2024-03-29 14:38:24, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_022157 2746 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens Ras-related GTP binding C (RRAGC), transcript variant 1, mRNA. ACCESSION NM_022157 VERSION NM_022157.3 GI:427918100 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2746) AUTHORS Sancak,Y., Peterson,T.R., Shaul,Y.D., Lindquist,R.A., Thoreen,C.C., Bar-Peled,L. and Sabatini,D.M. TITLE The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1 JOURNAL Science 320 (5882), 1496-1501 (2008) PUBMED 18497260 REFERENCE 2 (bases 1 to 2746) AUTHORS Suhr,M.L., Dysvik,B., Bruland,O., Warnakulasuriya,S., Amaratunga,A.N., Jonassen,I., Vasstrand,E.N. and Ibrahim,S.O. TITLE Gene expression profile of oral squamous cell carcinomas from Sri Lankan betel quid users JOURNAL Oncol. Rep. 18 (5), 1061-1075 (2007) PUBMED 17914555 REFERENCE 3 (bases 1 to 2746) AUTHORS Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M., Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S., Kim,Y.S. and Kim,N.S. TITLE Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags JOURNAL Biochem. Biophys. Res. Commun. 345 (3), 1022-1032 (2006) PUBMED 16712791 REFERENCE 4 (bases 1 to 2746) AUTHORS Sekiguchi,T., Todaka,Y., Wang,Y., Hirose,E., Nakashima,N. and Nishimoto,T. TITLE A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D JOURNAL J. Biol. Chem. 279 (9), 8343-8350 (2004) PUBMED 14660641 REFERENCE 5 (bases 1 to 2746) AUTHORS Sekiguchi,T., Hirose,E., Nakashima,N., Ii,M. and Nishimoto,T. TITLE Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B JOURNAL J. Biol. Chem. 276 (10), 7246-7257 (2001) PUBMED 11073942 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL139260.19, BG717489.1, BI461665.1, AK315791.1, BC016668.1, CA449149.1, CX761032.1, CB132041.1, HY264464.1, HY202961.1 and BQ003663.1. On Dec 5, 2012 this sequence version replaced gi:31542866. Summary: This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC016668.1, AF323609.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-4 AL139260.19 75921-75924 c 5-48 BG717489.1 11-54 49-51 AL139260.19 75874-75876 c 52-75 BI461665.1 5-28 76-869 AK315791.1 1-794 870-1597 BC016668.1 715-1442 1598-1599 CA449149.1 1-2 c 1600-1823 CX761032.1 511-734 1824-2275 CB132041.1 147-598 2276-2337 HY264464.1 2-63 c 2338-2728 HY202961.1 1-391 c 2729-2746 BQ003663.1 1-18 c FEATURES Location/Qualifiers source 1..2746 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="1" /map="1p34" gene 1..2746 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /note="Ras-related GTP binding C" /db_xref="GeneID:64121" /db_xref="HGNC:19902" /db_xref="HPRD:12198" /db_xref="MIM:608267" exon 1..414 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /inference="alignment:Splign:1.39.8" misc_feature 25..27 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /note="upstream in-frame stop codon" CDS 178..1377 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /note="isoform 1 is encoded by transcript variant 1; Rag C protein; ras-related GTP-binding protein C; GTPase-interacting protein 2" /codon_start=1 /product="ras-related GTP-binding protein C isoform 1" /protein_id="NP_071440.1" /db_xref="GI:11995472" /db_xref="CCDS:CCDS430.1" /db_xref="GeneID:64121" /db_xref="HGNC:19902" /db_xref="HPRD:12198" /db_xref="MIM:608267" /translation="
MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAAGGGVGAGAGGGCGPGGADSSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCGHQTSASSLKALTHNGTPRNAI
" misc_feature 181..183 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /experiment="experimental evidence, no additional details recorded" /note="N-acetylserine; propagated from UniProtKB/Swiss-Prot (Q9HB90.1); acetylation site" misc_feature 181..183 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q9HB90.1); phosphorylation site" misc_feature 364..1044 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /note="Gtr1/RagA G protein conserved region; Region: Gtr1_RagA; pfam04670" /db_xref="CDD:147030" misc_feature 364..888 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /note="Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D; Region: RagC_like; cd11385" /db_xref="CDD:206745" misc_feature 379..402 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /note="G1 box; other site" /db_xref="CDD:206745" misc_feature order(394..405,532..534,709..714,718..720,832..840) /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /note="GTP/Mg2+ binding site [chemical binding]; other site" /db_xref="CDD:206745" misc_feature 463..465 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /note="G2 box; other site" /db_xref="CDD:206745" misc_feature 475..483 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /note="Switch I region; other site" /db_xref="CDD:206745" misc_feature 523..534 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /note="G3 box; other site" /db_xref="CDD:206745" misc_feature order(529..534,589..594) /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /note="Switch II region; other site" /db_xref="CDD:206745" misc_feature 709..720 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /note="G4 box; other site" /db_xref="CDD:206745" misc_feature 832..840 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /note="G5 box; other site" /db_xref="CDD:206745" exon 415..618 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /inference="alignment:Splign:1.39.8" exon 619..818 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /inference="alignment:Splign:1.39.8" exon 819..933 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /inference="alignment:Splign:1.39.8" exon 934..1076 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /inference="alignment:Splign:1.39.8" exon 1077..1225 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /inference="alignment:Splign:1.39.8" exon 1226..2733 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /inference="alignment:Splign:1.39.8" STS 1262..1509 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /standard_name="RH50026" /db_xref="UniSTS:36282" STS 1271..1544 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /standard_name="SHGC-74629" /db_xref="UniSTS:8735" STS 1396..1526 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /standard_name="G29137" /db_xref="UniSTS:81671" variation 1581 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /replace="a" /replace="c" /db_xref="dbSNP:201546414" STS 1599..1733 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /standard_name="SHGC-74630" /db_xref="UniSTS:20965" STS 1715..1968 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /standard_name="SGC38299" /db_xref="UniSTS:71855" STS 1845..1925 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /standard_name="D1S261E" /db_xref="UniSTS:147342" variation 1874 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" /replace="c" /replace="t" /db_xref="dbSNP:9694" polyA_signal 2711..2716 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" polyA_site 2733 /gene="RRAGC" /gene_synonym="GTR2; RAGC; TIB929" ORIGIN
ggctgggcttcggctcggggcctatgagagccgggctccggggggcgggccggactgtggcggctgccgggggcggtggcggtggtggcggcggcggcggaggcggactggggaggcggcggcctggctcggcctggcctggcctgtcagggcgcgggcggcggcggctccagcaccatgtccctgcagtacggggcggaggagacgcccctcgccggcagttacggcgcggccgattcgtttccaaaggacttcggctacggcgtggaggaggaggaagaggaggcggcggcggcgggcggaggggttggggcaggggcaggcggtggctgtggtccggggggcgctgacagctccaagccgaggattctgctcatgggactccggcgcagcggcaagtcctccatccagaaggtggtgtttcataagatgtcacccaacgagaccctctttttggaaagtaccaacaagatttataaggatgacatttccaatagctcctttgtgaatttccagatatgggattttcctgggcaaatggacttttttgacccaacctttgactatgagatgatcttcaggggaacaggagcattgatatacgtcattgacgcacaggatgactacatggaggctttaacaagacttcacattactgtttctaaagcctacaaagttaacccagacatgaattttgaggtttttattcacaaagttgatggtctgtctgatgatcacaaaatagaaacacagagggacattcatcaaagggccaatgatgaccttgcagatgctgggctagaaaaactccatcttagcttttatctgactagtatctatgaccattcaatatttgaagcctttagtaaggtggtgcagaaactcattccacaactgccgaccttggaaaacctattaaatatctttatatcaaattcaggtattgaaaaagcttttctctttgatgttgtcagcaaaatctacattgcaacagacagttcccctgtggatatgcaatcttatgaactttgctgtgacatgatcgatgttgtaattgatgtgtcttgtatatatgggttaaaggaagatggaagtggaagtgcttatgacaaagaatctatggcaattatcaagctgaataatacaactgtcctttatttaaaggaggtgactaaatttttggcactggtctgcattctaagggaagaaagctttgaaagaaaaggtttaatagactacaacttccactgtttccgaaaagctattcatgaggtttttgaggtgggtgtgacttctcacaggagctgtggtcaccagactagtgcctccagtctgaaagcgctgacacacaatggcacgccacgaaacgccatctagtctgaatcccagcgtcggggctctgtgccagcttactcttcactccagggtcggatgccacgtgctacaggacatgggagctgctgcttgtgggaatctggtgcctgttccactagagacaaggggtagagtttctcatttggatgaaaaccccttcaactggtggtgtacaactgaagctactatatcttttttgaaaatggcaaaaaaaaaaaaaaaaaattctggagaccacagaactcaagtgtgtgtttctcctcttttgggtcccctttaagtagttgggatattttggacctggagataacaccagttacccatccttaccagggaatgttgccatcaattccagttgaaaataatagaaaagactgaatttttatatgcttcacttaggctttcatttgagtagactctaaaaattctgccttgcttaagttctaacactgcctctcagatttcagttttggacattgcacaactaagaccttttaaatgcatttgcttgctaactcggaagacacatagtctgcagcaagacattcctatattgaagaaatgagagaaaattttatgctgcatcaggtggagagcaaggctcaacggtggttgcattagttccctcggaagtattgaaaaaactttgaaatggaagaaaatttttgcacctatgttctgagtaccagatgtctgggttctttcttctgcattagataaatgatcatgctcagtgtaacaaagggaattaaaagttttcccacagtccccttctaggggagaaactcattgtgtcactgaaatgtttagcttactttaatcttgatatcagcctctacagaccttttattctaagctatcgagcttcttgattgcatttggttgaccacgagtgaccctaaggcattgggggactgtccactgggagttggagtgagcacgtggtgctgcaacaggcattgttttacatactttgtctctagtattctgacaccaagtgtcaactgtggtactttctttgcctaggatatgaattcataattgttgcttttgttgatggttgataccctttccattgatttaaacctaacacattatttctattccacatgcccagtagacatatattccaaagccactggaccacttgagtacataagtgccactgtttaatgcaatatgtatattcaggtctgtaaagctaacagtgtgacttggagtgcttcctgcaggtgattctgacttgagtatttacatggaccatggtgatatccaaaagaaaaatgctttttatatttatagattatttcattgaactatatatgaaatgggtatcaataaatgtatttactccaaaataaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:64121 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: NAS GeneID:64121 -> Molecular function: GO:0003924 [GTPase activity] evidence: IDA GeneID:64121 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:64121 -> Molecular function: GO:0005525 [GTP binding] evidence: IDA GeneID:64121 -> Molecular function: GO:0019003 [GDP binding] evidence: IDA GeneID:64121 -> Molecular function: GO:0046982 [protein heterodimerization activity] evidence: IPI GeneID:64121 -> Biological process: GO:0006184 [GTP catabolic process] evidence: IDA GeneID:64121 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: NAS GeneID:64121 -> Biological process: GO:0006915 [apoptotic process] evidence: NAS GeneID:64121 -> Biological process: GO:0007264 [small GTPase mediated signal transduction] evidence: TAS GeneID:64121 -> Biological process: GO:0008380 [RNA splicing] evidence: NAS GeneID:64121 -> Biological process: GO:0016049 [cell growth] evidence: NAS GeneID:64121 -> Biological process: GO:0034613 [cellular protein localization] evidence: ISS GeneID:64121 -> Biological process: GO:0071230 [cellular response to amino acid stimulus] evidence: ISS GeneID:64121 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:64121 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:64121 -> Cellular component: GO:0005764 [lysosome] evidence: IDA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_071440 -> EC 3.6.5.1 NP_071440 -> EC 3.6.5.2 NP_071440 -> EC 3.6.5.3 NP_071440 -> EC 3.6.5.4
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