LOCUS       NM_024016               1834 bp    mRNA    linear   PRI 16-JUN-2013
DEFINITION  Homo sapiens homeobox B8 (HOXB8), mRNA.
ACCESSION   NM_024016
VERSION     NM_024016.3  GI:85543349
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1834)
  AUTHORS   Stavnes,H.T., Holth,A., Don,T., Kaern,J., Vaksman,O., Reich,R.,
            Trope',C.G. and Davidson,B.
  TITLE     HOXB8 expression in ovarian serous carcinoma effusions is
            associated with shorter survival
  JOURNAL   Gynecol. Oncol. 129 (2), 358-363 (2013)
   PUBMED   23438671
  REMARK    GeneRIF: HOXB5 and HOXB8 are frequently expressed in ovarian serous
            carcinoma, with anatomic site-related differences for cytoplasmic
            staining. HOXB8 expression is associated with shorter survival in
            metastatic serous carcinoma.
REFERENCE   2  (bases 1 to 1834)
  AUTHORS   Kosaki,K., Kosaki,R., Suzuki,T., Yoshihashi,H., Takahashi,T.,
            Sasaki,K., Tomita,M., McGinnis,W. and Matsuo,N.
  TITLE     Complete mutation analysis panel of the 39 human HOX genes
  JOURNAL   Teratology 65 (2), 50-62 (2002)
   PUBMED   11857506
REFERENCE   3  (bases 1 to 1834)
  AUTHORS   Greer,J.M. and Capecchi,M.R.
  TITLE     Hoxb8 is required for normal grooming behavior in mice
  JOURNAL   Neuron 33 (1), 23-34 (2002)
   PUBMED   11779477
REFERENCE   4  (bases 1 to 1834)
  AUTHORS   Knoepfler,P.S., Sykes,D.B., Pasillas,M. and Kamps,M.P.
  TITLE     HoxB8 requires its Pbx-interaction motif to block differentiation
            of primary myeloid progenitors and of most cell line models of
            myeloid differentiation
  JOURNAL   Oncogene 20 (39), 5440-5448 (2001)
   PUBMED   11571641
REFERENCE   5  (bases 1 to 1834)
  AUTHORS   Fujino,T., Yamazaki,Y., Largaespada,D.A., Jenkins,N.A.,
            Copeland,N.G., Hirokawa,K. and Nakamura,T.
  TITLE     Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis
            homeobox genes
  JOURNAL   Exp. Hematol. 29 (7), 856-863 (2001)
   PUBMED   11438208
REFERENCE   6  (bases 1 to 1834)
  AUTHORS   Apiou,F., Flagiello,D., Cillo,C., Malfoy,B., Poupon,M.F. and
            Dutrillaux,B.
  TITLE     Fine mapping of human HOX gene clusters
  JOURNAL   Cytogenet. Cell Genet. 73 (1-2), 114-115 (1996)
   PUBMED   8646877
REFERENCE   7  (bases 1 to 1834)
  AUTHORS   Peverali,F.A., D'Esposito,M., Acampora,D., Bunone,G., Negri,M.,
            Faiella,A., Stornaiuolo,A., Pannese,M., Migliaccio,E., Simeone,A.
            et al.
  TITLE     Expression of HOX homeogenes in human neuroblastoma cell culture
            lines
  JOURNAL   Differentiation 45 (1), 61-69 (1990)
   PUBMED   1981366
REFERENCE   8  (bases 1 to 1834)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res. 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   9  (bases 1 to 1834)
  AUTHORS   Giampaolo,A., Acampora,D., Zappavigna,V., Pannese,M.,
            D'Esposito,M., Care,A., Faiella,A., Stornaiuolo,A., Russo,G.,
            Simeone,A. et al.
  TITLE     Differential expression of human HOX-2 genes along the
            anterior-posterior axis in embryonic central nervous system
  JOURNAL   Differentiation 40 (3), 191-197 (1989)
   PUBMED   2570724
REFERENCE   10 (bases 1 to 1834)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK096222.1, BF761142.1,
            AI672407.1, AW612644.1 and AI277015.1.
            On Jan 20, 2006 this sequence version replaced gi:25121964.
            
            Summary: This gene is a member of the Antp homeobox family and
            encodes a nuclear protein with a homeobox DNA-binding domain. It is
            included in a cluster of homeobox B genes located on chromosome 17.
            The encoded protein functions as a sequence-specific transcription
            factor that is involved in development. Increased expression of
            this gene is associated with colorectal cancer. Mice that have had
            the murine ortholog of this gene knocked out exhibit an excessive
            pathologic grooming behavior. This behavior is similar to the
            behavior of humans suffering from the obsessive-compulsive spectrum
            disorder trichotillomania. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096222.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025090 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               AK096222.1         1-482
            483-484             BF761142.1         66-67
            485-866             AK096222.1         485-866
            867-868             AI672407.1         90-91               c
            869-1583            AK096222.1         869-1583
            1584-1585           AW612644.1         255-256
            1586-1815           AK096222.1         1586-1815
            1816-1834           AI277015.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.3"
     gene            1..1834
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /note="homeobox B8"
                     /db_xref="GeneID:3218"
                     /db_xref="HGNC:5119"
                     /db_xref="HPRD:00851"
                     /db_xref="MIM:142963"
     exon            1..659
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(70)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138537883"
     STS             98..1489
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /db_xref="UniSTS:494539"
     STS             105..1546
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /db_xref="UniSTS:489938"
     misc_feature    113..115
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /note="upstream in-frame stop codon"
     STS             145..1158
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /db_xref="UniSTS:480723"
     variation       complement(152)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372183832"
     STS             184..1059
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /db_xref="UniSTS:482549"
     CDS             236..967
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /note="homeo box B8; homeo box 2D; homeobox protein
                     Hox-2D; homeobox protein Hox-2.4"
                     /codon_start=1
                     /product="homeobox protein Hox-B8"
                     /protein_id="NP_076921.1"
                     /db_xref="GI:13273317"
                     /db_xref="CCDS:CCDS11533.1"
                     /db_xref="GeneID:3218"
                     /db_xref="HGNC:5119"
                     /db_xref="HPRD:00851"
                     /db_xref="MIM:142963"
                     /translation="

MSSYFVNSLFSKYKTGESLRPNYYDCGFAQDLGGRPTVVYGPSSGGSFQHPSQIQEFYHGPSSLSTAPYQQNPCAVACHGDPGNFYGYDPLQRQSLFGAQDPDLVQYADCKLAAASGLGEEAEGSEQSPSPTQLFPWMRPQAAAGRRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKCEQEELEKQKLERAPEAADEGDAQKGDKK

"
     misc_feature    635..652
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P17481.2);
                     Region: Antp-type hexapeptide"
     misc_feature    686..850
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(686..688,692..694,743..745,761..763,800..802,
                     806..811,818..823,827..835,839..844)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(689..691,809..811,818..823,830..832)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     STS             254..394
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /standard_name="Hoxb8"
                     /db_xref="UniSTS:536655"
     variation       complement(280)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370314418"
     variation       complement(312)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202069371"
     variation       complement(328)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199877083"
     variation       complement(427)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374945607"
     variation       complement(433)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201120876"
     variation       complement(482)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150150478"
     variation       complement(493)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2303484"
     variation       complement(504)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:140795156"
     variation       complement(538)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112978726"
     variation       complement(577)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202042736"
     variation       complement(584)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61737568"
     variation       complement(590)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199840850"
     variation       complement(607)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200695320"
     exon            660..1823
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(709)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:150977043"
     variation       complement(724)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370269047"
     variation       complement(754)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:45441492"
     variation       complement(766)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:139515389"
     variation       complement(775)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376895204"
     variation       complement(784)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374013661"
     variation       complement(829)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147771525"
     variation       complement(844)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200705227"
     variation       complement(871)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199714142"
     variation       complement(885)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369933784"
     variation       complement(901)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376484541"
     variation       complement(908)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:112046402"
     variation       complement(914)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373819933"
     variation       complement(1020)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:368268515"
     variation       complement(1073)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:56052247"
     variation       complement(1209)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45572038"
     variation       complement(1293)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34679352"
     variation       complement(1334)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201858397"
     variation       complement(1382)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148900317"
     variation       complement(1405)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147839497"
     variation       complement(1442..1443)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace=""
                     /replace="tc"
                     /db_xref="dbSNP:371683237"
     variation       complement(1443..1444)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace=""
                     /replace="cg"
                     /replace="tc"
                     /db_xref="dbSNP:140231017"
     variation       complement(1444..1445)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace=""
                     /replace="gc"
                     /db_xref="dbSNP:201227589"
     variation       complement(1444)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:72829888"
     variation       complement(1449..1452)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace=""
                     /replace="ctcg"
                     /db_xref="dbSNP:68041649"
     variation       complement(1452..1455)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace=""
                     /replace="gctc"
                     /db_xref="dbSNP:71356525"
     variation       complement(1579)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:185485263"
     variation       complement(1716)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370594191"
     variation       complement(1739)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:9380"
     variation       complement(1778)
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:114859649"
     polyA_signal    1798..1803
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
     polyA_site      1823
                     /gene="HOXB8"
                     /gene_synonym="Hox-2.4; HOX2; HOX2D"
ORIGIN      

ccttttctattcctggaaaccacaaaaagtgtgtcggcttcgagatcttcttcgccttttctttcttttctttttttccctcctctctttccctctcctttcctggcgagggtgactaggagccggcgaatccgcgtttttttctctctctccctccctttccccctccccaccccctccccaacagcccccaactatagcctccgccgccgccgccgcctcaaaattcaataaaatgagctcttatttcgtcaactcactgttctccaaatacaaaaccggggagtccctgcgccccaattattatgactgcggcttcgcccaggacctgggcggccgacccaccgtggtgtacggtcccagcagcggcggcagcttccagcacccgtcgcaaatccaggagttctaccacgggccgtcgtcgctgtccacggctccctaccagcagaacccgtgcgccgtggcgtgccacggggaccccggcaatttctacggctacgacccgctgcaacgccagagcctattcggtgcgcaggatccagacctggtgcagtacgcagactgcaagcttgccgccgccagcggcctgggcgaggaggccgagggctccgagcagagcccgtcgcccacacagctcttcccctggatgcgcccgcaagcagccgccggacgcaggcgaggccgacagacctacagccgctaccagaccctggagctggagaaggagttcctatttaatccctatctgactcgtaagcggcgaatcgaggtatcgcacgccctgggactgacagagagacaggtcaaaatctggttccagaaccggaggatgaagtggaaaaaagagaacaacaaagacaagttccccagcagcaaatgcgagcaggaggagctggagaaacagaagctggagcgggccccagaggcggcggacgagggcgacgcgcagaagggcgacaagaagtaggcttcagctgggactgccagggccgcggccgcccgcacgtccgcgggtcccggccgcgccgccgccgcgcgcccctgcccgagagagctctggccccgctagcggggccaggagccgggcctcccaccgcagcgtcccccgccgcgccagtccccgctagtggtagtatctcgtaatagcttctgtgtgtgagctaccgtggatctccttcccttctcttgggggccggggggaaagaaaaggatttaagcaaaggctccctcgccctgtgagggcgagcggcaaaggcccggctgagccccccatgcccctcccctccccgtgtaaaaagcctccttgtgcaattgtcttttttttcctttgaacgtgcttctttgtaatgaccaaggtaccgatttctgctaagttctcccaacaacatgaaactgcctattcacgccgtaattctttctgtctcccttctctctctctctctcgctcgctcgctctcgctctcgctctctctcgctgcgtcctcatttcccctcccaatcctctctcccctctgcaaccccccagctcgctggctttctctctggcttctctcttttcctcctccacccaccccctttggtttgacaattttgtcttaagtgtttctcaaaagaggttactttagttagcatgcgcgctgtgggcaattgttacaagtgttcttaggtttactgtgaagagaatgtattctgtatccgtgaattgctttatgggggggagggagggctaattatatattttgttgttcctctatactttgttctgttgtctgcgcctgaaaagggcggaagagttacaataaagtttacaagcgagaacccgaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3218 -> Molecular function: GO:0000976 [transcription regulatory region sequence-specific DNA binding] evidence: IEA
            GeneID:3218 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: NAS
            GeneID:3218 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:3218 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: NAS
            GeneID:3218 -> Biological process: GO:0007275 [multicellular organismal development] evidence: NAS
            GeneID:3218 -> Biological process: GO:0007625 [grooming behavior] evidence: IEA
            GeneID:3218 -> Biological process: GO:0008344 [adult locomotory behavior] evidence: IEA
            GeneID:3218 -> Biological process: GO:0009952 [anterior/posterior pattern specification] evidence: IEA
            GeneID:3218 -> Biological process: GO:0019233 [sensory perception of pain] evidence: IEA
            GeneID:3218 -> Biological process: GO:0021516 [dorsal spinal cord development] evidence: IEA
            GeneID:3218 -> Biological process: GO:0045638 [negative regulation of myeloid cell differentiation] evidence: ISS
            GeneID:3218 -> Biological process: GO:0048704 [embryonic skeletal system morphogenesis] evidence: IEA
            GeneID:3218 -> Cellular component: GO:0005634 [nucleus] evidence: NAS