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2024-03-29 23:41:07, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_022970               4657 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens fibroblast growth factor receptor 2 (FGFR2),
            transcript variant 2, mRNA.
ACCESSION   NM_022970 NM_022969
VERSION     NM_022970.3  GI:189083816
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4657)
  AUTHORS   Rinella,E.S., Shao,Y., Yackowski,L., Pramanik,S., Oratz,R.,
            Schnabel,F., Guha,S., LeDuc,C., Campbell,C.L., Klugman,S.D.,
            Terry,M.B., Senie,R.T., Andrulis,I.L., Daly,M., John,E.M.,
            Roses,D., Chung,W.K. and Ostrer,H.
  TITLE     Genetic variants associated with breast cancer risk for Ashkenazi
            Jewish women with strong family histories but no identifiable
            BRCA1/2 mutation
  JOURNAL   Hum. Genet. 132 (5), 523-536 (2013)
   PUBMED   23354978
REFERENCE   2  (bases 1 to 4657)
  AUTHORS   Zhang,K., Chu,K., Wu,X., Gao,H., Wang,J., Yuan,Y.C., Loera,S.,
            Ho,K., Wang,Y., Chow,W., Un,F., Chu,P. and Yen,Y.
  TITLE     Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway
            in high-grade liposarcoma
  JOURNAL   Cancer Res. 73 (4), 1298-1307 (2013)
   PUBMED   23393200
  REMARK    GeneRIF: Data indicate that the FGFR/FRS2 signaling axis was
            generally activated in about 75% of FRS2-positive high-grade
            liposarcomas.
REFERENCE   3  (bases 1 to 4657)
  AUTHORS   Bourdeaut,F., Miquel,C., Di Rocco,F., Grison,C., Richer,W.,
            Brugieres,L., Pierron,G., James,S., Baujat,G., Delattre,O. and
            Collet,C.
  TITLE     Germline mutations in FGF receptors and medulloblastomas
  JOURNAL   Am. J. Med. Genet. A 161A (2), 382-385 (2013)
   PUBMED   23325524
  REMARK    GeneRIF: FGFR2 and FGFR3 gain of function mutants might be
            facilitators for oncogenic transformation in medulloblastoma.
REFERENCE   4  (bases 1 to 4657)
  AUTHORS   Hazan,F., Aykut,A., Unalp,A., Mese,T., Unal,N., Onay,H. and
            Ozkinay,F.
  TITLE     Ventricular septal defect in Crouzon Syndrome: case report
  JOURNAL   Genet. Couns. 23 (4), 519-522 (2012)
   PUBMED   23431754
  REMARK    GeneRIF: Crouzon Syndrome is caused by mutations in FGFR2 gene.
REFERENCE   5  (bases 1 to 4657)
  AUTHORS   Krakstad,C., Birkeland,E., Seidel,D., Kusonmano,K., Petersen,K.,
            Mjos,S., Hoivik,E.A., Wik,E., Halle,M.K., Oyan,A.M., Kalland,K.H.,
            Werner,H.M., Trovik,J. and Salvesen,H.
  TITLE     High-throughput mutation profiling of primary and metastatic
            endometrial cancers identifies KRAS, FGFR2 and PIK3CA to be
            frequently mutated
  JOURNAL   PLoS ONE 7 (12), E52795 (2012)
   PUBMED   23300780
  REMARK    GeneRIF: FGFR2, KRAS and PIK3CA are frequently mutated in primary
            and metastatic endometrial lesions.
REFERENCE   6  (bases 1 to 4657)
  AUTHORS   Dell,K.R. and Williams,L.T.
  TITLE     A novel form of fibroblast growth factor receptor 2. Alternative
            splicing of the third immunoglobulin-like domain confers ligand
            binding specificity
  JOURNAL   J. Biol. Chem. 267 (29), 21225-21229 (1992)
   PUBMED   1400433
REFERENCE   7  (bases 1 to 4657)
  AUTHORS   Luqmani,Y.A., Graham,M. and Coombes,R.C.
  TITLE     Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in
            normal and malignant human breast, and comparison with other normal
            tissues
  JOURNAL   Br. J. Cancer 66 (2), 273-280 (1992)
   PUBMED   1380281
REFERENCE   8  (bases 1 to 4657)
  AUTHORS   Katoh,M., Hattori,Y., Sasaki,H., Tanaka,M., Sugano,K., Yazaki,Y.,
            Sugimura,T. and Terada,M.
  TITLE     K-sam gene encodes secreted as well as transmembrane receptor
            tyrosine kinase
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (7), 2960-2964 (1992)
   PUBMED   1313574
REFERENCE   9  (bases 1 to 4657)
  AUTHORS   Miki,T., Bottaro,D.P., Fleming,T.P., Smith,C.L., Burgess,W.H.,
            Chan,A.M. and Aaronson,S.A.
  TITLE     Determination of ligand-binding specificity by alternative
            splicing: two distinct growth factor receptors encoded by a single
            gene
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (1), 246-250 (1992)
   PUBMED   1309608
REFERENCE   10 (bases 1 to 4657)
  AUTHORS   Dionne,C.A., Modi,W.S., Crumley,G., O'Brien,S.J., Schlessinger,J.
            and Jaye,M.
  TITLE     BEK, a receptor for multiple members of the fibroblast growth
            factor (FGF) family, maps to human chromosome 10q25.3----q26
  JOURNAL   Cytogenet. Cell Genet. 60 (1), 34-36 (1992)
   PUBMED   1582255
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC039243.1, CN345547.1,
            M55614.1, M80634.1, BC037338.2 and CB305736.1.
            On May 24, 2008 this sequence version replaced gi:108773805.
            
            Summary: The protein encoded by this gene is a member of the
            fibroblast growth factor receptor family, where amino acid sequence
            is highly conserved between members and throughout evolution. FGFR
            family members differ from one another in their ligand affinities
            and tissue distribution. A full-length representative protein
            consists of an extracellular region, composed of three
            immunoglobulin-like domains, a single hydrophobic membrane-spanning
            segment and a cytoplasmic tyrosine kinase domain. The extracellular
            portion of the protein interacts with fibroblast growth factors,
            setting in motion a cascade of downstream signals, ultimately
            influencing mitogenesis and differentiation. This particular family
            member is a high-affinity receptor for acidic, basic and/or
            keratinocyte growth factor, depending on the isoform. Mutations in
            this gene are associated with Crouzon syndrome, Pfeiffer syndrome,
            Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome,
            Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome,
            and syndromic craniosynostosis. Multiple alternatively spliced
            transcript variants encoding different isoforms have been noted for
            this gene. [provided by RefSeq, Jan 2009].
            
            Transcript Variant: This variant (2) uses an alternate internal
            in-frame coding exon compared to transcript variant 1, resulting in
            an isoform (2, also known as isoform K-sam-IIH1, IIIb, and BFR-1)
            with a different, 1 aa longer protein segment in the mid-region
            compared to isoform 1.
            
            Sequence Note: A downstream AUG translation start codon is selected
            for this RefSeq based on the presence of a strong Kozak consensus
            signal, a strong community standard for the use of the downstream
            start codon, and on a higher probability of an N-terminal signal
            peptide being present in the resulting protein. The use of an
            alternative in-frame upstream AUG start codon would result in a
            protein that is 19 aa longer at the N-terminus. Translation from
            the annotated downstream start codon is likely to occur via leaky
            scanning and/or reinitiation.
            
            CCDS Note: A downstream AUG translation start codon is selected for
            this CCDS representation based on a strong community standard for
            its use, and on a higher probability of a signal peptide being
            present in the protein N-terminus. The use of an alternative
            upstream AUG start codon would result in a protein that is 19 aa
            longer at the N-terminus. The upstream AUG has a weak Kozak signal
            while the downstream AUG has a strong Kozak signal. Due to leaky
            scanning by ribosomes, it is possible that some ribosomes may
            initiate translation from the downstream AUG codon while others
            start from the upstream AUG. The presence of multiple upstream ORFs
            suggests that a combination of leaky scanning and translational
            reinitiation may be necessary to achieve translation of the
            annotated ORF.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M80634.1, M97193.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: community standard (PMID:
                                                15863034)
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-411               BC039243.1         1-411
            412-635             CN345547.1         290-513
            636-1342            M55614.1           1-707
            1343-2486           M80634.1           1114-2257
            2487-3116           M55614.1           1852-2481
            3117-4515           BC037338.2         2498-3896
            4516-4657           CB305736.1         1-142               c
FEATURES             Location/Qualifiers
     source          1..4657
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26"
     gene            1..4657
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="fibroblast growth factor receptor 2"
                     /db_xref="GeneID:2263"
                     /db_xref="HGNC:3689"
                     /db_xref="MIM:176943"
     exon            1..497
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     variation       77
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41301041"
     variation       190
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:41301043"
     variation       290
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41301545"
     variation       330
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:41301547"
     variation       351..352
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace=""
                     /replace="cc"
                     /db_xref="dbSNP:41301549"
     variation       412
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1047111"
     exon            498..756
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    531..533
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="upstream in-frame stop codon"
     variation       574
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4647922"
     variation       587
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3135721"
     misc_feature    591..593
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="alternative translation initiation codon"
     CDS             648..3116
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /EC_number="2.7.10.1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; hydroxyaryl-protein kinase; protein tyrosine
                     kinase, receptor like 14; FGF receptor; bacteria-expressed
                     kinase; keratinocyte growth factor receptor; soluble FGFR4
                     variant 4; BEK fibroblast growth factor receptor; FGFR-2"
                     /codon_start=1
                     /product="fibroblast growth factor receptor 2 isoform 2
                     precursor"
                     /protein_id="NP_075259.4"
                     /db_xref="GI:221316638"
                     /db_xref="CCDS:CCDS7620.2"
                     /db_xref="GeneID:2263"
                     /db_xref="HGNC:3689"
                     /db_xref="MIM:176943"
                     /translation="
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
"
     sig_peptide     648..710
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     711..3113
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /product="fibroblast growth factor receptor 2 isoform 2"
     misc_feature    786..1019
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="First immunoglobulin (Ig)-like domain of fibroblast
                     growth factor receptor (FGFR); Region: Ig1_FGFR; cd04973"
                     /db_xref="CDD:143174"
     misc_feature    1137..1391
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="Second immunoglobulin (Ig)-like domain of
                     fibroblast growth factor (FGF) receptor; Region: Ig2_FGFR;
                     cd05857"
                     /db_xref="CDD:143265"
     misc_feature    order(1143..1145,1149..1151,1155..1157)
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="FGF binding site [polypeptide binding]; other site"
                     /db_xref="CDD:143265"
     misc_feature    order(1146..1148,1167..1175,1179..1181)
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:143265"
     misc_feature    1434..1718
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="Immunoglobulin I-set domain; Region: I-set;
                     pfam07679"
                     /db_xref="CDD:191810"
     misc_feature    1434..1718
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="Immunoglobulin; Region: IG; smart00409"
                     /db_xref="CDD:197707"
     misc_feature    2043..2954
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Fibroblast Growth Factor Receptor 2; Region: PTKc_FGFR2;
                     cd05101"
                     /db_xref="CDD:133232"
     misc_feature    2091..2921
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="Protein tyrosine kinase; Region: Pkinase_Tyr;
                     pfam07714"
                     /db_xref="CDD:203736"
     misc_feature    order(2103..2105,2109..2111,2115..2123,2133..2135,
                     2193..2195,2199..2201,2340..2354,2358..2360,2526..2528,
                     2538..2543,2547..2549,2580..2582,2634..2648,2673..2675,
                     2775..2777)
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="active site"
                     /db_xref="CDD:133232"
     misc_feature    order(2103..2105,2109..2111,2115..2120,2133..2135,
                     2193..2195,2340..2354,2358..2360,2547..2549,2580..2582)
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:133232"
     misc_feature    order(2526..2528,2538..2540,2634..2648,2673..2675,
                     2775..2777)
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:133232"
     misc_feature    2577..2654
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:133232"
     STS             666..1298
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /standard_name="Fgfr2"
                     /db_xref="UniSTS:547904"
     exon            757..1023
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     variation       806
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1047102"
     STS             849..967
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /standard_name="Fgfr2"
                     /db_xref="UniSTS:464672"
     variation       941
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1047101"
     exon            1024..1101
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     exon            1102..1271
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     STS             1135..1503
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /standard_name="GDB:554771"
                     /db_xref="UniSTS:157658"
     variation       1204
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:755793"
     exon            1272..1395
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     variation       1343
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1047100"
     exon            1396..1586
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     variation       1406
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3135755"
     STS             1413..1628
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /standard_name="Fgfr2"
                     /db_xref="UniSTS:547827"
     variation       1572
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4647921"
     exon            1587..1734
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     variation       1588
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3206759"
     variation       1594
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1129324"
     variation       1596
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1143401"
     variation       1609
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1129323"
     variation       1610
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1129322"
     variation       1618
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1129321"
     variation       1620
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1129320"
     variation       1628
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1143402"
     variation       1637
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1129318"
     variation       1645
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1047095"
     variation       1649
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1047090"
     variation       1663
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1047088"
     variation       1664
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1047087"
     variation       1672
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1065581"
     variation       1681
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1047083"
     variation       1685
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1047082"
     variation       1689
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1065582"
     variation       1691
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1047078"
     variation       1696
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1047077"
     variation       1700
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1047076"
     variation       1706
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1047074"
     variation       1710
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1129316"
     variation       1712
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1129314"
     variation       1715
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1129313"
     variation       1718
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1129312"
     exon            1735..1937
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     exon            1938..2089
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     exon            2090..2211
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     exon            2212..2322
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     exon            2323..2513
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     exon            2514..2636
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     variation       2591
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35337478"
     exon            2637..2707
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     exon            2708..2845
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     exon            2846..2951
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     variation       2939
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41294229"
     exon            2952..4643
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /inference="alignment:Splign:1.39.8"
     STS             2959..3104
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /standard_name="RH17739"
                     /db_xref="UniSTS:72918"
     STS             2977..3081
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /standard_name="FGFR2"
                     /db_xref="UniSTS:480054"
     STS             3105..3848
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /standard_name="FGFR2_647.2"
                     /db_xref="UniSTS:468057"
     STS             3157..3310
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /standard_name="D10S2143"
                     /db_xref="UniSTS:3056"
     variation       3300
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4647917"
     variation       3374
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1047058"
     variation       3375
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1047057"
     variation       3406
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3135824"
     variation       3437
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3135825"
     variation       3501
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41294349"
     variation       3519
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3135826"
     polyA_site      3549
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
     variation       3585
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41294351"
     variation       3613
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3135827"
     polyA_signal    3731..3736
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
     polyA_site      3755
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
     variation       3853
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3135828"
     variation       4041
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3135829"
     variation       4076
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41294353"
     STS             4235..4382
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /standard_name="RH66427"
                     /db_xref="UniSTS:82513"
     variation       4435
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3135830"
     polyA_signal    4613..4618
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
     variation       4614
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
                     /replace=""
                     /replace="ataaa"
                     /db_xref="dbSNP:41294355"
     polyA_site      4643
                     /gene="FGFR2"
                     /gene_synonym="BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1;
                     JWS; K-SAM; KGFR; TK14; TK25"
ORIGIN      
ggcggcggctggaggagagcgcggtggagagccgagcgggcgggcggcgggtgcggagcgggcgagggagcgcgcgcggccgccacaaagctcgggcgccgcggggctgcatgcggcgtacctggcccggcgcggcgactgctctccgggctggcgggggccggccgcgagccccgggggccccgaggccgcagcttgcctgcgcgctctgagccttcgcaactcgcgagcaaagtttggtggaggcaacgccaagcctgagtcctttcttcctctcgttccccaaatccgagggcagcccgcgggcgtcatgcccgcgctcctccgcagcctggggtacgcgtgaagcccgggaggcttggcgccggcgaagacccaaggaccactcttctgcgtttggagttgctccccgcaaccccgggctcgtcgctttctccatcccgacccacgcggggcgcggggacaacacaggtcgcggaggagcgttgccattcaagtgactgcagcagcagcggcagcgcctcggttcctgagcccaccgcaggctgaaggcattgcgcgtagtccatgcccgtagaggaagtgtgcagatgggattaacgtccacatggagatatggaagaggaccggggattggtaccgtaaccatggtcagctggggtcgtttcatctgcctggtcgtggtcaccatggcaaccttgtccctggcccggccctccttcagtttagttgaggataccacattagagccagaagagccaccaaccaaataccaaatctctcaaccagaagtgtacgtggctgcgccaggggagtcgctagaggtgcgctgcctgttgaaagatgccgccgtgatcagttggactaaggatggggtgcacttggggcccaacaataggacagtgcttattggggagtacttgcagataaagggcgccacgcctagagactccggcctctatgcttgtactgccagtaggactgtagacagtgaaacttggtacttcatggtgaatgtcacagatgccatctcatccggagatgatgaggatgacaccgatggtgcggaagattttgtcagtgagaacagtaacaacaagagagcaccatactggaccaacacagaaaagatggaaaagcggctccatgctgtgcctgcggccaacactgtcaagtttcgctgcccagccggggggaacccaatgccaaccatgcggtggctgaaaaacgggaaggagtttaagcaggagcatcgcattggaggctacaaggtacgaaaccagcactggagcctcattatggaaagtgtggtcccatctgacaagggaaattatacctgtgtagtggagaatgaatacgggtccatcaatcacacgtaccacctggatgttgtggagcgatcgcctcaccggcccatcctccaagccggactgccggcaaatgcctccacagtggtcggaggagacgtagagtttgtctgcaaggtttacagtgatgcccagccccacatccagtggatcaagcacgtggaaaagaacggcagtaaatacgggcccgacgggctgccctacctcaaggttctcaagcactcggggataaatagttccaatgcagaagtgctggctctgttcaatgtgaccgaggcggatgctggggaatatatatgtaaggtctccaattatatagggcaggccaaccagtctgcctggctcactgtcctgccaaaacagcaagcgcctggaagagaaaaggagattacagcttccccagactacctggagatagccatttactgcataggggtcttcttaatcgcctgtatggtggtaacagtcatcctgtgccgaatgaagaacacgaccaagaagccagacttcagcagccagccggctgtgcacaagctgaccaaacgtatccccctgcggagacaggtaacagtttcggctgagtccagctcctccatgaactccaacaccccgctggtgaggataacaacacgcctctcttcaacggcagacacccccatgctggcaggggtctccgagtatgaacttccagaggacccaaaatgggagtttccaagagataagctgacactgggcaagcccctgggagaaggttgctttgggcaagtggtcatggcggaagcagtgggaattgacaaagacaagcccaaggaggcggtcaccgtggccgtgaagatgttgaaagatgatgccacagagaaagacctttctgatctggtgtcagagatggagatgatgaagatgattgggaaacacaagaatatcataaatcttcttggagcctgcacacaggatgggcctctctatgtcatagttgagtatgcctctaaaggcaacctccgagaatacctccgagcccggaggccacccgggatggagtactcctatgacattaaccgtgttcctgaggagcagatgaccttcaaggacttggtgtcatgcacctaccagctggccagaggcatggagtacttggcttcccaaaaatgtattcatcgagatttagcagccagaaatgttttggtaacagaaaacaatgtgatgaaaatagcagactttggactcgccagagatatcaacaatatagactattacaaaaagaccaccaatgggcggcttccagtcaagtggatggctccagaagccctgtttgatagagtatacactcatcagagtgatgtctggtccttcggggtgttaatgtgggagatcttcactttagggggctcgccctacccagggattcccgtggaggaactttttaagctgctgaaggaaggacacagaatggataagccagccaactgcaccaacgaactgtacatgatgatgagggactgttggcatgcagtgccctcccagagaccaacgttcaagcagttggtagaagacttggatcgaattctcactctcacaaccaatgaggaatacttggacctcagccaacctctcgaacagtattcacctagttaccctgacacaagaagttcttgttcttcaggagatgattctgttttttctccagaccccatgccttacgaaccatgccttcctcagtatccacacataaacggcagtgttaaaacatgaatgactgtgtctgcctgtccccaaacaggacagcactgggaacctagctacactgagcagggagaccatgcctcccagagcttgttgtctccacttgtatatatggatcagaggagtaaataattggaaaagtaatcagcatatgtgtaaagatttatacagttgaaaacttgtaatcttccccaggaggagaagaaggtttctggagcagtggactgccacaagccaccatgtaacccctctcacctgccgtgcgtactggctgtggaccagtaggactcaaggtggacgtgcgttctgccttccttgttaattttgtaataattggagaagatttatgtcagcacacacttacagagcacaaatgcagtatataggtgctggatgtatgtaaatatattcaaattatgtataaatatatattatatatttacaaggagttattttttgtattgattttaaatggatgtcccaatgcacctagaaaattggtctctctttttttaatagctatttgctaaatgctgttcttacacataatttcttaattttcaccgagcagaggtggaaaaatacttttgctttcagggaaaatggtataacgttaatttattaataaattggtaatatacaaaacaattaatcatttatagttttttttgtaatttaagtggcatttctatgcaggcagcacagcagactagttaatctattgcttggacttaactagttatcagatcctttgaaaagagaatatttacaatatatgactaatttggggaaaatgaagttttgatttatttgtgtttaaatgctgctgtcagacgattgttcttagacctcctaaatgccccatattaaaagaactcattcataggaaggtgtttcattttggtgtgcaaccctgtcattacgtcaacgcaacgtctaactggacttcccaagataaatggtaccagcgtcctcttaaaagatgccttaatccattccttgaggacagaccttagttgaaatgatagcagaatgtgcttctctctggcagctggccttctgcttctgagttgcacattaatcagattagcctgtattctcttcagtgaattttgataatggcttccagactctttggcgttggagacgcctgttaggatcttcaagtcccatcatagaaaattgaaacacagagttgttctgctgatagttttggggatacgtccatctttttaagggattgctttcatctaattctggcaggacctcaccaaaagatccagcctcatacctacatcagacaaaatatcgccgttgttccttctgtactaaagtattgtgttttgctttggaaacacccactcactttgcaatagccgtgcaagatgaatgcagattacactgatcttatgtgttacaaaattggagaaagtatttaataaaacctgttaatttttatactgacaataaaaatgtttctacagatattaatgttaacaagacaaaataaatgtcacgcaacttatttttttaataaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:2263 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: NAS
            GeneID:2263 -> Molecular function: GO:0005007 [fibroblast growth factor-activated receptor activity] evidence: IDA
            GeneID:2263 -> Molecular function: GO:0005007 [fibroblast growth factor-activated receptor activity] evidence: IGI
            GeneID:2263 -> Molecular function: GO:0005007 [fibroblast growth factor-activated receptor activity] evidence: NAS
            GeneID:2263 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:2263 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:2263 -> Molecular function: GO:0008201 [heparin binding] evidence: IEA
            GeneID:2263 -> Molecular function: GO:0017134 [fibroblast growth factor binding] evidence: IDA
            GeneID:2263 -> Molecular function: GO:0017134 [fibroblast growth factor binding] evidence: IPI
            GeneID:2263 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
            GeneID:2263 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IPI
            GeneID:2263 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: ISS
            GeneID:2263 -> Biological process: GO:0001525 [angiogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0001657 [ureteric bud development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0001701 [in utero embryonic development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0002053 [positive regulation of mesenchymal cell proliferation] evidence: ISS
            GeneID:2263 -> Biological process: GO:0003148 [outflow tract septum morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0003149 [membranous septum morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:2263 -> Biological process: GO:0007173 [epidermal growth factor receptor signaling pathway] evidence: TAS
            GeneID:2263 -> Biological process: GO:0007267 [cell-cell signaling] evidence: ISS
            GeneID:2263 -> Biological process: GO:0007409 [axonogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0007528 [neuromuscular junction development] evidence: IEA
            GeneID:2263 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IDA
            GeneID:2263 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IGI
            GeneID:2263 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IMP
            GeneID:2263 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IEA
            GeneID:2263 -> Biological process: GO:0008286 [insulin receptor signaling pathway] evidence: TAS
            GeneID:2263 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: IDA
            GeneID:2263 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: IGI
            GeneID:2263 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: IPI
            GeneID:2263 -> Biological process: GO:0008543 [fibroblast growth factor receptor signaling pathway] evidence: TAS
            GeneID:2263 -> Biological process: GO:0008589 [regulation of smoothened signaling pathway] evidence: ISS
            GeneID:2263 -> Biological process: GO:0009791 [post-embryonic development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0009880 [embryonic pattern specification] evidence: ISS
            GeneID:2263 -> Biological process: GO:0009887 [organ morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0010453 [regulation of cell fate commitment] evidence: ISS
            GeneID:2263 -> Biological process: GO:0010518 [positive regulation of phospholipase activity] evidence: IMP
            GeneID:2263 -> Biological process: GO:0016331 [morphogenesis of embryonic epithelium] evidence: ISS
            GeneID:2263 -> Biological process: GO:0018108 [peptidyl-tyrosine phosphorylation] evidence: IDA
            GeneID:2263 -> Biological process: GO:0021769 [orbitofrontal cortex development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0021847 [ventricular zone neuroblast division] evidence: ISS
            GeneID:2263 -> Biological process: GO:0021860 [pyramidal neuron development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0022612 [gland morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0030177 [positive regulation of Wnt receptor signaling pathway] evidence: ISS
            GeneID:2263 -> Biological process: GO:0030282 [bone mineralization] evidence: ISS
            GeneID:2263 -> Biological process: GO:0030324 [lung development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0030855 [epithelial cell differentiation] evidence: ISS
            GeneID:2263 -> Biological process: GO:0030901 [midbrain development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0030916 [otic vesicle formation] evidence: ISS
            GeneID:2263 -> Biological process: GO:0031069 [hair follicle morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0032808 [lacrimal gland development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0033688 [regulation of osteoblast proliferation] evidence: TAS
            GeneID:2263 -> Biological process: GO:0035264 [multicellular organism growth] evidence: ISS
            GeneID:2263 -> Biological process: GO:0035265 [organ growth] evidence: ISS
            GeneID:2263 -> Biological process: GO:0035602 [fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow] evidence: ISS
            GeneID:2263 -> Biological process: GO:0035603 [fibroblast growth factor receptor signaling pathway involved in hemopoiesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0035604 [fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow] evidence: ISS
            GeneID:2263 -> Biological process: GO:0035607 [fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0038095 [Fc-epsilon receptor signaling pathway] evidence: TAS
            GeneID:2263 -> Biological process: GO:0040014 [regulation of multicellular organism growth] evidence: ISS
            GeneID:2263 -> Biological process: GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway] evidence: ISS
            GeneID:2263 -> Biological process: GO:0042472 [inner ear morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0042476 [odontogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0043410 [positive regulation of MAPK cascade] evidence: IMP
            GeneID:2263 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:2263 -> Biological process: GO:0045165 [cell fate commitment] evidence: ISS
            GeneID:2263 -> Biological process: GO:0045667 [regulation of osteoblast differentiation] evidence: TAS
            GeneID:2263 -> Biological process: GO:0045787 [positive regulation of cell cycle] evidence: ISS
            GeneID:2263 -> Biological process: GO:0045839 [negative regulation of mitosis] evidence: IEA
            GeneID:2263 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: ISS
            GeneID:2263 -> Biological process: GO:0046777 [protein autophosphorylation] evidence: IDA
            GeneID:2263 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
            GeneID:2263 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: TAS
            GeneID:2263 -> Biological process: GO:0048286 [lung alveolus development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0048489 [synaptic vesicle transport] evidence: IEA
            GeneID:2263 -> Biological process: GO:0048557 [embryonic digestive tract morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0048562 [embryonic organ morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0048565 [digestive tract development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0048568 [embryonic organ development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0048608 [reproductive structure development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0048701 [embryonic cranial skeleton morphogenesis] evidence: IMP
            GeneID:2263 -> Biological process: GO:0048705 [skeletal system morphogenesis] evidence: TAS
            GeneID:2263 -> Biological process: GO:0048730 [epidermis morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0048755 [branching morphogenesis of a nerve] evidence: ISS
            GeneID:2263 -> Biological process: GO:0048762 [mesenchymal cell differentiation] evidence: ISS
            GeneID:2263 -> Biological process: GO:0050679 [positive regulation of epithelial cell proliferation] evidence: ISS
            GeneID:2263 -> Biological process: GO:0051150 [regulation of smooth muscle cell differentiation] evidence: ISS
            GeneID:2263 -> Biological process: GO:0051781 [positive regulation of cell division] evidence: ISS
            GeneID:2263 -> Biological process: GO:0055010 [ventricular cardiac muscle tissue morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060045 [positive regulation of cardiac muscle cell proliferation] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060174 [limb bud formation] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060348 [bone development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060349 [bone morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060365 [coronal suture morphogenesis] evidence: IEA
            GeneID:2263 -> Biological process: GO:0060442 [branching involved in prostate gland morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060445 [branching involved in salivary gland morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060449 [bud elongation involved in lung branching] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060463 [lung lobe morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060484 [lung-associated mesenchyme development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060512 [prostate gland morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060523 [prostate epithelial cord elongation] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060601 [lateral sprouting from an epithelium] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060615 [mammary gland bud formation] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060667 [branch elongation involved in salivary gland morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060670 [branching involved in labyrinthine layer morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060687 [regulation of branching involved in prostate gland morphogenesis] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060688 [regulation of morphogenesis of a branching structure] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060915 [mesenchymal cell differentiation involved in lung development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0060916 [mesenchymal cell proliferation involved in lung development] evidence: ISS
            GeneID:2263 -> Biological process: GO:0061031 [endodermal digestive tract morphogenesis] evidence: IEA
            GeneID:2263 -> Biological process: GO:0070307 [lens fiber cell development] evidence: IEA
            GeneID:2263 -> Biological process: GO:0070372 [regulation of ERK1 and ERK2 cascade] evidence: ISS
            GeneID:2263 -> Biological process: GO:0070374 [positive regulation of ERK1 and ERK2 cascade] evidence: ISS
            GeneID:2263 -> Biological process: GO:0090263 [positive regulation of canonical Wnt receptor signaling pathway] evidence: ISS
            GeneID:2263 -> Cellular component: GO:0005576 [extracellular region] evidence: IEA
            GeneID:2263 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:2263 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:2263 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IEA
            GeneID:2263 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
            GeneID:2263 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:2263 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: IDA
            GeneID:2263 -> Cellular component: GO:0005938 [cell cortex] evidence: IDA
            GeneID:2263 -> Cellular component: GO:0009986 [cell surface] evidence: IDA
            GeneID:2263 -> Cellular component: GO:0016020 [membrane] evidence: NAS
            GeneID:2263 -> Cellular component: GO:0016021 [integral to membrane] evidence: NAS
            GeneID:2263 -> Cellular component: GO:0016023 [cytoplasmic membrane-bounded vesicle] evidence: IEA
            GeneID:2263 -> Cellular component: GO:0031012 [extracellular matrix] evidence: IDA
            GeneID:2263 -> Cellular component: GO:0060076 [excitatory synapse] evidence: ISS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_075259 -> EC 2.7.10.1

by @meso_cacase at DBCLS
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