2024-04-25 16:09:08, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_024011 2650 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens cyclin-dependent kinase 11A (CDK11A), transcript variant 1, mRNA. ACCESSION NM_024011 NM_033621 XM_001713742 XM_001713743 XM_001713744 XM_001713745 XM_001713746 XM_001713747 VERSION NM_024011.2 GI:148763346 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2650) AUTHORS Olson,J.E., Wang,X., Pankratz,V.S., Fredericksen,Z.S., Vachon,C.M., Vierkant,R.A., Cerhan,J.R. and Couch,F.J. TITLE Centrosome-related genes, genetic variation, and risk of breast cancer JOURNAL Breast Cancer Res. Treat. 125 (1), 221-228 (2011) PUBMED 20508983 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 2 (bases 1 to 2650) AUTHORS Malumbres,M., Harlow,E., Hunt,T., Hunter,T., Lahti,J.M., Manning,G., Morgan,D.O., Tsai,L.H. and Wolgemuth,D.J. TITLE Cyclin-dependent kinases: a family portrait JOURNAL Nat. Cell Biol. 11 (11), 1275-1276 (2009) PUBMED 19884882 REFERENCE 3 (bases 1 to 2650) AUTHORS Kong,X., Gan,H., Hao,Y., Cheng,C., Jiang,J., Hong,Y., Yang,J., Zhu,H., Chi,Y., Yun,X. and Gu,J. TITLE CDK11p58 phosphorylation of PAK1 Ser174 promotes DLC2 binding and roles on cell cycle progression JOURNAL J. Biochem. 146 (3), 417-427 (2009) PUBMED 19520772 REMARK GeneRIF: study identified p21 activated kinase 1 (PAK1) as a new CDK11(p58) substrate; mapped a new phosphorylation site of Ser174 on PAK1; results indicated PAK1 may serve as a downstream effector of CDK11(p58) during mitosis progression REFERENCE 4 (bases 1 to 2650) AUTHORS Shi,J., Hershey,J.W. and Nelson,M.A. TITLE Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis JOURNAL FEBS Lett. 583 (6), 971-977 (2009) PUBMED 19245811 REMARK GeneRIF: Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis. REFERENCE 5 (bases 1 to 2650) AUTHORS Wang,Y., Zong,H., Chi,Y., Hong,Y., Yang,Y., Zou,W., Yun,X. and Gu,J. TITLE Repression of estrogen receptor alpha by CDK11p58 through promoting its ubiquitin-proteasome degradation JOURNAL J. Biochem. 145 (3), 331-343 (2009) PUBMED 19122208 REMARK GeneRIF: These data identified a new negative regulatory protein of ERalpha and provided a new pathway by which CDK11(p58) negatively regulated cells. REFERENCE 6 (bases 1 to 2650) AUTHORS White,P.S., Maris,J.M., Beltinger,C., Sulman,E., Marshall,H.N., Fujimori,M., Kaufman,B.A., Biegel,J.A., Allen,C., Hilliard,C., Valentine,M.B., Look,A.T., Enomoto,H., Sakiyama,S. and Brodeur,G.M. TITLE A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (12), 5520-5524 (1995) PUBMED 7777541 REFERENCE 7 (bases 1 to 2650) AUTHORS Lahti,J.M., Valentine,M., Xiang,J., Jones,B., Amann,J., Grenet,J., Richmond,G., Look,A.T. and Kidd,V.J. TITLE Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma JOURNAL Nat. Genet. 7 (3), 370-375 (1994) PUBMED 7920654 REFERENCE 8 (bases 1 to 2650) AUTHORS Eipers,P.G., Lahti,J.M. and Kidd,V.J. TITLE Structure and expression of the human p58clk-1 protein kinase chromosomal gene JOURNAL Genomics 13 (3), 613-621 (1992) PUBMED 1639388 REFERENCE 9 (bases 1 to 2650) AUTHORS Eipers,P.G., Barnoski,B.L., Han,J., Carroll,A.J. and Kidd,V.J. TITLE Localization of the expressed human p58 protein kinase chromosomal gene to chromosome 1p36 and a highly related sequence to chromosome 15 JOURNAL Genomics 11 (3), 621-629 (1991) PUBMED 1774066 REFERENCE 10 (bases 1 to 2650) AUTHORS Bunnell,B.A., Heath,L.S., Adams,D.E., Lahti,J.M. and Kidd,V.J. TITLE Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (19), 7467-7471 (1990) PUBMED 2217177 REMARK Erratum:[Proc Natl Acad Sci U S A 1991 Mar 15;88(6):2612] COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC388505.1, AF067519.1, AL043340.1 and BC094827.1. This sequence is a reference standard in the RefSeqGene project. On or before Nov 15, 2008 this sequence version replaced gi:169160760, gi:169160762, gi:169160764, gi:169160766, gi:169160768, gi:169160770, gi:16357497. Summary: This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF067519.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-433 DC388505.1 1-433 434-952 AF067519.1 405-923 953-1554 AL043340.1 93-694 1555-2650 BC094827.1 532-1627 FEATURES Location/Qualifiers source 1..2650 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="1" /map="1p36.33" gene 1..2650 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /note="cyclin-dependent kinase 11A" /db_xref="GeneID:728642" /db_xref="HGNC:1730" /db_xref="MIM:116951" exon 1..95 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" misc_feature 91..93 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /note="upstream in-frame stop codon" exon 96..219 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" CDS 109..2451 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /EC_number="2.7.11.22" /note="isoform 1 is encoded by transcript variant 1; cell division cycle 2-like 2 (PITSLRE proteins); PITSLRE protein kinase beta; PITSLRE B; galactosyltransferase-associated protein kinase p58/GTA; cell division protein kinase 11A; PITSLRE serine/threonine-protein kinase CDC2L2; cell division cycle 2-like protein kinase 2" /codon_start=1 /product="cyclin-dependent kinase 11A isoform 1" /protein_id="NP_076916.2" /db_xref="GI:148763347" /db_xref="CCDS:CCDS44042.1" /db_xref="GeneID:728642" /db_xref="HGNC:1730" /db_xref="MIM:116951" /translation="
MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
" misc_feature 382..384 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 802..804 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 910..912 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 916..918 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 1357..2232 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /note="Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; Region: STKc_CDC2L1; cd07843" /db_xref="CDD:173741" misc_feature 1366..2238 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /note="cyclin-dependent kinase A; Provisional; Region: PLN00009" /db_xref="CDD:177649" misc_feature order(1393..1404,1417..1419,1456..1458,1462..1464, 1513..1515,1555..1557,1609..1620,1627..1629,1633..1638, 1747..1749,1753..1755,1759..1764,1768..1770,1801..1803, 1810..1812,1846..1848,1852..1863,1867..1869,1981..1986) /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /note="active site" /db_xref="CDD:173741" misc_feature order(1393..1404,1417..1419,1456..1458,1462..1464, 1555..1557,1609..1620,1627..1629,1636..1638,1759..1764, 1768..1770,1801..1803) /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:173741" misc_feature order(1489..1497,1501..1503,1510..1515,1519..1524, 1531..1536,1570..1572,1576..1578,1597..1599,1714..1716, 1723..1734,1816..1818,1822..1833,1843..1848,2188..2190, 2200..2208) /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /note="CDK/cyclin interface [polypeptide binding]; other site" /db_xref="CDD:173741" misc_feature order(1513..1515,1633..1635,1747..1749,1753..1755, 1810..1812,1846..1848,1852..1863,1867..1869,1981..1986) /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:173741" misc_feature order(1798..1833,1837..1869) /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /note="activation loop (A-loop); other site" /db_xref="CDD:173741" misc_feature 1846..1848 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 2314..2316 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 2317..2319 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" exon 220..335 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" variation 277 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /replace="c" /replace="t" /db_xref="dbSNP:17424353" exon 336..463 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" exon 464..596 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" exon 597..733 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" exon 734..856 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" exon 857..952 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" exon 953..1111 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" STS 1059..2475 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /db_xref="UniSTS:484401" exon 1112..1177 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" exon 1178..1353 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" exon 1354..1444 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" exon 1445..1566 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" variation 1554 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /replace="c" /replace="t" /db_xref="dbSNP:2377226" exon 1567..1672 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" exon 1673..1794 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" exon 1795..1902 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" exon 1903..2019 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" exon 2020..2168 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" exon 2169..2358 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" exon 2359..2628 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" /inference="alignment:Splign:1.39.8" polyA_signal 2599..2604 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" polyA_site 2628 /gene="CDK11A" /gene_synonym="CDC2L2; CDC2L3; CDK11-p110; CDK11-p46; CDK11-p58; p58GTA; PITSLRE" ORIGIN
atcattaggcgtcaacacaggaagtgaggatacttctggcgagcgccggttgctgtttcttctcaggctcagggaccggccgcggccccgtagggtgttttaactcaaatgggtgatgaaaaggactcttggaaagtgaaaactttagatgaaattcttcaggaaaagaaacgaaggaaggaacaagaggagaaagcagagataaaacgcttaaaaaattctgatgaccgggattccaagcgggattcccttgaggagggggagctgagagatcactgcatggagatcacaataaggaactccccgtatagaagagaagactcaatggaagacagaggagaagaagatgattctttggccatcaaaccaccccagcaaatgtctcggaaagaaaaagttcatcacagaaaagatgaaaagagaaaagaaaaatgtaggcatcatagccattcagcagaaggggggaagcatgctagagtgaaagaaagagagcacgaacgtcggaaacgacatcgagaagaacaggataaagctcgccgggaatgggaaagacagaagagaagggaaatggcaagggagcattccaggagagaaagggaccgcttggagcagttagaaaggaagcgggagcgggagcgcaagatgcgggagcagcagaaggagcagcgggagcagaaggagcgcgagcggcgggcggaggagcggcgcaaggagcgggaggcccgcagggaagtgtctgcacatcaccgaacgatgagagaggactacagcgacaaagtgaaagccagccactggagtcgcagcccgcctcggccgccgcgggagcggttcgagttgggagacggccggaagccagtaaaagaagagaaaatggaagaaagggacctgctgtccgacttacaggacatcagcgacagcgagaggaagaccagctcggccgagtcctcgtcagcggaatcaggctcaggttctgaggaagaagaggaggaggaggaagaggaggaggaggaagggagcaccagtgaagaatcagaggaggaggaggaggaagaggaagaggaggaggaggagaccggcagcaactctgaggaggcatcagagcagtctgccgaagaagtaagtgaggaagaaatgagtgaagatgaagaacgagaaaatgaaaaccacctcttggttgttccagagtcacggttcgaccgagattccggggagagtgaagaagcagaggaagaagtgggtgagggaacgccgcagagcagcgccctgacagagggcgactatgtgcccgactcccctgccctgttgcccatcgagctcaagcaggagctgcccaagtacctgccggccctgcagggctgccggagcgtcgaggagttccagtgcctgaacaggatcgaggagggcacctatggagtggtctacagagcaaaagacaagaaaacagatgaaattgtggctctaaagcggctgaagatggagaaggagaaggagggcttcccgatcacgtccctgagggagatcaacaccatcctcaaggcccagcatcccaacattgtcaccgttagagagattgtggtgggcagcaacatggacaagatctacatcgtgatgaactacgtggagcacgacctcaagagcctgatggagaccatgaaacagcccttcctgccaggggaggtgaagaccctgatgatccagctgctgcggggggtgaaacacctgcacgacaactggatcctgcaccgtgacctcaagacgtccaacctgctgctgagccacgccggcatcctcaaggtgggtgattttgggctggcgcgggagtacggatcccctctgaaggcctacaccccggtcgtggtgacccagtggtaccgcgccccagagctgctgcttggtgccaaggaatactccacggccgtggacatgtggtcagtgggctgcatcttcggggagctgctgactcagaagcctctgttccccgggaattcggaaatcgatcagatcaacaaagtgttcaaggagctggggacccccagtgagaaaatctggcccggctacagtgagctcccagtagtcaaaaagatgaccttcagcgagcacccctacaacaacctccgcaagcgcttcggggctctgctctcagaccagggcttcgacctcatgaacaagttcctgacctacttccccgggaggaggatcagcgctgaggacggcctcaagcatgagtatttccgcgagacccccctccccatcgacccctccatgttccccacgtggcccgccaagagcgagcagcagcgtgtgaagcggggcaccagcccgaggccccctgagggaggcctgggctacagccagctgggtgacgacgacctgaaggagacgggcttccaccttaccaccacgaaccagggggcctctgccgcgggccccggcttcagcctcaagttctgaaggtcagagtggaccccgtcatggggagaactcagccgggaccacaggcgtggctactgcggctggagctgcgatgagactcggaactcctcgtcttactttgtgctccatgttttgtttttgtattttggtttgtaaatttgtagaattaaatcattttccttgttgtggaggaaaaaaaaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:728642 -> Molecular function: GO:0004672 [protein kinase activity] evidence: NAS GeneID:728642 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA GeneID:728642 -> Molecular function: GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] evidence: IEA GeneID:728642 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA GeneID:728642 -> Biological process: GO:0001558 [regulation of cell growth] evidence: IEP GeneID:728642 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: NAS GeneID:728642 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA GeneID:728642 -> Biological process: GO:0006915 [apoptotic process] evidence: NAS GeneID:728642 -> Biological process: GO:0007067 [mitosis] evidence: NAS GeneID:728642 -> Biological process: GO:0050684 [regulation of mRNA processing] evidence: IDA GeneID:728642 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:728642 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_076916 -> EC 2.7.11.22
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