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2024-04-27 06:26:35, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_025126 2055 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens ring finger protein 34, E3 ubiquitin protein ligase
(RNF34), transcript variant 2, mRNA.
ACCESSION NM_025126
VERSION NM_025126.3 GI:378925639
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2055)
AUTHORS Lin,M.L., Lu,Y.C., Su,H.L., Lin,H.T., Lee,C.C., Kang,S.E.,
Lai,T.C., Chung,J.G. and Chen,S.S.
TITLE Destabilization of CARP mRNAs by aloe-emodin contributes to
caspase-8-mediated p53-independent apoptosis of human carcinoma
cells
JOURNAL J. Cell. Biochem. 112 (4), 1176-1191 (2011)
PUBMED 21308745
REMARK GeneRIF: Data indicate AE induces caspase-8-mediated activation of
mitochondrial death pathways by decreasing the stability of CARP
mRNAs in a p53-independent manner.
REFERENCE 2 (bases 1 to 2055)
AUTHORS Erlbruch,A., Hung,C.W., Seidler,J., Borrmann,K., Gesellchen,F.,
Konig,N., Kubler,D., Herberg,F.W., Lehmann,W.D. and Bossemeyer,D.
TITLE Uncoupling of bait-protein expression from the prey protein
environment adds versatility for cell and tissue interaction
proteomics and reveals a complex of CARP-1 and the PKA Cbeta1
subunit
JOURNAL Proteomics 10 (16), 2890-2900 (2010)
PUBMED 20564261
REMARK GeneRIF: The previously unknown small molecule inhibitor-dependent
interaction of Cbeta1 with the cell cycle and apoptosis regulatory
protein-1 was verified.
REFERENCE 3 (bases 1 to 2055)
AUTHORS Yang,W., Dicker,D.T., Chen,J. and El-Deiry,W.S.
TITLE CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing
MDM2
JOURNAL Cell Cycle 7 (5), 670-682 (2008)
PUBMED 18382127
REMARK GeneRIF: CARPs together with MDM2 enhance p53 degradation, thereby
inhibiting p53-mediated cell death.
REFERENCE 4 (bases 1 to 2055)
AUTHORS Yang,W., Rozan,L.M., McDonald,E.R. III, Navaraj,A., Liu,J.J.,
Matthew,E.M., Wang,W., Dicker,D.T. and El-Deiry,W.S.
TITLE CARPs are ubiquitin ligases that promote MDM2-independent p53 and
phospho-p53ser20 degradation
JOURNAL J. Biol. Chem. 282 (5), 3273-3281 (2007)
PUBMED 17121812
REFERENCE 5 (bases 1 to 2055)
AUTHORS Konishi,T., Sasaki,S., Watanabe,T., Kitayama,J. and Nagawa,H.
TITLE Overexpression of hRFI (human ring finger homologous to inhibitor
of apoptosis protein type) inhibits death receptor-mediated
apoptosis in colorectal cancer cells
JOURNAL Mol. Cancer Ther. 4 (5), 743-750 (2005)
PUBMED 15897238
REFERENCE 6 (bases 1 to 2055)
AUTHORS Sasaki,S., Watanabe,T., Konishi,T., Kitayama,J. and Nagawa,H.
TITLE Effects of expression of hRFI on adenoma formation and tumor
progression in colorectal adenoma-carcinoma sequence
JOURNAL J. Exp. Clin. Cancer Res. 23 (3), 507-512 (2004)
PUBMED 15595643
REMARK GeneRIF: hRFI may act as an oncogenic molecule affecting the
apoptotic pathway
REFERENCE 7 (bases 1 to 2055)
AUTHORS McDonald,E.R. III and El-Deiry,W.S.
TITLE Suppression of caspase-8- and -10-associated RING proteins results
in sensitization to death ligands and inhibition of tumor cell
growth
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (16), 6170-6175 (2004)
PUBMED 15069192
REFERENCE 8 (bases 1 to 2055)
AUTHORS Sasaki,S., Nakamura,T., Arakawa,H., Mori,M., Watanabe,T., Nagawa,H.
and Croce,C.M.
TITLE Isolation and characterization of a novel gene, hRFI,
preferentially expressed in esophageal cancer
JOURNAL Oncogene 21 (32), 5024-5030 (2002)
PUBMED 12118383
REMARK GeneRIF: a novel gene, hRFI, preferentially expressed in esophageal
cancer (hRFI)
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF306709.1 and AK025439.1.
On Mar 1, 2012 this sequence version replaced gi:37595536.
Summary: The protein encoded by this gene contains a RINF finger, a
motif known to be involved in protein-protein and protein-DNA
interactions. This protein interacts with DNAJA3/hTid-1, which is a
DnaJ protein reported to function as a modulator of apoptosis.
Overexpression of this gene in Hela cells was shown to confer the
resistance to TNF-alpha induced apoptosis, suggesting an
anti-apoptotic function of this protein. This protein can be
cleaved by caspase-3 during the induction of apoptosis. This
protein also targets p53 and phospho-p53 for degradation.
Alternatively splicing results in multiple transcript variants
encoding distinct isoforms. [provided by RefSeq, Feb 2012].
Transcript Variant: This variant (2) lacks an exon in the 5' coding
region which results in the use of an alternate translational start
codon, compared to variant 1. The resulting isoform (2) lacks one
amino acid in the N-terminus, compared isoform 1.
##Evidence-Data-START##
Transcript exon combination :: AK025439.1, AF306709.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1470 AF306709.1 43-1512
1471-2055 AK025439.1 1436-2020
FEATURES Location/Qualifiers
source 1..2055
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q24.31"
gene 1..2055
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/note="ring finger protein 34, E3 ubiquitin protein
ligase"
/db_xref="GeneID:80196"
/db_xref="HGNC:17297"
/db_xref="MIM:608299"
exon 1..136
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/inference="alignment:Splign:1.39.8"
misc_feature 35..37
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/note="upstream in-frame stop codon"
variation 37
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:374975607"
variation 39..41
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace=""
/replace="cac"
/db_xref="dbSNP:200012941"
variation 56
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:61733229"
variation 61
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="g"
/db_xref="dbSNP:182031296"
variation 76
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="g"
/db_xref="dbSNP:371429893"
variation 78
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:375539157"
variation 82
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="t"
/db_xref="dbSNP:368256317"
variation 121
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:199515654"
CDS 131..1249
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/EC_number="6.3.2.-"
/note="isoform 2 is encoded by transcript variant 2; RING
finger protein RIFF; FYVE-RING finger protein MOMO;
caspases-8 and -10-associated RING finger protein 1; E3
ubiquitin-protein ligase RNF34; caspase regulator CARP1;
human RING finger homologous to inhibitor of apoptosis
protein"
/codon_start=1
/product="E3 ubiquitin-protein ligase RNF34 isoform 2"
/protein_id="NP_079402.2"
/db_xref="GI:37595537"
/db_xref="CCDS:CCDS31915.1"
/db_xref="GeneID:80196"
/db_xref="HGNC:17297"
/db_xref="MIM:608299"
/translation="
MKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGPFRFTPNPEFSTYPPAATEGPNIVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLKVKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMDTSSLNSSRSQTSSFFTRSFFSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQSEITSANTEDDDDDDDEDDDDEEENAEDRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRLYKENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS
"
misc_feature 311..>400
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/note="FYVE domain; Zinc-binding domain; targets proteins
to membrane lipids via interaction with
phosphatidylinositol-3-phosphate, PI3P; present in Fab1,
YOTB, Vac1, and EEA1; Region: FYVE; cd00065"
/db_xref="CDD:28947"
misc_feature order(314..316,323..325,362..364,371..373,386..388,
395..397)
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/note="Zn binding sites [ion binding]; other site"
/db_xref="CDD:28947"
misc_feature order(350..367,380..382)
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/note="phosphatidylinositol 3-phosphate binding site
[chemical binding]; other site"
/db_xref="CDD:28947"
misc_feature 824..829
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/experiment="experimental evidence, no additional details
recorded"
/note="Cleavage, by caspase-3; propagated from
UniProtKB/Swiss-Prot (Q969K3.1); cleavage site"
misc_feature 890..892
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q969K3.1); phosphorylation site"
misc_feature 1091..1225
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/note="Zinc finger, C3HC4 type (RING finger); Region:
zf-C3HC4_3; pfam13920"
/db_xref="CDD:206091"
misc_feature 1091..1213
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/note="Zinc finger, C3HC4 type (RING finger); Region:
zf-C3HC4_2; pfam13923"
/db_xref="CDD:206094"
exon 137..355
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/inference="alignment:Splign:1.39.8"
variation 163
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:201929209"
STS 179..324
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/standard_name="RH64995"
/db_xref="UniSTS:84284"
variation 185
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:145495936"
variation 191
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:377206024"
variation 239
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:112773484"
variation 268
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:200788702"
variation 290
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:370393586"
variation 294
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="c"
/db_xref="dbSNP:61760895"
variation 307
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="g"
/db_xref="dbSNP:144086612"
variation 328
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="g"
/replace="t"
/db_xref="dbSNP:146497196"
variation 334
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:374454541"
exon 356..763
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/inference="alignment:Splign:1.39.8"
variation 391
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:367629594"
variation 392
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:141105657"
variation 401
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:200116682"
variation 452
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:11545004"
variation 488
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="g"
/replace="t"
/db_xref="dbSNP:371636385"
variation 497
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace=""
/replace="g"
/db_xref="dbSNP:5801434"
variation 532
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:202010836"
variation 542
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:376080046"
variation 548
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:143210041"
variation 569
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="g"
/db_xref="dbSNP:181816892"
variation 592
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:148275322"
variation 622
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="g"
/db_xref="dbSNP:201204148"
variation 660
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:41507449"
variation 677
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="g"
/replace="t"
/db_xref="dbSNP:200332742"
variation 705
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:368427013"
variation 746
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:150408238"
exon 764..856
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/inference="alignment:Splign:1.39.8"
variation 769
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:138199363"
variation 797..799
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace=""
/replace="gat"
/db_xref="dbSNP:72059744"
variation 799..801
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace=""
/replace="tga"
/db_xref="dbSNP:370767127"
variation 799
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="c"
/db_xref="dbSNP:185279212"
variation 805
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="g"
/db_xref="dbSNP:190921881"
variation 805
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace=""
/replace="tga"
/db_xref="dbSNP:77544919"
variation 808
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:202132357"
variation 811
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:377017432"
variation 832
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="t"
/db_xref="dbSNP:61739898"
variation 835
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="t"
/db_xref="dbSNP:61751317"
variation 845
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="g"
/replace="t"
/db_xref="dbSNP:368005152"
variation 854
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="c"
/db_xref="dbSNP:184904177"
exon 857..1058
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/inference="alignment:Splign:1.39.8"
variation 863
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:143285387"
variation 882
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="g"
/replace="t"
/db_xref="dbSNP:139288912"
variation 944
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="g"
/db_xref="dbSNP:34812514"
variation 945
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace=""
/replace="g"
/replace="t"
/db_xref="dbSNP:34201718"
variation 964
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:375929001"
variation 975
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:201019913"
variation 990
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="t"
/db_xref="dbSNP:183189219"
variation 992
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="g"
/replace="t"
/db_xref="dbSNP:186249284"
variation 1010
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:1110337"
variation 1014
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:113432721"
variation 1023
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:373568534"
variation 1024
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="g"
/replace="t"
/db_xref="dbSNP:143217753"
exon 1059..2025
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/inference="alignment:Splign:1.39.8"
variation 1063
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:200513045"
variation 1068
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:369744966"
variation 1095..1096
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace=""
/replace="cccccc"
/replace="gaaaccccc"
/db_xref="dbSNP:139170044"
variation 1123
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:373171102"
variation 1130
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:144819272"
variation 1177
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:376706808"
variation 1185
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:61754471"
variation 1208
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:370848382"
variation 1223
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:372856839"
variation 1234
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:377078507"
variation 1235
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:370330071"
variation 1245
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:200273600"
variation 1268
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:147553178"
variation 1288
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:374677569"
variation 1294
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="c"
/db_xref="dbSNP:28557279"
variation 1295
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:111571472"
variation 1304
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:372267828"
variation 1323
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:77286564"
variation 1457
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:377270647"
variation 1499
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="g"
/replace="t"
/db_xref="dbSNP:183521191"
variation 1517
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:140213777"
variation 1671
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="c"
/db_xref="dbSNP:3751132"
variation 1715
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:151100805"
STS 1783..1994
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/standard_name="NIB1331"
/db_xref="UniSTS:58859"
STS 1850..2000
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/standard_name="D12S1398"
/db_xref="UniSTS:32605"
STS 1857..1985
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/standard_name="G62101"
/db_xref="UniSTS:139128"
variation 1860
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:11545005"
variation 1941
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="a"
/replace="g"
/db_xref="dbSNP:8462"
variation 1978
/gene="RNF34"
/gene_synonym="CARP-1; CARP1; hRFI; RFI; RIF; RIFF"
/replace="c"
/replace="t"
/db_xref="dbSNP:141042508"
ORIGIN
acgtccggacgctcggtcgcctcccggggcgcggtaatcaccgcccagagggaaggaggtcggcagtgtgaggagctgctatggtgctgagtttcctggtagagccggccgagctgaggcggtcgcggccatgaaggcgggtgccacgtctatgtgggcttcgtgctgtgggctgctgaatgaagtcatgggaactggagctgtcaggggccagcagtcagcatttgcaggagccaccggtccattcagatttacaccaaaccctgagttttccacctacccaccagcagctacggaagggcccaacatagtttgtaaagcctgtgggctttcattttcagtctttagaaagaagcatgtttgctgtgactgcaagaaggatttttgctccgtttgttcagtcttacaagaaaatctccgtagatgttctacttgtcacttattacaagagacagcatttcagcgccctcagttaatgcgactgaaggtgaaggacctgcggcagtatctcattctgagaaatatacccatagatacttgtcgtgagaaagaagacttggtggatctagtactgtgccatcatggactaggctctgaggacgacatggacacaagcagtctgaattcttcaaggtcccagacttctagcttttttacacgttcgtttttttcaaactatacagccccctctgctactatgtcttcgtttcagggagagcttatggatggagaccaaacatccagatctggagtgccggcacaggtacaaagtgaaatcacttcagcaaacacagaagatgatgatgacgacgatgatgaggatgatgatgatgaagaagaaaacgcagaggatcggaaccccgggctctccaaggagagagtgagagcttcactgtctgacttgtcaagccttgatgatgtggaaggaatgagcgtgcgccagctgaaggaaattctggctcggaattttgtcaactattctggctgttgtgaaaaatgggaactggtagagaaagtaaaccggttatacaaagagaatgaagaaaaccaaaagtcctatggcgagcggctgcagctgcaggatgaggaagacgacagcctgtgtcgcatctgcatggatgccgtcatcgactgtgtcctactggagtgtgggcacatggttacctgcaccaagtgcggcaagcgcatgagtgagtgtcccatctgccggcagtatgtggtgcgagccgtgcacgtgttcaagtcctgaaacaggctcccctcaccaggacagtcacccccaaacttgacccccaacatttcaatgcacagaagggactggaaagttatgttcaaaggctgaagctattttaaaacattattttgactactaagtggggacagaaagatccatcctgagttgtggaaacattggtccatgccgtgagcctgtctgcctgtggacacgtgagcttcccgggctcagctgggctttatcacacatcccgtgaacactcattgaagtcagcctgtttgcgccatgtgggcatcagccactgctgtcttgggaggacacttatcctgttctcttatttccccttcatcctatttttaacttaaactgctcagatgtttgaaacttctgtcctctttggatgagatcagtgtccacaagtggccgacatggaacatgctgagcagtggctcctctgaatgttcactttattagtcatgtatattttaaatgctaacatttgatgaatgtaagtttccacattgttgctgtttctgcatttaaacataattgggaacaactgacattctctagtcgactgccagggccttagactccacatgtccatttttgttcaggtatagctttttatagcaagggctgcatctagcttcttttattagaagtgtgtgtgctaaattccttattaatgtgtaatcagtttacattgttttgtatagtgaaggtgtattttcagtgctacccgctagctgattttaactttaggaataaaattagttttaaaagcttttaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:80196 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IEA
GeneID:80196 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:80196 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:80196 -> Cellular component: GO:0012505 [endomembrane system] evidence: IEA
GeneID:80196 -> Cellular component: GO:0016020 [membrane] evidence: IEA
GeneID:80196 -> Cellular component: GO:0016607 [nuclear speck] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_079402 -> EC 6.3.2.-
by
@meso_cacase at
DBCLS
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