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2024-04-20 16:26:50, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_030791 3323 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens sphingosine-1-phosphate phosphatase 1 (SGPP1), mRNA.
ACCESSION NM_030791
VERSION NM_030791.2 GI:40254975
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3323)
AUTHORS Milara,J., Navarro,R., Juan,G., Peiro,T., Serrano,A., Ramon,M.,
Morcillo,E. and Cortijo,J.
TITLE Sphingosine-1-phosphate is increased in patients with idiopathic
pulmonary fibrosis and mediates epithelial to mesenchymal
transition
JOURNAL Thorax 67 (2), 147-156 (2012)
PUBMED 22106015
REMARK GeneRIF: S1P is elevated in patients with IPF, correlates with the
lung function and mediates EMT.
REFERENCE 2 (bases 1 to 3323)
AUTHORS Demirkan,A., van Duijn,C.M., Ugocsai,P., Isaacs,A.,
Pramstaller,P.P., Liebisch,G., Wilson,J.F., Johansson,A., Rudan,I.,
Aulchenko,Y.S., Kirichenko,A.V., Janssens,A.C., Jansen,R.C.,
Gnewuch,C., Domingues,F.S., Pattaro,C., Wild,S.H., Jonasson,I.,
Polasek,O., Zorkoltseva,I.V., Hofman,A., Karssen,L.C.,
Struchalin,M., Floyd,J., Igl,W., Biloglav,Z., Broer,L., Pfeufer,A.,
Pichler,I., Campbell,S., Zaboli,G., Kolcic,I., Rivadeneira,F.,
Huffman,J., Hastie,N.D., Uitterlinden,A., Franke,L., Franklin,C.S.,
Vitart,V., Nelson,C.P., Preuss,M., Bis,J.C., O'Donnell,C.J.,
Franceschini,N., Witteman,J.C., Axenovich,T., Oostra,B.A.,
Meitinger,T., Hicks,A.A., Hayward,C., Wright,A.F., Gyllensten,U.,
Campbell,H. and Schmitz,G.
CONSRTM DIAGRAM Consortium; CARDIoGRAM Consortium; CHARGE Consortium;
EUROSPAN consortium
TITLE Genome-wide association study identifies novel loci associated with
circulating phospho- and sphingolipid concentrations
JOURNAL PLoS Genet. 8 (2), E1002490 (2012)
PUBMED 22359512
REFERENCE 3 (bases 1 to 3323)
AUTHORS Lepine,S., Allegood,J.C., Edmonds,Y., Milstien,S. and Spiegel,S.
TITLE Autophagy induced by deficiency of sphingosine-1-phosphate
phosphohydrolase 1 is switched to apoptosis by calpain-mediated
autophagy-related gene 5 (Atg5) cleavage
JOURNAL J. Biol. Chem. 286 (52), 44380-44390 (2011)
PUBMED 22052905
REMARK GeneRIF: doxorubicin switches protective autophagy in SPP1-depleted
cells to apoptosis by calpain-mediated Atg5 cleavage.
REFERENCE 4 (bases 1 to 3323)
AUTHORS McGuire,P.G., Rangasamy,S., Maestas,J. and Das,A.
TITLE Pericyte-derived sphingosine 1-phosphate induces the expression of
adhesion proteins and modulates the retinal endothelial cell
barrier
JOURNAL Arterioscler. Thromb. Vasc. Biol. 31 (12), E107-E115 (2011)
PUBMED 21940944
REMARK GeneRIF: Under normal circumstances, the retinal vascular pericytes
maintain pericyte-endothelial contacts and vascular barrier
function through the secretion of sphingosine 1-phosphate.
REFERENCE 5 (bases 1 to 3323)
AUTHORS Lepine,S., Allegood,J.C., Park,M., Dent,P., Milstien,S. and
Spiegel,S.
TITLE Sphingosine-1-phosphate phosphohydrolase-1 regulates ER
stress-induced autophagy
JOURNAL Cell Death Differ. 18 (2), 350-361 (2011)
PUBMED 20798685
REMARK GeneRIF: SPP1 by regulating intracellular S1P homeostasis, can
control the UPR and ER stress-induced autophagy.
REFERENCE 6 (bases 1 to 3323)
AUTHORS Le Stunff,H., Mikami,A., Giussani,P., Hobson,J.P., Jolly,P.S.,
Milstien,S. and Spiegel,S.
TITLE Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth
factor-induced chemotaxis
JOURNAL J. Biol. Chem. 279 (33), 34290-34297 (2004)
PUBMED 15180992
REMARK GeneRIF: sphingosine-1-phosphate phosphatase 1 has a role in
epidermal growth factor-induced chemotaxis
REFERENCE 7 (bases 1 to 3323)
AUTHORS Johnson,K.R., Johnson,K.Y., Becker,K.P., Bielawski,J., Mao,C. and
Obeid,L.M.
TITLE Role of human sphingosine-1-phosphate phosphatase 1 in the
regulation of intra- and extracellular sphingosine-1-phosphate
levels and cell viability
JOURNAL J. Biol. Chem. 278 (36), 34541-34547 (2003)
PUBMED 12815058
REMARK GeneRIF: sphingosine-1-phosphate phosphatase 1 plays roles in the
regulation of intra- and extracellular sphingosine-1-phosphate
levels and cell viability
REFERENCE 8 (bases 1 to 3323)
AUTHORS Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
TITLE The DNA sequence and analysis of human chromosome 14
JOURNAL Nature 421 (6923), 601-607 (2003)
PUBMED 12508121
REFERENCE 9 (bases 1 to 3323)
AUTHORS Ogawa,C., Kihara,A., Gokoh,M. and Igarashi,Y.
TITLE Identification and characterization of a novel human
sphingosine-1-phosphate phosphohydrolase, hSPP2
JOURNAL J. Biol. Chem. 278 (2), 1268-1272 (2003)
PUBMED 12411432
REFERENCE 10 (bases 1 to 3323)
AUTHORS Mandala,S.M., Thornton,R., Galve-Roperh,I., Poulton,S.,
Peterson,C., Olivera,A., Bergstrom,J., Kurtz,M.B. and Spiegel,S.
TITLE Molecular cloning and characterization of a lipid phosphohydrolase
that degrades sphingosine-1- phosphate and induces cell death
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (14), 7859-7864 (2000)
PUBMED 10859351
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC063839.1.
On Dec 20, 2003 this sequence version replaced gi:13540568.
Summary: Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid
metabolite that regulates diverse biologic processes. SGPP1
catalyzes the degradation of S1P via salvage and recycling of
sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed
10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by
OMIM, Jun 2009].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC063839.1, AJ293294.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..3323
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q23.2"
gene 1..3323
/gene="SGPP1"
/gene_synonym="SPPase1"
/note="sphingosine-1-phosphate phosphatase 1"
/db_xref="GeneID:81537"
/db_xref="HGNC:17720"
/db_xref="HPRD:10226"
/db_xref="MIM:612826"
exon 1..778
/gene="SGPP1"
/gene_synonym="SPPase1"
/inference="alignment:Splign:1.39.8"
variation complement(39)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368823952"
variation complement(57)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="g"
/replace="t"
/db_xref="dbSNP:374820252"
CDS 95..1420
/gene="SGPP1"
/gene_synonym="SPPase1"
/note="spp1; hSPP1; hSPPase1; sphingosine-1-phosphatase 1"
/codon_start=1
/product="sphingosine-1-phosphate phosphatase 1"
/protein_id="NP_110418.1"
/db_xref="GI:13540569"
/db_xref="CCDS:CCDS9760.1"
/db_xref="GeneID:81537"
/db_xref="HGNC:17720"
/db_xref="HPRD:10226"
/db_xref="MIM:612826"
/translation="
MSLRQRLAQLVGRLQDPQKVARFQRLCGVEAPPRRSADRREDEKAEAPLAGDPRLRGRQPGAPGGPQPPGSDRNQCPAKPDGGGAPNGVRNGLAAELGPASPRRAGALRRNSLTGEEGQLARVSNWPLYCLFCFGTELGNELFYILFFPFWIWNLDPLVGRRLVVIWVLVMYLGQCTKDIIRWPRPASPPVVKLEVFYNSEYSMPSTHAMSGTAIPISMVLLTYGRWQYPLIYGLILIPCWCSLVCLSRIYMGMHSILDIIAGFLYTILILAVFYPFVDLIDNFNQTHKYAPFIIIGLHLALGIFSFTLDTWSTSRGDTAEILGSGAGIACGSHVTYNMGLVLDPSLDTLPLAGPPITVTLFGKAILRILIGMVFVLIIRDVMKKITIPLACKIFNIPCDDIRKARQHMEVELPYRYITYGMVGFSITFFVPYIFFFIGIS
"
misc_feature 395..397
/gene="SGPP1"
/gene_synonym="SPPase1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9BX95.2); phosphorylation site"
misc_feature 428..430
/gene="SGPP1"
/gene_synonym="SPPase1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9BX95.2); phosphorylation site"
misc_feature 428..430
/gene="SGPP1"
/gene_synonym="SPPase1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 434..436
/gene="SGPP1"
/gene_synonym="SPPase1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9BX95.2); phosphorylation site"
misc_feature 470..919
/gene="SGPP1"
/gene_synonym="SPPase1"
/note="PAP2_like proteins, sphingosine-1-phosphatase
subfamily. Sphingosine-1-phosphatase is an intracellular
enzyme located in the endoplasmic reticulum, which
regulates the level of sphingosine-1-phosphate (S1P), a
bioactive lipid. S1P acts as a second...; Region:
PAP2_SPPase1; cd03388"
/db_xref="CDD:48092"
misc_feature 488..550
/gene="SGPP1"
/gene_synonym="SPPase1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9BX95.2);
transmembrane region"
misc_feature 521..1399
/gene="SGPP1"
/gene_synonym="SPPase1"
/note="phosphatidic acid phosphatase family protein;
Region: PLN02525"
/db_xref="CDD:178140"
misc_feature 581..643
/gene="SGPP1"
/gene_synonym="SPPase1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9BX95.2);
transmembrane region"
misc_feature order(626..628,647..649,710..718,839..841,857..859,
869..871)
/gene="SGPP1"
/gene_synonym="SPPase1"
/note="active site"
/db_xref="CDD:48092"
misc_feature 704..766
/gene="SGPP1"
/gene_synonym="SPPase1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9BX95.2);
transmembrane region"
misc_feature 773..835
/gene="SGPP1"
/gene_synonym="SPPase1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9BX95.2);
transmembrane region"
misc_feature 863..925
/gene="SGPP1"
/gene_synonym="SPPase1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9BX95.2);
transmembrane region"
misc_feature 962..1024
/gene="SGPP1"
/gene_synonym="SPPase1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9BX95.2);
transmembrane region"
misc_feature 1058..1120
/gene="SGPP1"
/gene_synonym="SPPase1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9BX95.2);
transmembrane region"
misc_feature 1169..1231
/gene="SGPP1"
/gene_synonym="SPPase1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9BX95.2);
transmembrane region"
misc_feature 1352..1414
/gene="SGPP1"
/gene_synonym="SPPase1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9BX95.2);
transmembrane region"
variation complement(204)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="g"
/db_xref="dbSNP:200531351"
variation complement(228)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149126697"
variation complement(298)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="g"
/replace="t"
/db_xref="dbSNP:8006901"
variation complement(355)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368742875"
variation complement(421)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150004807"
variation complement(430)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="g"
/replace="t"
/db_xref="dbSNP:370251232"
variation complement(438)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="g"
/db_xref="dbSNP:12881596"
variation complement(447)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367745142"
variation complement(499)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139371509"
variation complement(526)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374359547"
variation complement(530)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142268829"
variation complement(556)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149177989"
variation complement(641)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145224231"
variation complement(652)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="g"
/db_xref="dbSNP:200260508"
variation complement(706)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="g"
/db_xref="dbSNP:182077306"
variation complement(715)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146370444"
variation complement(727)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139269196"
variation complement(733)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="c"
/db_xref="dbSNP:111401687"
variation complement(765)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370691997"
exon 779..868
/gene="SGPP1"
/gene_synonym="SPPase1"
/inference="alignment:Splign:1.39.8"
variation complement(788)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372510510"
variation complement(814)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:55989059"
exon 869..3309
/gene="SGPP1"
/gene_synonym="SPPase1"
/inference="alignment:Splign:1.39.8"
variation complement(904)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143514270"
variation complement(936)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377711063"
variation complement(942)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139614441"
variation complement(948)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374247390"
variation complement(959)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201068316"
variation complement(960)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150520184"
variation complement(998)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375401366"
variation complement(1003)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141626991"
variation complement(1043)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:190170493"
variation complement(1054)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="g"
/db_xref="dbSNP:201520860"
variation complement(1093)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="g"
/replace="t"
/db_xref="dbSNP:61745034"
variation complement(1101)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369187489"
variation complement(1109)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144474145"
variation complement(1141)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375905471"
variation complement(1157)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144006374"
variation complement(1160)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371248974"
variation complement(1174)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368755533"
variation complement(1197)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375386498"
variation complement(1281)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:75962998"
variation complement(1288)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147082083"
variation complement(1291)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:45627131"
variation complement(1301)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201466945"
variation complement(1339)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372059271"
variation complement(1341)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138943256"
variation complement(1354)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150194548"
variation complement(1375)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:185707956"
variation complement(1392)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="t"
/db_xref="dbSNP:74058052"
variation complement(1456)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="t"
/db_xref="dbSNP:193247435"
variation complement(1464)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="g"
/replace="t"
/db_xref="dbSNP:367721099"
variation complement(1601..1602)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace=""
/replace="a"
/db_xref="dbSNP:111383610"
variation complement(1892)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:189175291"
variation complement(1913)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143946334"
variation complement(1918)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:183649415"
variation complement(1949)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143676185"
variation complement(2071..2072)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace=""
/replace="t"
/db_xref="dbSNP:201670268"
variation complement(2221)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="t"
/db_xref="dbSNP:77874447"
variation complement(2265)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="t"
/db_xref="dbSNP:79124485"
variation complement(2282)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11850853"
variation complement(2341)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:114870788"
variation complement(2397)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138090368"
variation complement(2406)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:191843664"
variation complement(2413)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="t"
/db_xref="dbSNP:147018869"
variation complement(2463)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142906951"
variation complement(2487)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace=""
/replace="g"
/db_xref="dbSNP:76807918"
variation complement(2547)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="g"
/replace="t"
/db_xref="dbSNP:138628642"
variation complement(2657)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370429078"
variation complement(2782)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:187069469"
variation complement(2825)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="g"
/replace="t"
/db_xref="dbSNP:182603306"
variation complement(2836..2837)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace=""
/replace="c"
/db_xref="dbSNP:34901872"
variation complement(2877)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:45487994"
variation complement(2930)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140912878"
variation complement(2968)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="g"
/replace="t"
/db_xref="dbSNP:192972570"
variation complement(3034)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="c"
/db_xref="dbSNP:79033277"
variation complement(3036)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="t"
/db_xref="dbSNP:74418152"
variation complement(3038)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="c"
/db_xref="dbSNP:80242189"
STS 3064..3186
/gene="SGPP1"
/gene_synonym="SPPase1"
/standard_name="RH17831"
/db_xref="UniSTS:14748"
variation complement(3068)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:188623122"
variation complement(3157)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:79522475"
STS 3168..3304
/gene="SGPP1"
/gene_synonym="SPPase1"
/standard_name="WI-16352"
/db_xref="UniSTS:68832"
variation complement(3182)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:151076326"
variation complement(3186)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:184089110"
variation complement(3267)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="a"
/replace="g"
/db_xref="dbSNP:17178795"
variation complement(3298)
/gene="SGPP1"
/gene_synonym="SPPase1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370310195"
ORIGIN
gcgctgtgccggttccgctgccgctggccaggagcgcggggacagttcggggctgcgccggaggccggcccgccttcccgggggttccgttatcatgtcgctgaggcagcgcctggcccagctggttggccgtctgcaggacccgcagaaagtggcccgtttccagcggctgtgcggggtggaagcgccgccgcgccgctcagcagaccggagggaggatgagaaagcggaggcgcctctcgccggagaccctcgactgcgagggcggcagccaggggcgcctggaggcccccagcctcccgggagcgaccgcaatcagtgcccggccaagccggacggcggcggcgcccccaacggcgtgcggaacgggctggcggccgagctgggcccggcctcgccgcggcgcgcgggcgctctgcgccgcaactcgctgacgggcgaggagggccagctggcccgcgtgagcaactggccgctctactgcctgttctgcttcggcacggagctgggcaacgaactcttctacatcctgttcttccccttctggatctggaacctggaccctctggtgggccggaggctcgtggtcatctgggtgctggtcatgtacctgggccagtgcaccaaggacatcatccgctggccgaggcccgcctcgccgcccgtggtcaagttggaggtcttctacaactctgagtacagcatgccctccacccatgccatgtccggcaccgccatccccatttctatggtcctcctcacctatggccgctggcagtaccctcttatatatggactgattcttattccctgctggtgttctctagtttgcctaagtagaatttacatgggaatgcactctattctggatattattgctggattcctatataccattttaatcttagctgtcttctatccatttgtggacctgattgacaacttcaaccaaactcacaaatatgctccattcatcatcatcgggcttcatttagctttggggatcttttctttcactcttgacacctggagcacatcccgaggagacacagccgagatactaggaagtggtgctggaattgcatgtggatctcatgttacttataacatgggtctagtattagatccttctctagatacattacctttagctgggccccccattactgtgactctgtttggaaaagccatattgcggatcctcatagggatggtatttgtactaataatcagagatgtaatgaaaaagatcaccattcctttagcctgcaaaatcttcaatataccgtgtgatgatattcgaaaagcaagacagcacatggaagttgaacttccttatcggtatattacctatggaatggttggtttctccatcacattttttgttccttacatatttttctttattggtatctcttgatggagaagtattgtttatgataagaaaggagggtatcagttactgatacccaaaaatatattccaggtaaagccaggtcagaattaggcttttgcaggaatttaacttaaataattatttaagtaaattcataagagtcagtgcattttatcattgcacatccagatactgttttaggtgagctgagctatttcgttactgagaaaatgataagtatccatttagaatgttcatgtaatgtttggagagttttgtattatggattcaacttatatataatatatataaggtacataatatgcaattatgtatctgatatatattatatataaaataatatacctaagtgtttttttaaactatgggagtgtattataaaatcaataataatatgcaaacagttgtgcctgtgtatttgaactacatacaggtatgttgttattaacagatatatttaacatttatttactatgggagccatttcctaattgaattgcgtaattactagaccagaatgcatatgctactatacattgatttactgcctgtttttacactgccattacctttcatgttatccatgatgttgaacatgggaggcatttttaatggaccaaatttttagaaaaattagtttttggatttttttttaagttctgtatactgttttgaatgaactttatttgcagctattctggatgtcagtttaataattcaggtactgaattttattgcttgctaattgtgcctttccgttgctaaattaagaaatgctatgtgtactgtgatgtaaaaataagacattaactttatcttaagttacatataatcaagcaaatattttaaaaaatgtatgtcagggtgacaggcataaaagtaaattacccttaactctttagcctttatttagaaagaaatgtggaatgggctaaactttctcaccaatttattagaaagctaaatggataaatacttccctttttgtagatatttttctgtgcattgtaagttataggagcaggacatattttttgtacattgtcttgattgtttatactgcaggtaggtatttccagtgaatggaaacgttgaaatttatagatgggacaatgcacatacttcatatgtaaacaaagcatttttctaaataatttggaaaggattggatttagcaccgttaacttttaatacccatttattggctatttaaggtaaattataaaacctaaaattagtatcagtattttagatcctattattttttcaactttctattattttcacagtggaaaatttgcgtatagtattaaactattcttttttctgtctacctttatattttgaagtgtggttgtacttacgttaatagtaagtgtatttgtagaaagtttttcataaagaagagattaactttccatataaataaataccaggtatgaaattactgattttagtgcaatatctgtatgattatccagaactatcacttcagatgtttctattttgggcaccataactatttgagctcatatttttataattctgattgagaatttaggggcatggtaatttttaccaaaactgaagctggtaattttaagtaaagcaactaaatttaccctttacttattagttaaaaggaaaccaaggcatgtaggaaaatattggtacgttggaaaatgtgaaaagagctttactttcaaaatgtatgtttaatgaattgaattttagggaccgtttcccataatttgggcctatgctatcctgttgatttttatgtctagcttaaaaggtatttgaaaatgttccatttgtgttttattattttctgtcctatgacagttctatgctaaatgtattttaaaataaaagccaaattgaagattaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:81537 -> Molecular function: GO:0042392 [sphingosine-1-phosphate phosphatase activity] evidence: IEA
GeneID:81537 -> Biological process: GO:0006665 [sphingolipid metabolic process] evidence: TAS
GeneID:81537 -> Biological process: GO:0006668 [sphinganine-1-phosphate metabolic process] evidence: IEA
GeneID:81537 -> Biological process: GO:0006670 [sphingosine metabolic process] evidence: IEA
GeneID:81537 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:81537 -> Biological process: GO:0030148 [sphingolipid biosynthetic process] evidence: TAS
GeneID:81537 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:81537 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
GeneID:81537 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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