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2024-03-29 14:38:24, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_022157               2746 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens Ras-related GTP binding C (RRAGC), transcript variant
            1, mRNA.
ACCESSION   NM_022157
VERSION     NM_022157.3  GI:427918100
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2746)
  AUTHORS   Sancak,Y., Peterson,T.R., Shaul,Y.D., Lindquist,R.A., Thoreen,C.C.,
            Bar-Peled,L. and Sabatini,D.M.
  TITLE     The Rag GTPases bind raptor and mediate amino acid signaling to
            mTORC1
  JOURNAL   Science 320 (5882), 1496-1501 (2008)
   PUBMED   18497260
REFERENCE   2  (bases 1 to 2746)
  AUTHORS   Suhr,M.L., Dysvik,B., Bruland,O., Warnakulasuriya,S.,
            Amaratunga,A.N., Jonassen,I., Vasstrand,E.N. and Ibrahim,S.O.
  TITLE     Gene expression profile of oral squamous cell carcinomas from Sri
            Lankan betel quid users
  JOURNAL   Oncol. Rep. 18 (5), 1061-1075 (2007)
   PUBMED   17914555
REFERENCE   3  (bases 1 to 2746)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem. Biophys. Res. Commun. 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   4  (bases 1 to 2746)
  AUTHORS   Sekiguchi,T., Todaka,Y., Wang,Y., Hirose,E., Nakashima,N. and
            Nishimoto,T.
  TITLE     A novel human nucleolar protein, Nop132, binds to the G proteins,
            RRAG A/C/D
  JOURNAL   J. Biol. Chem. 279 (9), 8343-8350 (2004)
   PUBMED   14660641
REFERENCE   5  (bases 1 to 2746)
  AUTHORS   Sekiguchi,T., Hirose,E., Nakashima,N., Ii,M. and Nishimoto,T.
  TITLE     Novel G proteins, Rag C and Rag D, interact with GTP-binding
            proteins, Rag A and Rag B
  JOURNAL   J. Biol. Chem. 276 (10), 7246-7257 (2001)
   PUBMED   11073942
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139260.19, BG717489.1,
            BI461665.1, AK315791.1, BC016668.1, CA449149.1, CX761032.1,
            CB132041.1, HY264464.1, HY202961.1 and BQ003663.1.
            On Dec 5, 2012 this sequence version replaced gi:31542866.
            
            Summary: This gene encodes a member of the GTR/RAG GTP-binding
            protein family. The encoded protein is a monomeric guanine
            nucleotide-binding protein which forms a heterodimer with RRAGA and
            RRAGB and is primarily localized to the cytoplasm. The encoded
            protein promotes intracellular localization of the mTOR complex.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016668.1, AF323609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL139260.19        75921-75924         c
            5-48                BG717489.1         11-54
            49-51               AL139260.19        75874-75876         c
            52-75               BI461665.1         5-28
            76-869              AK315791.1         1-794
            870-1597            BC016668.1         715-1442
            1598-1599           CA449149.1         1-2                 c
            1600-1823           CX761032.1         511-734
            1824-2275           CB132041.1         147-598
            2276-2337           HY264464.1         2-63                c
            2338-2728           HY202961.1         1-391               c
            2729-2746           BQ003663.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2746
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34"
     gene            1..2746
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /note="Ras-related GTP binding C"
                     /db_xref="GeneID:64121"
                     /db_xref="HGNC:19902"
                     /db_xref="HPRD:12198"
                     /db_xref="MIM:608267"
     exon            1..414
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    25..27
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /note="upstream in-frame stop codon"
     CDS             178..1377
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /note="isoform 1 is encoded by transcript variant 1; Rag C
                     protein; ras-related GTP-binding protein C;
                     GTPase-interacting protein 2"
                     /codon_start=1
                     /product="ras-related GTP-binding protein C isoform 1"
                     /protein_id="NP_071440.1"
                     /db_xref="GI:11995472"
                     /db_xref="CCDS:CCDS430.1"
                     /db_xref="GeneID:64121"
                     /db_xref="HGNC:19902"
                     /db_xref="HPRD:12198"
                     /db_xref="MIM:608267"
                     /translation="
MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAAGGGVGAGAGGGCGPGGADSSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCGHQTSASSLKALTHNGTPRNAI
"
     misc_feature    181..183
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylserine; propagated from
                     UniProtKB/Swiss-Prot (Q9HB90.1); acetylation site"
     misc_feature    181..183
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9HB90.1); phosphorylation site"
     misc_feature    364..1044
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /note="Gtr1/RagA G protein conserved region; Region:
                     Gtr1_RagA; pfam04670"
                     /db_xref="CDD:147030"
     misc_feature    364..888
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /note="Rag GTPase, subfamily of Ras-related GTPases,
                     includes Ras-related GTP-binding proteins C and D; Region:
                     RagC_like; cd11385"
                     /db_xref="CDD:206745"
     misc_feature    379..402
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /note="G1 box; other site"
                     /db_xref="CDD:206745"
     misc_feature    order(394..405,532..534,709..714,718..720,832..840)
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206745"
     misc_feature    463..465
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /note="G2 box; other site"
                     /db_xref="CDD:206745"
     misc_feature    475..483
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206745"
     misc_feature    523..534
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /note="G3 box; other site"
                     /db_xref="CDD:206745"
     misc_feature    order(529..534,589..594)
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206745"
     misc_feature    709..720
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /note="G4 box; other site"
                     /db_xref="CDD:206745"
     misc_feature    832..840
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /note="G5 box; other site"
                     /db_xref="CDD:206745"
     exon            415..618
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /inference="alignment:Splign:1.39.8"
     exon            619..818
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /inference="alignment:Splign:1.39.8"
     exon            819..933
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /inference="alignment:Splign:1.39.8"
     exon            934..1076
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /inference="alignment:Splign:1.39.8"
     exon            1077..1225
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /inference="alignment:Splign:1.39.8"
     exon            1226..2733
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /inference="alignment:Splign:1.39.8"
     STS             1262..1509
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /standard_name="RH50026"
                     /db_xref="UniSTS:36282"
     STS             1271..1544
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /standard_name="SHGC-74629"
                     /db_xref="UniSTS:8735"
     STS             1396..1526
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /standard_name="G29137"
                     /db_xref="UniSTS:81671"
     variation       1581
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201546414"
     STS             1599..1733
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /standard_name="SHGC-74630"
                     /db_xref="UniSTS:20965"
     STS             1715..1968
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /standard_name="SGC38299"
                     /db_xref="UniSTS:71855"
     STS             1845..1925
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /standard_name="D1S261E"
                     /db_xref="UniSTS:147342"
     variation       1874
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:9694"
     polyA_signal    2711..2716
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
     polyA_site      2733
                     /gene="RRAGC"
                     /gene_synonym="GTR2; RAGC; TIB929"
ORIGIN      
ggctgggcttcggctcggggcctatgagagccgggctccggggggcgggccggactgtggcggctgccgggggcggtggcggtggtggcggcggcggcggaggcggactggggaggcggcggcctggctcggcctggcctggcctgtcagggcgcgggcggcggcggctccagcaccatgtccctgcagtacggggcggaggagacgcccctcgccggcagttacggcgcggccgattcgtttccaaaggacttcggctacggcgtggaggaggaggaagaggaggcggcggcggcgggcggaggggttggggcaggggcaggcggtggctgtggtccggggggcgctgacagctccaagccgaggattctgctcatgggactccggcgcagcggcaagtcctccatccagaaggtggtgtttcataagatgtcacccaacgagaccctctttttggaaagtaccaacaagatttataaggatgacatttccaatagctcctttgtgaatttccagatatgggattttcctgggcaaatggacttttttgacccaacctttgactatgagatgatcttcaggggaacaggagcattgatatacgtcattgacgcacaggatgactacatggaggctttaacaagacttcacattactgtttctaaagcctacaaagttaacccagacatgaattttgaggtttttattcacaaagttgatggtctgtctgatgatcacaaaatagaaacacagagggacattcatcaaagggccaatgatgaccttgcagatgctgggctagaaaaactccatcttagcttttatctgactagtatctatgaccattcaatatttgaagcctttagtaaggtggtgcagaaactcattccacaactgccgaccttggaaaacctattaaatatctttatatcaaattcaggtattgaaaaagcttttctctttgatgttgtcagcaaaatctacattgcaacagacagttcccctgtggatatgcaatcttatgaactttgctgtgacatgatcgatgttgtaattgatgtgtcttgtatatatgggttaaaggaagatggaagtggaagtgcttatgacaaagaatctatggcaattatcaagctgaataatacaactgtcctttatttaaaggaggtgactaaatttttggcactggtctgcattctaagggaagaaagctttgaaagaaaaggtttaatagactacaacttccactgtttccgaaaagctattcatgaggtttttgaggtgggtgtgacttctcacaggagctgtggtcaccagactagtgcctccagtctgaaagcgctgacacacaatggcacgccacgaaacgccatctagtctgaatcccagcgtcggggctctgtgccagcttactcttcactccagggtcggatgccacgtgctacaggacatgggagctgctgcttgtgggaatctggtgcctgttccactagagacaaggggtagagtttctcatttggatgaaaaccccttcaactggtggtgtacaactgaagctactatatcttttttgaaaatggcaaaaaaaaaaaaaaaaaattctggagaccacagaactcaagtgtgtgtttctcctcttttgggtcccctttaagtagttgggatattttggacctggagataacaccagttacccatccttaccagggaatgttgccatcaattccagttgaaaataatagaaaagactgaatttttatatgcttcacttaggctttcatttgagtagactctaaaaattctgccttgcttaagttctaacactgcctctcagatttcagttttggacattgcacaactaagaccttttaaatgcatttgcttgctaactcggaagacacatagtctgcagcaagacattcctatattgaagaaatgagagaaaattttatgctgcatcaggtggagagcaaggctcaacggtggttgcattagttccctcggaagtattgaaaaaactttgaaatggaagaaaatttttgcacctatgttctgagtaccagatgtctgggttctttcttctgcattagataaatgatcatgctcagtgtaacaaagggaattaaaagttttcccacagtccccttctaggggagaaactcattgtgtcactgaaatgtttagcttactttaatcttgatatcagcctctacagaccttttattctaagctatcgagcttcttgattgcatttggttgaccacgagtgaccctaaggcattgggggactgtccactgggagttggagtgagcacgtggtgctgcaacaggcattgttttacatactttgtctctagtattctgacaccaagtgtcaactgtggtactttctttgcctaggatatgaattcataattgttgcttttgttgatggttgataccctttccattgatttaaacctaacacattatttctattccacatgcccagtagacatatattccaaagccactggaccacttgagtacataagtgccactgtttaatgcaatatgtatattcaggtctgtaaagctaacagtgtgacttggagtgcttcctgcaggtgattctgacttgagtatttacatggaccatggtgatatccaaaagaaaaatgctttttatatttatagattatttcattgaactatatatgaaatgggtatcaataaatgtatttactccaaaataaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:64121 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: NAS
            GeneID:64121 -> Molecular function: GO:0003924 [GTPase activity] evidence: IDA
            GeneID:64121 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:64121 -> Molecular function: GO:0005525 [GTP binding] evidence: IDA
            GeneID:64121 -> Molecular function: GO:0019003 [GDP binding] evidence: IDA
            GeneID:64121 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IPI
            GeneID:64121 -> Biological process: GO:0006184 [GTP catabolic process] evidence: IDA
            GeneID:64121 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: NAS
            GeneID:64121 -> Biological process: GO:0006915 [apoptotic process] evidence: NAS
            GeneID:64121 -> Biological process: GO:0007264 [small GTPase mediated signal transduction] evidence: TAS
            GeneID:64121 -> Biological process: GO:0008380 [RNA splicing] evidence: NAS
            GeneID:64121 -> Biological process: GO:0016049 [cell growth] evidence: NAS
            GeneID:64121 -> Biological process: GO:0034613 [cellular protein localization] evidence: ISS
            GeneID:64121 -> Biological process: GO:0071230 [cellular response to amino acid stimulus] evidence: ISS
            GeneID:64121 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:64121 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:64121 -> Cellular component: GO:0005764 [lysosome] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_071440 -> EC 3.6.5.1
            NP_071440 -> EC 3.6.5.2
            NP_071440 -> EC 3.6.5.3
            NP_071440 -> EC 3.6.5.4

by @meso_cacase at DBCLS
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