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2020-10-24 06:46:18, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_024624               5188 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens structural maintenance of chromosomes 6 (SMC6),
            transcript variant 2, mRNA.
ACCESSION   NM_024624
VERSION     NM_024624.5  GI:214010214
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5188)
  AUTHORS   Stephan,A.K., Kliszczak,M. and Morrison,C.G.
  TITLE     The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance
            of genome stability
  JOURNAL   FEBS Lett. 585 (18), 2907-2913 (2011)
   PUBMED   21550342
  REMARK    GeneRIF: Studies indicate that Nse1 may function as a ubiquitin
            ligase, and is targeted to chromatin through its interaction with
            the Smc5/6 complex.
            Review article
REFERENCE   2  (bases 1 to 5188)
  AUTHORS   Couch,F.J., Wang,X., Bamlet,W.R., de Andrade,M., Petersen,G.M. and
            McWilliams,R.R.
  TITLE     Association of mitotic regulation pathway polymorphisms with
            pancreatic cancer risk and outcome
  JOURNAL   Cancer Epidemiol. Biomarkers Prev. 19 (1), 251-257 (2010)
   PUBMED   20056645
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   3  (bases 1 to 5188)
  AUTHORS   Pebernard,S., Perry,J.J., Tainer,J.A. and Boddy,M.N.
  TITLE     Nse1 RING-like domain supports functions of the Smc5-Smc6
            holocomplex in genome stability
  JOURNAL   Mol. Biol. Cell 19 (10), 4099-4109 (2008)
   PUBMED   18667531
  REMARK    GeneRIF: Nse1 RING-like motif is a protein-protein interaction
            domain required for Smc5-Smc6 holocomplex integrity and recruitment
            to, or retention at, DNA lesions
REFERENCE   4  (bases 1 to 5188)
  AUTHORS   Taylor,E.M., Copsey,A.C., Hudson,J.J., Vidot,S. and Lehmann,A.R.
  TITLE     Identification of the proteins, including MAGEG1, that make up the
            human SMC5-6 protein complex
  JOURNAL   Mol. Cell. Biol. 28 (4), 1197-1206 (2008)
   PUBMED   18086888
  REMARK    GeneRIF: The four non-SMC components of the human complex were
            identified and characterized and it was demonstrated that the
            MAGEG1 protein is part of this complex.
REFERENCE   5  (bases 1 to 5188)
  AUTHORS   Potts,P.R. and Yu,H.
  TITLE     The SMC5/6 complex maintains telomere length in ALT cancer cells
            through SUMOylation of telomere-binding proteins
  JOURNAL   Nat. Struct. Mol. Biol. 14 (7), 581-590 (2007)
   PUBMED   17589526
  REMARK    GeneRIF: SMC5/6 complex facilitates telomere homologous
            recombination and elongation in alternative lengthening of
            telomeres cells through SUMOylation of telomere-binding proteins.
REFERENCE   6  (bases 1 to 5188)
  AUTHORS   Potts,P.R., Porteus,M.H. and Yu,H.
  TITLE     Human SMC5/6 complex promotes sister chromatid homologous
            recombination by recruiting the SMC1/3 cohesin complex to
            double-strand breaks
  JOURNAL   EMBO J. 25 (14), 3377-3388 (2006)
   PUBMED   16810316
  REMARK    GeneRIF: SMC5/6 complex is recruited to nuclease-induced
            double-strand breaks (DSBs) and is required for the recruitment of
            cohesin to DSBs.
REFERENCE   7  (bases 1 to 5188)
  AUTHORS   Potts,P.R. and Yu,H.
  TITLE     Human MMS21/NSE2 is a SUMO ligase required for DNA repair
  JOURNAL   Mol. Cell. Biol. 25 (16), 7021-7032 (2005)
   PUBMED   16055714
  REMARK    GeneRIF: the human SMC5/6 complex and the SUMO ligase activity of
            hMMS21 are required for the prevention of DNA damage-induced
            apoptosis by facilitating DNA repair in human cells
REFERENCE   8  (bases 1 to 5188)
  AUTHORS   Harvey,S.H., Sheedy,D.M., Cuddihy,A.R. and O'Connell,M.J.
  TITLE     Coordination of DNA damage responses via the Smc5/Smc6 complex
  JOURNAL   Mol. Cell. Biol. 24 (2), 662-674 (2004)
   PUBMED   14701739
REFERENCE   9  (bases 1 to 5188)
  AUTHORS   Taylor,E.M., Moghraby,J.S., Lees,J.H., Smit,B., Moens,P.B. and
            Lehmann,A.R.
  TITLE     Characterization of a novel human SMC heterodimer homologous to the
            Schizosaccharomyces pombe Rad18/Spr18 complex
  JOURNAL   Mol. Biol. Cell 12 (6), 1583-1594 (2001)
   PUBMED   11408570
REFERENCE   10 (bases 1 to 5188)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep. 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB451629.1, BC039828.1, AL832979.1 and CD369665.1.
            On Nov 25, 2008 this sequence version replaced gi:142387737.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR, compared to variant 1. Both variants 1 and 2 encode the
            same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832979.1, BC039828.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DB451629.1         1-16
            17-3859             BC039828.1         1-3843
            3860-4954           AL832979.1         3823-4917
            4955-5188           CD369665.1         2-235               c
FEATURES             Location/Qualifiers
     source          1..5188
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.2"
     gene            1..5188
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="structural maintenance of chromosomes 6"
                     /db_xref="GeneID:79677"
                     /db_xref="HGNC:20466"
                     /db_xref="HPRD:10242"
                     /db_xref="MIM:609387"
     exon            1..204
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     variation       59
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3747514"
     misc_feature    138..140
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="upstream in-frame stop codon"
     exon            205..329
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     CDS             210..3485
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="SMC protein 6; SMC6 structural maintenance of
                     chromosomes 6-like 1"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 6"
                     /protein_id="NP_078900.1"
                     /db_xref="GI:13375848"
                     /db_xref="CCDS:CCDS1690.1"
                     /db_xref="GeneID:79677"
                     /db_xref="HGNC:20466"
                     /db_xref="HPRD:10242"
                     /db_xref="MIM:609387"
                     /translation="
MAKRKEENFSSPKNAKRPRQEELEDFDKDGDEDECKGTTLTAAEVGIIESIHLKNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNRGSSLKGFVKDGQNSADISITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSATGSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKHEMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEKISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELKKSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKREELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSEFRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQILNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIATLEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLKDELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPERIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKKFIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQPGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDLILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFRPVTQEEDDDQR
"
     misc_feature    351..>821
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="P-loop containing Nucleoside Triphosphate
                     Hydrolases; Region: P-loop_NTPase; cl09099"
                     /db_xref="CDD:213113"
     misc_feature    435..458
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="Walker A/P-loop; other site"
                     /db_xref="CDD:72971"
     misc_feature    order(444..449,453..461,780..782)
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:72971"
     misc_feature    699..3416
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="Chromosome segregation ATPases [Cell division and
                     chromosome partitioning]; Region: Smc; COG1196"
                     /db_xref="CDD:31389"
     misc_feature    771..782
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="Q-loop/lid; other site"
                     /db_xref="CDD:72971"
     misc_feature    1563..2186
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96SB8.2);
                     Region: Flexible hinge"
     misc_feature    2214..2216
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q96SB8.2); phosphorylation site"
     misc_feature    <2979..>3284
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="P-loop containing Nucleoside Triphosphate
                     Hydrolases; Region: P-loop_NTPase; cl09099"
                     /db_xref="CDD:213113"
     misc_feature    3087..3092
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="Q-loop/lid; other site"
                     /db_xref="CDD:72971"
     misc_feature    <3138..3434
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="Eukaryotic SMC6 proteins; SMC proteins are large
                     (approximately 110 to 170 kDa), and each is arranged into
                     five recognizable domains.  Amino-acid sequence homology
                     of SMC proteins between species is largely confined to the
                     amino- and carboxy-terminal...; Region: ABC_SMC6_euk;
                     cd03276"
                     /db_xref="CDD:73035"
     misc_feature    3168..3197
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="ABC transporter signature motif; other site"
                     /db_xref="CDD:73035"
     misc_feature    3168..3197
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="ABC transporter signature motif; other site"
                     /db_xref="CDD:72971"
     misc_feature    3240..3257
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="Walker B; other site"
                     /db_xref="CDD:73035"
     misc_feature    3240..3257
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="Walker B; other site"
                     /db_xref="CDD:72971"
     misc_feature    3264..3275
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="D-loop; other site"
                     /db_xref="CDD:73035"
     misc_feature    3264..3275
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="D-loop; other site"
                     /db_xref="CDD:72971"
     misc_feature    3345..3365
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="H-loop/switch region; other site"
                     /db_xref="CDD:73035"
     exon            330..447
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            448..553
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            554..690
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            691..752
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            753..833
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            834..935
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            936..1055
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            1056..1154
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            1155..1301
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            1302..1390
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            1391..1555
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            1556..1734
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     variation       1599
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35195207"
     exon            1735..1939
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            1940..2054
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            2055..2215
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            2216..2351
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     variation       2280
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1065381"
     exon            2352..2432
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            2433..2603
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            2604..2741
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            2742..2887
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     variation       2886
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:35604590"
     exon            2888..3013
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     variation       2991
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:35257753"
     exon            3014..3119
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            3120..3272
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            3273..3370
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     exon            3371..5172
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:1.39.8"
     STS             3637..3820
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /standard_name="RH67770"
                     /db_xref="UniSTS:41697"
     STS             4829..4986
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /standard_name="RH94239"
                     /db_xref="UniSTS:88716"
ORIGIN      
gagggcggggcgcaggcgcggttagtaccgcggtgggcgccggggctcccgggaatctaccttctcctgcggccggcacgcggttcccagggggccagcggcggtcagccgaggtcgagacgcccgcagggtggccttagcggccggtcgtaccacggcagccccgccgatcaggttcctttgggagacttcgacttgttggcgacctgatggccaaaagaaaggaagaaaatttttcctctcctaaaaatgccaaaaggccaagacaagaagaattggaggattttgataaagatggtgacgaagacgaatgtaaaggtactactttgactgcagcagaagttggaataattgagagtattcacctaaaaaacttcatgtgtcattcaatgcttggaccttttaagtttggttctaatgtcaactttgttgttggcaacaatggaagtgggaagagtgcagtactcacagctctcatagtcggtcttggtggaagagcagttgctactaatagaggatcctctttaaaaggttttgtgaaagatggacagaactctgcagatatctcaataacattgaggaacagaggagatgatgcctttaaagccagtgtgtatggtaactctatacttatacagcaacacatcagcatagatggaagtcgatcttataaacttaaaagtgcaacaggctccgtggtttccacgaggaaagaagagctgattgcaattcttgatcattttaacatccaggtggataatccagtttctgttttaacacaagaaatgagcaagcagttcttacagtctaaaaatgaaggagacaaatacaaattcttcatgaaagcaacgcaacttgaacagatgaaggaagattattcatacattatggaaacgaaagaaagaacaaaggagcagatacatcaaggagaagagcggcttactgaactaaagcgccagtgtgtagagaaagaggaacgttttcaaagtattgctggtttaagtacaatgaagactaatttagagtccttgaaacatgaaatggcttgggcagtggtcaatgaaattgaaaaacaattgaatgccatcagagataatatcaaaattggagaagatcgtgctgctagacttgacaggaaaatggaagaacagcaggtcagacttaatgaggcagaacaaaagtacaaggatattcaagacaaactagaaaagattagtgaagagacaaatgcacgagcaccagaatgtatggcattgaaagcagatgttgttgctaagaaaagggcctataatgaagctgaggttttatataaccgatccttaaacgaatataaagcattaaagaaagatgatgagcagctttgtaaacgaattgaagagctgaaaaaaagtactgaccaatctttggaacctgaacggttggaaagacaaaaaaaaatatcttggttaaaagagagagtaaaggcctttcaaaatcaagaaaattcagtcaatcaagagatcgaacagtttcagcaagccatagaaaaggacaaagaagaacatggcaaaattaagagagaagaattagatgtgaagcatgcactgagctacaatcagaggcaactgaaagaattgaaagatagtaaaactgatcgactcaaaagatttggccctaatgttccagctcttcttgaagccatagatgatgcttatagacaaggacattttacctataaacctgtaggccctttaggagcttgcattcatcttcgggacccagaacttgctttggctattgaatcttgcttaaaagggcttctgcaggcctattgttgccataatcatgctgatgaaagggtccttcaggcactcatgaaaaggttttatttaccagggacctcacggccaccgataatagtttctgagtttcggaatgagatatatgatgtaagacacagagctgcttatcatccagactttccaacagttctgacagctttagaaatagataatgcggttgtggcaaatagcctaattgacatgagaggcatagagacagtgctactaatcaaaaataattctgtagctcgtgcagtaatgcagtcccaaaagccacccaaaaattgtagagaagcttttactgctgatggtgatcaagtttttgcaggacgttattattcatctgaaaatacaagacctaagttcctaagcagagatgtggattctgaaataagtgacttggagaatgaggttgaaaataagacggcccagatattaaatcttcagcaacatttatctgcccttgaaaaagatattaaacacaatgaggaacttcttaaaaggtgccaactacattataaagaactaaagatgaaaataagaaaaaatatttctgaaattcgggaacttgagaacatagaagaacaccagtctgtagatattgcaactttggaagatgaagctcaggaaaataaaagcaaaatgaaaatggttgaggaacatatggagcaacaaaaagaaaatatggagcatcttaaaagtctgaaaatagaagcagaaaataagtatgatgcaattaaattcaaaattaatcaactatcggagctagcagacccacttaaggatgaattaaaccttgctgattctgaagtggataaccaaaaacgagggaaacgacattatgaagaaaaacaaaaagaacacttggataccttaaataaaaagaaacgagaactggatatgaaagagaaagaactagaggagaaaatgtcacaagcaagacaaatctgcccagagcgtatagaagtagaaaaatctgcatcaattctggacaaagaaattaatcgattaaggcagaagatacaggcagaacatgctagtcatggagatcgagaggaaataatgaggcagtaccaagaagcaagagagacctatcttgatctggatagtaaagtgaggactttaaaaaagtttattaaattactgggagaaatcatggagcacagattcaagacatatcaacaatttagaaggtgtttgactttacgatgcaaattatactttgacaacttactatctcagcgggcctattgtggaaaaatgaattttgaccacaagaatgaaactctaagtatatcagttcagcctggagaaggaaataaagctgctttcaatgacatgagagccttgtctggaggtgaacgttctttctccacagtgtgttttattctttccctgtggtccatcgcagaatctcctttcagatgcctggatgaatttgatgtctacatggatatggttaataggagaattgccatggacttgatactgaagatggcagattcccagcgttttagacagtttatcttgctcacacctcaaagcatgagttcacttccatccagtaaactgataagaattctccgaatgtctgatcctgaaagaggacaaactacattgcctttcagacctgtgactcaagaagaagatgatgaccaaaggtgatttgtaacttaacatgccttgtcctgatgttgaaggatttgtgaagggaaaaaaaattctggactctttgatataataaaatgagactggaggcattctgaaatgaaagaaactcctttatatatccaaccacaatcaaacatataaataagcctggaaaaccaactacaacctgcaatttaagattactattactttaagaaaatcaatttcatagtattggttttaaatctttttaagtttttttaatacgatctatttttataggttctttttcagaagtaaaattttgtacatatatacatgtacatatctgtttagtttgggttcatttctataacattttgtaagaaaataaaagtttgagcacctgattatatttagttttgcttttccagatattacattctatagttaccaaaaatggttgaagggagggatttctcattgcagagggtggggtgcaagggaataagacacttgtacggaacactgaagctttgccaacttctacacatgccttttttgcagtcctttaactgtccaccctaccaagagcttataaccagtatcagaactggataatgacgcagtttttcactctgacctccatcatgcttgcctgatttaaaagccctcagtttgcagtccagggactgttcaggcttgtcctcagctgagaggacacaggctagagggactgtgcagaaccaggctgggagaagggctgggaaaactgggagtggagggtggatcctcatggagcaggagagtagctcatggctccaggagcctgaggccatgcagttgatggtgagctgacatcaattctaagactcatcctaattgaggggtgttaaaaagtgtgctgcttagaatgaccaaatatagttattgtaaaaaatgatatttatgaactttttattttagaaaacatgaattttattgctccctgtattatttgtttgatactaggattcatgctaaactttttaagaatgtattggatatcaagaagcattccttacattagtagcaataaatattagaataaatatgaaattgaactattttcagaaaaagggcagtatattaagagcagggactgttctctagttattgaggaaaactggactttgtttgtgtttttggtggaggaagaagtttaagatactttagtcttaaattgaggtttgccaaatgagaagttcaaaaacttgggctttctaatcagaatttccaggaggaggaaagtgtgtgctgaatattttaaacatttcccactgatcatacaaagtctgatttttaaatttacacttataatgcctttgtattaaaattatttttaacatgtgcttttccaaattaaaaatgaagtagagtataccaaatgcataaactttcattagctaaggaactcatgtctgaattttgttgtagttttgaatgttgtgctctttcatacagaatgggaaacataatcctcaggtatcccagcatctcttgttgaattgaagattattcattgctttggcctcacaaagttttgatttcaactatcataagtgaaaatatcttcctttaatgttctaagtagtgataatattactagaatgaaagaataaaaagaaattgttcttttaaaatatgtgtaacttctaaaaataaaacttaaaatttatatgtaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:79677 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:79677 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:79677 -> Biological process: GO:0000722 [telomere maintenance via recombination] evidence: IMP
            GeneID:79677 -> Biological process: GO:0000724 [double-strand break repair via homologous recombination] evidence: IEA
            GeneID:79677 -> Biological process: GO:0090398 [cellular senescence] evidence: IMP
            GeneID:79677 -> Cellular component: GO:0000781 [chromosome, telomeric region] evidence: IDA
            GeneID:79677 -> Cellular component: GO:0005622 [intracellular] evidence: IDA
            GeneID:79677 -> Cellular component: GO:0016605 [PML body] evidence: IDA
            GeneID:79677 -> Cellular component: GO:0030915 [Smc5-Smc6 complex] evidence: IDA

by @meso_cacase at DBCLS
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