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2024-04-23 22:41:07, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_022336 4226 bp mRNA linear PRI 11-MAY-2013
DEFINITION Homo sapiens ectodysplasin A receptor (EDAR), mRNA.
ACCESSION NM_022336
VERSION NM_022336.3 GI:188219612
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4226)
AUTHORS Kamberov,Y.G., Wang,S., Tan,J., Gerbault,P., Wark,A., Tan,L.,
Yang,Y., Li,S., Tang,K., Chen,H., Powell,A., Itan,Y., Fuller,D.,
Lohmueller,J., Mao,J., Schachar,A., Paymer,M., Hostetter,E.,
Byrne,E., Burnett,M., McMahon,A.P., Thomas,M.G., Lieberman,D.E.,
Jin,L., Tabin,C.J., Morgan,B.A. and Sabeti,P.C.
TITLE Modeling recent human evolution in mice by expression of a selected
EDAR variant
JOURNAL Cell 152 (4), 691-702 (2013)
PUBMED 23415220
REMARK GeneRIF: Study generated a knockin mouse model and found that, as
in humans, hair thickness is increased in EDAR370A mice; new
biological targets affected by the mutation were identified,
including mammary and eccrine glands. Building on these results
EDAR370A was found to be associated with an increased number of
active eccrine glands in the Han Chinese.
REFERENCE 2 (bases 1 to 4226)
AUTHORS Bashyam,M.D., Chaudhary,A.K., Reddy,E.C., Reddy,V., Acharya,V.,
Nagarajaram,H.A., Devi,A.R., Bashyam,L., Dalal,A.B., Gupta,N.,
Kabra,M., Agarwal,M., Phadke,S.R., Tainwala,R., Kumar,R. and
Hariharan,S.V.
TITLE A founder ectodysplasin A receptor (EDAR) mutation results in a
high frequency of the autosomal recessive form of hypohidrotic
ectodermal dysplasia in India
JOURNAL Br. J. Dermatol. 166 (4), 819-829 (2012)
PUBMED 22032522
REMARK GeneRIF: This is the first report of a founder EDAR mutation and of
a significantly high frequency of autosomal recessive HED.
REFERENCE 3 (bases 1 to 4226)
AUTHORS Naqvi,S.K., Wasif,N., Javaid,H. and Ahmad,W.
TITLE Two novel mutations in the gene EDAR causing autosomal recessive
hypohidrotic ectodermal dysplasia
JOURNAL Orthod Craniofac Res 14 (3), 156-159 (2011)
PUBMED 21771270
REMARK GeneRIF: screening of all the 12 exons and splice junctions of gene
EDAR revealed a novel missense mutation (c.1163T>C; p.Ile388Thr) in
family A and a novel insertion mutation (c.1014insA; p.V339SfsX6)
in family B.
REFERENCE 4 (bases 1 to 4226)
AUTHORS Cluzeau,C., Hadj-Rabia,S., Jambou,M., Mansour,S., Guigue,P.,
Masmoudi,S., Bal,E., Chassaing,N., Vincent,M.C., Viot,G.,
Clauss,F., Maniere,M.C., Toupenay,S., Le Merrer,M., Lyonnet,S.,
Cormier-Daire,V., Amiel,J., Faivre,L., de Prost,Y., Munnich,A.,
Bonnefont,J.P., Bodemer,C. and Smahi,A.
TITLE Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90%
of hypohidrotic/anhidrotic ectodermal dysplasia cases
JOURNAL Hum. Mutat. 32 (1), 70-72 (2011)
PUBMED 20979233
REMARK GeneRIF: WNT10A and EDAR were each responsible for 16% of
hypohidrotic/anhidrotic ectodermal dysplasia cases.
REFERENCE 5 (bases 1 to 4226)
AUTHORS Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
CONSRTM DREAM investigators
TITLE Variation at the NFATC2 locus increases the risk of
thiazolidinedione-induced edema in the Diabetes REduction
Assessment with ramipril and rosiglitazone Medication (DREAM) study
JOURNAL Diabetes Care 33 (10), 2250-2253 (2010)
PUBMED 20628086
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 6 (bases 1 to 4226)
AUTHORS Kumar,A., Eby,M.T., Sinha,S., Jasmin,A. and Chaudhary,P.M.
TITLE The ectodermal dysplasia receptor activates the nuclear
factor-kappaB, JNK, and cell death pathways and binds to
ectodysplasin A
JOURNAL J. Biol. Chem. 276 (4), 2668-2677 (2001)
PUBMED 11035039
REFERENCE 7 (bases 1 to 4226)
AUTHORS Yan,M., Wang,L.C., Hymowitz,S.G., Schilbach,S., Lee,J., Goddard,A.,
de Vos,A.M., Gao,W.Q. and Dixit,V.M.
TITLE Two-amino acid molecular switch in an epithelial morphogen that
regulates binding to two distinct receptors
JOURNAL Science 290 (5491), 523-527 (2000)
PUBMED 11039935
REFERENCE 8 (bases 1 to 4226)
AUTHORS Monreal,A.W., Ferguson,B.M., Headon,D.J., Street,S.L.,
Overbeek,P.A. and Zonana,J.
TITLE Mutations in the human homologue of mouse dl cause autosomal
recessive and dominant hypohidrotic ectodermal dysplasia
JOURNAL Nat. Genet. 22 (4), 366-369 (1999)
PUBMED 10431241
REFERENCE 9 (bases 1 to 4226)
AUTHORS Ho,L., Williams,M.S. and Spritz,R.A.
TITLE A gene for autosomal dominant hypohidrotic ectodermal dysplasia
(EDA3) maps to chromosome 2q11-q13
JOURNAL Am. J. Hum. Genet. 62 (5), 1102-1106 (1998)
PUBMED 9545409
REFERENCE 10 (bases 1 to 4226)
AUTHORS Aswegan,A.L., Josephson,K.D., Mowbray,R., Pauli,R.M., Spritz,R.A.
and Williams,M.S.
TITLE Autosomal dominant hypohidrotic ectodermal dysplasia in a large
family
JOURNAL Am. J. Med. Genet. 72 (4), 462-467 (1997)
PUBMED 9375732
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF130988.1, AC092160.5,
AC133784.2, AC073415.6 and AI017384.1.
This sequence is a reference standard in the RefSeqGene project.
On May 15, 2008 this sequence version replaced gi:142372361.
Summary: This gene encodes a member of the tumor necrosis factor
receptor family. The encoded transmembrane protein is a receptor
for the soluble ligand ectodysplasin A, and can activate the
nuclear factor-kappaB, JNK, and caspase-independent cell death
pathways. It is required for the development of hair, teeth, and
other ectodermal derivatives. Mutations in this gene result in
autosomal dominant and recessive forms of hypohidrotic ectodermal
dysplasia. [provided by RefSeq, Jul 2008].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF130988.1, AK313781.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025082, ERS025084 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-14 AF130988.1 2-15
15-268 AC092160.5 27026-27279 c
269-1819 AF130988.1 270-1820
1820-2135 AC133784.2 1-316 c
2136-3376 AC073415.6 211428-212668 c
3377-4212 AF130988.1 3378-4213
4213-4226 AI017384.1 1-14 c
FEATURES Location/Qualifiers
source 1..4226
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q13"
gene 1..4226
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/note="ectodysplasin A receptor"
/db_xref="GeneID:10913"
/db_xref="HGNC:2895"
/db_xref="HPRD:04974"
/db_xref="MIM:604095"
exon 1..413
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/inference="alignment:Splign:1.39.8"
variation 62
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:3749110"
misc_feature 366..368
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/note="upstream in-frame stop codon"
STS 409..1806
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/db_xref="UniSTS:483654"
exon 414..482
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/inference="alignment:Splign:1.39.8"
CDS 432..1778
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/note="downless, mouse, homolog of; ectodysplasin 1,
anhidrotic receptor; tumor necrosis factor receptor
superfamily member EDAR; EDA-A1 receptor; downless
homolog; ectodysplasin-A receptor; ectodermal dysplasia
receptor; anhidrotic ectodysplasin receptor 1"
/codon_start=1
/product="tumor necrosis factor receptor superfamily
member EDAR precursor"
/protein_id="NP_071731.1"
/db_xref="GI:11641231"
/db_xref="CCDS:CCDS2081.1"
/db_xref="GeneID:10913"
/db_xref="HGNC:2895"
/db_xref="HPRD:04974"
/db_xref="MIM:604095"
/translation="
MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPYLSCGYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGASANFPGTSGSSTLSPFQHAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMFYILKTKPSAPACCTSHPGKSVEAQVSKDEEKKEAPDNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSPELCLLSLVHLAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASQPHAAS
"
sig_peptide 432..509
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 510..1775
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/product="tumor necrosis factor receptor superfamily
member EDAR"
misc_feature 519..644
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UNE0.1);
Region: TNFR-Cys 1"
misc_feature <621..812
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/note="Tumor necrosis factor receptor (TNFR) domain;
superfamily of TNF-like receptor domains. When bound to
TNF-like cytokines, TNFRs trigger multiple signal
transduction pathways, they are involved in inflammation
response, apoptosis, autoimmunity and...; Region: TNFR;
cl12111"
/db_xref="CDD:209448"
misc_feature 648..770
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UNE0.1);
Region: TNFR-Cys 2"
misc_feature order(666..668,693..695,726..728,795..797)
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/note="antiparallel homodimerization interface
[polypeptide binding]; other site"
/db_xref="CDD:29147"
misc_feature order(672..674,690..698)
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/note="50's loop TNF binding site; other site"
/db_xref="CDD:29147"
misc_feature 774..875
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UNE0.1);
Region: TNFR-Cys 3"
misc_feature 993..1055
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9UNE0.1);
transmembrane region"
misc_feature 1401..1403
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1539..1724
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/note="Death domain; Region: Death; pfam00531"
/db_xref="CDD:201284"
exon 483..605
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/inference="alignment:Splign:1.39.8"
variation 587
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3749101"
exon 606..787
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/inference="alignment:Splign:1.39.8"
variation 732
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:61761320"
variation 750
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:61761321"
exon 788..873
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/inference="alignment:Splign:1.39.8"
exon 874..960
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/inference="alignment:Splign:1.39.8"
exon 961..1086
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/inference="alignment:Splign:1.39.8"
exon 1087..1161
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/inference="alignment:Splign:1.39.8"
variation 1154
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3749108"
exon 1162..1234
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/inference="alignment:Splign:1.39.8"
exon 1235..1394
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/inference="alignment:Splign:1.39.8"
variation 1244
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:3749098"
variation 1301
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/replace="c"
/replace="t"
/db_xref="dbSNP:3749099"
exon 1395..1455
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/inference="alignment:Splign:1.39.8"
exon 1456..4214
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/inference="alignment:Splign:1.39.8"
STS 3839..4107
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/standard_name="SGC44330"
/db_xref="UniSTS:9289"
STS 3855..4043
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
/standard_name="RH103303"
/db_xref="UniSTS:97634"
polyA_signal 4196..4201
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
polyA_site 4214
/gene="EDAR"
/gene_synonym="DL; ECTD10A; ECTD10B; ED1R; ED3; ED5;
EDA-A1R; EDA1R; EDA3; HRM1"
ORIGIN
ggggcagacggccggagagccaggtgtgccagggacctatggcagcagggctgaacgtgcccgctccagcctctccagtgctgggagagacctctagatggtgcaggtgagtttgcaatgagggaaagcccctcggcaaggactgagtttccaaacttgcagacagggcagggagcggtcaaggaagagttcccgggaagccctttaaacggaaaggaagcggggctagtgtcagagaggtgtgccaggtcccaggcagccctgctggcccctaaggacatagagtacctgcttctgagagggctgccacggtggccacctgtgaagcctgtcacccagaactggatggtacctgactttcttcatagacccatcttctgctgggactgaagctgacctccaacagaagccaggtgagcccttgggagaggatggcccatgtgggggactgcacgcagacgccctggctccccgtcctggtggtgtctctgatgtgctcagcccgagcggaatactcaaactgcggtgagaacgagtactacaaccagactacggggctgtgccaggagtgccccccgtgtgggccgggagaggagccctacctgtcctgtggctacggcaccaaagacgaggactacggctgcgtcccctgcccggcggagaagttttccaaaggaggctaccagatatgcaggcgtcacaaagactgtgagggcttcttccgggccaccgtgctgacaccaggggacatggagaatgacgctgagtgtggcccttgcctccctggctactacatgctggagaacagaccgaggaacatctatggcatggtctgctactcctgcctcctggcaccccccaacaccaaggaatgtgtgggagccacttcaggagcttctgccaacttccctggcacctcgggcagcagcaccctgtctcccttccagcacgcccacaaagaactctcaggccaaggacacctggccactgccctgatcattgcaatgtccaccatcttcatcatggccatcgccatcgtcctcatcatcatgttctacatcctgaagacaaagccctctgccccagcctgttgcaccagccacccggggaagagcgtggaggcccaagtgagcaaggacgaggagaagaaagaggccccagacaacgtggtgatgttctccgagaaggatgaatttgagaagctgacagcaactccagcaaagcccaccaagagcgagaacgatgcctcatccgagaatgagcagctgctgagccggagcgtcgacagtgatgaggagcccgcccctgacaagcagggctccccggagctgtgcctgctgtcgctggttcacctggccagggagaagtctgccaccagcaacaagtcagccgggattcaaagccggaggaaaaagatcctcgatgtgtatgccaacgtgtgtggagtcgtggaaggtcttagccccacggagctgccatttgattgcctcgagaagactagccgaatgctcagctccacgtacaactctgagaaggctgttgtgaaaacgtggcgccacctcgccgagagcttcggcctgaagagggatgagattgggggcatgacagacggcatgcaactctttgaccgcatcagcacggcaggctacagcatccctgagctactcacaaaactggtgcagattgagcggctggatgctgtggagtccttgtgtgcagacatactggagtgggcgggggttgtgccacctgcctcccagccacatgctgcatcctgaaaagcatgcctgtgggctgtcctcccaggacaagccaaggagccaacgagggctctggagctgtgagtggtgccaaaagactgccaagaatcaaggcttttgtgatatgtcaccgtatgccttaggatgttcaaggagccagacgaaataaggcctgtcttccaatttaaccaaagataaaggactagagccgggatactttcagatgctcgcctgtacctcaccaggcagagtaaatatctactcactcatacagccagcccaccagcccaccattaactcactgaacaatgagacaatgttgaggactcaaatgaatcaaaccccgtgggaatgacagaagtgaagaatctggtccctgtctttaaggagtttgcactccagtagaagacagaaggaacgtatgtttacaaaccacttcactggaagacgtcaaacaagctgaatgaaggggcgcttagaaaacgttaatagaagttctaagcgggagatgactccctactgggatgatgaaggatggcatcctagtgaagaagcagctcaaacattttgataaaatggcaacaaaatgcagacaccctgctccaggtattatttcaggtttagtacaagtctgttaataccctatgtggtttcattaggataactttttacctatccttgaggtcatccatattcttacaggccttccagtcaataatggaagagctcactctatacaaaaccaatatgcaaggcatgtgtttgtccaagcaattggatgtgtgcagtagccaatttcatttactgcattactctttggcctgggaaccctgtggtctgcactacatgtgaatggccttccacttcagtcttaggcagatttgaccttttaggggcagcaatgctgaaggacacagcaatttaaattataatgtgtcaggctgtgttttcacttcaaacatgtatgagtagtcagctgtaattagagaaatgatgacttcctaagagttcagccacgcataattctagatttcaagagcatctaagacttgtggattagcctcatggcatgagagtttcagactcagccttctgagccagtcagggaaagtggagttctgcagcgcaaatgagagcctgggcttgatgtcgagggagctggcttctagttgtgccaccttgggccttgtcttttcctctctctgcctcagtttctcgtctgccaatgagatgttagttagtgattctataattggggcaggtagggttcaggtgagcaaaaagaaagtggagctataggaaatgccaggcctttgaggtgctctatggaagtcaacacagtgtggtttgtccatttaaatgggaataaaaacagaaaaactcagacttggcattttcacaataactgcaatggtttgacataacatttataggcagaaagttaataaactggcattgttcttggcatattattgtactatccctgtaactgccaagagctcaggagccaggctagtgatcacaccaggggttagagttcactgctgaactccctgatggcaggtctgtgtttattactacattaaaacaaagtctctgacttataaagcgaggttgtaaaaattacaagttgcatgactgaaaaaatgctttagggggaaaatcagtcatatctttaacaccaacaagcaatttcccaccaacgaatgtagtacatactgtgagaggatcataatgaggtcctgaatatttaatatcatcatttactgtgtctgtttgctgctgtttttcgaacctatttggtttaccctgcaagctaaatactccacggcagagcttaattatccttttaattcctctttgaaatcctgtggtgcccccttccccctgccttgtgatgatgatgagtgagtctccccttaattagactgcaaatgtcacttgtgatgagtgtgccattccaggataacagcttgcaccctcctcagaatgttttcagcgaaagagtggggtggctgttctctgctcctggtgctttggcctcatttcacactattagaattctggggctgtaaggccagccagtgtcagctcatgttccattggctctccacctgccatttttagggagctattccttatatagttacaaattcccttgtcatttacttatttggaaacatgggatttactctgacaagctttagcctatgttatgggattcagaacaatgagatcataataattctcactgaccaaagctgggactccatcctgccatttttgtgtggagatattcataattctgcaatactttaaaacatttagaaaacaccccagggtaggtctgtggcccttagacagtgaagtcttaattgtcaatattatttttgtctaattctgtatatatataacttattatattttataatctcaataaacacattaataagaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10913 -> Molecular function: GO:0004872 [receptor activity] evidence: IDA
GeneID:10913 -> Molecular function: GO:0004888 [transmembrane signaling receptor activity] evidence: NAS
GeneID:10913 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:10913 -> Biological process: GO:0001942 [hair follicle development] evidence: IEA
GeneID:10913 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:10913 -> Biological process: GO:0008544 [epidermis development] evidence: TAS
GeneID:10913 -> Biological process: GO:0030154 [cell differentiation] evidence: IEA
GeneID:10913 -> Biological process: GO:0042346 [positive regulation of NF-kappaB import into nucleus] evidence: IEA
GeneID:10913 -> Biological process: GO:0042475 [odontogenesis of dentin-containing tooth] evidence: IEA
GeneID:10913 -> Biological process: GO:0043473 [pigmentation] evidence: IEA
GeneID:10913 -> Biological process: GO:0060662 [salivary gland cavitation] evidence: IEA
GeneID:10913 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
GeneID:10913 -> Cellular component: GO:0016021 [integral to membrane] evidence: NAS
GeneID:10913 -> Cellular component: GO:0045177 [apical part of cell] evidence: IEA
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