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2024-04-26 17:42:27, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_022491 4728 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens suppressor of defective silencing 3 homolog (S.
cerevisiae) (SUDS3), mRNA.
ACCESSION NM_022491 XM_045014
VERSION NM_022491.2 GI:75677350
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4728)
AUTHORS Smith,K.T., Sardiu,M.E., Martin-Brown,S.A., Seidel,C.,
Mushegian,A., Egidy,R., Florens,L., Washburn,M.P. and Workman,J.L.
TITLE Human family with sequence similarity 60 member A (FAM60A) protein:
a new subunit of the Sin3 deacetylase complex
JOURNAL Mol. Cell Proteomics 11 (12), 1815-1828 (2012)
PUBMED 22984288
REMARK GeneRIF: studies reveal that loss of FAM60A or another component of
the Sin3 complex, SDS3, leads to a change in cell morphology and an
increase in cell migration
REFERENCE 2 (bases 1 to 4728)
AUTHORS Oudot-Mellakh,T., Cohen,W., Germain,M., Saut,N., Kallel,C.,
Zelenika,D., Lathrop,M., Tregouet,D.A. and Morange,P.E.
TITLE Genome wide association study for plasma levels of natural
anticoagulant inhibitors and protein C anticoagulant pathway: the
MARTHA project
JOURNAL Br. J. Haematol. 157 (2), 230-239 (2012)
PUBMED 22443383
REFERENCE 3 (bases 1 to 4728)
AUTHORS Ramakrishna,S., Suresh,B., Bae,S.M., Ahn,W.S., Lim,K.H. and
Baek,K.H.
TITLE Hyaluronan binding motifs of USP17 and SDS3 exhibit anti-tumor
activity
JOURNAL PLoS ONE 7 (5), E37772 (2012)
PUBMED 22662218
REMARK GeneRIF: Our results have demonstrated that these hyaluronan
binding motifs (HABMs) in USP17 and its substrate SDS3 are mainly
involved in the inhibition of anchorage-independent tumor growth.
REFERENCE 4 (bases 1 to 4728)
AUTHORS Ramakrishna,S., Suresh,B., Lee,E.J., Lee,H.J., Ahn,W.S. and
Baek,K.H.
TITLE Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC
activity
JOURNAL J. Biol. Chem. 286 (12), 10505-10514 (2011)
PUBMED 21239494
REMARK GeneRIF: SDS3, being a substrate of USP17, may play an important
role in developing a novel therapeutic means to inhibit specific
HDAC activities in cancer.
REFERENCE 5 (bases 1 to 4728)
AUTHORS Silveira,A.C., Hurst,D.R., Vaidya,K.S., Ayer,D.E. and Welch,D.R.
TITLE Over-expression of the BRMS1 family member SUDS3 does not suppress
metastasis of human cancer cells
JOURNAL Cancer Lett. 276 (1), 32-37 (2009)
PUBMED 19070953
REMARK GeneRIF: the composition of SIN3-HDAC (BRMS1/SUDS3) complexes
uniquely affects protein expression and biological behaviors
REFERENCE 6 (bases 1 to 4728)
AUTHORS Hurst,D.R., Mehta,A., Moore,B.P., Phadke,P.A., Meehan,W.J.,
Accavitti,M.A., Shevde,L.A., Hopper,J.E., Xie,Y., Welch,D.R. and
Samant,R.S.
TITLE Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the
Hsp90 chaperone
JOURNAL Biochem. Biophys. Res. Commun. 348 (4), 1429-1435 (2006)
PUBMED 16919237
REFERENCE 7 (bases 1 to 4728)
AUTHORS Fleischer,T.C., Yun,U.J. and Ayer,D.E.
TITLE Identification and characterization of three new components of the
mSin3A corepressor complex
JOURNAL Mol. Cell. Biol. 23 (10), 3456-3467 (2003)
PUBMED 12724404
REFERENCE 8 (bases 1 to 4728)
AUTHORS Wysocka,J., Myers,M.P., Laherty,C.D., Eisenman,R.N. and Herr,W.
TITLE Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone
H3-K4 methyltransferase are tethered together selectively by the
cell-proliferation factor HCF-1
JOURNAL Genes Dev. 17 (7), 896-911 (2003)
PUBMED 12670868
REFERENCE 9 (bases 1 to 4728)
AUTHORS Alland,L., David,G., Shen-Li,H., Potes,J., Muhle,R., Lee,H.C.,
Hou,H. Jr., Chen,K. and DePinho,R.A.
TITLE Identification of mammalian Sds3 as an integral component of the
Sin3/histone deacetylase corepressor complex
JOURNAL Mol. Cell. Biol. 22 (8), 2743-2750 (2002)
PUBMED 11909966
REFERENCE 10 (bases 1 to 4728)
AUTHORS Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
Ohara,O.
TITLE Characterization of long cDNA clones from human adult spleen
JOURNAL DNA Res. 7 (6), 357-366 (2000)
PUBMED 11214971
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC098404.1, AK024460.1, AC026367.14 and AA916093.1.
On Sep 15, 2005 this sequence version replaced gi:42734348.
Summary: SDS3 is a subunit of the histone deacetylase (see HDAC1;
MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex
(Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar
2008].
##Evidence-Data-START##
Transcript exon combination :: BC098404.1, AK024460.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2608 BC098404.1 24-2631
2609-4292 AK024460.1 2592-4275
4293-4695 AC026367.14 151884-152286
4696-4728 AA916093.1 6-38 c
FEATURES Location/Qualifiers
source 1..4728
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q24.23"
gene 1..4728
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/note="suppressor of defective silencing 3 homolog (S.
cerevisiae)"
/db_xref="GeneID:64426"
/db_xref="HGNC:29545"
/db_xref="MIM:608250"
exon 1..281
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/inference="alignment:Splign:1.39.8"
CDS 140..1126
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/note="sin3A-associated protein, 45kDa; 45 kDa
Sin3-associated polypeptide; suppressor of defective
silencing 3 protein homolog"
/codon_start=1
/product="sin3 histone deacetylase corepressor complex
component SDS3"
/protein_id="NP_071936.2"
/db_xref="GI:75677351"
/db_xref="CCDS:CCDS44993.1"
/db_xref="GeneID:64426"
/db_xref="HGNC:29545"
/db_xref="MIM:608250"
/translation="
MSAAGLLAPAPAQAGAPPAPEYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSSPEHLPATPAESPAQRFEARIEDGKLYYDKRWYHKSQAIYLESKDNQKLSCVISSVGANEIWVRKTSDSTKMRIYLGQLQRGLFVIRRRSAA
"
misc_feature 143..649
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9H7L9.2);
Region: Mediates interaction with USP17L2"
misc_feature 143..145
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylserine; propagated from
UniProtKB/Swiss-Prot (Q9H7L9.2); acetylation site"
misc_feature 233..235
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9H7L9.2); phosphorylation site"
misc_feature 272..274
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9H7L9.2); phosphorylation site"
misc_feature 272..274
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 284..286
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9H7L9.2); phosphorylation site"
misc_feature 284..286
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 296..298
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9H7L9.2); phosphorylation site"
misc_feature 302..304
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 317..808
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/note="Sds3-like; Region: Sds3; pfam08598"
/db_xref="CDD:203995"
misc_feature 701..817
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9H7L9.2);
Region: Sin3 interaction domain (SID) (By similarity)"
misc_feature 821..823
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9H7L9.2); phosphorylation site"
misc_feature 839..841
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9H7L9.2); phosphorylation site"
misc_feature 839..841
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 845..847
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 848..850
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 869..871
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q9H7L9.2); phosphorylation site"
exon 282..351
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/inference="alignment:Splign:1.39.8"
variation 333
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:181326809"
variation 334
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:200129355"
exon 352..407
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/inference="alignment:Splign:1.39.8"
variation 387
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:202206050"
variation 400
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:377137852"
exon 408..479
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/inference="alignment:Splign:1.39.8"
exon 480..499
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/inference="alignment:Splign:1.39.8"
variation 480
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201143743"
variation 490
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:375696563"
exon 500..656
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/inference="alignment:Splign:1.39.8"
variation 525
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:372566624"
variation 544
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:376397874"
STS 571..1168
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/db_xref="UniSTS:485516"
variation 594
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:369923125"
variation 602
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373116917"
variation 612
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201081140"
exon 657..752
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/inference="alignment:Splign:1.39.8"
variation 736
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374953856"
exon 753..814
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/inference="alignment:Splign:1.39.8"
variation 796
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201151599"
exon 815..836
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/inference="alignment:Splign:1.39.8"
variation 819
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:374831127"
variation 821
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199697453"
exon 837..942
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/inference="alignment:Splign:1.39.8"
variation 874
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:373735232"
variation 877
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:376431460"
variation 888
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:112917165"
variation 892
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:370809170"
variation 906
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373198095"
variation 916
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:377336278"
variation 918
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:370306899"
variation 928
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:374489963"
exon 943..1027
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/inference="alignment:Splign:1.39.8"
variation 945
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:370035802"
variation 1023
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:370752292"
exon 1028..4728
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/inference="alignment:Splign:1.39.8"
variation 1030
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:367623642"
variation 1081
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:56009326"
variation 1090
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:147756379"
variation 1286
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373927287"
variation 1300
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:112562821"
variation 1328
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:79975928"
variation 1331
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:188884207"
variation 1459
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:12422721"
variation 1514
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="t"
/db_xref="dbSNP:186355165"
variation 1521
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:367953358"
variation 1558
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:371796193"
variation 1580
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:146772078"
variation 1599
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:1060964"
variation 1709
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:114728101"
variation 1727
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:79160548"
variation 1754
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:191311511"
variation 1760
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373284170"
variation 1770
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:182736622"
variation 1795
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:368500589"
variation 1830
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="t"
/db_xref="dbSNP:116141634"
variation 1832
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:372619924"
variation 1837
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:148959194"
variation 2072
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:375879476"
variation 2114
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:185250919"
variation 2123
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:189758406"
variation 2128
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:143641179"
variation 2202
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:368711159"
variation 2231
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:369494681"
variation 2276
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:183082510"
variation 2305
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:192889379"
variation 2355
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:148082556"
variation 2397
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:141861010"
variation 2401
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:12322820"
variation 2477..2479
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace=""
/replace="ggg"
/db_xref="dbSNP:151190913"
variation 2478
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:376862094"
variation 2620
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace=""
/replace="t"
/db_xref="dbSNP:200630129"
variation 2636
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace=""
/replace="c"
/db_xref="dbSNP:371322382"
variation 2688
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:187852779"
variation 2724
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:146029330"
variation 2868..2869
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace=""
/replace="at"
/db_xref="dbSNP:375986124"
variation 2904
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:191709252"
variation 2941
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:138760591"
variation 2958
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:141699543"
variation 3041
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:146247118"
variation 3042
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:371731242"
variation 3053
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:11830714"
variation 3084..3085
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace=""
/replace="g"
/db_xref="dbSNP:111670274"
variation 3206
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:76599736"
variation 3295
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:61943443"
variation 3316
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:369143555"
variation 3388
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:183577809"
variation 3393
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:78688600"
variation 3470..3471
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace=""
/replace="ac"
/db_xref="dbSNP:139713595"
variation 3486
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:4334055"
variation 3506
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:139165504"
variation 3541
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:4511309"
variation 3651
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:76860495"
variation 3688
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:149899809"
variation 3692
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:2279833"
variation 3701
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:2893767"
variation 3756
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:371859432"
variation 3829
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:201008617"
variation 3883
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:375157948"
variation 3960
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:10850968"
variation 3963
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:76012935"
variation 3965
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="c"
/db_xref="dbSNP:79359597"
variation 4103..4104
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace=""
/replace="t"
/db_xref="dbSNP:77800626"
STS 4106..4284
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/standard_name="RH94298"
/db_xref="UniSTS:91293"
variation 4106
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373797364"
variation 4169..4170
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace=""
/replace="a"
/db_xref="dbSNP:370853288"
variation 4172
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="t"
/db_xref="dbSNP:8467"
STS 4187..4420
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/standard_name="RH81039"
/db_xref="UniSTS:89211"
variation 4198
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:192799757"
variation 4293
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:7795"
variation 4320
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:1045542"
variation 4342
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:183753899"
variation 4367
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:114856354"
variation 4370..4371
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace=""
/replace="t"
/db_xref="dbSNP:200852799"
variation 4371
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:1045552"
variation 4384..4385
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace=""
/replace="tt"
/db_xref="dbSNP:75342426"
variation 4385
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace=""
/replace="t"
/db_xref="dbSNP:58110534"
variation 4417
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="g"
/db_xref="dbSNP:375500153"
variation 4438
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:191437265"
variation 4454
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:7305647"
variation 4492
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="a"
/replace="g"
/db_xref="dbSNP:143972387"
variation 4658
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="g"
/replace="t"
/db_xref="dbSNP:184794406"
variation 4701
/gene="SUDS3"
/gene_synonym="SAP45; SDS3"
/replace="c"
/replace="t"
/db_xref="dbSNP:7295288"
ORIGIN
gcggagacggggaaggggtcgccgtggctgccggtcctcgagttgggggctgccgcggacactgctaggcagacggcgagtaccgagcgcgggtggccgcggtgtccgtgggccacgctcagctgcggtcagaggcgacatgagtgccgcggggctgctggccccggccccggcccaggctggagcgccgccggcccccgagtactaccccgaggaggatgaagagctggagagcgccgaggacgacgagcgcagctgtcggggccgcgagtcggacgaagacactgaggatgctagtgaaactgacctggcaaagcatgatgaagaagactatgtagaaatgaaggaacagatgtatcaggacaaactggcttctctcaagaggcagttgcaacaactgcaagaaggtacattacaggaatatcagaagagaatgaaaaaactagatcagcagtacaaagagaggatacggaatgcagaactcttcctccagctggaaactgaacaagtggaacgaaattacattaaagaaaagaaggcagcagtgaaagaatttgaagacaagaaggttgagctgaaagagaacctgattgctgagctagaagaaaagaagaaaatgattgaaaatgaaaagctgacaatggaactgactggagattctatggaggtgaaacctatcatgaccagaaagttgcggaggcgaccaaatgatcccgtccccatcccagacaagaggaggaaacctgctccagcccagctaaactatttgttaacagatgaacagatcatggaggatctgagaacattaaataagcttaagtcacccaagagaccagcatctccatcctctcctgagcacttgcctgcaacacccgcggaatctccagcccagaggttcgaagctcggatagaagatggcaaactgtactatgacaaaagatggtaccacaagagccaggccatctatctggagtcaaaggacaaccagaaactgagctgcgtgatcagttctgtaggagccaatgagatctgggtgaggaagacaagtgacagcaccaagatgaggatctacctgggccagcttcagcgcgggctcttcgtgatccgccggcgctcagctgcttgactttctacagtgctcttctcttgaccctttttctggagtgggttttatttttgttttgtttcgttttctccttaatagaaaaatgttaacttactgggaatagctactcagccttggaaatggagagcactgcagtgaattctttagggcacttttgtggccggatgcttccaactttgtcagtcttttctgcctcaacttcttccagacatcagtcaccatgagactgttttactttcaggcgtattggggggtttgatttactttccttttatttctttattttttgcttatacttgtttttgaaaacctcctctgagtttgaagggacagctatttttattgattatctttaagtctctctaccatggagaagagcaggaagggatacactctccagtgcattttcatgttttgaatctgattagtggatcacgtagctactttccctgtcgcgtccaattcactatttgcccagaagcttggggcagaggtcctagcaggagatgatgaattctcgtggctctcggccttctcagagaaataaatgctttgtgtaacatctgtgcacaccatccattccgctcgctgagcgatggaaaagcttgcctggaagactatgtgcactgaagtaaatggggttgggggaggggacatttcatatttataatgtgctgaaggtaccatattttaaatgttatttaatgcaggtgatttattcaaacatttgttctagcttaagctggaataagcagtggtcatttcagaagttttcatttgtaattccttcctctcccttgttcccaagtaggtagtagtaagtatgtgccacaggctgattatctgggtaatcttttacgggtgggaggtgagattgatagtgcaataatcagtgatctatagaccctcatgcacgattcaagtttcactcttgtggctgatgccattattgcacattggccattccaaacctgtggagaactttgttgtcaggccctgagcgctcacagcttcatttggcccaggttgaagacaaggaaagctctgctgtggctgcctctggactgacaccctccctaatgagtcctgatgaaacagcctttcctacatccttccctcactcccatgattggagaaatgattcattgggtgatgagtgttggggttttctatactcatgttgccatcttgagatgttcaaaaaatttggggttagagcaactgttagcgtctctatgagcaatcagtagaacttacacatcctaggaaatctttctttgtaagtaattcttttggtctcaagtgattctcttcatgttgtctcttgatgtacatacccccaagcaagttggggggactgtgatgacaattaaatcaccttctctgaagttctggctctgcagagaccaaaccttactgacttgtacagacttgtacaagtaaagacttatacagatagatttttgttttaacttacaatccgttttttcctcttttttttttttttttctggtgttggagtcttatttagaaaacaggataaatgacgctgttatcaaaagttgcctggggttctgtatttcttctctgccctccaatccccgactgctatgatgtttactacagtgaacccagcccatggtaaacacaggcttcacctgttcttgtttgttagccttgactgtgaggcaggacttccctcgcttgaactgttacacatacgatgtgtgtgtcacatcacatattgtgcagctgttggttttcatgtagtgccctgcgatggaaattagatatatttcatgtatttttccattgaaggtggagtttttcaatgatcatgtgttttgtcctcctaaacagtataccaaagtttgtttttatagttgaggattgtattgataaccactggggttccgcattgaagcaggaacaaattgcctctttttctggccttctctgtgggacctctgcttttgtgaagcaactatttatttgaagaccagggtatgggcacttttgccttctctcctctctgacttttgagggtattgagggcgcccttagtcatagtctcgactccgccattgccttctcctcggcgtcctcacaactcttaattgggcctagtgaaaatgggggcaggtgagaagtccattttgagaatcagcatagtaaattacatttctaatcccagaggacttaatattttcttttgtcaccccagaggtgaaaaatcagcagttgaagcctgacaggcctcagtggtgaccaggaacagaagcagccttcctgttagtagatgggggtacttctgtggtgggcagaagccttactaaaggggaagacagactttgaagtttctagacgagaaggaggctagcttctagcctgggtggccattattccaaaaggtcattgtttctcactagaccccagggcaccagatgaatttccaagtttaaactctttcctgcaggtgattactttgaaaaaggttggtccagaccattttgatcaagaacctgtatatgtgttgtgttagaggcatctgcctcaagtctatgtacagtgtttgctgcgggtgtgttccaatattcattttacctctgcttgggggttttgtgtgttcccctccccccatgccctgcctacccccttttccctgaaccacgtccttttgaataatttccagatggatttctgtagccataccaaagccagggtgttttcattcatgcggatactagtatttatagatgtctgactacctaacttaatttttgtttttgaacttctaattggggccagtgtaaggtcgatcccagaggctgatctgcaaatcaagctacatgtatttgtgtataagaccctgtgttcaggactgggtgacttttctaagaaatatggggtttagaatggggttgactgtattttttaacctaattctggagagaagattgtattttttacagttttttgggtttggcttccttctcacatttctttagctttgaatttttactaaataaatttcctcctgattaattttttttttctcatctgggaatttgaaatctcggtgcttactgttacaccaatttgtccaaagagttgaaatcactttaatgccagaacatggtaaatttgcagccatttcaagcaggtgatggtctttttttataacatcgttaacgggtaccattaaatattctgagaggtgaatgtaaaatataaaaggtataggtttttttttttttttaaagaaaacaataaactttcaaagagaaaaccagcatgaagtctgtattgtatccattgacttgataagtgatagaaatttattttaggtttttgatccattgcttatggggaaaggaagttagggcagaggaagggatattctagacatttaattcttagtgaagactaagatacagaatgatgtcaggctaatactcagttttgtaaagagcaatctggggtgttgacccttaaatgtttgtgcactcttcttgttgcagataaaagtcattaaaaatcaagtgaatagaatggatcttgggtggaaaaacaatcttgaaataaacttgtgattgaggata
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:64426 -> Molecular function: GO:0004407 [histone deacetylase activity] evidence: IDA
GeneID:64426 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:64426 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
GeneID:64426 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: IEA
GeneID:64426 -> Molecular function: GO:0042826 [histone deacetylase binding] evidence: ISS
GeneID:64426 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:64426 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:64426 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:64426 -> Biological process: GO:0016575 [histone deacetylation] evidence: IDA
GeneID:64426 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IMP
GeneID:64426 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: ISS
GeneID:64426 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:64426 -> Cellular component: GO:0016580 [Sin3 complex] evidence: ISS
by
@meso_cacase at
DBCLS
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