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2020-10-24 07:21:27, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_031421               2298 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens tetratricopeptide repeat domain 25 (TTC25), mRNA.
ACCESSION   NM_031421
VERSION     NM_031421.2  GI:134152711
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2298)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep. 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF593846.1 and AL136760.1.
            On Mar 28, 2007 this sequence version replaced gi:13899232.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136760.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025084, ERS025085 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                CF593846.1         29-49
            22-2298             AL136760.1         1-2277
FEATURES             Location/Qualifiers
     source          1..2298
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..2298
                     /gene="TTC25"
                     /note="tetratricopeptide repeat domain 25"
                     /db_xref="GeneID:83538"
                     /db_xref="HGNC:25280"
                     /db_xref="HPRD:10888"
     misc_feature    30..32
                     /gene="TTC25"
                     /note="upstream in-frame stop codon"
     CDS             90..2108
                     /gene="TTC25"
                     /note="TPR repeat protein 25"
                     /codon_start=1
                     /product="tetratricopeptide repeat protein 25"
                     /protein_id="NP_113609.1"
                     /db_xref="GI:13899233"
                     /db_xref="GeneID:83538"
                     /db_xref="HGNC:25280"
                     /db_xref="HPRD:10888"
                     /translation="
MSDPEGETLRSTFPSYMAEGERLYLCGEFSKAAQSFSNALYLQDGDKNCLVARSKCFLKMGDLERSLKDAEASLQSDPAFCKGILQKAETLYTMGDFEFALVFYHRGYKLRPDREFRVGIQKAQEAINNSVGSPSSIKLENKGDLSFLSKQAENIKAQQKPQPMKHLLHPTKGEPKWKASLKSEKTVRQLLGELYVDKEYLEKLLLDEDLIKGTMKGGLTVEDLIMTGINYLDTHSNFWRQQKPIYARERDRKLMQEKWLRDHKRRPSQTAHYILKSLEDIDMLLTSGSAEGSLQKAEKVLKKVLEWNKEEVPNKDELVGNLYSCIGNAQIELGQMEAALQSHRKDLEIAKEYDLPDAKSRALDNIGRVFARVGKFQQAIDTWEEKIPLAKTTLEKTWLFHEIGRCYLELDQAWQAQNYGEKSQQCAEEEGDIEWQLNASVLVAQAQVKLRDFESAVNNFEKALERAKLVHNNEAQQAIISALDDANKGIIRELRKTNYVENLKEKSEGEASLYEDRIITREKDMRRVRDEPEKVVKQWDHSEDEKETDEDDEAFGEALQSPASGKQSVEAGKARSDLGAVAKGLSGELGTRSGETGRKLLEAGRRESREIYRRPSGELEQRLSGEFSRQEPEELKKLSEVGRREPEELGKTQFGEIGETKKTGNEMEKEYE
"
     misc_feature    126..227
                     /gene="TTC25"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96NG3.2);
                     Region: TPR 1"
     misc_feature    135..428
                     /gene="TTC25"
                     /note="Tetratricopeptide repeat domain; typically contains
                     34 amino acids
                     [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-
                     X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in
                     a variety of organisms including bacteria, cyanobacteria,
                     yeast, fungi; Region: TPR; cd00189"
                     /db_xref="CDD:29151"
     misc_feature    135..323
                     /gene="TTC25"
                     /note="TPR repeat; Region: TPR_11; pfam13414"
                     /db_xref="CDD:205592"
     misc_feature    order(138..143,150..155,240..245,249..254,261..266,
                     342..347,354..359,366..371)
                     /gene="TTC25"
                     /note="binding surface"
                     /db_xref="CDD:29151"
     misc_feature    order(147..149,183..185,195..197,204..206,249..251,
                     285..287,297..299,306..308,351..353,387..389,399..401,
                     408..410)
                     /gene="TTC25"
                     /note="TPR motif; other site"
                     /db_xref="CDD:29151"
     misc_feature    231..329
                     /gene="TTC25"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96NG3.2);
                     Region: TPR 2"
     misc_feature    330..431
                     /gene="TTC25"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96NG3.2);
                     Region: TPR 3"
     misc_feature    912..1022
                     /gene="TTC25"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96NG3.2);
                     Region: TPR 4"
     misc_feature    957..1265
                     /gene="TTC25"
                     /note="Tetratricopeptide repeat domain; typically contains
                     34 amino acids
                     [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-
                     X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in
                     a variety of organisms including bacteria, cyanobacteria,
                     yeast, fungi; Region: TPR; cl02429"
                     /db_xref="CDD:207591"
     misc_feature    order(978..980,990..992,999..1001,1068..1070,1104..1106,
                     1116..1118,1125..1127,1188..1190,1224..1226,1236..1238,
                     1245..1247)
                     /gene="TTC25"
                     /note="TPR motif; other site"
                     /db_xref="CDD:29151"
     misc_feature    1035..1244
                     /gene="TTC25"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:205602"
     misc_feature    1047..1148
                     /gene="TTC25"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96NG3.2);
                     Region: TPR 5"
     misc_feature    order(1059..1064,1068..1073,1080..1085,1179..1184,
                     1191..1196,1203..1208)
                     /gene="TTC25"
                     /note="binding surface"
                     /db_xref="CDD:29151"
     misc_feature    1167..1268
                     /gene="TTC25"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96NG3.2);
                     Region: TPR 6"
     misc_feature    1170..1376
                     /gene="TTC25"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:205602"
     misc_feature    1278..1379
                     /gene="TTC25"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96NG3.2);
                     Region: TPR 7"
     misc_feature    1284..1493
                     /gene="TTC25"
                     /note="Tetratricopeptide repeat; Region: TPR_12;
                     pfam13424"
                     /db_xref="CDD:205602"
     misc_feature    1398..1499
                     /gene="TTC25"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96NG3.2);
                     Region: TPR 8"
     variation       91
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201800581"
     variation       99
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:34516580"
     variation       142
                     /gene="TTC25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35516909"
     variation       144
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201321025"
     variation       151
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190929235"
     variation       154
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377736469"
     variation       160
                     /gene="TTC25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200374561"
     variation       168
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199737978"
     variation       286
                     /gene="TTC25"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:139256162"
     variation       296
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370318195"
     variation       308
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377117826"
     variation       359
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375473709"
     variation       361
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367818261"
     variation       383
                     /gene="TTC25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201095186"
     variation       399
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75504508"
     variation       430
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34520854"
     variation       498
                     /gene="TTC25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:202226204"
     variation       522
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375976105"
     variation       538
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370585734"
     variation       553
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370683881"
     variation       579
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374672260"
     variation       613
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368731263"
     variation       644
                     /gene="TTC25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370238675"
     variation       673
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367688207"
     variation       674
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372198587"
     variation       675
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199823863"
     variation       705
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376776759"
     variation       740
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3809878"
     variation       743
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147969617"
     variation       753
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375888994"
     variation       769
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200498473"
     variation       818
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188182718"
     variation       828
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:181295455"
     variation       838
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148926603"
     variation       872
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371648458"
     variation       882
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184013464"
     variation       885
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374566388"
     variation       886
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373685258"
     variation       928
                     /gene="TTC25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370180388"
     variation       1001
                     /gene="TTC25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372893438"
     variation       1091
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369010092"
     variation       1169
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374840031"
     variation       1457
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200778987"
     variation       1469
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376342938"
     variation       1498
                     /gene="TTC25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370563740"
     variation       1501
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144272262"
     variation       1508
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374922478"
     variation       1541
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370439442"
     variation       1593
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373808757"
     variation       1610
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201461009"
     variation       1671
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368318610"
     variation       1685
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372293526"
     variation       1712
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376733724"
     variation       1743
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373880984"
     variation       1782
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375089566"
     variation       1817
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368871475"
     variation       1848
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191841643"
     variation       1891
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184299114"
     variation       1908
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200610016"
     variation       1936
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188595090"
     variation       1951
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375862808"
     variation       1976
                     /gene="TTC25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:146613555"
     variation       1978
                     /gene="TTC25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:373037467"
     variation       1999
                     /gene="TTC25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377325585"
     variation       2000
                     /gene="TTC25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371241893"
     variation       2005
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201580105"
     variation       2048
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375459379"
     variation       2058
                     /gene="TTC25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377453536"
     variation       2085
                     /gene="TTC25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:375330943"
     variation       2118
                     /gene="TTC25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367854624"
     variation       2261
                     /gene="TTC25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:149214074"
ORIGIN      
gctaagaaacggagcttccacaaaccagatagaggttctccagcttttctttgattgtctctgctttagcgtctctaaatccggtcaccatgtcggaccccgaaggcgagaccttgcgaagcacctttccctcttatatggccgaaggcgagcggctctacctgtgcggggaattttctaaagccgcgcagagcttcagcaacgctctttaccttcaggatggagacaagaactgcctggttgctcgctcaaagtgcttcctgaagatgggagacttggagagatccctgaaggatgctgaggcttcgctccagagtgacccagctttctgtaaggggattttgcaaaaggctgagacactgtacaccatgggagactttgagtttgccttggtattctatcatcgaggctacaagctgaggcctgatcgggaattcagagttggcattcagaaagcccaggaagccatcaacaactcagtgggaagtccttcttccattaagctggagaacaaaggggacctctccttcttaagcaagcaggctgagaatataaaagcccagcagaagcctcagcccatgaaacacctcttacaccccaccaagggagagcccaagtggaaggcctcgctcaagagtgagaagactgtccgccagcttctgggggagctctacgtggacaaagagtatttggagaagctcctattggatgaagacctgatcaaaggcaccatgaagggcggcctgactgtggaggacctcatcatgacgggcatcaactacctggatactcacagcaacttctggaggcagcagaagccgatctacgccagggagcgggaccggaagctgatgcaagagaaatggctgcgggaccacaaacgccgtccctcacagacagcccattacatcctcaagagcctggaggacattgatatgttgctcacaagtggcagtgctgaagggagtcttcagaaagctgagaaagtgctgaagaaggtactggaatggaacaaggaagaggtacccaacaaggatgaactggttggaaacttgtatagctgcatagggaatgcccagattgagctggggcagatggaggcagccctgcagagccacagaaaggacctggagatcgccaaggaatatgaccttcctgatgcaaaatcgagagcccttgacaacattggcagagtttttgccagagttgggaaattccagcaagccattgacacgtgggaagaaaagatccctctggcaaaaaccaccctggagaagacctggctgttccacgagatcggccgctgctacttggagctggaccaggcctggcaggcccagaattatggcgagaagtcccagcagtgtgccgaggaggaaggggacattgagtggcaactgaatgccagtgttctggtggcccaggcacaagtgaagctgagagacttcgagtcagccgtgaacaattttgagaaggccctggagagagcaaagcttgtgcataacaacgaggcgcagcaggccatcatcagtgccttggacgatgccaacaagggtatcatcagagaactgaggaaaaccaactacgtggagaatctcaaagaaaaaagcgagggagaagcttcactgtatgaagatagaataataacaagagagaaggacatgaggagagtgagagatgagcccgagaaggtggtgaagcagtgggaccatagtgaggatgagaaagagacagatgaggacgatgaggcttttggggaagctctgcagagcccagcaagcggaaagcagagtgtggaagcaggaaaagccagaagcgatttgggagcagttgccaagggcctgtcaggagaattaggcacaagatcaggagaaacaggcaggaagctactagaagctggcagaagagagtcaagagaaatttataggaggccttcgggagaattagagcaaagactctcaggagaattcagcagacaggaaccagaagaactaaagaaactttcagaagtgggcagaagagagccagaagaactgggaaaaacacaatttggagaaataggagaaacgaaaaaaacaggaaatgagatggaaaaggaatatgaatgaagccatcggtagagatgaggatcaggaagctggtgttcagagggatcatgggattttattaaactggattttcaagcgatttgtctgttataggaaaaatgagggttttacttctgctgctttccatcactattttgccattaaataggtgtctttcactcttgcaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:83538 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA

by @meso_cacase at DBCLS
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