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2024-04-18 15:15:43, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_024755 4164 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens SAFB-like, transcription modulator (SLTM), transcript
variant 1, mRNA.
ACCESSION NM_024755
VERSION NM_024755.2 GI:63176610
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4164)
AUTHORS Salyakina,D., Ma,D.Q., Jaworski,J.M., Konidari,I., Whitehead,P.L.,
Henson,R., Martinez,D., Robinson,J.L., Sacharow,S., Wright,H.H.,
Abramson,R.K., Gilbert,J.R., Cuccaro,M.L. and Pericak-Vance,M.A.
TITLE Variants in several genomic regions associated with asperger
disorder
JOURNAL Autism Res 3 (6), 303-310 (2010)
PUBMED 21182207
REFERENCE 2 (bases 1 to 4164)
AUTHORS Gratacos,M., Costas,J., de Cid,R., Bayes,M., Gonzalez,J.R.,
Baca-Garcia,E., de Diego,Y., Fernandez-Aranda,F.,
Fernandez-Piqueras,J., Guitart,M., Martin-Santos,R., Martorell,L.,
Menchon,J.M., Roca,M., Saiz-Ruiz,J., Sanjuan,J., Torrens,M.,
Urretavizcaya,M., Valero,J., Vilella,E., Estivill,X. and
Carracedo,A.
CONSRTM Psychiatric Genetics Network Group
TITLE Identification of new putative susceptibility genes for several
psychiatric disorders by association analysis of regulatory and
non-synonymous SNPs of 306 genes involved in neurotransmission and
neurodevelopment
JOURNAL Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816
(2009)
PUBMED 19086053
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AI215187.1, AK000867.1, AW205376.1, AK023275.1 and AI745094.1.
On May 11, 2005 this sequence version replaced gi:13376087.
Transcript Variant: This variant (1) represents the longest
transcript and it encodes the longest isoform (a).
##Evidence-Data-START##
Transcript exon combination :: BC140851.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-85 AI215187.1 1-85
86-464 AK000867.1 1-379
465-474 AW205376.1 464-473
475-1569 AK000867.1 390-1484
1570-4123 AK023275.1 47-2600
4124-4164 AI745094.1 1-41 c
FEATURES Location/Qualifiers
source 1..4164
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q22.1"
gene 1..4164
/gene="SLTM"
/gene_synonym="Met"
/note="SAFB-like, transcription modulator"
/db_xref="GeneID:79811"
/db_xref="HGNC:20709"
exon 1..250
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
variation 35
/gene="SLTM"
/gene_synonym="Met"
/replace="c"
/replace="t"
/db_xref="dbSNP:2279719"
CDS 89..3193
/gene="SLTM"
/gene_synonym="Met"
/note="isoform a is encoded by transcript variant 1;
modulator of estrogen-induced transcription"
/codon_start=1
/product="SAFB-like transcription modulator isoform a"
/protein_id="NP_079031.2"
/db_xref="GI:63176611"
/db_xref="CCDS:CCDS10168.2"
/db_xref="GeneID:79811"
/db_xref="HGNC:20709"
/translation="
MAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGVKTVLISRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDAFIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGIEDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSLAEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEASKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKEKDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLSSNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTELHGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSEKSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGDHCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFERLRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERERLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPYWSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVGQSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTVIIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVERPERSGREVSGHSVRGAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPPSQGPSYHDTRRMGDGRAGAGMITQHSSNASPINRIVQISGNSMPRGSGSGFKPFKGGPPRRF
"
misc_feature 92..94
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylalanine; propagated from
UniProtKB/Swiss-Prot (Q9NWH9.2); acetylation site"
misc_feature 152..256
/gene="SLTM"
/gene_synonym="Met"
/note="Putative DNA-binding (bihelical) motif predicted to
be involved in chromosomal organisation; Region: SAP;
smart00513"
/db_xref="CDD:128789"
misc_feature 365..367
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NWH9.2); phosphorylation site"
misc_feature 365..367
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 377..379
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NWH9.2); phosphorylation site"
misc_feature 377..379
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 518..520
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NWH9.2); phosphorylation site"
misc_feature 953..955
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NWH9.2); phosphorylation site"
misc_feature 1241..1465
/gene="SLTM"
/gene_synonym="Met"
/note="RRM (RNA recognition motif), also known as RBD (RNA
binding domain) or RNP (ribonucleoprotein domain), is a
highly abundant domain in eukaryotes found in proteins
involved in post-transcriptional gene expression processes
including mRNA and rRNA...; Region: RRM; cd00590"
/db_xref="CDD:100104"
misc_feature order(1247..1249,1367..1369,1373..1375)
/gene="SLTM"
/gene_synonym="Met"
/note="RNA/DNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:100104"
misc_feature 1289..1291
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q9NWH9.2); acetylation site"
misc_feature 1349..1351
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NWH9.2); phosphorylation site"
misc_feature 1349..1351
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1457..1465
/gene="SLTM"
/gene_synonym="Met"
/note="RRM dimerization site [polypeptide binding]; other
site"
/db_xref="CDD:100104"
misc_feature 1715..1717
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1736..1738
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NWH9.2); phosphorylation site"
misc_feature 1739..1741
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NWH9.2); phosphorylation site"
misc_feature 1739..1741
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1745..1747
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NWH9.2); phosphorylation site"
misc_feature 1745..1747
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1856..1858
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2330..2332
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NWH9.2); phosphorylation site"
misc_feature 2486..2488
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NWH9.2); phosphorylation site"
misc_feature 2813..2815
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NWH9.2); phosphorylation site"
misc_feature 2918..2920
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NWH9.2); phosphorylation site"
misc_feature 3071..3073
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3092..3094
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NWH9.2); phosphorylation site"
misc_feature 3092..3094
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3128..3130
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NWH9.2); phosphorylation site"
misc_feature 3143..3145
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NWH9.2); phosphorylation site"
misc_feature 3149..3151
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NWH9.2); phosphorylation site"
misc_feature 3158..3160
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q9NWH9.2); acetylation site"
exon 251..338
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 339..403
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 404..601
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 602..649
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 650..677
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 678..1146
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 1147..1196
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 1197..1315
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 1316..1465
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 1466..1569
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 1570..1736
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 1737..1822
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 1823..1986
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 1987..2167
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 2168..2292
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 2293..2463
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 2464..2778
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 2779..2923
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 2924..3084
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
exon 3085..4147
/gene="SLTM"
/gene_synonym="Met"
/inference="alignment:Splign:1.39.8"
STS 3880..4063
/gene="SLTM"
/gene_synonym="Met"
/standard_name="RH103377"
/db_xref="UniSTS:97704"
STS 3896..4036
/gene="SLTM"
/gene_synonym="Met"
/standard_name="RH67863"
/db_xref="UniSTS:29986"
polyA_signal 4122..4127
/gene="SLTM"
/gene_synonym="Met"
polyA_site 4142
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
polyA_site 4147
/gene="SLTM"
/gene_synonym="Met"
/experiment="experimental evidence, no additional details
recorded"
ORIGIN
gcggccgccgaggcctgggtggaagttggcgctgctgccgccgccctgcagcccactcgctgcctcggcagcgcgctgctcttctaagatggctgccgctaccggtgcggtggcagcctcggccgcctcgggtcaggcggaaggtaaaaagatcaccgatctgcgggtcatcgatctgaagtccgagctgaagcggcggaacttagacatcaccggagtcaagaccgtgctcatctcccgactcaagcaggctattgaagaggaaggaggcgatccagataatattgaattaactgtttcaactgatactccaaacaagaaaccaactaaaggcaaaggtaaaaaacatgaagcagatgagttgagtggagatgcttctgtggaagatgatgcttttatcaaggactgtgaattggagaatcaagaggcacatgagcaagatggaaatgatgaactaaaggactctgaagaatttggtgaaaatgaagaagaaaatgtgcattccaaggagttactctctgcagaagaaaacaagagagctcatgaattaatagaggcagaaggaatagaagatatagaaaaagaggacatcgaaagtcaggaaattgaagctcaagaaggtgaagatgatacctttctaacagcccaagatggtgaggaagaagaaaatgagaaagatatagcaggttctggtgatggtacacaagaagtatctaaacctcttccttcagaagggagcctagctgaggctgatcacacagctcatgaagagatggaagctcatacgactgtgaaagaagctgaggatgacaacatctcggtcacaatccaggctgaagatgccatcactctggattttgatggtgatgacctcctagaaacaggtaaaaatgtgaaaattacagattctgaagcaagtaagccaaaagatgggcaggacgccattgcacagagcccggagaaggaaagcaaggattatgagatgaatgcgaaccataaagatggtaagaaggaagactgcgtgaagggtgaccctgtcgagaaggaagccagagaaagttctaagaaagcagaatctggagacaaagaaaaggatactttgaagaaagggccctcgtctactggggcctctggtcaagcaaagagctcttcaaaggaatctaaagacagcaagacatcatctaaagatgacaaaggaagtacaagtagtactagtggtagcagtggaagctcaactaaaaatatctgggttagtggactttcatctaataccaaagctgctgatttgaagaacctctttggcaaatatggaaaggttctgagtgcaaaagtagttacaaatgctcgaagtcctggggcaaaatgctatggcattgtaactatgtcttcaagcacagaggtgtccaggtgtattgcacatcttcatcgcactgagctgcatggacagctgatttctgttgaaaaagtaaaaggtgatccctctaagaaagaaatgaagaaagaaaatgatgaaaagagtagttcaagaagttctggagataaaaaaaatacgagtgatagaagtagcaagacacaagcctctgtcaaaaaagaagagaaaagatcgtctgagaaatctgaaaaaaaagaaagcaaggatactaagaaaatagaaggtaaagatgagaagaatgataatggagcaagtggccaaacatcagaatcgattaaaaaaagtgaagaaaagaagcgaataagttccaagagtccaggacatatggtaatactagaccaaactaaaggagatcattgtagaccatcaagaagaggaagatatgagaaaattcatggaagaagtaaggaaaaggagagagctagtctagataaaaaaagagataaagactacagaaggaaagagatcttgccttttgaaaagatgaaggaacaaaggttgagagaacatttagttcgttttgaaaggctgcgacgagcaatggaacttcgaagacgaagagagattgcagagagagagcgtcgagagcgagaacgcattagaataattcgtgaacgggaagaacgggaacgcttacagagagagagagagcgcctagaaattgaaaggcaaaaactagagagagagagaatggaacgcgaacgcttggaaagggaacgcattcgtattgaacaggaacgtcgtaaggaagctgaacggattgctcgagaaagagaggaactcagaaggcaacaacagcagcttcgttatgaacaagaaaaaaggaattccttgaaacgcccacgtgatgtagatcataggcgagatgatccttactggagcgagaataaaaagttgtctctagatacagatgcacgatttggccatggatccgactactctcgccaacagaacagatttaatgactttgatcaccgagagaggggcaggtttcctgagagttcagcagtacagtcttcatcttttgaaaggcgggatcgctttgttggtcaaagtgaggggaaaaaagcacgacctactgcacgaagggaagatccaagcttcgaaagatatcccaaaaatttcagtgactccagaagaaatgagcctccaccaccaagaaatgaacttagagaatcagacaggcgagaagtacgaggggagcgagacgaaaggagaacggtgattattcatgacaggcctgatatcactcatcctagacatcctcgagaggcagggcccaatccttccagacccaccagctggaaaagtgaaggaagcatgtccactgacaaacgggaaacaagagttgaaaggccagaacgatctgggagagaagtatcagggcacagtgtgagaggcgctccccctgggaatcgtagcagcgcttcggggtacgggagcagagagggagacagaggagtcatcacagaccgaggaggtggatcacagcactatcctgaggagcgacatgtggttgaacgccatggacgggacacaagcggaccaaggaaagagtggcatggtccaccctctcaagggcctagctatcatgatacgaggcgaatgggtgacggccgggcaggagcaggcatgataacccaacattcaagtaacgcatccccaattaatagaattgtacaaatcagtggcaattccatgccaagaggaagtggctccggatttaagccatttaagggtggacctccgcgacgattctgaaaatgagctctctgccaaggttttaagataatttattgaaatctcctgtaaactttacttgactacttatgaagaggacctctgacttgcttgagagttctgtcagacttttctttttaaaaatttaacatgattgcttttctcaattttggagaagatgtttaaatagttctgttgtaacttttaatagttttgtgtatcattcaactttttttcttgcagcaccgaggcacatttgaaaagatggaattgaagtcgttttgtttaacgctgtgtgaatataaagagtagtttgcagctgtgtggtagtggtttaatttgcagccttagctctgtggtgtctggctctagagttacttctttttaccaagcattttcagcctccattttgaaggctgtctacacttaagaagtcttagctgtctaatttttagagaataagattgttcattgcatttctgagtattatgtaacctatttttgcagaaggtactgttacattaagtgcatctgtgtatcctggtttaaaaaaatgtaatcttttttgaaataaaccttcatattctgtatagttgctaaagtgttgagaacctttttaattgtaaaatgagaaccgattttcagtttagtgtagcagcacacttgttcaggtttgcatggtatgaaaccaaatagattcatgaaaccttggccatgaggtttgtttcacaaggttcttagaccgagttgtgcaggtaagtgcacttttaggtaatctgcactgtttgtttgatggataaattccatctctgggaattgtgtgggtattaatgtttccatgttcccaactatgttgagaagtggaaaaaaacccaggttctagatgggtgaatcagttgggttttgtaaatacttgtatgtggggaagacattgttgtctttttgtgaaaataaaaatccacacctggaagtgtaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:79811 -> Molecular function: GO:0000166 [nucleotide binding] evidence: IEA
GeneID:79811 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA
GeneID:79811 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:79811 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:79811 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:79811 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:79811 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
by
@meso_cacase at
DBCLS
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