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2020-10-24 07:08:21, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_025235               6274 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase 2 (TNKS2), mRNA.
ACCESSION   NM_025235
VERSION     NM_025235.3  GI:197927276
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6274)
  AUTHORS   Kang,H.W., Wang,F., Wei,Q., Zhao,Y.F., Liu,M., Li,X. and Tang,H.
  TITLE     miR-20a promotes migration and invasion by regulating TNKS2 in
            human cervical cancer cells
  JOURNAL   FEBS Lett. 586 (6), 897-904 (2012)
   PUBMED   22449978
  REMARK    GeneRIF: Data suggest that miR-20a can promote migration and
            invasion of cervical cancer cells through the upregulation of
            TNKS2.
REFERENCE   2  (bases 1 to 6274)
  AUTHORS   Guettler,S., LaRose,J., Petsalaki,E., Gish,G., Scotter,A.,
            Pawson,T., Rottapel,R. and Sicheri,F.
  TITLE     Structural basis and sequence rules for substrate recognition by
            Tankyrase explain the basis for cherubism disease
  JOURNAL   Cell 147 (6), 1340-1354 (2011)
   PUBMED   22153077
  REMARK    GeneRIF: Study reports crystal structures of a representative
            ankyrin repeat clusters of TNKS2 bound to targeting peptides from
            six substrates.
            Erratum:[Cell. 2012 Jan 20;148(1-2):376]
REFERENCE   3  (bases 1 to 6274)
  AUTHORS   Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M.,
            Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P.,
            Middeldorp,J.M. and de Sanjose,S.
  TITLE     Single nucleotide polymorphisms of matrix metalloproteinase 9
            (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus
            in chronic lymphocytic leukemia: results from the European
            case-control study EpiLymph
  JOURNAL   Haematologica 96 (2), 323-327 (2011)
   PUBMED   21048031
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   4  (bases 1 to 6274)
  AUTHORS   Zee,R.Y., Ridker,P.M. and Chasman,D.I.
  TITLE     Genetic variants in eleven telomere-associated genes and the risk
            of incident cardio/cerebrovascular disease: The Women's Genome
            Health Study
  JOURNAL   Clin. Chim. Acta 412 (1-2), 199-202 (2011)
   PUBMED   20937264
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 6274)
  AUTHORS   Callow,M.G., Tran,H., Phu,L., Lau,T., Lee,J., Sandoval,W.N.,
            Liu,P.S., Bheddah,S., Tao,J., Lill,J.R., Hongo,J.A., Davis,D.,
            Kirkpatrick,D.S., Polakis,P. and Costa,M.
  TITLE     Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt
            signaling
  JOURNAL   PLoS ONE 6 (7), E22595 (2011)
   PUBMED   21799911
  REMARK    GeneRIF: RNF146 RING-type ubiquitin E3 ligase as a positive
            regulator of Wnt signaling that operates with tankyrase to maintain
            low steady-state levels of Axin proteins
REFERENCE   6  (bases 1 to 6274)
  AUTHORS   Cook,B.D., Dynek,J.N., Chang,W., Shostak,G. and Smith,S.
  TITLE     Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2
            at human telomeres
  JOURNAL   Mol. Cell. Biol. 22 (1), 332-342 (2002)
   PUBMED   11739745
REFERENCE   7  (bases 1 to 6274)
  AUTHORS   Kaminker,P.G., Kim,S.H., Taylor,R.D., Zebarjadian,Y., Funk,W.D.,
            Morin,G.B., Yaswen,P. and Campisi,J.
  TITLE     TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes
            rapid induction of cell death upon overexpression
  JOURNAL   J. Biol. Chem. 276 (38), 35891-35899 (2001)
   PUBMED   11454873
REFERENCE   8  (bases 1 to 6274)
  AUTHORS   Lyons,R.J., Deane,R., Lynch,D.K., Ye,Z.S., Sanderson,G.M.,
            Eyre,H.J., Sutherland,G.R. and Daly,R.J.
  TITLE     Identification of a novel human tankyrase through its interaction
            with the adaptor protein Grb14
  JOURNAL   J. Biol. Chem. 276 (20), 17172-17180 (2001)
   PUBMED   11278563
REFERENCE   9  (bases 1 to 6274)
  AUTHORS   Kuimov,A.N., Kuprash,D.V., Petrov,V.N., Vdovichenko,K.K.,
            Scanlan,M.J., Jongeneel,C.V., Lagarkova,M.A. and Nedospasov,S.A.
  TITLE     Cloning and characterization of TNKL, a member of tankyrase gene
            family
  JOURNAL   Genes Immun. 2 (1), 52-55 (2001)
   PUBMED   11294570
REFERENCE   10 (bases 1 to 6274)
  AUTHORS   Monz,D., Munnia,A., Comtesse,N., Fischer,U., Steudel,W.I.,
            Feiden,W., Glass,B. and Meese,E.U.
  TITLE     Novel tankyrase-related gene detected with meningioma-specific sera
  JOURNAL   Clin. Cancer Res. 7 (1), 113-119 (2001)
   PUBMED   11205898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF438201.1, AF309033.1 and BQ019749.1.
            On Sep 4, 2008 this sequence version replaced gi:21361945.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF438201.1, AF309033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2657              AF438201.1         83-2739
            2658-6074           AF309033.1         2612-6028
            6075-6274           BQ019749.1         18-217              c
FEATURES             Location/Qualifiers
     source          1..6274
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.3"
     gene            1..6274
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="tankyrase, TRF1-interacting ankyrin-related
                     ADP-ribose polymerase 2"
                     /db_xref="GeneID:80351"
                     /db_xref="HGNC:15677"
                     /db_xref="HPRD:06182"
                     /db_xref="MIM:607128"
     exon            1..496
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       8..9
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace=""
                     /replace="ggagctggca"
                     /db_xref="dbSNP:148775233"
     variation       9..10
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace=""
                     /replace="ggagctggca"
                     /db_xref="dbSNP:71959546"
     variation       22..23
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace=""
                     /replace="ctggcaggag"
                     /db_xref="dbSNP:59118225"
     variation       70
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138273949"
     variation       105
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149184100"
     variation       239
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:190428414"
     CDS             298..3798
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /EC_number="2.4.2.30"
                     /note="tankyrase 2; TNKS-2; tankyrase II; tankyrase-like
                     protein; tankyrase-related protein; poly [ADP-ribose]
                     polymerase 5B; TRF1-interacting ankyrin-related ADP-ribose
                     polymerase 2; ADP-ribosyltransferase diphtheria toxin-like
                     6"
                     /codon_start=1
                     /product="tankyrase-2"
                     /protein_id="NP_079511.1"
                     /db_xref="GI:13376842"
                     /db_xref="CCDS:CCDS7417.1"
                     /db_xref="GeneID:80351"
                     /db_xref="HGNC:15677"
                     /db_xref="HPRD:06182"
                     /db_xref="MIM:607128"
                     /translation="
MSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFEREQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEGMVDG
"
     misc_feature    379..531
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="Ankyrin repeats (many copies); Region: Ank_4;
                     pfam13637"
                     /db_xref="CDD:205814"
     misc_feature    445..789
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="ankyrin repeats;  ankyrin repeats mediate
                     protein-protein interactions in very diverse families of
                     proteins. The number of ANK repeats in a protein can range
                     from 2 to over 20 (ankyrins, for example). ANK repeats may
                     occur in combinations with other...; Region: ANK; cd00204"
                     /db_xref="CDD:29261"
     misc_feature    466..564
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     Region: ANK 1"
     misc_feature    481..759
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="Ankyrin repeats (3 copies); Region: Ank_2;
                     pfam12796"
                     /db_xref="CDD:205076"
     misc_feature    565..663
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     Region: ANK 2"
     misc_feature    664..762
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     Region: ANK 3"
     misc_feature    904..906
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN, partial;
                     propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     hydroxylation site"
     misc_feature    913..1248
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="ankyrin repeats;  ankyrin repeats mediate
                     protein-protein interactions in very diverse families of
                     proteins. The number of ANK repeats in a protein can range
                     from 2 to over 20 (ankyrins, for example). ANK repeats may
                     occur in combinations with other...; Region: ANK; cd00204"
                     /db_xref="CDD:29261"
     misc_feature    925..1023
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     Region: ANK 4"
     misc_feature    940..1218
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="Ankyrin repeats (3 copies); Region: Ank_2;
                     pfam12796"
                     /db_xref="CDD:205076"
     misc_feature    1009..1011
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="(3S)-3-hydroxyhistidine, by HIF1AN, partial;
                     propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     hydroxylation site"
     misc_feature    1024..1122
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     Region: ANK 5"
     misc_feature    1108..1110
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN, partial;
                     propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     hydroxylation site"
     misc_feature    1123..1221
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     Region: ANK 6"
     misc_feature    1384..1491
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     Region: ANK 7"
     misc_feature    1390..2034
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="ankyrin repeats;  ankyrin repeats mediate
                     protein-protein interactions in very diverse families of
                     proteins. The number of ANK repeats in a protein can range
                     from 2 to over 20 (ankyrins, for example). ANK repeats may
                     occur in combinations with other...; Region: ANK; cd00204"
                     /db_xref="CDD:29261"
     misc_feature    1399..1680
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="Ankyrin repeats (3 copies); Region: Ank_2;
                     pfam12796"
                     /db_xref="CDD:205076"
     misc_feature    1492..1590
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     Region: ANK 8"
     misc_feature    1576..1578
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN, partial;
                     propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     hydroxylation site"
     misc_feature    1591..1689
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     Region: ANK 9"
     misc_feature    1606..1965
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="Ankyrin repeats (3 copies); Region: Ank_2;
                     pfam12796"
                     /db_xref="CDD:205076"
     misc_feature    1849..2214
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="ankyrin repeats;  ankyrin repeats mediate
                     protein-protein interactions in very diverse families of
                     proteins. The number of ANK repeats in a protein can range
                     from 2 to over 20 (ankyrins, for example). ANK repeats may
                     occur in combinations with other...; Region: ANK; cd00204"
                     /db_xref="CDD:29261"
     misc_feature    1849..1851
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN, partial;
                     propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     hydroxylation site"
     misc_feature    1870..1968
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     Region: ANK 10"
     misc_feature    1885..2163
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="Ankyrin repeats (3 copies); Region: Ank_2;
                     pfam12796"
                     /db_xref="CDD:205076"
     misc_feature    1930..1956
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     Region: HIF1AN-binding"
     misc_feature    1954..1956
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="(3S)-3-hydroxyhistidine, by HIF1AN, partial;
                     propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     hydroxylation site"
     misc_feature    1969..2067
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     Region: ANK 11"
     misc_feature    2053..2055
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN, partial;
                     propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     hydroxylation site"
     misc_feature    2068..2166
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     Region: ANK 12"
     misc_feature    2308..2658
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="ankyrin repeats;  ankyrin repeats mediate
                     protein-protein interactions in very diverse families of
                     proteins. The number of ANK repeats in a protein can range
                     from 2 to over 20 (ankyrins, for example). ANK repeats may
                     occur in combinations with other...; Region: ANK; cd00204"
                     /db_xref="CDD:29261"
     misc_feature    2308..2310
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN, partial;
                     propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     hydroxylation site"
     misc_feature    2329..2427
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     Region: ANK 13"
     misc_feature    2344..2622
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="Ankyrin repeats (3 copies); Region: Ank_2;
                     pfam12796"
                     /db_xref="CDD:205076"
     misc_feature    2413..2415
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN, partial;
                     propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     hydroxylation site"
     misc_feature    2428..2526
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     Region: ANK 14"
     misc_feature    2512..2514
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN, partial;
                     propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     hydroxylation site"
     misc_feature    2527..2625
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H2K2.1);
                     Region: ANK 15"
     misc_feature    2908..3105
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="SAM domain of tankyrase1,2 subfamily; Region:
                     SAM_tankyrase1,2; cd09524"
                     /db_xref="CDD:188923"
     misc_feature    2926..3099
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="SAM domain (Sterile alpha motif); Region: SAM_2;
                     pfam07647"
                     /db_xref="CDD:203706"
     misc_feature    3109..3777
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /note="Tankyrases interact with the telomere reverse
                     transcriptase complex (TERT). Tankyrase 1
                     poly-ADP-ribosylates Telomere Repeat Binding Factor 1
                     (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or
                     TRF1. The tankyrases also contain multiple ankyrin...;
                     Region: tankyrase_like; cd01438"
                     /db_xref="CDD:30069"
     variation       358
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374420951"
     variation       371
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200480328"
     variation       379
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371748408"
     variation       384
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373693017"
     variation       389
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368410431"
     variation       400
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:376227217"
     exon            497..721
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       513
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149057366"
     variation       530
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371801860"
     variation       533
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376514770"
     variation       568
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201518095"
     variation       573
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369816721"
     variation       631
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372595864"
     variation       638
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:375628632"
     variation       647
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:147839149"
     variation       650
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61756248"
     variation       651
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:189629328"
     variation       684
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376748564"
     variation       708
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140299054"
     exon            722..817
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       755
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371197134"
     variation       809
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150342370"
     exon            818..854
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     exon            855..930
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       861
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138819481"
     variation       868
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145339417"
     variation       895
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149386270"
     variation       912
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145689481"
     exon            931..1025
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       995
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372097584"
     exon            1026..1092
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       1029
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202102264"
     variation       1075
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200360192"
     variation       1089
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368810318"
     exon            1093..1279
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       1178
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370455144"
     variation       1226
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201298866"
     variation       1263
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138258878"
     exon            1280..1401
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       1284
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200034235"
     variation       1296
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:193025940"
     variation       1308
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142723604"
     variation       1316
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146154837"
     variation       1333
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140168418"
     variation       1350
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141531302"
     variation       1373
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150887943"
     variation       1377
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111341432"
     variation       1380
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200935543"
     variation       1399
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369265938"
     exon            1402..1493
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       1413
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201826505"
     variation       1443
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:61749237"
     exon            1494..1572
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       1534
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375561548"
     variation       1543
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:78066006"
     exon            1573..1744
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       1591
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41286934"
     variation       1620
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140304512"
     variation       1622
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202191207"
     variation       1645
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201015037"
     variation       1659
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:112229271"
     variation       1674
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:61756246"
     variation       1695
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200278821"
     variation       1704
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369522806"
     exon            1745..1824
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       1789
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201449859"
     variation       1801
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199739075"
     exon            1825..1970
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       1840
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370769267"
     variation       1859
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147855760"
     variation       1861
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201349109"
     variation       1884
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148894170"
     variation       1921
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143595087"
     exon            1971..2136
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       1972
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:185509308"
     variation       2047
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12355309"
     variation       2067
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368882919"
     variation       2082
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376963141"
     variation       2094
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:150996069"
     exon            2137..2356
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       2295
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140823899"
     variation       2338
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369175719"
     exon            2357..2466
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       2358
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111818851"
     variation       2403
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200916374"
     variation       2463
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376518462"
     variation       2464
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145701051"
     exon            2467..2655
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       2483
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377093087"
     variation       2485
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369439385"
     variation       2536
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373621241"
     variation       2547
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375987433"
     variation       2577
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370045797"
     variation       2592
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372597306"
     exon            2656..2908
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       2658
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3758499"
     variation       2670
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142783979"
     variation       2704
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144949883"
     variation       2751
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:138704125"
     variation       2772
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73327827"
     variation       2785
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375144007"
     variation       2800
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372097848"
     variation       2806
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376200055"
     variation       2822
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145821862"
     variation       2834
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376390039"
     exon            2909..2991
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       2940
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200020202"
     variation       2941
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144839601"
     variation       2961
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373328045"
     variation       2980
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148151682"
     exon            2992..3112
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       2995
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200252145"
     variation       3018
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:377222592"
     variation       3091
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143952810"
     variation       3103
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147167784"
     exon            3113..3210
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       3141
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61756247"
     variation       3165
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144218813"
     exon            3211..3285
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     exon            3286..3391
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       3308
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147361517"
     variation       3332
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139013609"
     variation       3371
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370429610"
     exon            3392..3578
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       3397
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374295764"
     variation       3412
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372001710"
     variation       3453
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:57058393"
     variation       3469
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145048843"
     variation       3494
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138100133"
     variation       3514
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200883409"
     variation       3567
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149086273"
     variation       3576
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199620806"
     exon            3579..3735
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       3593
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201234782"
     variation       3596
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371518074"
     variation       3602
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200094091"
     variation       3659
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:75794258"
     variation       3701
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369360355"
     exon            3736..6274
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /inference="alignment:Splign:1.39.8"
     variation       3790
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78123770"
     variation       3799
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146581308"
     variation       3806
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201220567"
     variation       3992
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:374080423"
     variation       3993..4001
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace=""
                     /replace="gttttttca"
                     /db_xref="dbSNP:144316780"
     variation       3994..4002
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace=""
                     /replace="ttttttcag"
                     /db_xref="dbSNP:74594203"
     variation       4001
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201061571"
     variation       4045
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143819836"
     variation       4073
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184788145"
     variation       4138
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113323307"
     variation       4140
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189518244"
     variation       4142
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114508333"
     variation       4271
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147332671"
     variation       4323
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74712340"
     variation       4366
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141016151"
     variation       4387
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:144863523"
     variation       4414
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:180693010"
     STS             4554..4744
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /standard_name="RH45093"
                     /db_xref="UniSTS:21412"
     variation       4655
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:186084725"
     variation       4701
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190949718"
     variation       4782
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:181246479"
     variation       4823
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:186484885"
     variation       4880
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112017833"
     variation       4946
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190394568"
     variation       5034
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:376499713"
     variation       5054
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147512282"
     variation       5059
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1539042"
     variation       5067
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:9633689"
     variation       5107
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41286942"
     variation       5119
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:74353173"
     variation       5194
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:202086804"
     variation       5581
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182939246"
     variation       5670
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187567225"
     variation       5714
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2258946"
     variation       5757
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369644433"
     STS             5809..6047
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /standard_name="R58932"
                     /db_xref="UniSTS:6050"
     STS             5854..6055
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /standard_name="D10S2170"
                     /db_xref="UniSTS:3728"
     variation       5877
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139344799"
     variation       5885..5886
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34843104"
     variation       5891
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372004441"
     variation       5906
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190903612"
     variation       5948
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:111308061"
     variation       6004
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375635957"
     polyA_signal    6056..6061
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
     variation       6146
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:149909485"
     variation       6188
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144940292"
     variation       6196
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:117020425"
     variation       6236
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:183442774"
     variation       6237
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149041264"
     variation       6268
                     /gene="TNKS2"
                     /gene_synonym="ARTD6; PARP-5b; PARP-5c; PARP5B; PARP5C;
                     pART6; TANK2; TNKL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143163793"
ORIGIN      
ggctggacggagctggcaggaggggccttgccagcttccgccgccgcgtcgtttcaggacccggacggcggattcgcgctgcctccgccgccgcggggcagccggggggcagggagcccagcgaggggcgcgcgtgggcgcggccatgggactgcgccggatccggtgacagcagggagccaagcggcccgggccctgagcgcgtcttctccggggggcctcgccctcctgctcgcggggccggggctcctgctccggttgctggcgctgttgctggctgtggcggcggccaggatcatgtcgggtcgccgctgcgccggcgggggagcggcctgcgcgagcgccgcggccgaggccgtggagccggccgcccgagagctgttcgaggcgtgccgcaacggggacgtggaacgagtcaagaggctggtgacgcctgagaaggtgaacagccgcgacacggcgggcaggaaatccaccccgctgcacttcgccgcaggttttgggcggaaagacgtagttgaatatttgcttcagaatggtgcaaatgtccaagcacgtgatgatgggggccttattcctcttcataatgcatgctcttttggtcatgctgaagtagtcaatctccttttgcgacatggtgcagaccccaatgctcgagataattggaattatactcctctccatgaagctgcaattaaaggaaagattgatgtttgcattgtgctgttacagcatggagctgagccaaccatccgaaatacagatggaaggacagcattggatttagcagatccatctgccaaagcagtgcttactggtgaatataagaaagatgaactcttagaaagtgccaggagtggcaatgaagaaaaaatgatggctctactcacaccattaaatgtcaactgccacgcaagtgatggcagaaagtcaactccattacatttggcagcaggatataacagagtaaagattgtacagctgttactgcaacatggagctgatgtccatgctaaagataaaggtgatctggtaccattacacaatgcctgttcttatggtcattatgaagtaactgaacttttggtcaagcatggtgcctgtgtaaatgcaatggacttgtggcaattcactcctcttcatgaggcagcttctaagaacagggttgaagtatgttctcttctcttaagttatggtgcagacccaacactgctcaattgtcacaataaaagtgctatagacttggctcccacaccacagttaaaagaaagattagcatatgaatttaaaggccactcgttgctgcaagctgcacgagaagctgatgttactcgaatcaaaaaacatctctctctggaaatggtgaatttcaagcatcctcaaacacatgaaacagcattgcattgtgctgctgcatctccatatcccaaaagaaagcaaatatgtgaactgttgctaagaaaaggagcaaacatcaatgaaaagactaaagaattcttgactcctctgcacgtggcatctgagaaagctcataatgatgttgttgaagtagtggtgaaacatgaagcaaaggttaatgctctggataatcttggtcagacttctctacacagagctgcatattgtggtcatctacaaacctgccgcctactcctgagctatgggtgtgatcctaacattatatcccttcagggctttactgctttacagatgggaaatgaaaatgtacagcaactcctccaagagggtatctcattaggtaattcagaggcagacagacaattgctggaagctgcaaaggctggagatgtcgaaactgtaaaaaaactgtgtactgttcagagtgtcaactgcagagacattgaagggcgtcagtctacaccacttcattttgcagctgggtataacagagtgtccgtggtggaatatctgctacagcatggagctgatgtgcatgctaaagataaaggaggccttgtacctttgcacaatgcatgttcttatggacattatgaagttgcagaacttcttgttaaacatggagcagtagttaatgtagctgatttatggaaatttacacctttacatgaagcagcagcaaaaggaaaatatgaaatttgcaaacttctgctccagcatggtgcagaccctacaaaaaaaaacagggatggaaatactcctttggatcttgttaaagatggagatacagatattcaagatctgcttaggggagatgcagctttgctagatgctgccaagaagggttgtttagccagagtgaagaagttgtcttctcctgataatgtaaattgccgcgatacccaaggcagacattcaacacctttacatttagcagctggttataataatttagaagttgcagagtatttgttacaacacggagctgatgtgaatgcccaagacaaaggaggacttattcctttacataatgcagcatcttacgggcatgtagatgtagcagctctactaataaagtataatgcatgtgtcaatgccacggacaaatgggctttcacacctttgcacgaagcagcccaaaagggacgaacacagctttgtgctttgttgctagcccatggagctgacccgactcttaaaaatcaggaaggacaaacacctttagatttagtttcagcggatgatgtcagcgctcttctgacagcagccatgcccccatctgctctgccctcttgttacaagcctcaagtgctcaatggtgtgagaagcccaggagccactgcagatgctctctcttcaggtccatctagcccatcaagcctttctgcagccagcagtcttgacaacttatctgggagtttttcagaactgtcttcagtagttagttcaagtggaacagagggtgcttccagtttggagaaaaaggaggttccaggagtagattttagcataactcaattcgtaaggaatcttggacttgagcacctaatggatatatttgagagagaacagatcactttggatgtattagttgagatggggcacaaggagctgaaggagattggaatcaatgcttatggacataggcacaaactaattaaaggagtcgagagacttatctccggacaacaaggtcttaacccatatttaactttgaacacctctggtagtggaacaattcttatagatctgtctcctgatgataaagagtttcagtctgtggaggaagagatgcaaagtacagttcgagagcacagagatggaggtcatgcaggtggaatcttcaacagatacaatattctcaagattcagaaggtttgtaacaagaaactatgggaaagatacactcaccggagaaaagaagtttctgaagaaaaccacaaccatgccaatgaacgaatgctatttcatgggtctccttttgtgaatgcaattatccacaaaggctttgatgaaaggcatgcgtacataggtggtatgtttggagctggcatttattttgctgaaaactcttccaaaagcaatcaatatgtatatggaattggaggaggtactgggtgtccagttcacaaagacagatcttgttacatttgccacaggcagctgctcttttgccgggtaaccttgggaaagtctttcctgcagttcagtgcaatgaaaatggcacattctcctccaggtcatcactcagtcactggtaggcccagtgtaaatggcctagcattagctgaatatgttatttacagaggagaacaggcttatcctgagtatttaattacttaccagattatgaggcctgaaggtatggtcgatggataaatagttattttaagaaactaattccactgaacctaaaatcatcaaagcagcagtggcctctacgttttactcctttgctgaaaaaaaatcatcttgcccacaggcctgtggcaaaaggataaaaatgtgaacgaagtttaacattctgacttgataaagctttaataatgtacagtgttttctaaatatttcctgttttttcagcactttaacagatgccattccaggttaaactgggttgtctgtactaaattataaacagagttaacttgaaccttttatatgttatgcattgattctaacaaactgtaatgccctcaacagaactaattttactaatacaatactgtgttctttaaaacacagcatttacactgaatacaatttcatttgtaaaactgtaaataagagcttttgtactagcccagtatttatttacattgctttgtaatataaatctgttttagaactgcagcggtttacaaaattttttcatatgtattgttcatctatacttcatcttacatcgtcatgattgagtgatctttacatttgattccagaggctatgttcagttgttagttgggaaagattgagttatcagatttaatttgccgatgggagcctttatctgtcattagaaatctttctcatttaagaacttatgaatatgctgaagatttaatttgtgatacctttgtatgtatgagacacattccaaagagctctaactatgataggtcctgattactaaagaagcttctttactggcctcaatttctagctttcatgttggaaaattttctgcagtccttctgtgaaaattagagcaaagtgctcctgttttttagagaaactaaatcttgctgttgaacaattattgtgttcttttcatggaacataagtaggatgttacatttccagggtgggaagggtaatcctaaatcatttcccaatctattctaattaccttaaatctaaaggggaaaaaaaaaatcacaaacaggactgggtagttttttatcctaagtatattttttcctgttctttttacttggttttattgctgtatttatagccaatctatacatcatgggtaaacttaacccagaactataaaatgtagttgtctcagtcccctccaggcctcctgaatgggcaagtgcagtgaaacaggtgcttcttgctcctgggttttctctccatgatgttatgcccaattggaaatatgctgtcagtttgtgcaccatatggtgaccacgcctgtgctcagtttggcagctatagaaggaaatgctgtcccataaaatgccattcctattttctaatataaaactcttttccaggaagcatgcttaagcatcttgttacagagacatacatccattatggcttggcaatctcttttatttgttgactctagctcccttcaaagtcgaggaaagatctttactcacttaatgaggacattccccatcactgtctgtaccagttcacctttattttacgttttattcagtctgtaaattaactggccctttgcagtaacttgtacataaagtgctagaaaatcatgttccttgtcctgagtaagagttaatcagagtaaatgcatttctggagttgtttctgtgatgtaaattatgatcattatttaagaagtcaaatcctgatcttgaagtgctttttatacagctctctaataattacaaatatccgaaagtcatttcttggaacacaagtggagtatgccaaattttatatgaatttttcagattatctaagcttccaggttttataattagaagataatgagagaattaatggggtttatatttacattatctctcaactatgtagcccatattactcaccctatgagtgaatctggaattgcttttcatgtgaaatcattgtggtctatgagtttacaatactgcaaactgtgttattttatctaatccattgcttaatgagtgtgtttttccatgaatgaatataccgtggttcatatgttagcatggcagcattttcagatagctttttgtttgttgggaagttggggttttggggggagggggagtattagtacgttgcatgaaatagcttactttataatgatggaattgctttttcttttgtcttgtgatttttttttttgaagtgaaatttaactttttgtgcaagtagtactattatacccatcttcagtgtcttacttgtactgtatcacattccataccctcatttaattcttaataaaactgttcacttgtttttctgggtagcatggtaattactggaatagtataaatgtgttgaatggtctttgagaaaatgaattaagattacaataaaccacaattgcaggaaaacaatgtagttctgagtctaatagtgataaagaatgcagtttgaagtttgaaatattgaatattgtagctgtacttgctcattaaaatgaaagtagctgtga
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:80351 -> Molecular function: GO:0003950 [NAD+ ADP-ribosyltransferase activity] evidence: IDA
            GeneID:80351 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:80351 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
            GeneID:80351 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:80351 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: IDA
            GeneID:80351 -> Biological process: GO:0006471 [protein ADP-ribosylation] evidence: IDA
            GeneID:80351 -> Biological process: GO:0016055 [Wnt receptor signaling pathway] evidence: IEA
            GeneID:80351 -> Biological process: GO:0032212 [positive regulation of telomere maintenance via telomerase] evidence: IC
            GeneID:80351 -> Biological process: GO:0035264 [multicellular organism growth] evidence: IEA
            GeneID:80351 -> Biological process: GO:0040014 [regulation of multicellular organism growth] evidence: IEA
            GeneID:80351 -> Biological process: GO:0070198 [protein localization to chromosome, telomeric region] evidence: IMP
            GeneID:80351 -> Biological process: GO:0070213 [protein auto-ADP-ribosylation] evidence: IDA
            GeneID:80351 -> Biological process: GO:0090263 [positive regulation of canonical Wnt receptor signaling pathway] evidence: IMP
            GeneID:80351 -> Cellular component: GO:0000139 [Golgi membrane] evidence: IEA
            GeneID:80351 -> Cellular component: GO:0000242 [pericentriolar material] evidence: IDA
            GeneID:80351 -> Cellular component: GO:0000784 [nuclear chromosome, telomeric region] evidence: IC
            GeneID:80351 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:80351 -> Cellular component: GO:0005635 [nuclear envelope] evidence: IDA
            GeneID:80351 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:80351 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_079511 -> EC 2.4.2.30

by @meso_cacase at DBCLS
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