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2024-04-26 06:27:11, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_030952 3443 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens NUAK family, SNF1-like kinase, 2 (NUAK2), mRNA.
ACCESSION NM_030952
VERSION NM_030952.1 GI:13569921
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3443)
AUTHORS Liu,C., Wu,J. and Zou,M.H.
TITLE Activation of AMP-activated protein kinase alleviates
high-glucose-induced dysfunction of brain microvascular endothelial
cell tight-junction dynamics
JOURNAL Free Radic. Biol. Med. 53 (6), 1213-1221 (2012)
PUBMED 22796592
REMARK GeneRIF: Activation of AMP-activated protein kinase protects the
integrity of the blood-brain barrier by suppressing the induction
of NADPH oxidase-derived superoxide anions.
REFERENCE 2 (bases 1 to 3443)
AUTHORS Namiki,T., Coelho,S.G. and Hearing,V.J.
TITLE NUAK2: an emerging acral melanoma oncogene
JOURNAL Oncotarget 2 (9), 695-704 (2011)
PUBMED 21911917
REMARK GeneRIF: Considers possible roles of NUAK2 in tumorigenesis in
general and suggest that NUAK2 has pivotal roles in acral
melanomagenesis.
Review article
REFERENCE 3 (bases 1 to 3443)
AUTHORS Namiki,T., Tanemura,A., Valencia,J.C., Coelho,S.G., Passeron,T.,
Kawaguchi,M., Vieira,W.D., Ishikawa,M., Nishijima,W., Izumo,T.,
Kaneko,Y., Katayama,I., Yamaguchi,Y., Yin,L., Polley,E.C., Liu,H.,
Kawakami,Y., Eishi,Y., Takahashi,E., Yokozeki,H. and Hearing,V.J.
TITLE AMP kinase-related kinase NUAK2 affects tumor growth, migration,
and clinical outcome of human melanoma
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 108 (16), 6597-6602 (2011)
PUBMED 21460252
REMARK GeneRIF: This study further supports the importance of NUAK2 in
cancer development and tumor progression, while AMPK has
antioncogenic properties.
REFERENCE 4 (bases 1 to 3443)
AUTHORS Vallenius,T., Vaahtomeri,K., Kovac,B., Osiceanu,A.M., Viljanen,M.
and Makela,T.P.
TITLE An association between NUAK2 and MRIP reveals a novel mechanism for
regulation of actin stress fibers
JOURNAL J. Cell. Sci. 124 (PT 3), 384-393 (2011)
PUBMED 21242312
REMARK GeneRIF: MLCP (myosin light chain phosphatase) activation is
counteracted by a previously unrecognized association between MRIP
(myosin phosphatase Rho-interacting protein) and the inducible
kinase NUAK2
REFERENCE 5 (bases 1 to 3443)
AUTHORS Koh,H.J., Toyoda,T., Fujii,N., Jung,M.M., Rathod,A.,
Middelbeek,R.J., Lessard,S.J., Treebak,J.T., Tsuchihara,K.,
Esumi,H., Richter,E.A., Wojtaszewski,J.F., Hirshman,M.F. and
Goodyear,L.J.
TITLE Sucrose nonfermenting AMPK-related kinase (SNARK) mediates
contraction-stimulated glucose transport in mouse skeletal muscle
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 107 (35), 15541-15546 (2010)
PUBMED 20713714
REMARK GeneRIF: Data show that SNARK is activated by muscle contraction
and is a unique mediator of contraction-stimulated glucose
transport in skeletal muscle.
REFERENCE 6 (bases 1 to 3443)
AUTHORS Legembre,P., Schickel,R., Barnhart,B.C. and Peter,M.E.
TITLE Identification of SNF1/AMP kinase-related kinase as an
NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced
motility and invasiveness
JOURNAL J. Biol. Chem. 279 (45), 46742-46747 (2004)
PUBMED 15345718
REMARK GeneRIF: SNARK is an NF-kappaB-regulated anti-apoptotic gene that
contributes to the tumor-promoting activity of CD95 in
apoptosis-resistant tumor cells
REFERENCE 7 (bases 1 to 3443)
AUTHORS Lizcano,J.M., Goransson,O., Toth,R., Deak,M., Morrice,N.A.,
Boudeau,J., Hawley,S.A., Udd,L., Makela,T.P., Hardie,D.G. and
Alessi,D.R.
TITLE LKB1 is a master kinase that activates 13 kinases of the AMPK
subfamily, including MARK/PAR-1
JOURNAL EMBO J. 23 (4), 833-843 (2004)
PUBMED 14976552
REFERENCE 8 (bases 1 to 3443)
AUTHORS Suzuki,A., Kusakai,G., Kishimoto,A., Minegichi,Y., Ogura,T. and
Esumi,H.
TITLE Induction of cell-cell detachment during glucose starvation through
F-actin conversion by SNARK, the fourth member of the AMP-activated
protein kinase catalytic subunit family
JOURNAL Biochem. Biophys. Res. Commun. 311 (1), 156-161 (2003)
PUBMED 14575707
REFERENCE 9 (bases 1 to 3443)
AUTHORS Lefebvre,D.L., Bai,Y., Shahmolky,N., Sharma,M., Poon,R.,
Drucker,D.J. and Rosen,C.F.
TITLE Identification and characterization of a novel
sucrose-non-fermenting protein kinase/AMP-activated protein
kinase-related protein kinase, SNARK
JOURNAL Biochem. J. 355 (PT 2), 297-305 (2001)
PUBMED 11284715
REMARK GeneRIF: This study describes the cloning and characterization of
the rat SNARK homolog, mapping of the human SNARK gene to 1q32, and
a potential functional role as mediator of the cellular response to
metabolic stress.
REFERENCE 10 (bases 1 to 3443)
AUTHORS Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
Wiemann,S.
TITLE Systematic subcellular localization of novel proteins identified by
large-scale cDNA sequencing
JOURNAL EMBO Rep. 1 (3), 287-292 (2000)
PUBMED 11256614
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AL136891.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AL136891.1, AK074830.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025098 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..3443
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q32.1"
gene 1..3443
/gene="NUAK2"
/gene_synonym="SNARK"
/note="NUAK family, SNF1-like kinase, 2"
/db_xref="GeneID:81788"
/db_xref="HGNC:29558"
/db_xref="HPRD:12172"
/db_xref="MIM:608131"
exon 1..358
/gene="NUAK2"
/gene_synonym="SNARK"
/inference="alignment:Splign:1.39.8"
variation 90
/gene="NUAK2"
/gene_synonym="SNARK"
/replace="c"
/replace="t"
/db_xref="dbSNP:3738746"
CDS 128..2014
/gene="NUAK2"
/gene_synonym="SNARK"
/EC_number="2.7.11.1"
/note="SNF1/AMP activated protein kinase; SNF1/AMP
kinase-related kinase; omphalocele kinase 2"
/codon_start=1
/product="NUAK family SNF1-like kinase 2"
/protein_id="NP_112214.1"
/db_xref="GI:13569922"
/db_xref="CCDS:CCDS1453.1"
/db_xref="GeneID:81788"
/db_xref="HGNC:29558"
/db_xref="HPRD:12172"
/db_xref="MIM:608131"
/translation="
MESLVFARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGKGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASHWWVNWGYATRVGEQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPGGGSTTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVSASAEGVQEDPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVSGDPKEQKPPQASGLLLHRKGILKLNGKFSQTALELAAPTTFGSLDELAPPRPLARASRPSGAVSEDSILSSESFDQLDLPERLPEPPLRGCVSVDNLTGLEEPPSEGPGSCLRRWRQDPLGDSCFSLTDCQEVTATYRQALRVCSKLT
"
misc_feature 284..1036
/gene="NUAK2"
/gene_synonym="SNARK"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature 284..1018
/gene="NUAK2"
/gene_synonym="SNARK"
/note="Protein Kinases, catalytic domain; Region:
PKc_like; cl09925"
/db_xref="CDD:213116"
misc_feature order(302..316,326..328,362..364,368..370,464..466,
512..523,533..535,539..541,650..652,656..658,662..667,
671..673,704..706,713..715,758..769)
/gene="NUAK2"
/gene_synonym="SNARK"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(302..316,326..328,362..364,368..370,464..466,
512..523,533..535,650..652,656..658,662..667,671..673,
704..706)
/gene="NUAK2"
/gene_synonym="SNARK"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(314..316,533..535,539..541,650..652,656..658,
662..664,713..715,758..769)
/gene="NUAK2"
/gene_synonym="SNARK"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature order(701..721,758..769)
/gene="NUAK2"
/gene_synonym="SNARK"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature 749..751
/gene="NUAK2"
/gene_synonym="SNARK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by LKB1; propagated from
UniProtKB/Swiss-Prot (Q9H093.1); phosphorylation site"
misc_feature 1430..1432
/gene="NUAK2"
/gene_synonym="SNARK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9H093.1); phosphorylation site"
misc_feature 1694..1696
/gene="NUAK2"
/gene_synonym="SNARK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9H093.1); phosphorylation site"
misc_feature 1757..1759
/gene="NUAK2"
/gene_synonym="SNARK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9H093.1); phosphorylation site"
misc_feature 1766..1768
/gene="NUAK2"
/gene_synonym="SNARK"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9H093.1); phosphorylation site"
variation 255
/gene="NUAK2"
/gene_synonym="SNARK"
/replace="a"
/replace="c"
/db_xref="dbSNP:76756527"
exon 359..479
/gene="NUAK2"
/gene_synonym="SNARK"
/inference="alignment:Splign:1.39.8"
exon 480..631
/gene="NUAK2"
/gene_synonym="SNARK"
/inference="alignment:Splign:1.39.8"
variation 559
/gene="NUAK2"
/gene_synonym="SNARK"
/replace="a"
/replace="g"
/db_xref="dbSNP:2275868"
exon 632..697
/gene="NUAK2"
/gene_synonym="SNARK"
/inference="alignment:Splign:1.39.8"
exon 698..817
/gene="NUAK2"
/gene_synonym="SNARK"
/inference="alignment:Splign:1.39.8"
exon 818..950
/gene="NUAK2"
/gene_synonym="SNARK"
/inference="alignment:Splign:1.39.8"
STS 845..1255
/gene="NUAK2"
/gene_synonym="SNARK"
/standard_name="MARC_27500-27501:1034792583:1"
/db_xref="UniSTS:269104"
exon 951..3401
/gene="NUAK2"
/gene_synonym="SNARK"
/inference="alignment:Splign:1.39.8"
STS 2622..2831
/gene="NUAK2"
/gene_synonym="SNARK"
/standard_name="RH80030"
/db_xref="UniSTS:87680"
STS 2648..2765
/gene="NUAK2"
/gene_synonym="SNARK"
/standard_name="D11S2560"
/db_xref="UniSTS:37928"
STS 2652..2779
/gene="NUAK2"
/gene_synonym="SNARK"
/standard_name="D15S1477"
/db_xref="UniSTS:474482"
STS 2659..2746
/gene="NUAK2"
/gene_synonym="SNARK"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
STS 2680..2786
/gene="NUAK2"
/gene_synonym="SNARK"
/standard_name="D11S2612"
/db_xref="UniSTS:70572"
STS 3105..3290
/gene="NUAK2"
/gene_synonym="SNARK"
/standard_name="RH93941"
/db_xref="UniSTS:89399"
STS 3218..3363
/gene="NUAK2"
/gene_synonym="SNARK"
/standard_name="SHGC-76220"
/db_xref="UniSTS:24807"
ORIGIN
gtgctttactgcgcgctctggtactgctgtggctccccgtcctggtgcgggacctgtgccccgcgcttcagccctccccgcacagcctactgattcccctgccgcccttgctcacctcctgctcgccatggagtcgctggttttcgcgcggcgctccggccccactccctcggccgcagagctagcccggccgctggcggaagggctgatcaagtcgcccaagcccctaatgaagaagcaggcggtgaagcggcaccaccacaagcacaacctgcggcaccgctacgagttcctggagaccctgggcaaaggcacctacgggaaggtgaagaaggcgcgggagagctcggggcgcctggtggccatcaagtcaatccggaaggacaaaatcaaagatgagcaagatctgatgcacatacggagggagattgagatcatgtcatcactcaaccaccctcacatcattgccatccatgaagtgtttgagaacagcagcaagatcgtgatcgtcatggagtatgccagccggggcgacctttatgactacatcagcgagcggcagcagctcagtgagcgcgaagctaggcatttcttccggcagatcgtctctgccgtgcactattgccatcagaacagagttgtccaccgagatctcaagctggagaacatcctcttggatgccaatgggaatatcaagattgctgacttcggcctctccaacctctaccatcaaggcaagttcctgcagacattctgtgggagccccctctatgcctcgccagagattgtcaatgggaagccctacacaggcccagaggtggacagctggtccctgggtgttctcctctacatcctggtgcatggcaccatgccctttgatgggcatgaccataagatcctagtgaaacagatcagcaacggggcctaccgggagccacctaaaccctctgatgcctgtggcctgatccggtggctgttgatggtgaaccccacccgccgggccaccctggaggatgtggccagtcactggtgggtcaactggggctacgccacccgagtgggagagcaggaggctccgcatgagggtgggcaccctggcagtgactctgcccgcgcctccatggctgactggctccggcgttcctcccgccccctcctggagaatggggccaaggtgtgcagcttcttcaagcagcatgcacctggtgggggaagcaccacccctggcctggagcgccagcattcgctcaagaagtcccgcaaggagaatgacatggcccagtctctccacagtgacacggctgatgacactgcccatcgccctggcaagagcaacctcaagctgccaaagggcattctcaagaagaaggtgtcagcctctgcagaaggggtacaggaggaccctccggagctcagcccaatccctgcgagcccagggcaggctgccccgctgctccccaagaagggcattctcaagaagccccgacagcgcgagtctggctactactcctctcccgagcccagtgaatctggggagctcttggacgcaggcgacgtgtttgtgagtggggatcccaaggagcagaagcctccgcaagcttcagggctgctcctccatcgcaaaggcatcctcaaactcaatggcaagttctcccagacagccttggagctcgcggcccccaccaccttcggctccctggatgaactcgccccacctcgccccctggcccgggccagccgaccctcaggggctgtgagcgaggacagcatcctgtcctctgagtcctttgaccagctggacttgcctgaacggctcccagagcccccactgcggggctgtgtgtctgtggacaacctcacggggcttgaggagcccccctcagagggccctggaagctgcctgaggcgctggcggcaggatcctttgggggacagctgcttttccctgacagactgccaggaggtgacagcgacctaccgacaggcactgagggtctgctcaaagctcacctgagtggagtaggcattgccccagcccggtcaggctctcagatgcagctggttgcaccccgaggggagatgccttctcccccacctcccaggacctgcatcccagctcagaaggctgagagggtttgcagtggagccctgagcagggctggatatgggaagtaggcaaatgaaatgcgccaagggttcagtgtctgtcttcagccctgctgaacgaagaggatactaaagagaggggaacgggaatgcccgcgacagagtccacattgcctgtttcttgtgtacatgggggggccacagagacctggaaagagaactctcccagggcccatctcctgcatcccatgaatactctgtacacatggtgccttctaaggacagctccttccctactcattccctgcccaagtggggccagacctctttacacacacattcccgttcctaccaaccaccagaactggatggtggcacccctaatgtgcatgaggcatcctgggaatggtctggagtaacgcttcgttatttttatttttatttttatttatttatttatttttttgagacggagtttcgctcttggtgcccaggctagagtgcaatggcgcgatctcagctcacctcaacctccgcctcccgggttcaagcgattctcctgcctcagcctccctagtagctgggattacaggcgcccgccaccatgcccggctaattttgtatttttagtagagacagggtttctccatgttggtcaggctggtctcaaactcccgacctcaggtgatccacccacctcggcctcccaaagtgctgggattacaggcgtgagccaccgcgccccacctaacccttccttatttagcctaggagtaagagaacacaatctctgtttcttcaatggttctcttcccttttccatcctccaaacctggcctgagcctcctgaagttgctgctgtgaatctgaaagacttgaaaagcctccgcctgctgtgtggacttcatctcaaggggcccagcctcctctggactccaccttggacctcagtgactcagaacttctgcctctaagctgctctaaagtccagactatggatgtgttctctaggccttcaggactctagaatgtccatatttatttttatgttcttggctttgtgttttaggaaaagtgaatcttgctgttttcaataatgtgaatgctatgttctgggaaaatccactatgacatctaagttttgtgtacagagagatatttttgcaactatttccacctcctcccacaaccccccacactccactccacactcttgagtctctttacctaatggtctctacctaatggacctccgtggccaaaaagtaccattaaaaccagaaaggtgattggaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:81788 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: IDA
GeneID:81788 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:81788 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:81788 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
GeneID:81788 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:81788 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:81788 -> Biological process: GO:0030036 [actin cytoskeleton organization] evidence: IDA
GeneID:81788 -> Biological process: GO:0042149 [cellular response to glucose starvation] evidence: IDA
GeneID:81788 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_112214 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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