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2024-03-29 10:20:42, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_025158               2660 bp    mRNA    linear   PRI 20-APR-2013
DEFINITION  Homo sapiens RUN and FYVE domain containing 1 (RUFY1), transcript
            variant 1, mRNA.
ACCESSION   NM_025158
VERSION     NM_025158.4  GI:365733603
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2660)
  AUTHORS   Boraska,V., Davis,O.S., Cherkas,L.F., Helder,S.G., Harris,J.,
            Krug,I., Liao,T.P., Treasure,J., Ntalla,I., Karhunen,L.,
            Keski-Rahkonen,A., Christakopoulou,D., Raevuori,A., Shin,S.Y.,
            Dedoussis,G.V., Kaprio,J., Soranzo,N., Spector,T.D., Collier,D.A.
            and Zeggini,E.
  TITLE     Genome-wide association analysis of eating disorder-related
            symptoms, behaviors, and personality traits
  JOURNAL   Am. J. Med. Genet. B Neuropsychiatr. Genet. 159B (7), 803-811
            (2012)
   PUBMED   22911880
REFERENCE   2  (bases 1 to 2660)
  AUTHORS   Yamamoto,H., Koga,H., Katoh,Y., Takahashi,S., Nakayama,K. and
            Shin,H.W.
  TITLE     Functional cross-talk between Rab14 and Rab4 through a dual
            effector, RUFY1/Rabip4
  JOURNAL   Mol. Biol. Cell 21 (15), 2746-2755 (2010)
   PUBMED   20534812
  REMARK    GeneRIF: These findings suggest that Rab14 and Rab4 act
            sequentially, together with RUFY1.
REFERENCE   3  (bases 1 to 2660)
  AUTHORS   Hayakawa,A., Hayes,S., Leonard,D., Lambright,D. and Corvera,S.
  TITLE     Evolutionarily conserved structural and functional roles of the
            FYVE domain
  JOURNAL   Biochem. Soc. Symp. 74, 95-105 (2007)
   PUBMED   17233583
  REMARK    Review article
REFERENCE   4  (bases 1 to 2660)
  AUTHORS   Fouraux,M.A., Deneka,M., Ivan,V., van der Heijden,A.,
            Raymackers,J., van Suylekom,D., van Venrooij,W.J., van der
            Sluijs,P. and Pruijn,G.J.
  TITLE     Rabip4' is an effector of rab5 and rab4 and regulates transport
            through early endosomes
  JOURNAL   Mol. Biol. Cell 15 (2), 611-624 (2004)
   PUBMED   14617813
REFERENCE   5  (bases 1 to 2660)
  AUTHORS   Yang,J., Kim,O., Wu,J. and Qiu,Y.
  TITLE     Interaction between tyrosine kinase Etk and a RUN domain- and FYVE
            domain-containing protein RUFY1. A possible role of ETK in
            regulation of vesicle trafficking
  JOURNAL   J. Biol. Chem. 277 (33), 30219-30226 (2002)
   PUBMED   11877430
  REMARK    GeneRIF: interaction with tyrosine kinase Etk
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB988835.1, AF361055.2,
            BC032571.1, AK075021.1 and BQ014980.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Dec 23, 2011 this sequence version replaced gi:94721335.
            
            Summary: This gene encodes a protein that contains a RUN domain and
            a FYVE-type zinc finger domain. The encoded protein binds to
            phosphatidylinositol-3-phosphate (PI3P) and plays a role in early
            endosomal trafficking, tethering and fusion through interactions
            with small GTPases including Rab4, Rab5 and Rab14. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            observed for this gene. [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform (a,
            also known as rabip4').
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF312367.1, AF361055.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               CB988835.1         28-300
            274-1397            AF361055.2         247-1370
            1398-1550           BC032571.1         1142-1294
            1551-2374           AK075021.1         1465-2288
            2375-2660           BQ014980.1         1-286               c
FEATURES             Location/Qualifiers
     source          1..2660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..2660
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /note="RUN and FYVE domain containing 1"
                     /db_xref="GeneID:80230"
                     /db_xref="HGNC:19760"
                     /db_xref="MIM:610327"
     exon            1..319
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     CDS             10..2136
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /note="isoform a is encoded by transcript variant 1;
                     la-binding protein 1; FYVE-finger protein EIP1;
                     rab4-interacting protein; zinc finger FYVE
                     domain-containing protein 12"
                     /codon_start=1
                     /product="RUN and FYVE domain-containing protein 1 isoform
                     a"
                     /protein_id="NP_079434.3"
                     /db_xref="GI:94721336"
                     /db_xref="CCDS:CCDS4445.2"
                     /db_xref="GeneID:80230"
                     /db_xref="HGNC:19760"
                     /db_xref="MIM:610327"
                     /translation="
MADREGGCAAGRGRELEPELEPGPGPGSALEPGEEFEIVDRSQLPGPGDLRSATRPRAAEGWSAPILTLARRATGNLSASCGSALRAAAGLGGGDSGDGTARAASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS
"
     misc_feature    448..>744
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /note="RUN domain; Region: RUN; pfam02759"
                     /db_xref="CDD:190411"
     misc_feature    1174..1176
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (Q96T51.2); phosphorylation site"
     misc_feature    1207..1209
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine; propagated from
                     UniProtKB/Swiss-Prot (Q96T51.2); phosphorylation site"
     misc_feature    1852..1884
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96T51.2);
                     Region: Interaction with RAB4 (By similarity)"
     misc_feature    1861..1863
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    1924..2112
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /note="FYVE zinc finger; Region: FYVE; pfam01363"
                     /db_xref="CDD:201748"
     misc_feature    1939..2100
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /note="FYVE domain; Zinc-binding domain; targets proteins
                     to membrane lipids via interaction with
                     phosphatidylinositol-3-phosphate, PI3P; present in Fab1,
                     YOTB, Vac1, and EEA1; Region: FYVE; cd00065"
                     /db_xref="CDD:28947"
     misc_feature    order(1951..1953,1960..1962,1999..2001,2008..2010,
                     2023..2025,2032..2034,2083..2085,2092..2094)
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /note="Zn binding sites [ion binding]; other site"
                     /db_xref="CDD:28947"
     misc_feature    order(1987..2004,2017..2019,2077..2079)
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /note="phosphatidylinositol 3-phosphate binding site
                     [chemical binding]; other site"
                     /db_xref="CDD:28947"
     variation       68
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370133739"
     variation       75
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374837764"
     exon            320..493
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     variation       323
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:35796542"
     variation       328
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200485640"
     variation       329
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146021243"
     variation       401
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:62395251"
     variation       403
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145492098"
     variation       439
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113157637"
     exon            494..611
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     variation       513
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:141246652"
     variation       538
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201989633"
     variation       549
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377209673"
     variation       578
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370342000"
     variation       582
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145001113"
     exon            612..713
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     variation       631
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367832710"
     variation       636
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146463794"
     variation       667
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370320088"
     exon            714..837
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     variation       714
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141995707"
     variation       758
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148285472"
     variation       765
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147187303"
     variation       788
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191142171"
     variation       795
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140249165"
     variation       805
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:186494640"
     variation       807
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150352195"
     variation       828
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199642534"
     exon            838..899
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     exon            900..965
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     variation       903
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:6879322"
     exon            966..1035
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     variation       987
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376303394"
     variation       993
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370693366"
     exon            1036..1137
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     variation       1048
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142874966"
     variation       1061
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:74936220"
     variation       1066
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200257884"
     variation       1077
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374363197"
     variation       1110
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56252946"
     variation       1125
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:141988339"
     exon            1138..1254
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     variation       1159
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:75258376"
     variation       1190
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148588709"
     variation       1229
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142906534"
     variation       1253
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111890912"
     exon            1255..1422
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     variation       1258
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375970287"
     variation       1284
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150673433"
     variation       1334
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368906088"
     variation       1338
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73809484"
     variation       1345
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372933390"
     variation       1364
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111312725"
     variation       1367
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200339000"
     variation       1398
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4701135"
     exon            1423..1520
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     variation       1425
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75505498"
     variation       1434
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373665202"
     variation       1447
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:202054173"
     variation       1478
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149667846"
     variation       1486
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376644224"
     exon            1521..1640
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     variation       1533
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367823926"
     variation       1538
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112734071"
     variation       1552
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199831256"
     variation       1573
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:148906843"
     variation       1590
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201050880"
     variation       1597
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371925695"
     variation       1600
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113842455"
     variation       1617
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200915326"
     variation       1632
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200817886"
     variation       1633
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368440829"
     exon            1641..1770
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     variation       1654
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201776757"
     variation       1677
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201494659"
     variation       1696
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201227020"
     variation       1698
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199910786"
     variation       1727
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202150230"
     variation       1737
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:72824522"
     variation       1762
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:73336111"
     exon            1771..1865
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     variation       1777
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368354140"
     variation       1792
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372903598"
     variation       1797
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141042003"
     variation       1818
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374496321"
     variation       1819
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367784503"
     variation       1821
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371382038"
     variation       1839
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188712175"
     exon            1866..1914
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     variation       1887
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371703522"
     variation       1909
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201990443"
     exon            1915..1992
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     variation       1936
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373274069"
     variation       1939
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377322004"
     variation       1944
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200182514"
     variation       1946
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145048480"
     variation       1953
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138909927"
     variation       1983
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200755968"
     exon            1993..2643
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /inference="alignment:Splign:1.39.8"
     variation       2049
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17355294"
     variation       2062
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:369641186"
     variation       2064
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373507858"
     variation       2072
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376438789"
     variation       2073
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11541392"
     variation       2077
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201071293"
     variation       2078
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373401342"
     variation       2100
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375786356"
     variation       2122
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:138313632"
     variation       2124
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201845769"
     variation       2127
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370086474"
     variation       2139
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148955712"
     variation       2143
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201055157"
     variation       2147
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370835233"
     variation       2151
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375012431"
     variation       2153
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368273358"
     variation       2165
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372873984"
     variation       2178
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:62397300"
     variation       2180
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376031039"
     variation       2205..2206
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34379285"
     variation       2224
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:8087"
     STS             2257..2376
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /standard_name="RH99066"
                     /db_xref="UniSTS:84617"
     variation       2284
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183307287"
     variation       2310
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:10072198"
     variation       2330
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11541393"
     variation       2434
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371385294"
     variation       2483
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143694823"
     variation       2497
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138228772"
     polyA_signal    2609..2614
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
     variation       2619
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113545203"
     polyA_site      2629
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
     variation       2639
                     /gene="RUFY1"
                     /gene_synonym="RABIP4; ZFYVE12"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73810815"
ORIGIN      
acggccaagatggccgaccgggaaggcggctgcgctgctgggcgggggcgggagctggagccggagctggagccggggccggggcccgggtcagcgcttgagccgggagaagagtttgagatcgtggaccgaagccagctgcccggcccaggcgacctgcggagcgcaacgaggccgcgggcggccgagggctggtcggcgcccatcctgaccctggcacgcagggccaccgggaacctgtcggcgagctgcgggagcgcgctgcgcgcggccgcggggctgggcggcggggacagcggggacggcacggcgcgcgcagcttctaagtgccagatgatggaggagcgtgccaacctgatgcacatgatgaaactcagcatcaaggtgttgctccagtcggctctgagcctgggccgcagcctggatgcggaccatgcccccttgcagcagttctttgtagtgatggagcactgcctcaaacatgggctgaaagttaagaagagttttattggccaaaataaatcattctttggtcctttggagctggtggagaaactttgtccagaagcatcagatatagcgactagtgtcagaaatcttccagaattaaagacagctgtgggaagaggccgagcgtggctttatcttgcactcatgcaaaagaaactggcagattatctgaaagtgcttatagacaataaacatctcttaagcgagttctatgagcctgaggctttaatgatggaggaagaagggatggtgattgttggtctgctggtgggactcaatgttctcgatgccaatctctgcttgaaaggagaagacttggattctcaggttggagtaatagatttttccctctaccttaaggatgtgcaggatcttgatggtggcaaggagcatgaaagaattactgatgtccttgatcaaaaaaattatgtggaagaacttaaccggcacttgagctgcacagttggggatcttcaaaccaagatagatggcttggaaaagactaactcaaagcttcaagaagagctttcagctgcaacagaccgaatttgctcacttcaagaagaacagcagcagttaagagaacaaaatgaattaattcgagaaagaagtgaaaagagtgtagagataacaaaacaggataccaaagttgagctggagacttacaagcaaactcggcaaggtctggatgaaatgtacagtgatgtgtggaagcagctaaaagaggagaagaaagtccggttggaactggaaaaagaactggagttacaaattggaatgaaaaccgaaatggaaattgcaatgaagttactggaaaaggacacccacgagaagcaggacacactagttgccctccgccagcagctggaagaagtcaaagcgattaatttacagatgtttcacaaagctcagaatgcagagagcagtttgcagcagaagaatgaagccatcacatcctttgaaggaaaaaccaaccaagttatgtccagcatgaaacaaatggaagaaaggttgcagcactcggagcgggcgaggcagggggctgaggagcggagccacaagctgcagcaggagctgggcgggaggatcggcgccctgcagctgcagctctcccagctgcacgagcaatgctcaagcctggagaaagaattgaaatcagaaaaagagcaaagacaggctcttcagcgcgaattacagcacgagaaagacacttcctctctactcaggatggagctgcaacaagtggaaggactgaaaaaggagttgcgggagcttcaggacgagaaggcagagctgcagaagatctgcgaggagcaggaacaagccctccaggaaatgggcctgcacctcagccagtccaagctgaagatggaagatataaaagaagtgaaccaggcactgaagggccacgcctggctgaaagatgacgaagcgacacactgtaggcagtgtgagaaggagttctccatttcccggagaaagcaccactgccggaactgtggccacatcttctgcaacacctgctccagcaacgagctggccctgccctcctaccccaagccggtgcgagtgtgcgacagctgccacaccctgctcctgcagcgctgctcctccacggcctcctgaacgtccgtcctcaggagcacagcctcacggacagtgccaaaccctgtgggtctccaggggcttgggaaatgtgttctttcccaagagtatcaaaggaaagaatcaaatttcttgcccggtcactggcactccagaagacagcgtgccggaaccggcagctctcacctttctgtgacttgttcggaattaactcctctggatggaaacttccatcttacttggttacatcacggctctggttcagatacaacttcatgattttgctactatcatttttcacttttcaaagaatttaacctattttacagcagttcagttctgctagtgagtagttttcctctcctaccttccttctaaaaacctgattcatgcacagcgtttgacacacatggagtctgccagtgtgccttctctgcttcagacaagagatctgccatttcatgcccttgtgactacctatcattggccctgcaataaaatcatttatttttcactctggtgcgtgcaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:80230 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:80230 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
            GeneID:80230 -> Molecular function: GO:0008289 [lipid binding] evidence: IEA
            GeneID:80230 -> Molecular function: GO:0008565 [protein transporter activity] evidence: IEA
            GeneID:80230 -> Biological process: GO:0006897 [endocytosis] evidence: IEA
            GeneID:80230 -> Biological process: GO:0030100 [regulation of endocytosis] evidence: IEA
            GeneID:80230 -> Cellular component: GO:0031901 [early endosome membrane] evidence: IEA

by @meso_cacase at DBCLS
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