Home |
Help |
Advanced search
2024-04-19 22:42:15, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_030661 3257 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens homeobox A3 (HOXA3), transcript variant 1, mRNA. ACCESSION NM_030661 VERSION NM_030661.4 GI:84043946 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3257) AUTHORS Yerges,L.M., Klei,L., Cauley,J.A., Roeder,K., Kammerer,C.M., Moffett,S.P., Ensrud,K.E., Nestlerode,C.S., Marshall,L.M., Hoffman,A.R., Lewis,C., Lang,T.F., Barrett-Connor,E., Ferrell,R.E., Orwoll,E.S. and Zmuda,J.M. CONSRTM MrOS Research Group TITLE High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men JOURNAL J. Bone Miner. Res. 24 (12), 2039-2049 (2009) PUBMED 19453261 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 2 (bases 1 to 3257) AUTHORS Chung,N., Jee,B.K., Chae,S.W., Jeon,Y.W., Lee,K.H. and Rha,H.K. TITLE HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells JOURNAL Mol. Biol. Rep. 36 (2), 227-235 (2009) PUBMED 17972163 REMARK GeneRIF: HOXA7, HOXB3, HOXA3, and HOXB13 expression levels changed during angiogenesis, sugessting these proteins might be involved in the angiogenesis of hMSCs. REFERENCE 3 (bases 1 to 3257) AUTHORS Wissmuller,S., Kosian,T., Wolf,M., Finzsch,M. and Wegner,M. TITLE The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors JOURNAL Nucleic Acids Res. 34 (6), 1735-1744 (2006) PUBMED 16582099 REMARK Publication Status: Online-Only REFERENCE 4 (bases 1 to 3257) AUTHORS Manzanares,M., Nardelli,J., Gilardi-Hebenstreit,P., Marshall,H., Giudicelli,F., Martinez-Pastor,M.T., Krumlauf,R. and Charnay,P. TITLE Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain JOURNAL EMBO J. 21 (3), 365-376 (2002) PUBMED 11823429 REFERENCE 5 (bases 1 to 3257) AUTHORS Kosaki,K., Kosaki,R., Suzuki,T., Yoshihashi,H., Takahashi,T., Sasaki,K., Tomita,M., McGinnis,W. and Matsuo,N. TITLE Complete mutation analysis panel of the 39 human HOX genes JOURNAL Teratology 65 (2), 50-62 (2002) PUBMED 11857506 REFERENCE 6 (bases 1 to 3257) AUTHORS Mulder,G.B., Manley,N. and Maggio-Price,L. TITLE Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1 JOURNAL Teratology 58 (6), 263-275 (1998) PUBMED 9894676 REFERENCE 7 (bases 1 to 3257) AUTHORS Manley,N.R. and Capecchi,M.R. TITLE Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands JOURNAL Dev. Biol. 195 (1), 1-15 (1998) PUBMED 9520319 REFERENCE 8 (bases 1 to 3257) AUTHORS Apiou,F., Flagiello,D., Cillo,C., Malfoy,B., Poupon,M.F. and Dutrillaux,B. TITLE Fine mapping of human HOX gene clusters JOURNAL Cytogenet. Cell Genet. 73 (1-2), 114-115 (1996) PUBMED 8646877 REFERENCE 9 (bases 1 to 3257) AUTHORS Scott,M.P. TITLE Vertebrate homeobox gene nomenclature JOURNAL Cell 71 (4), 551-553 (1992) PUBMED 1358459 REFERENCE 10 (bases 1 to 3257) AUTHORS McAlpine,P.J. and Shows,T.B. TITLE Nomenclature for human homeobox genes JOURNAL Genomics 7 (3), 460 (1990) PUBMED 1973146 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC015180.1 and AC004079.1. On Dec 29, 2005 this sequence version replaced gi:24497511. Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode isoform a. ##Evidence-Data-START## Transcript exon combination :: BC015180.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support ERS025081, ERS025084 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1610 BC015180.1 1-1610 1611-3257 AC004079.1 88585-90231 c FEATURES Location/Qualifiers source 1..3257 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="7" /map="7p15.2" gene 1..3257 /gene="HOXA3" /gene_synonym="HOX1; HOX1E" /note="homeobox A3" /db_xref="GeneID:3200" /db_xref="HGNC:5104" /db_xref="HPRD:00842" /db_xref="MIM:142954" exon 1..80 /gene="HOXA3" /gene_synonym="HOX1; HOX1E" /inference="alignment:Splign:1.39.8" exon 81..726 /gene="HOXA3" /gene_synonym="HOX1; HOX1E" /inference="alignment:Splign:1.39.8" misc_feature 189..191 /gene="HOXA3" /gene_synonym="HOX1; HOX1E" /note="upstream in-frame stop codon" CDS 201..1532 /gene="HOXA3" /gene_synonym="HOX1; HOX1E" /note="isoform a is encoded by transcript variant 1; homeo box A3; homeo box 1E; Hox-1.5-like protein; homeobox protein HOX-A3; homeobox protein Hox-1E" /codon_start=1 /product="homeobox protein Hox-A3 isoform a" /protein_id="NP_109377.1" /db_xref="GI:13562112" /db_xref="CCDS:CCDS5404.1" /db_xref="GeneID:3200" /db_xref="HGNC:5104" /db_xref="HPRD:00842" /db_xref="MIM:142954" /translation="
MQKATYYDSSAIYGGYPYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGGHPKAHELSEACLRTLSAPPSQPPSLGEPPLHPPPPQAAPPAPQPPQPAPQPPAPTPAAPPPPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSSSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYEPQSPPPFSKPPQGTYGLPPASYPASLPSCAPPPPPQKRYTAAGAGAGGTPDYDPHAHGLQGNGSYGTPHIQGSPVFVGGSYVEPMSNSGPALFGLTHLPHAASGAMDYGGAGPLGSGHHHGPGPGEPHPTYTDLTGHHPSQGRIQEAPKLTHL
"
misc_feature 663..680
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O43365.1);
Region: Antp-type hexapeptide"
misc_feature 774..950
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/note="Homeodomain; DNA binding domains involved in the
transcriptional regulation of key eukaryotic developmental
processes; may bind to DNA as monomers or as homo- and/or
heterodimers, in a sequence-specific manner; Region:
homeodomain; cd00086"
/db_xref="CDD:28970"
misc_feature order(774..788,792..794,843..845,861..863,900..902,
906..911,918..923,927..935,939..944)
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:28970"
misc_feature order(780..782,789..791,909..911,918..923,930..932)
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/note="specific DNA base contacts [nucleotide binding];
other site"
/db_xref="CDD:28970"
misc_feature 1326..1523
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/note="Domain of unknown function (DUF4074); Region:
DUF4074; pfam13293"
/db_xref="CDD:205473"
STS 216..452
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/standard_name="REN100374"
/db_xref="UniSTS:425171"
STS 434..694
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/standard_name="REN100373"
/db_xref="UniSTS:425170"
exon 727..3257
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/inference="alignment:Splign:1.39.8"
STS 807..1544
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/standard_name="ECD05388"
/db_xref="UniSTS:286454"
STS 813..1047
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/standard_name="REN100365"
/db_xref="UniSTS:425162"
STS 1023..1291
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/standard_name="REN100364"
/db_xref="UniSTS:425161"
STS 1260..1510
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/standard_name="REN100363"
/db_xref="UniSTS:425160"
STS 1453..1682
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/standard_name="REN100362"
/db_xref="UniSTS:425159"
STS 1617..1902
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/standard_name="ECD20411"
/db_xref="UniSTS:301414"
STS 1664..1899
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/standard_name="REN100361"
/db_xref="UniSTS:425158"
STS 1898..2134
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/standard_name="REN100360"
/db_xref="UniSTS:425157"
STS 1994..2743
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/standard_name="ECD04964"
/db_xref="UniSTS:286032"
variation 2001
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/replace="c"
/replace="t"
/db_xref="dbSNP:3173606"
STS 2111..2384
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/standard_name="REN100359"
/db_xref="UniSTS:425156"
STS 2356..2580
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/standard_name="REN100358"
/db_xref="UniSTS:425155"
polyA_signal 2415..2420
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
polyA_site 2435
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/experiment="experimental evidence, no additional details
recorded"
STS 2559..2811
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/standard_name="REN100357"
/db_xref="UniSTS:425154"
STS 2805..3054
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/standard_name="REN100356"
/db_xref="UniSTS:425153"
polyA_signal 3229..3234
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
polyA_site 3257
/gene="HOXA3"
/gene_synonym="HOX1; HOX1E"
/experiment="experimental evidence, no additional details
recorded"
ORIGIN
tctcactagcctcagagcactctcagaagttcagaaactaagaccagaaaagagaagatttttagacagctcatgaaacggtctgcgcggggcggccattggcggcggagtgtcacgtgaccgcgggggcgtgccaatgtgcgccctcacgggtgtcaaacccctgtcagagtgtgcgatcaagatcgtgaaacaacgcgatgcaaaaagcgacctactacgacagctcggcgatctacggtggctacccctaccaggcagccaacgggttcgcttataatgccaatcagcagccgtacccggcgtccgccgctttgggcgccgacggcgagtaccaccgacccgcctgctccctccagtctccctccagcgccgggggccaccccaaggcacacgaactgagtgaggcgtgcctgcgcaccctgagcgccccacctagccagcctccaagcctgggagagccgcccctgcacccgccgccgccccaggccgcgccccctgccccacagccgcctcagcccgcacctcagccccctgcacctacccctgccgcgcccccgcctccctcttctgcctcccctcctcagaatgccagcaacaaccctacccctgccaacgcggccaagagccccctgctcaactcacccacagtggccaaacaaatcttcccctggatgaaagagtctcgacaaaacacaaagcagaaaaccagcagctccagctcaggcgaaagctgcgctggcgacaagagcccgccggggcaggcttcgtccaagcgcgcgcgcacggcctacacgagcgcgcagctggtggagctggagaaagagttccacttcaaccgctacctgtgccggccgcgccgggtggagatggccaatctgctgaacctcactgagcgccagatcaagatctggttccagaatcgccgcatgaagtacaaaaaggatcagaagggcaagggcatgctaacgtcatcggggggccagtctccaagtcgcagccccgtgccccccggagccggtggctatctgaactctatgcattcgctggtcaacagcgtcccgtatgagccccagtcgcccccgcccttctccaagcccccccagggtacctacgggctgccccccgcctcctaccctgcgtccctgcccagctgcgcacccccgccacccccacagaagcgctacacggcggcaggggcgggcgcagggggcacccccgactatgacccgcacgctcatggcctgcagggcaacggcagctatgggaccccacacatacagggaagccccgtcttcgtggggggcagctatgtggagcccatgagcaactccgggccagccctctttggtctaactcacctcccccacgctgcctcgggcgccatggactatgggggtgccgggccgctgggcagcggccaccaccacgggccggggcctggggagccgcaccccacctacacggaccttaccggccaccatccttctcagggaagaattcaggaagcacccaagctcacccacctgtgatagtgggcttggggctacgcgccaggagagtctccccccacccaccttttttctttggttgcttttttttttttttttttttaggttcttcctgccctttccttccttccttttctctcttctccgccccgcactccgtttcccggtttcccccctcgttggtaaggcgtttttatagtttatgtgacgtagcaatcttggttgctggaatggctgtatcatagcgatatttatctcttcctgctcctcgataggccactggccctgcaccctttaccttctccactctttgatcagaaacagggtatatgaacaaattttctagtcgagttttcaatgtgaatttgttcttacattatggctcccgaggggaagcgattactttttttaattttaaattttttttttaattgcacttcttgtaaagagtgagaaaaaaaatcaaaggcgctttgaaacaggggctctctgtgcaaggatgactaagtgtacgtctttccgtgtgtgtatgctggtgaacagtcagatttatttatatttttttgcaagcattgaataatctaagttttaaatattatttatccccatccgttcgtatttatattaaagaattctgtaccctgatggttcagaagggttcttgggccttttgttcaattgtgtattggcgtacttagaattttttttatttgaaagagaaatataattcctttaaacggtaacgatacaataaaaccagagaagatccagcttttgaaaacagtgatttaggtttgtaacatccggcaaaactgaaaaaaaaaatctgtaaacgcgaaaaatactagatttgttttgagagttcttcattccttgctgctcacattctgagaaacaaaaagaaataaagtttttattctgaataatatccgtgttaagaaggggttctttggccgaagacgtgggtctgcgtggaattcaggccgaggcgagccggcagagcaggccggacgcagcagccctctggctccagcatggggcctggccaggctattcgcctggaagctcggcgaattctcaggatggcggctggggctccaggcggctgcggcagctctggtaacgccgtgcggcgggccagctgggctgcccggttcccagctgctgcggaggcaggctgagggcgcaggggctgccgagtgctgtgcacggaagaaacaaagacatcccggcccaaggcgcagcgggagcgcacaggtgccccgcggcccagccgggggataacgcagggcggtcttctgctccatgctcttcctcgggtcaaagcggaccaactaacgcctaaacctcggtattagccagccgcgcagaggatgccgagcactttccgggagcaatcggactcctggtctcctccggggatgcttcgcggtctgttatcgcgtcaggaggaaagaattgctccaaaaatctgcacgcggagcgaaacagtttgaaagggactgaggctcacccaggtctccagcaaacggaggactgaactggggagagtcaccctgagccagcccttccctggactgccggaatcccagcattagcttcctgctgaatgtagtatttggcattctctgaatttatttcctctccttcccccacccagctttctttttatggccccagggggagggggagagagcaaggagatcggtatctttgtaataaaactgcaattttataaatttttca
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3200 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
GeneID:3200 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
GeneID:3200 -> Molecular function: GO:0071837 [HMG box domain binding] evidence: IEA
GeneID:3200 -> Biological process: GO:0001525 [angiogenesis] evidence: IEP
GeneID:3200 -> Biological process: GO:0001974 [blood vessel remodeling] evidence: IEA
GeneID:3200 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:3200 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IEA
GeneID:3200 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
GeneID:3200 -> Biological process: GO:0010159 [specification of organ position] evidence: IEA
GeneID:3200 -> Biological process: GO:0021615 [glossopharyngeal nerve morphogenesis] evidence: IEA
GeneID:3200 -> Biological process: GO:0030878 [thyroid gland development] evidence: IEA
GeneID:3200 -> Biological process: GO:0048538 [thymus development] evidence: IEA
GeneID:3200 -> Biological process: GO:0048645 [organ formation] evidence: IEA
GeneID:3200 -> Biological process: GO:0048704 [embryonic skeletal system morphogenesis] evidence: IEA
GeneID:3200 -> Biological process: GO:0051216 [cartilage development] evidence: IEA
GeneID:3200 -> Biological process: GO:0060017 [parathyroid gland development] evidence: IEA
GeneID:3200 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:3200 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.