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2024-04-26 05:54:07, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_025222 4292 bp mRNA linear PRI 12-MAY-2013
DEFINITION Homo sapiens WD repeat domain 82 (WDR82), mRNA.
ACCESSION NM_025222
VERSION NM_025222.3 GI:147904339
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4292)
CONSRTM Psychiatric GWAS Consortium Bipolar Disorder Working Group
TITLE Large-scale genome-wide association analysis of bipolar disorder
identifies a new susceptibility locus near ODZ4
JOURNAL Nat. Genet. 43 (10), 977-983 (2011)
PUBMED 21926972
REMARK Erratum:[Nat Genet. 2012 Sep;44(9):1072. Fullerton, Janice M
[added]; Hyoun, Phil L [corrected to Lee, Phil H]; Meng, Fan Guo
[corrected to Meng, Fan]]
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 4292)
AUTHORS Lee,J.H., You,J., Dobrota,E. and Skalnik,D.G.
TITLE Identification and characterization of a novel human PP1
phosphatase complex
JOURNAL J. Biol. Chem. 285 (32), 24466-24476 (2010)
PUBMED 20516061
REMARK GeneRIF: mammalian Wdr82 functions in a variety of cellular
processes; PTW/PP1 phosphatase complex (PNUTS, Tox4, Wdr82, PP1)
has a role in the regulation of chromatin structure during the
transition from mitosis into interphase
REFERENCE 3 (bases 1 to 4292)
AUTHORS Wu,M., Wang,P.F., Lee,J.S., Martin-Brown,S., Florens,L.,
Washburn,M. and Shilatifard,A.
TITLE Molecular regulation of H3K4 trimethylation by Wdr82, a component
of human Set1/COMPASS
JOURNAL Mol. Cell. Biol. 28 (24), 7337-7344 (2008)
PUBMED 18838538
REMARK GeneRIF: Data show that Wdr82, which associates with chromatin in a
histone H2B ubiquitination-dependent manner, is a specific
component of Set1 complexes but not that of MLL1-4 complexes.
REFERENCE 4 (bases 1 to 4292)
AUTHORS Lee,J.H. and Skalnik,D.G.
TITLE Wdr82 is a C-terminal domain-binding protein that recruits the
Setd1A Histone H3-Lys4 methyltransferase complex to transcription
start sites of transcribed human genes
JOURNAL Mol. Cell. Biol. 28 (2), 609-618 (2008)
PUBMED 17998332
REMARK GeneRIF: suggest a model for how the mammalian RNA polymerase II
machinery is linked with histone H3-Lys4 histone methyltransferase
complexes at transcriptionally active genes
REFERENCE 5 (bases 1 to 4292)
AUTHORS Lee,J.H., Tate,C.M., You,J.S. and Skalnik,D.G.
TITLE Identification and characterization of the human Set1B histone
H3-Lys4 methyltransferase complex
JOURNAL J. Biol. Chem. 282 (18), 13419-13428 (2007)
PUBMED 17355966
REFERENCE 6 (bases 1 to 4292)
AUTHORS Higa,L.A., Wu,M., Ye,T., Kobayashi,R., Sun,H. and Zhang,H.
TITLE CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat
proteins and regulates histone methylation
JOURNAL Nat. Cell Biol. 8 (11), 1277-1283 (2006)
PUBMED 17041588
REFERENCE 7 (bases 1 to 4292)
AUTHORS Lee,J.H. and Skalnik,D.G.
TITLE CpG-binding protein (CXXC finger protein 1) is a component of the
mammalian Set1 histone H3-Lys4 methyltransferase complex, the
analogue of the yeast Set1/COMPASS complex
JOURNAL J. Biol. Chem. 280 (50), 41725-41731 (2005)
PUBMED 16253997
REFERENCE 8 (bases 1 to 4292)
AUTHORS Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
TITLE The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins:
a bioinformatics assessment
JOURNAL Genome Res. 13 (10), 2265-2270 (2003)
PUBMED 12975309
REMARK Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DB500464.1, AY358264.1, AK098435.1, AC092045.2 and AI478905.1.
On May 22, 2007 this sequence version replaced gi:21361950.
Summary: TMEM113 (WDR82) is a component of the mammalian SET1A (MIM
611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase
complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al.,
2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010].
##Evidence-Data-START##
Transcript exon combination :: BX648628.1, AY358264.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-265 DB500464.1 1-265
266-1483 AY358264.1 1-1218
1484-1958 AK098435.1 930-1404
1959-4263 AC092045.2 156103-158407
4264-4292 AI478905.1 1-29 c
FEATURES Location/Qualifiers
source 1..4292
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p21.2"
gene 1..4292
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/note="WD repeat domain 82"
/db_xref="GeneID:80335"
/db_xref="HGNC:28826"
/db_xref="MIM:611059"
exon 1..443
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/inference="alignment:Splign:1.39.8"
misc_feature 70..72
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/note="upstream in-frame stop codon"
CDS 283..1224
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/note="transmembrane protein 113"
/codon_start=1
/product="WD repeat-containing protein 82"
/protein_id="NP_079498.2"
/db_xref="GI:147904340"
/db_xref="CCDS:CCDS2851.2"
/db_xref="GeneID:80335"
/db_xref="HGNC:28826"
/db_xref="MIM:611059"
/translation="
MKLTDSVLRSFRVAKVFRENSDKINCFDFSPNGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFDPEGLIFAAGVNSEMVKLYDLRSFDKGPFATFKMQYDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANSKAVTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGKHTGPITCLQFNPKFMTFASACSNMAFWLPTIDD
"
misc_feature 325..1182
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/note="WD40 domain, found in a number of eukaryotic
proteins that cover a wide variety of functions including
adaptor/regulatory modules in signal transduction,
pre-mRNA processing and cytoskeleton assembly; typically
contains a GH dipeptide 11-24 residues from...; Region:
WD40; cd00200"
/db_xref="CDD:238121"
misc_feature 331..>1191
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/note="FOG: WD40 repeat [General function prediction
only]; Region: COG2319"
/db_xref="CDD:225201"
misc_feature 337..456
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6UXN9.1);
Region: WD 1"
misc_feature order(340..342,394..396,406..408,424..429,463..468,
520..522,538..540,556..561,595..600,649..651,664..666,
682..687,724..726,769..771,784..786,802..807,856..861,
913..915,925..927,943..948,982..984,991..993,1045..1047,
1060..1062,1078..1083,1117..1119,1123..1125,1177..1179)
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/note="structural tetrad; other site"
/db_xref="CDD:238121"
misc_feature 595..714
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6UXN9.1);
Region: WD 2"
misc_feature 718..834
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6UXN9.1);
Region: WD 3"
misc_feature 856..975
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6UXN9.1);
Region: WD 4"
misc_feature 988..1110
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6UXN9.1);
Region: WD 5"
misc_feature 1120..1221
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q6UXN9.1);
Region: WD 6"
exon 444..541
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/inference="alignment:Splign:1.39.8"
exon 542..608
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/inference="alignment:Splign:1.39.8"
exon 609..708
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/inference="alignment:Splign:1.39.8"
variation 692
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/replace="c"
/replace="g"
/db_xref="dbSNP:11542801"
exon 709..825
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/inference="alignment:Splign:1.39.8"
exon 826..981
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/inference="alignment:Splign:1.39.8"
variation 855
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/replace="c"
/replace="t"
/db_xref="dbSNP:3210487"
exon 982..1051
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/inference="alignment:Splign:1.39.8"
exon 1052..1194
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/inference="alignment:Splign:1.39.8"
exon 1195..4292
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/inference="alignment:Splign:1.39.8"
STS 1587..1723
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/standard_name="SHGC-77002"
/db_xref="UniSTS:8374"
STS 2132..2318
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/standard_name="RH65382"
/db_xref="UniSTS:84283"
STS 2179..2318
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/standard_name="G59796"
/db_xref="UniSTS:136945"
variation 2633
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/replace="c"
/replace="t"
/db_xref="dbSNP:11542802"
variation 2782
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/replace="g"
/replace="t"
/db_xref="dbSNP:11542803"
variation 3021
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/replace="c"
/replace="g"
/db_xref="dbSNP:11542804"
STS 3117..3241
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/standard_name="SHGC-34682"
/db_xref="UniSTS:70165"
STS 3336..3460
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/standard_name="STS-H08817"
/db_xref="UniSTS:82871"
STS 3548..3674
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/standard_name="D15S1477"
/db_xref="UniSTS:474482"
STS 3562..3679
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/standard_name="D11S2560"
/db_xref="UniSTS:37928"
STS 3581..3668
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/standard_name="D8S2279"
/db_xref="UniSTS:473907"
variation 3785
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/replace="a"
/replace="g"
/db_xref="dbSNP:1060330"
STS 3901..4118
/gene="WDR82"
/gene_synonym="MST107; MSTP107; PRO2730; PRO34047; SWD2;
TMEM113; WDR82A"
/standard_name="STS-N92524"
/db_xref="UniSTS:80380"
ORIGIN
ttctgcctgtcgccccaaaatggcggacacaatgagccggcgacgcgccggttgtccgtgaggtggctgtgaggacgaacggtcggcgaggctccacagtccaggcagaagaccctcgaccaagcaggaagaagaggaggaggcggcccaactgttggccgacttcccgctagccgccggcgcggcgcccgccccgcctgggttggcccctcggcagcccgcccgctcgccgccgggccccgccccggccctgcgccgccgctgccttccccagccgccgccatgaagctgaccgacagcgtgttgcggagcttccgcgtcgctaaggtgttccgcgaaaactcggacaagattaactgcttcgatttcagccccaacggcgagacggtcatctcgagtagcgacgacgactccatcgtgctctatgactgccaggagggcaaaccaaagagaaccctgtacagtaagaaatatggtgtggacctcatcagatacactcatgcagcaaacacagttgtttacagctctaacaaaatagacgatactattcgttacttgtccttgcatgacaacaaatacatcagatactttcctggacatagcaaaagggtggtggccttgtccatgtcacctgtggatgacactttcatttctgggtctcttgataagaccattcgactctgggatctccggtctcctaactgccagggcctcatgcatctgcaggggaagccagtttgttcttttgatccagaagggttaattttcgctgcaggtgtcaactctgaaatggtcaagctttatgaccttcgttcttttgataaggggccatttgctacctttaagatgcagtatgatcgaacttgtgagtggacaggacttaaattcagcaatgatggcaagctcatcctcatttccaccaacggcagcttcattcgtctgattgatgcattcaaaggagtggtgatgcacacatttgggggttatgccaacagcaaagctgtcacactggaggcttcatttactccagactctcagtttattatgattggttcagaggatggcaagatccatgtctggaatggagagagcggtataaaagtagctgtgttggatggtaaacacacaggcccgattacctgtttgcaattcaaccccaagttcatgacttttgccagtgcgtgttccaacatggccttttggttgcccaccattgatgactgaccctgttgctgcttggctatttctgtatagtgagggcggccagcaggaagaaactcagagggaactgagataatagtgggattggatcatttgactgggctggagaacatccttttacatggccttcccatggatgtgctgtacatctgctcaaaagaaaataattactttgatgagcgtcttcaaaaggactcttggtgcaacagactcaattggaactcagcttttctaactgtcactgcaccaagctctgctggaggagtgaccagactcacgatttggtatagtggggctctcaagcatcttcaatttgaatgtacatgctgctgaggagccggtgaagtcatcagttccgcacatcccttctaccctccaactgcatgggaagccaaagtcctggttttgaaatgcttgggcagctcagccgcttgccctcaccctgcatgtcttgttactgggtctccctgtgtacttgtggcattatccacaaccatcatgtttcttaggtgccaaacatttacagaaacattttcatatatcttggggtcagagaaagggacagatacagaaggaccttgcttgcaggaagccatgcagttagtttctgcagttagtcgtgtgaggctaggtggttgggcaggcctcgggctgtaggtgttgggtgggaaaaagacccaagggcctgaaagggagggaaaggggagggtagcgggagggtagcaggtgagttcctagggctggaaggtttagcagcagcctggtgcagtgccctgtcatcaagacaaacccacggtcctcctgggtgcctaccaagcttggtttgtacaaaagcaaggtgggagtctatttttgtacatgagatacatcacacttacctgtgggccagtattgtgaagtgagtctgagttgtttacactgatgccttccctgcccaccacaaattgtgtacatagtcttcagatgataccacccctttccccagctcccaaccaagagctggttctaggcctgtgttatatgtcatatttagcgtttttatatatgacctttgatttctgttgtttgtattttagcacagtgtatgcaccttcatttaaatacatctgtgtgcatacagatacgcatatatgtgtgtgcgtatgcatatatctctcatctgtagtttccaagagttcagctgaagcagatggagtcctgcagcccaggagacaccctgcatccctgctaatagtgtttgccacaagtattagtgagtcttccttattaatattttcatttcagaagactgaagcaaagctgatagtgtttgctgtttctttggcagctaagtgagggtcttgggatgacttgctgtgttcctcaagctgcactttggggccatctctgcagtattagccccctttttgcttggtggtactctgtctgtgcctgtgtgtgtgtgtgatagtcactcttgcatggcttccatgtctggtttgtggcatttggggataaggtgctgaagccagagcatttgcagtttgtttgaggcctcgttgccaatgatagatcactcctgttgacctggtatgtctgcttgcttgctgcttttccttgctttctcttggaagaggaaaggactctggtcaggcccaggctgagtgagatgagctgcagctggctcatggccttcttagagcagagagaggagtatgtcattttactaagttcctaaacaaacatttatgcaggcaacactccttgcagatccagaaactgaggcacaatagggttatgacttgctcaagaatatgtagctgctagggggtaaatcaaggcatcacaatttctgttcagcgggcaggaataggctgtgaattgctagcactttttttttttaagcaattactttttgacttgttcctctgaaagtgcaagaggcgtacacctttcccaaatgtagactagaatctgcaggatgccacccactgtatagttctgctttcccagagaggaagaacttttagaaaccaaatgatcttaattgttattgcccacccctggcttttccgggtagaaaattcacagtaggaatgattgttaagagagagtgcttggaaccatgggttaacaggaaaggctacctaacttcacatatctgcaaccagagcagccaccaagcattacttagcagcaggaaaatgattgtatttgagttcctgtgtgtccaaaactgagcaccatgttctttgaaaacatgccacctcaaggctgggcgcggtggctcacacctgtaatcccagcactttgggaggccgaggcgggcggatcaccggaggtcgggagtttgagaccagcctgaccaacatggagaaaccccatctctactaaaaatacaaaattagccgggcgtggtggcatgcgcctataatctcagctacttgggaggctgaggcaggagaattgcttgaacccaggaggcggaggttgcggtgagttgagatcgtgccattgcactccggcctgggcaacaacagcaaaactccgtctcaaaaaaaaaaaaaaaaaaatgccacctcacagtctctatcgttgggccctgtggttgcaaagctgcctcctgaattaagaaggaaagggaaaagatatagctggaagcgagtggaagagatgctgagggctggggctgcacagacgtgctcagcagggctacaggtgctcaagccctattggggatgggtggggagtggggcagcggcgtttgccaccttaagaattggggccaaagccactgatgtttatttgacagtgacactgcactgggtacttaaagaaattatttcccgttgtaattataattactgcttattaaggaaaatatgggaattttagaaagaatcaagtttgccacccaaatgctaccactgttaatcttttggtgttaaatgttccccctagacatttctgtgcatagatttttggtgtgtttacatagtcgttattctgtatatacaattttatgtcccttttgtacttaacgtataaacattttttccatgttacagtcttaaacagaattttatggctgc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:80335 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
GeneID:80335 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:80335 -> Molecular function: GO:0042800 [histone methyltransferase activity (H3-K4 specific)] evidence: IDA
GeneID:80335 -> Biological process: GO:0051568 [histone H3-K4 methylation] evidence: IDA
GeneID:80335 -> Cellular component: GO:0000785 [chromatin] evidence: IDA
GeneID:80335 -> Cellular component: GO:0035097 [histone methyltransferase complex] evidence: IDA
GeneID:80335 -> Cellular component: GO:0048188 [Set1C/COMPASS complex] evidence: IDA
GeneID:80335 -> Cellular component: GO:0072357 [PTW/PP1 phosphatase complex] evidence: IDA
by
@meso_cacase at
DBCLS
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