GGRNA | NM_024309.3

LOCUS       NM_024309               1993 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens TNFAIP3 interacting protein 2 (TNIP2), transcript
            variant 1, mRNA.
ACCESSION   NM_024309
VERSION     NM_024309.3  GI:239787091
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1993)
  AUTHORS   Leotoing,L., Chereau,F., Baron,S., Hube,F., Valencia,H.J.,
            Bordereaux,D., Demmers,J.A., Strouboulis,J. and Baud,V.
  TITLE     A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2
            (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase
            alpha (IKKalpha)-mediated NF-kappaB transcriptional activity
  JOURNAL   J. Biol. Chem. 286 (37), 32277-32288 (2011)
   PUBMED   21784860
  REMARK    GeneRIF: ABIN-2 acts as a positive regulator of NF-kappaB-dependent
            transcription by activating IKKalpha.
REFERENCE   2  (bases 1 to 1993)
  AUTHORS   Dong,G., Chanudet,E., Zeng,N., Appert,A., Chen,Y.W., Au,W.Y.,
            Hamoudi,R.A., Watkins,A.J., Ye,H., Liu,H., Gao,Z., Chuang,S.S.,
            Srivastava,G. and Du,M.Q.
  TITLE     A20, ABIN-1/2, and CARD11 mutations and their prognostic value in
            gastrointestinal diffuse large B-cell lymphoma
  JOURNAL   Clin. Cancer Res. 17 (6), 1440-1451 (2011)
   PUBMED   21266526
  REMARK    GeneRIF: A20, ABIN-1/2, and CARD11 mutations have prognostic value
            in gastrointestinal diffuse large B-cell lymphoma
REFERENCE   3  (bases 1 to 1993)
  AUTHORS   Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci
            C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI,
            Ardlie KG, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J,
            Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding
            B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner
            DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW,
            Padyukov L, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S,
            Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma
            IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P, Altshuler D,
            Karlson EW, Toes RE, de Vries N, Begovich AB, Siminovitch KA,
            Worthington J, Klareskog L, Gregersen PK, Daly MJ and Plenge RM.
  CONSRTM   BIRAC Consortium; YEAR Consortium
  TITLE     Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with
            rheumatoid arthritis risk
  JOURNAL   Nat. Genet. 41 (12), 1313-1318 (2009)
   PUBMED   19898481
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1993)
  AUTHORS   Handoyo,H., Stafford,M.J., McManus,E., Baltzis,D., Peggie,M. and
            Cohen,P.
  TITLE     IRAK1-independent pathways required for the
            interleukin-1-stimulated activation of the Tpl2 catalytic subunit
            and its dissociation from ABIN2
  JOURNAL   Biochem. J. 424 (1), 109-118 (2009)
   PUBMED   19754427
  REMARK    GeneRIF: The IRAK1-, IKKbeta- and PP2-independent dissociation of
            Tpl2 from ABIN2 is one of the two signalling events involved in
            activation of the native Tpl2 complex by IL-1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1993)
  AUTHORS   Verstrepen,L., Carpentier,I., Verhelst,K. and Beyaert,R.
  TITLE     ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling
  JOURNAL   Biochem. Pharmacol. 78 (2), 105-114 (2009)
   PUBMED   19464428
  REMARK    GeneRIF: This review defines ABIN-2 based on three different
            parameters: ability to bind A20; ability to inhibit NF-kappaB
            activation upon overexpression; the presence of specific short
            amino acid regions of strong homology, designated ABIN homology
            domains.
            Review article
REFERENCE   6  (bases 1 to 1993)
  AUTHORS   Liu,W.K., Chien,C.Y., Chou,C.K. and Su,J.Y.
  TITLE     An LKB1-interacting protein negatively regulates TNFalpha-induced
            NF-kappaB activation
  JOURNAL   J. Biomed. Sci. 10 (2), 242-252 (2003)
   PUBMED   12595760
  REMARK    GeneRIF: FLIP1 has a role in the regulation of NF-kappaB activity
            related to the role of LKB1 in tumor suppression
REFERENCE   7  (bases 1 to 1993)
  AUTHORS   Wu,W.S., Xu,Z.X. and Chang,K.S.
  TITLE     The promyelocytic leukemia protein represses A20-mediated
            transcription
  JOURNAL   J. Biol. Chem. 277 (35), 31734-31739 (2002)
   PUBMED   12080044
  REMARK    GeneRIF: transcription repressed by promyelocytic leukemia protein
            expression
REFERENCE   8  (bases 1 to 1993)
  AUTHORS   Van Huffel,S., Delaei,F., Heyninck,K., De Valck,D. and Beyaert,R.
  TITLE     Identification of a novel A20-binding inhibitor of nuclear
            factor-kappa B activation termed ABIN-2
  JOURNAL   J. Biol. Chem. 276 (32), 30216-30223 (2001)
   PUBMED   11390377
REFERENCE   9  (bases 1 to 1993)
  AUTHORS   Klinkenberg,M., Van Huffel,S., Heyninck,K. and Beyaert,R.
  TITLE     Functional redundancy of the zinc fingers of A20 for inhibition of
            NF-kappaB activation and protein-protein interactions
  JOURNAL   FEBS Lett. 498 (1), 93-97 (2001)
   PUBMED   11389905
REFERENCE   10 (bases 1 to 1993)
  AUTHORS   Heyninck,K., De Valck,D., Vanden Berghe,W., Van Criekinge,W.,
            Contreras,R., Fiers,W., Haegeman,G. and Beyaert,R.
  TITLE     The zinc finger protein A20 inhibits TNF-induced
            NF-kappaB-dependent gene expression by interfering with an RIP- or
            TRAF2-mediated transactivation signal and directly binds to a novel
            NF-kappaB-inhibiting protein ABIN
  JOURNAL   J. Cell Biol. 145 (7), 1471-1482 (1999)
   PUBMED   10385526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF372839.1, AL110117.3 and BC002740.2.
            On Jun 11, 2009 this sequence version replaced gi:34147369.
            
            Summary: TNIP2 binds to the C-terminal zinc finger domain of A20
            (TNFAIP3; MIM 191163) and is involved in activation of the ERK (see
            MAPK3; MIM 601795) MAP kinase pathway in various cell types (Van
            Huffel et al., 2001 [PubMed 11390377]; Papoutsopoulou et al., 2006
            [PubMed 16633345]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF372839.1, AK096296.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1361              AF372839.1         1-1361
            1362-1362           AL110117.3         6761-6761
            1363-1993           BC002740.2         1321-1951
FEATURES             Location/Qualifiers
     source          1..1993
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..1993
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /note="TNFAIP3 interacting protein 2"
                     /db_xref="GeneID:79155"
                     /db_xref="HGNC:19118"
                     /db_xref="MIM:610669"
     exon            1..363
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /inference="alignment:Splign:1.39.8"
     CDS             88..1377
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     A20-binding inhibitor of NF-kappaB activation-2; fetal
                     liver LKB1-interacting protein; TNFAIP3-interacting
                     protein 2; A20-binding inhibitor of NF-kappa-B activation
                     2"
                     /codon_start=1
                     /product="TNFAIP3-interacting protein 2 isoform 1"
                     /protein_id="NP_077285.3"
                     /db_xref="GI:239787092"
                     /db_xref="CCDS:CCDS3362.1"
                     /db_xref="GeneID:79155"
                     /db_xref="HGNC:19118"
                     /db_xref="MIM:610669"
                     /translation="

MSRDPGSGGWEEAPRAAAALCTLYHEAGQRLRRLQDQLAARDALIARLRARLAALEGDAAPSLVDALLEQVARFREQLRRQEGGAAEAQMRQEIERLTERLEEKEREMQQLLSQPQHEREKEVVLLRRSMAEGERARAASDVLCRSLANETHQLRRTLTATAHMCQHLAKCLDERQHAQRNVGERSPDQSEHTDGHTSVQSVIEKLQEENRLLKQKVTHVEDLNAKWQRYNASRDEYVRGLHAQLRGLQIPHEPELMRKEISRLNRQLEEKINDCAEVKQELAASRTARDAALERVQMLEQQILAYKDDFMSERADRERAQSRIQELEEKVASLLHQVSWRQDSREPDAGRIHAGSKTAKYLAADALELMVPGGWRPGTGSQQPEPPAEGGHPGAAQRGQGDLQCPHCLQCFSDEQGEELLRHVAECCQ

"
     misc_feature    727..831
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /note="TSG101 and ALIX binding domain of CEP55; Region:
                     EABR; pfam12180"
                     /db_xref="CDD:152615"
     misc_feature    952..1128
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8NFZ5.1);
                     Region: Ubiquitin-binding domain (UBD)"
     exon            364..654
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /inference="alignment:Splign:1.39.8"
     exon            655..744
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /inference="alignment:Splign:1.39.8"
     exon            745..993
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /inference="alignment:Splign:1.39.8"
     exon            994..1113
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /inference="alignment:Splign:1.39.8"
     exon            1114..1974
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /inference="alignment:Splign:1.39.8"
     variation       1274
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2269495"
     variation       1362
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:232712"
     variation       1683
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:10587"
     STS             1719..1926
                     /gene="TNIP2"
                     /gene_synonym="ABIN2; FLIP1; KLIP"
                     /standard_name="SHGC-68050"
                     /db_xref="UniSTS:5182"
ORIGIN

ggaaagttccgggaagggcggcagccggcggggcccgggcgcggaagttgccggcggccgcgcggcctcccgggcgggcctacagccatgtcccgggacccggggtcgggcggctgggaggaggccccgcgcgcagctgccgcgctctgcaccctgtaccacgaggccggacagcggctgcgccgcctgcaggaccagctcgctgcccgcgacgccctcatcgctcgcctccgcgcccgcctggccgcgctggagggggacgccgcgccgtccctagtggacgcgctgctggagcaggttgcgcgcttccgggagcagctgcgaaggcaggagggcggcgccgccgaggcccagatgcgccaggaaattgagaggctgactgagcgactagaagaaaaagagagggagatgcagcagctgctgagccagccccaacacgagcgagagaaggaagtcgtcctgctacggaggagcatggcagaaggggagcgcgcccgggccgccagtgacgtcctgtgccgctccttggccaacgagacccatcagctgcggaggacgctgaccgccaccgcccacatgtgtcagcatctggccaagtgtctggatgaacgacagcatgcacaaaggaatgtgggggagagaagtcctgaccagtcggaacacacagatgggcacacctctgtccagagtgttattgagaagttgcaggaagaaaatcgactgttaaaacagaaggtgactcacgttgaagacctcaatgccaagtggcagcgctacaacgccagcagggacgaatacgtgagggggctccatgcgcagctcagggggctgcagatcccccacgagcccgagctgatgaggaaggagatctcccggctcaacagacagttggaagagaaaataaatgactgtgccgaagtgaagcaggagctggcggcctccaggacggcccgggatgctgcgttggagcgggtgcagatgctggaacagcagattctcgcttacaaggatgacttcatgtcagaaagggccgatcgggaacgggctcaaagtaggattcaagaactggaggaaaaggtcgcctctttgctgcaccaggtgtcctggagacaggattctcgagagccagacgccggccggattcacgctgggagcaaaactgccaagtatttggccgccgacgcattagagcttatggtgcctggtggctggaggcctgggactgggtcccagcagccagaaccccctgcagagggcgggcatcctggcgcggcccagagaggccagggggaccttcagtgccctcactgcctgcagtgcttcagtgacgagcaaggggaagagctcctcaggcatgtggctgagtgctgccagtgaccgagactcacccgtgcccttgcggcctcctggcccggtgcagctgccctcagggacagggtgggtgctctcagatgccatgggttgagctctactgagagccaaggcccctagaatagttgcggggcactctgatcgttcactttggtccctttggctatggaacaggctgggtcacagggaactgccagtgaggctggaggctggaggtggagatggggtcaggaacatctggcagagggaggtcccagtctgtgtctccatcaggcttaagccagagctatctggtgctggtgtgccagcccctcccccagcctgcctagaaaggggtggctgcctgagggagtcacttgtatggtccccagggtgggagccccatcctgttctatggaataaagcgtcgcctctctgcctcgaaccagtcaaatggagtattgcggctgcacgtcacactagggtggccacccccgccattgcgagccacatgtctgcactgagaaactgcatttcagtagcatttgtcatccagccggaagttaaagcacacttactttattcacctatttttataataaacgttcttgctgctgtgactgcaaaaaaaaaaaaaaaaaaa

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