1999
/gene="TTC25"
/replace="a"
/replace="c"
/db_xref="dbSNP:377325585"
variation 2000
/gene="TTC25"
/replace="a"
/replace="c"
/db_xref="dbSNP:371241893"
variation 2005
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:201580105"
variation 2048
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:375459379"
variation 2058
/gene="TTC25"
/replace="a"
/replace="g"
/db_xref="dbSNP:377453536"
variation 2085
/gene="TTC25"
/replace="g"
/replace="t"
/db_xref="dbSNP:375330943"
variation 2118
/gene="TTC25"
/replace="c"
/replace="t"
/db_xref="dbSNP:367854624"
variation 2261
/gene="TTC25"
/replace="a"
/replace="c"
/db_xref="dbSNP:149214074"
ORIGIN
gctaagaaacggagcttccacaaaccagatagaggttctccagcttttctttgattgtctctgctttagcgtctctaaatccggtcaccatgtcggaccccgaaggcgagaccttgcgaagcacctttccctcttatatggccgaaggcgagcggctctacctgtgcggggaattttctaaagccgcgcagagcttcagcaacgctctttaccttcaggatggagacaagaactgcctggttgctcgctcaaagtgcttcctgaagatgggagacttggagagatccctgaaggatgctgaggcttcgctccagagtgacccagctttctgtaaggggattttgcaaaaggctgagacactgtacaccatgggagactttgagtttgccttggtattctatcatcgaggctacaagctgaggcctgatcgggaattcagagttggcattcagaaagcccaggaagccatcaacaactcagtgggaagtccttcttccattaagctggagaacaaaggggacctctccttcttaagcaagcaggctgagaatataaaagcccagcagaagcctcagcccatgaaacacctcttacaccccaccaagggagagcccaagtggaaggcctcgctcaagagtgagaagactgtccgccagcttctgggggagctctacgtggacaaagagtatttggagaagctcctattggatgaagacctgatcaaaggcaccatgaagggcggcctgactgtggaggacctcatcatgacgggcatcaactacctggatactcacagcaacttctggaggcagcagaagccgatctacgccagggagcgggaccggaagctgatgcaagagaaatggctgcgggaccacaaacgccgtccctcacagacagcccattacatcctcaagagcctggaggacattgatatgttgctcacaagtggcagtgctgaagggagtcttcagaaagctgagaaagtgctgaagaaggtactggaatggaacaaggaagaggtacccaacaaggatgaactggttggaaacttgtatagctgcatagggaatgcccagattgagctggggcagatggaggcagccctgcagagccacagaaaggacctggagatcgccaaggaatatgaccttcctgatgcaaaatcgagagcccttgacaacattggcagagtttttgccagagttgggaaattccagcaagccattgacacgtgggaagaaaagatccctctggcaaaaaccaccctggagaagacctggctgttccacgagatcggccgctgctacttggagctggaccaggcctggcaggcccagaattatggcgagaagtcccagcagtgtgccgaggaggaaggggacattgagtggcaactgaatgccagtgttctggtggcccaggcacaagtgaagctgagagacttcgagtcagccgtgaacaattttgagaaggccctggagagagcaaagcttgtgcataacaacgaggcgcagcaggccatcatcagtgccttggacgatgccaacaagggtatcatcagagaactgaggaaaaccaactacgtggagaatctcaaagaaaaaagcgagggagaagcttcactgtatgaagatagaataataacaagagagaaggacatgaggagagtgagagatgagcccgagaaggtggtgaagcagtgggaccatagtgaggatgagaaagagacagatgaggacgatgaggcttttggggaagctctgcagagcccagcaagcggaaagcagagtgtggaagcaggaaaagccagaagcgatttgggagcagttgccaagggcctgtcaggagaattaggcacaagatcaggagaaacaggcaggaagctactagaagctggcagaagagagtcaagagaaatttataggaggccttcgggagaattagagcaaagactctcaggagaattcagcagacaggaaccagaagaactaaagaaactttcagaagtgggcagaagagagccagaagaactgggaaaaacacaatttggagaaataggagaaacgaaaaaaacaggaaatgagatggaaaaggaatatgaatgaagccatcggtagagatgaggatcaggaagctggtgttcagagggatcatgggattttattaaactggattttcaagcgatttgtctgttataggaaaaatgagggttttacttctgctgctttccatcactattttgccattaaataggtgtctttcactcttgcaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:83538 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
by
@meso_cacase at
DBCLS
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