Home |
Help |
Advanced search
2024-04-25 17:20:53, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_022351 5140 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens N-terminal EF-hand calcium binding protein 1 (NECAB1),
mRNA.
ACCESSION NM_022351
VERSION NM_022351.4 GI:221219006
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5140)
AUTHORS Wu,H., Li,D., Shan,Y., Wan,B., Hexige,S., Guo,J., Wu,C. and Yu,L.
TITLE EFCBP1/NECAB1, a brain-specifically expressed gene with highest
abundance in temporal lobe, encodes a protein containing EF-hand
and antibiotic biosynthesis monooxygenase domains
JOURNAL DNA Seq. 18 (1), 73-79 (2007)
PUBMED 17364817
REFERENCE 2 (bases 1 to 5140)
AUTHORS Sugita,S., Ho,A. and Sudhof,T.C.
TITLE NECABs: a family of neuronal Ca(2+)-binding proteins with an
unusual domain structure and a restricted expression pattern
JOURNAL Neuroscience 112 (1), 51-63 (2002)
PUBMED 12044471
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DB481874.1 and AF414126.2.
On Jan 23, 2009 this sequence version replaced gi:142358119.
##Evidence-Data-START##
Transcript exon combination :: BC068448.1, AK095533.1, BC068448.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-76 DB481874.1 1-76
77-5140 AF414126.2 166-5229
FEATURES Location/Qualifiers
source 1..5140
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q21.3"
gene 1..5140
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/note="N-terminal EF-hand calcium binding protein 1"
/db_xref="GeneID:64168"
/db_xref="HGNC:20983"
/db_xref="HPRD:16851"
exon 1..293
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/inference="alignment:Splign:1.39.8"
CDS 195..1250
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/note="EF hand calcium binding protein 1; EF-hand calcium
binding protein 1; synaptotagmin interacting protein 1;
neuronal calcium binding protein; EF-hand calcium-binding
protein 1; neuronal calcium-binding protein 1"
/codon_start=1
/product="N-terminal EF-hand calcium-binding protein 1"
/protein_id="NP_071746.1"
/db_xref="GI:24308279"
/db_xref="CCDS:CCDS47889.1"
/db_xref="GeneID:64168"
/db_xref="HGNC:20983"
/db_xref="HPRD:16851"
/translation="
MEDSQETSPSSNNSSEELSSALHLSKGMSIFLDILRRADKNDDGKLSFEEFKAYFADGVLSGEELHELFHTIDTHNTNNLDTEELCEYFSQHLGEYENVLAALEDLNLSILKAMGKTKKDYQEASNLEQFVTRFLLKETLNQLQSLQNSLECAMETTEEQTRQERQGPAKPEVLSIQWPGKRSSRRVQRHNSFSPNSPQFNVSGPGLLEEDNQWMTQINRLQKLIDRLEKKDLKLEPPEEEIIEGNTKSHIMLVQRQMSVIEEDLEEFQLALKHYVESASSQSGCLRISIQKLSNESRYMIYEFWENSSVWNSHLQTNYSKTFQRSNVDFLETPELTSTMLVPASWWILNN
"
misc_feature 285..464
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/note="EF-hand, calcium binding motif; A diverse
superfamily of calcium sensors and calcium signal
modulators; most examples in this alignment model have 2
active canonical EF hands. Ca2+ binding induces a
conformational change in the EF-hand motif, leading to...;
Region: EFh; cd00051"
/db_xref="CDD:28933"
misc_feature 300..461
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/note="EF-hand domain pair; Region: EF_hand_5; pfam13499"
/db_xref="CDD:205677"
misc_feature order(309..311,315..317,321..323,342..344,411..413,
417..419,423..425,444..446)
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28933"
misc_feature 954..1169
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/note="Antibiotic biosynthesis monooxygenase; Region: ABM;
pfam03992"
/db_xref="CDD:202845"
exon 294..318
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/inference="alignment:Splign:1.39.8"
exon 319..427
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/inference="alignment:Splign:1.39.8"
exon 428..453
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/inference="alignment:Splign:1.39.8"
exon 454..551
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/inference="alignment:Splign:1.39.8"
exon 552..688
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/inference="alignment:Splign:1.39.8"
exon 689..810
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/inference="alignment:Splign:1.39.8"
exon 811..887
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/inference="alignment:Splign:1.39.8"
exon 888..941
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/inference="alignment:Splign:1.39.8"
exon 942..1054
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/inference="alignment:Splign:1.39.8"
exon 1055..1132
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/inference="alignment:Splign:1.39.8"
exon 1133..1224
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/inference="alignment:Splign:1.39.8"
exon 1225..5140
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/inference="alignment:Splign:1.39.8"
STS 3026..3174
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/standard_name="RH102239"
/db_xref="UniSTS:96573"
STS 4442..4569
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/standard_name="RH93833"
/db_xref="UniSTS:91492"
variation complement(4582..4583)
/gene="NECAB1"
/gene_synonym="EFCBP1; STIP-1"
/replace=""
/replace="ttct"
/db_xref="dbSNP:3830308"
ORIGIN
agaggccggaggagggagggggggacaccgagcgcggagagcgcggagagcgcggagggaggcgcgcgcgggagcgaacaccctcccggatccagagcccggcggcggcgaagcagcagctgcggccgcgcccttgccagagccggtgcgtccgcctagccccgctccgcctgaggccgtcagggctcccgaggatggaagattcccaggagacatcgccgtcctccaacaactcctcggaggagctcagctctgctctgcacctgtccaagggcatgtcgatcttcctcgacatactgaggagagcagacaaaaatgatgatggaaaattatcctttgaagaattcaaagcatattttgcagatggtgttctcagtggagaagaattacacgagcttttccataccattgatacacataatactaataatcttgacacagaagagctatgtgaatatttttctcagcacttgggcgagtatgagaatgtactagcagcacttgaagacctgaatctttccatcctgaaggcaatgggcaaaacaaagaaagactaccaagaagcctccaatttggaacaattcgtaactagatttttattgaaggaaaccctgaatcagctgcagtctctccagaattccctggaatgtgccatggaaactactgaggagcaaacccgtcaagaaaggcaagggccagccaagccagaagtcctgtcgattcaatggcctggaaaacgatcaagccgccgagtccagagacacaacagcttctccccaaacagccctcagtttaatgtcagcggtccaggcttattagaagaagacaaccagtggatgacccagataaatagactccagaaattaattgatagactggaaaagaaggatctcaaactcgaaccaccagaagaagaaattattgaagggaatactaaatctcacatcatgcttgtgcagcggcagatgtctgtgatagaagaggacctggaagaattccagctcgctctgaaacactacgtggagagtgcttcctcccaaagtggatgcttgcgtatttctatacagaagctttcaaatgaatctcgctacatgatctatgagttctgggagaatagtagtgtatggaatagccaccttcagacaaattatagcaagacattccaaagaagtaatgtggatttcttggaaactccagaactcacatctacaatgctagttcctgcttcgtggtggatcctgaacaactagatgttcctagacattttctttatggttccaagtgcaaaacaggtgttcttatctaaaacgtcaattagaaaattatctgcggttgttaatctactgtatatttttgtttggtatatttactaagtgcactctttcaaaacttattctataactttatcaattcatgtgaattttagctcaattttcaaagttcactaatattctcaatatttaatgctaaatgctttgctacattgtaactcacctaaaaccttttagtgacaaaatcctaatatgtggaaaaaagcatatgcataaaggaataatattgtgaaaatgaatctgttatgataaagaaaaaataaagtggaaacttttagagtattacttcatagggcagattttgtaaactgtcgtatactgtaaagggttaaatcagcgttttgtgatttttaagtaactgtgagtgaagtttattcttcaacaatgtctactccatccccaacccaactcacagccctatgactactatctttgcattagttaaaaagttagtatataggcatcaaacaaccttggctgtaacctatagaatctctatccacgtatcaggttatagactggtttttcaaaagtgaacaatcctgtgataagttggagtaccatttagtaatacagcaacattgtgtcatttattagcatcataattctttgttatgtaagttaaatatatcaagaaagaagagactgtttggaaaaatgtggttcaagttttatgctatatagttttggtatgcgatacagacagctaacttttcttatgaaaaatacatatttgcatgtaaacaatgatttcaaaatacttgaaaaataaaattttaacccaaatgaataactaagaaatataaaacaagcacaaaatcttagggaagtcataaaatagtagtgaaagtattagacagaagacatctgttttcgaatttcaacactagaatgactaaaactatctacctatagaactatctgtagatagtatactatctacactctgctcaacaagctcagaaattaaatatttttaataataaaaatctgttctggttataaaccttgctaatgaaaatacaatacatataaaaatgtatagccatgttattttctagtataaattcctttgaaactataagtctttgaggaaaattataaggtaaaattttcctgtttttccccctttgaaaaactcaggaaaaaaggaagattgaactaataaaattttatttcttaaatataaatttgacctaaaatattttctcaaactaattcatgaaacagcaacttttaccaatacctttgtatactctcagttctcattcagtataaataaaattttaaaatcctttcatagttctattagaaataagtagtaaattttgatatattgtacatacacacgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtatttgtgtgcctctggtcaactctaaggatgacagacactgtgtaacaacacctgggtcaactcttttaatttatatacaaagcaaagaacaacattaatggagatgcacaatgattattcaaacaagctatatatatgtacaaaggcaaacagacacataacagtctctgcagactgattgtatatagtaagaaaagatcaaaagactttaaaacctaaatgacttttgacatacaaactcttcttgagaatgtttgttgtaaatggtttcaaaaatacaaattatagccaatcaaaacattgctttggttggtgcatttaagtatccaactcaaaaagcatatcaaatattttgggtactaggcagtttccaaagtagcatggtagtattacttgttaaaagggttctgttttcattaacagtactaagtggaagggatctgcagattccaaactggaataagctctatcatattctgaaacaagaattagaatgacttgagaacgggcaaataacaaagcaaaccaatataattatatggtcattctgaccccagctcttatacaaattatacatgtatttttgtgtatgtttgtgagagttgtatgtatgtgaatgtgtgtgagtgtgtattcacatacacatatatactggaacctatagtagaaaaggaaactagtagggccaaaaaaaaaaagaaaaagaaaaagaaaaaagaaaaaaaaagaaaaaactgggacctaagtataaatatctcatcctaaagtaaacaataagtttatagttaacgaagatttttttctatttaaaaccccattttcctaaagaacaaagtagtaaaataaaaaaaaatttaaaaaattaaaaaataaaaaaaagaggtcactaaaagaccaagatgggaaacgtaacatggaatacaagcttgaatctgggaaacaagctcaaaaaacagtgaaaaaaaaagtactggtttaggagttcaaaattcagtgaaacaaactttttgccaatagacctagggatctaagaaatagaattagggagagtttacacttacttacctatatatcagcagatttttctggaagaaaccctttttttttttttttttaaacagtaacatccagagtgacaaattgcaggagatttaatgtataaaatttctaggaattaaaagcttaaacccaaaaattgttcatccatatataagaaattatcgaattaaaacttaatgtatgtcaattattttcaaatgtctaaattcctttggaaataaaaatatcagttttactttgaaattgctcaacttctgctattcatatggtctgattagtgacataagtagcagccgtttttcaacttcagtttcattcactaccattgtttccaaattatcaatctctgctagtaattatgaatttaagaccatattattatcaaaaacctagagaccaatcatatatctgaaaagaaatacccattaaaaattctgcctcctgtttattgagaactatgcattgaacattctgaatcattctaagcctctggagagactgtaatgatccattcatgagctggtatgaaatcagtgggaagcagaacaacagaaggaactttaaaagcaacaagcaattatgtaccatatatacactgtagcaaatattttatatttgagagtctttacagcttacatttccattccattattacaagtgatgaaaaacaaaaaattgcaagtagtatgcaaattataaatatacagtcttcccacttcactaaccaaattcctactttccagtgttacttcccaatttatgcaggaaacctcctgcaaagctgaaactgattagaaaattctttatattttaaaatagctctttctcatttttagagaagtcaaatagccaaccatcaaaattaagaataaattgaattgtcacagtccattacagttattgttgctagatccacctcatttgcagatgtccaaacttaaattcatctgttcttaaaatgctacttaaaactttggttgttttcctgtaatataaaagaaaaagttaatttatcaattgattgaatacagtttttactaattagtttatcaaaccaaatactgtgaacgtaccaggtgtttacagatttaaatgcatgttaccatagaaactattaaagtaactagaactgtcaaataacaaaacggctcatgtttttaaaatatatgtaactcattttaaaatatattaaattgtattccaaacctgttcttctgtttctgtggcacctaggtttaaaatatgtattaatgtgtaaatcacaagtaaaatgaattctaatgtacaagtttgttttaaaaagtgtatgtcaagcttttatttacacaataaaatgttattaaagatggaaagtcta
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:64168 -> Molecular function: GO:0005509 [calcium ion binding] evidence: IEA
GeneID:64168 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:64168 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:64168 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:64168 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.