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2024-04-26 00:16:23, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_022111 8484 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens claspin (CLSPN), transcript variant 1, mRNA.
ACCESSION NM_022111
VERSION NM_022111.3 GI:299522982
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8484)
AUTHORS Sato,K., Sundaramoorthy,E., Rajendra,E., Hattori,H.,
Jeyasekharan,A.D., Ayoub,N., Schiess,R., Aebersold,R.,
Nishikawa,H., Sedukhina,A.S., Wada,H., Ohta,T. and
Venkitaraman,A.R.
TITLE A DNA-damage selective role for BRCA1 E3 ligase in claspin
ubiquitylation, CHK1 activation, and DNA repair
JOURNAL Curr. Biol. 22 (18), 1659-1666 (2012)
PUBMED 22863316
REMARK GeneRIF: findings identify claspin as an in vivo substrate for the
BRCA1 E3 ligase and suggest that its modification selectively
triggers CHK1 activation for the homology-directed repair of a
subset of genotoxic lesions
REFERENCE 2 (bases 1 to 8484)
AUTHORS Liu,S., Song,N. and Zou,L.
TITLE The conserved C terminus of Claspin interacts with Rad9 and
promotes rapid activation of Chk1
JOURNAL Cell Cycle 11 (14), 2711-2716 (2012)
PUBMED 22732499
REMARK GeneRIF: The conserved C terminus of Claspin interacts with Rad9
and ensures timely activation of the ATR-Chk1 pathway.
REFERENCE 3 (bases 1 to 8484)
AUTHORS Benevolo,M., Musio,A., Vocaturo,A., Dona,M.G., Rollo,F.,
Terrenato,I., Carosi,M., Pescarmona,E., Vocaturo,G. and
Mottolese,M.
TITLE Claspin as a biomarker of human papillomavirus-related high grade
lesions of uterine cervix
JOURNAL J Transl Med 10, 132 (2012)
PUBMED 22731782
REMARK GeneRIF: analysis of claspin expression could be clinically
relevant in the diagnosis of HPV-related cervical lesions, in
particular when applied to cervico-vaginal cytology
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 8484)
AUTHORS Yoshimura,A., Akita,M., Hosono,Y., Abe,T., Kobayashi,M.,
Yamamoto,K., Tada,S., Seki,M. and Enomoto,T.
TITLE Functional relationship between Claspin and Rad17
JOURNAL Biochem. Biophys. Res. Commun. 414 (2), 298-303 (2011)
PUBMED 21945441
REMARK GeneRIF: the functions of Claspin and the functional relationship
between Claspin and Rad17 were studied.
REFERENCE 5 (bases 1 to 8484)
AUTHORS Izawa,N., Wu,W., Sato,K., Nishikawa,H., Kato,A., Boku,N., Itoh,F.
and Ohta,T.
TITLE HERC2 Interacts with Claspin and regulates DNA origin firing and
replication fork progression
JOURNAL Cancer Res. 71 (17), 5621-5625 (2011)
PUBMED 21775519
REMARK GeneRIF: In the presence of BRCA1, endogenous HERC2 interacts with
Claspin, a protein essential for G(2)-M checkpoint activation and
replication fork stability.
REFERENCE 6 (bases 1 to 8484)
AUTHORS Sorensen,C.S., Syljuasen,R.G., Lukas,J. and Bartek,J.
TITLE ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and
Cdc25A in the absence of DNA damage
JOURNAL Cell Cycle 3 (7), 941-945 (2004)
PUBMED 15190204
REFERENCE 7 (bases 1 to 8484)
AUTHORS Lin,S.Y., Li,K., Stewart,G.S. and Elledge,S.J.
TITLE Human Claspin works with BRCA1 to both positively and negatively
regulate cell proliferation
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (17), 6484-6489 (2004)
PUBMED 15096610
REMARK GeneRIF: determination of properties of both a tumor suppressor and
an oncogene
REFERENCE 8 (bases 1 to 8484)
AUTHORS Chini,C.C. and Chen,J.
TITLE Human claspin is required for replication checkpoint control
JOURNAL J. Biol. Chem. 278 (32), 30057-30062 (2003)
PUBMED 12766152
REMARK GeneRIF: Claspin has a potentially critical role in replication
checkpoint control in mammalian cells
REFERENCE 9 (bases 1 to 8484)
AUTHORS Zou,L. and Elledge,S.J.
TITLE Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
JOURNAL Science 300 (5625), 1542-1548 (2003)
PUBMED 12791985
REFERENCE 10 (bases 1 to 8484)
AUTHORS Kumagai,A. and Dunphy,W.G.
TITLE Claspin, a novel protein required for the activation of Chk1 during
a DNA replication checkpoint response in Xenopus egg extracts
JOURNAL Mol. Cell 6 (4), 839-849 (2000)
PUBMED 11090622
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AF297866.1, BC137279.1 and
AL354864.16.
On Jun 25, 2010 this sequence version replaced gi:21735568.
Summary: The product of this gene is an essential upstream
regulator of checkpoint kinase 1 and triggers a checkpoint arrest
of the cell cycle in response to replicative stress or DNA damage.
The protein is also required for efficient DNA replication during a
normal S phase. Multiple transcript variants encoding different
isoforms have been found for this gene. [provided by RefSeq, Jun
2010].
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC137279.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025085 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-21 AF297866.1 1-21
22-4301 BC137279.1 1-4280
4302-8484 AL354864.16 77956-82138
FEATURES Location/Qualifiers
source 1..8484
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p34.2"
gene 1..8484
/gene="CLSPN"
/note="claspin"
/db_xref="GeneID:63967"
/db_xref="HGNC:19715"
/db_xref="HPRD:09257"
/db_xref="MIM:605434"
exon 1..104
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
misc_feature 54..56
/gene="CLSPN"
/note="upstream in-frame stop codon"
CDS 81..4100
/gene="CLSPN"
/note="isoform 1 is encoded by transcript variant 1;
hClaspin; claspin homolog"
/codon_start=1
/product="claspin isoform 1"
/protein_id="NP_071394.2"
/db_xref="GI:21735569"
/db_xref="CCDS:CCDS396.1"
/db_xref="GeneID:63967"
/db_xref="HGNC:19715"
/db_xref="HPRD:09257"
/db_xref="MIM:605434"
/translation="
MTGEVGSEVHLEINDPNVISQEEADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGSELSKGTTRKERKAARLSKEALKQLHSETQRLIRESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCNRQTGRGTSFFPTAGGFRSPSPGLFRASLVSSASKSSGKLSEPSLPIEDSQDLYNASPEPKTLFLGAGDFQFCLEDDTQSQLLDADGFLNVRNHRNQYQALKPRLPLASMDENAMDANMDELLDLCTGKFTSQAEKHLPRKSDKKENMEELLNLCSGKFTSQDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLRNPFEAIRPGSAQQVKTGSLLNQPKAVLQKLAALSDHNPSAPRNSRNFVFHTLSPVKAEAAKESSKSQVKKRGPSFMTSPSPKHLKTDDSTSGLTRSIFKYLES
"
misc_feature 273..275
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 273..275
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 279..281
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 279..281
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 303..305
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 327..329
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 753..755
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 2232..2234
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 2238..2240
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 2247..2249
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 2364..2366
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2370..2372
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2502..2504
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 2508..2510
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 2508..2510
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2577..2579
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 2577..2579
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2595..2597
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 2595..2597
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2616..2618
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 2616..2618
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2751..2753
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q9HAW4.3); acetylation site"
misc_feature 2808..2837
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9HAW4.3);
Region: CKB motif 1"
misc_feature 2826..2828
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by CHEK1; propagated from
UniProtKB/Swiss-Prot (Q9HAW4.3); phosphorylation site"
misc_feature 2826..2828
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:04356"
misc_feature 2895..2924
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9HAW4.3);
Region: CKB motif 2"
misc_feature 2928..2930
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3006..3035
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9HAW4.3);
Region: CKB motif 3"
misc_feature 3114..3116
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 3132..3134
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 3138..3140
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 3294..3296
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:03457"
misc_feature 3519..3521
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3546..3548
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 3546..3548
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3939..3941
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3945..3947
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9HAW4.3); phosphorylation site"
misc_feature 3945..3947
/gene="CLSPN"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
exon 105..213
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 214..662
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 663..824
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 825..902
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
variation 852
/gene="CLSPN"
/replace="a"
/replace="g"
/db_xref="dbSNP:35435909"
exon 903..975
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 976..1084
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 1085..1659
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 1660..1851
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 1852..2108
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 2109..2287
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 2288..2352
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 2353..2552
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 2553..2707
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 2708..2934
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
variation 2754
/gene="CLSPN"
/replace="a"
/replace="c"
/db_xref="dbSNP:34390044"
exon 2935..3046
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 3047..3122
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 3123..3223
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 3224..3388
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 3389..3510
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 3511..3638
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 3639..3744
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 3745..3827
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
exon 3828..3989
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
variation 3919
/gene="CLSPN"
/replace="c"
/replace="t"
/db_xref="dbSNP:35490896"
exon 3990..8484
/gene="CLSPN"
/inference="alignment:Splign:1.39.8"
STS 4409..5008
/gene="CLSPN"
/standard_name="PMC156606P1"
/db_xref="UniSTS:271408"
STS 4490..5950
/gene="CLSPN"
/standard_name="GDB:312794"
/db_xref="UniSTS:30247"
STS 4545..5948
/gene="CLSPN"
/standard_name="L17971"
/db_xref="UniSTS:43966"
STS 4570..4991
/gene="CLSPN"
/standard_name="G38154"
/db_xref="UniSTS:53341"
variation 4849
/gene="CLSPN"
/replace="g"
/replace="t"
/db_xref="dbSNP:1062047"
STS 4943..5012
/gene="CLSPN"
/standard_name="D1S1423"
/db_xref="UniSTS:149619"
STS 5320..5443
/gene="CLSPN"
/standard_name="RH91339"
/db_xref="UniSTS:88492"
STS 5472..5611
/gene="CLSPN"
/standard_name="SHGC-37119"
/db_xref="UniSTS:32226"
polyA_signal 5606..5611
/gene="CLSPN"
STS 5618..6666
/gene="CLSPN"
/standard_name="D11S1910"
/db_xref="UniSTS:149174"
polyA_site 5628
/gene="CLSPN"
variation 5807
/gene="CLSPN"
/replace="c"
/replace="t"
/db_xref="dbSNP:609070"
STS 5930..6051
/gene="CLSPN"
/standard_name="G44334"
/db_xref="UniSTS:95121"
variation 5963
/gene="CLSPN"
/replace="c"
/replace="t"
/db_xref="dbSNP:620296"
STS 5992..6771
/gene="CLSPN"
/standard_name="RH36905"
/db_xref="UniSTS:87932"
STS 7212..7359
/gene="CLSPN"
/standard_name="L17791"
/db_xref="UniSTS:42740"
STS 7490..7559
/gene="CLSPN"
/standard_name="D1S1423"
/db_xref="UniSTS:149619"
polyA_signal 8462..8467
/gene="CLSPN"
polyA_site 8484
/gene="CLSPN"
ORIGIN
gacggcgggagccgctgctctccggctgagggaatcagagacagctccgtccctagtggagcgcaggggaggcagaagtcatgacaggcgaggtgggttctgaggttcacctagaaatcaatgacccaaacgtcatttcacaagaggaagcagatagtccttcagatagtggacagggcagctatgaaacaattggacccttgagtgaaggagattcagatgaagagatatttgtaagtaagaagttgaaaaacaggaaggttctacaagacagtgattccgaaacagaggacacaaatgcctctccagagaaaactacctatgacagtgccgaggaggaaaataaagagaatttatatgctgggaaaaatacaaaaatcaaaaggatttacaaaactgtggcagacagtgatgaaagttacatggaaaagtctttgtatcaggaaaatcttgaagcgcaagtgaaaccttgcttagagctgagtcttcagtctggaaactctacagactttaccactgacagaaagagttccaaaaagcacatacatgataaagaaggaactgcaggaaaagcaaaagtaaaatcaaaaagaagacttgagaaagaggagagaaaaatggaaaaaattagacagctaaaaaagaaggaaacaaaaaaccaggaagatgatgtagaacagccatttaatgacagtggctgtcttcttgtggataaagacctttttgaaactgggttggaggatgaaaataactctccattggaagatgaagagtcattagaatcaataagagcagctgtaaaaaacaaagtaaaaaagcacaagaaaaaagaaccatctttggagagtggggtccattcatttgaggaaggaagtgagttatcaaaaggaaccacgaggaaggaaagaaaggcagccagattaagtaaagaagcattaaaacaactgcatagtgagactcagcgccttattcgagagtctgcactgaaccttccatatcatatgcctgagaataaaaccattcatgatttcttcaaacgtaaaccccggcccacttgccacggaaatgccatggcactattgaagtcatctaaatatcagtcaagccatcacaaagaaatcatagacactgcaaatactactgaaatgaacagtgatcaccatagtaaaggttctgagcagacaacaggtgcagaaaatgaagtggaaactaatgcactccctgtagtttcaaaggaaacccagatcattactggatcagatgagtcttgcaggaaggatttggtaaaaaatgaagagctagaaattcaggagaaacagaagcagagtgacattagaccttcacctggggacagctcagtgttgcaacaggaatccaacttcctcgggaacaatcacagtgaggaatgtcaggttggagggcttgtagcatttgaacctcatgccctggagggtgaaggcccccaaaatccagaagaaacagatgagaaagtggaagagcctgagcagcaaaataaatcatcagcagttgggccacctgaaaaagtgagacggtttactctggatagacttaagcaactgggagtagatgtttccattaaaccacggctaggtgctgatgaagattcctttgtgatacttgaacctgaaaccaacagagaactggaagccttgaagcagcgtttctggaagcatgctaatccagcagccaaacccagggctggtcagacagtgaatgtgaacgtcatagtgaaagacatgggcactgatggaaaggaagagctaaaagcagatgtggtacctgtgactttagcacctaagaagttggatggagcaagccacacaaaaccaggtgaaaagcttcaggtgttaaaagctaaactgcaagaagcaatgaaactccgaaggtttgaggagcgccagaagcgccaagcactgtttaaattagataatgaagatgggtttgaggaagaggaggaggaagaggaagaaatgacagatgagtctgaggaagatggagaagagaaggtagagaaagaagagaaagaggaagaactagaggaagaggaggagaaagaagaggaggaggaagaagaaggaaatcaggagactgcagaattccttcttagtagtgaagaaatagaaacaaaagatgaaaaagaaatggataaagaaaataatgatggcagtagtgaaattggcaaggcagttggcttcctctctgttcccaagtctctctcatcagattctactttacttctgtttaaggacagctcttccaagatgggttactttcctactgaagaaaaatcagaaacagatgaaaactcaggcaagcagcctagcaaactggatgaggatgattcatgttcattgctaacaaaggagagcagccacaatagcagctttgagctgattggctccacgattccatcctatcagccttgcaacagacaaacaggccgtgggaccagttttttccctacagcaggaggattcagatctccttcccctgggctatttcgagccagtttggtcagctcagcttctaagagttcagggaaactgtctgagccttcacttcccatagaggattcccaggatctgtataacgcctccccagagcctaagacacttttcctaggagcaggagacttccagttctgtttagaagatgacactcagagccaactgttggatgcagatgggttcttaaatgttagaaaccacaggaatcagtaccaagctttgaagcctcgattgccattggccagtatggatgagaatgccatggatgccaacatggatgagctgttggatttgtgtactggaaagttcacatctcaggctgaaaaacatctacccaggaagagtgacaagaaagagaacatggaggaacttctgaacctttgttcaggaaaattcacttctcaggatgcctccactccagcctcatcagagttaaataaacaggagaaggagagcagcatgggtgatccaatggaagaagcacttgctctttgctcaggctcttttcccacagacaaggaagaggaagacgaggaggaggaatttggagactttcggcttgtttcaaatgataatgagtttgatagtgatgaggatgaacacagtgactctggtaatgatctggcactggaagaccatgaagatgatgatgaagaagaactcctgaagcgatctgagaagttgaaaaggcaaatgaggttgaggaaatacctggaggatgaggcagaggtgtcaggaagtgatgtgggaagcgaagatgagtatgatggggaagaaattgatgaatatgaagaggacgtaattgatgaagtacttccttctgatgaggaactgcagagtcaaatcaagaaaatacacatgaaaactatgttggatgatgataagcgacagctacgtttataccaagagaggtaccttgctgatggggatctgcacagcgatggtcctgggcgaatgaggaagtttcgatggaaaaacatagatgatgcttcccagatggacttgttccacagagactctgatgatgatcagactgaagaacagcttgatgagtcagaagccaggtggaggaaggagcgaattgaacgagagcagtggcttcgggacatggcacagcaggggaaaattacagctgaagaagaagaagaaattggggaggacagtcagtttatgatactggccaagaaagttacagccaaagcactgcagaagaatgccagtcgccctatggttattcaggaatcaaagtctttgctcagaaatccttttgaagccatcagaccaggaagtgctcaacaggtgaagacaggctcactgctaaaccagcccaaagctgtgcttcagaaactggctgctctctctgaccataaccccagtgctcctcgaaattcaagaaactttgtctttcatacactttctcctgtcaaggctgaggcggcaaaggaatcgtctaagtctcaggtaaagaaaaggggtccatctttcatgacttctccttcacctaagcacctcaaaacagatgatagcacttcaggattgacgcgaagcatcttcaaatatttggagagctaacaccatcaaaggtgccaaaatctacattgagactgctttgagaagtttctagcactgaaagttggaattgacactccagccaatgatccttccttctttcataatcaatgcaataagattgcagacagaaattccagtgatttctactgcacagctctggacatctcttttcctagtattattccctgaattggccactgatttcaattctgcagtatttacaacatcaacaactcatggaatacttgggtgaggtttcctttttttttttttttttaagatgggagtctcactctgttgcccagcttggagtgcagtggcgtgatctcggctcaccacaatctctgcctcccaggttcaagcgattctcctccttcagcctcccgagtagctgggattacaggcatgtgccaatacgcccagctaatttttgtatttttagtagagacggggtttcaccatgttggccaggctggtcttgaactcctgacctcaaatgatccatccacctcggccccacaaagtgctggtcacatgcatgagtcactgcacctggccttgggttaggtttcacttcctccattagacatttgacattttattgtagcagctttctgggttaatatctctttgtgattgatagaagtggttggaagaggaagagtagggaaaagtgtgacattacagattaaacagtgaaaatcagtaccataatgactcctttacacccatgagatacgtaccatgatgaccagggctcggtgaaagaaagatttctttttttttttttgagatagtctcactttgttgcccagtctggagtgcagtggcgcaatctcggctcacggcaacctctgcctcccgggttcaagtgattctcctgtctcagcctcccaagtagctgggactacaggtgcatgccaccacacctggctaatttttgtatttttagtggagacagggagtcaccatgttggccaggctggtctcgatctcctgacctcaagtgatccagctgcctcagcctcccaaagtgctgagattacaggcgtgagccactgtgcccagccaaaagaacgatttcttagatggaggacctaggaaccaacagatgggctgctgtattactcttacccctttcattttcctgtatgcttcttcccaaggcagcatcaaattttgaattaatttttgctgcttaataaggacttaaactggtacccaagtcagaaagactctgcctctaattttctggggcttggggatgaagataaagtgttacacccagtgtttgtccaccacagtctgtggggcagagagacccttcctgggactgaattctcaatttgaagcactgttgttcaaagatctcccttctgggtctgacaagaagaaacataacccttatttattgcattcttctggcttacatacattgccctcactaatcaatggacatttcagcatttcattactaattttgagagaaggccaccatggaatttaataaaaatattattgaagagaattgccatcattctccattttccctgaactaccacaagcttctcagaattttagacaaatgtttttcccctcagaactgagcatcagtgctgctttggaaaaacattccatgtgaatactgtggtttcagtgtcaggacctgtacttgggcagttggaagagagtgtgccagttttttactgggagatgggaacaccaatttaattgatgcaattaggttgtaggttttttacagtttttcttttcttttctttttctttttcttttcttttcttttctttttttttttttgagacataggctggctctgtcacctaggctggaatacaatggcatgatctcggcttactgcaacctccgcctcctaggttcaagcaattctgcctcggcctcccaaatagcagggattacaggcacctgccaccactcccagctaattttttgtatttttattagagatgaggtttcgccatgttggccaggctggtcttgaactcctgacctgaggtgatccacccgtctcggcctcccaaagtgctgggattataggcatgagccaccgcacccggccggttttctacagttttctaatactcaagatgttgactttgacaatacttatgtttgtatacttgtaatcttataatggggaaaatgtgtataaagatgttttaatatgtatgtagtttttcaataaatcttaatgccttgaagggaagatttgctgtccagcttgaatgctcattcttgggtcagtgcctgtctaaccttgaggagcatttcattttcaggttatctccatcccagggaaaccctctgggtctaaactgagaagctgctgcaattgtcccctcactggcttctcagtcctagtgaattgatcaagttaacttaccaagtggtttgggttcagctcaggtgaagaggataattgagtttacataaatggtaccttctattatagctctttgtttaaaaaacttattttttagagacagtctcattctgttgcccaggttagagtgcagtggcacaatcatagctcactgtacccttgaactcctgggcttcagcatcctccttcctcaacctttggaatagctgggccacattacaggcatatgccaccatgcccagctaattattttattttagtagagacagggtcttgctgtgttgccccagctgatcttgaactcctggcctcaagtaatcctcccaccttggcctcccaaaatgctggggtcacaggctcagccaccatgcccagcctgttacagctttgattggcctttctctttagctaagtttgtatgtacttcattttatccatgggttcaagatacatgtttttgcctctttctttgaactctctaaacagttcccaaggcaaagtagcccttgctgggcaaaagagaactgagcaggaaggctagatatttcttccctcttgtttccctacatgtcttttgaggagagatagaaaagacaattggaattgacaactgaggataagaaaattcagccaggtccggtggctcacgccagcactttaggagactgaggtgggtgcattgcttgaactcaggagttcgagaccagcctgggaaacatggtgaaatcccaactctaaaaaaaaaaaaaaaaagaaaaaaaaaagaaaattagtgcctgagaaatccagggagaaaatggtttctgggctgggcgtggtggcttatgcctgtaatctcagcactttgggaggctgaggcagctggatcacctaaggtcaggagttggagaccagactgaccaacaaggtgaaaccccgtctctactaaaaatacaaaaatcagccaggcttggtggtggcaggtgcctgtagtcccagctacttgggaggctgagacaagagaattgcttgaacctgggaggcagaggttgcagtgagccgagatcacgccactgctctccagcatgggcgacagagtgagactccctctcaaaaaaaaaaagaaagaaagaaaatggtttctgattgaggctcctgggagaaagcactctttggagaaagaaaacttgagtcaaactctgggttacttttccttatgccaggatggctgctataaagtaagctaagccttgatcttggtaacaggattgacatggacagtttcaatctgacccatatgccctttgcccaaagcactgagccagcagcatcagttatgttttaatgaaattgaagccccaggacctgccactatggctctgaggaggactcagcttcactagcttggaaattacatatttggagggatgagagcccatgagtgtgggagatagggtaggctcagtgtcagtgtttttgtttcttccttgttccatacacttgagtagggatacatggtattaacctctttaaacaggtctctaatttcatctcattaattcacagttgcacagccatactagggtctcttccataaaccataagattttattcaccaaagctctagagacaaggtactcagatctctgtggcatccctcattttctcaactgcttctctacaaacttctcctcactttgagagtttctaatgctcaggctgggagactttttagggggtgtttttggtttttatctcctagggttatgtctaatcactcttgtggcatcctgtcctgggatttgtgctcctaaggatagaggagagtatttctgggaggagtgttcccatgatactatttgattatgtcatccttgagatggtattgtatcttctacccttatatcctactcatcgcctggcacacagcttggaatgtagtggtgcctaccacagtttgaataaataacactacacctttca
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:63967 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:63967 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:63967 -> Molecular function: GO:0010997 [anaphase-promoting complex binding] evidence: IPI
GeneID:63967 -> Biological process: GO:0000077 [DNA damage checkpoint] evidence: IMP
GeneID:63967 -> Biological process: GO:0006260 [DNA replication] evidence: TAS
GeneID:63967 -> Biological process: GO:0006281 [DNA repair] evidence: IEA
GeneID:63967 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:63967 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
GeneID:63967 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
GeneID:63967 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: IDA
GeneID:63967 -> Biological process: GO:0031572 [G2 DNA damage checkpoint] evidence: IDA
GeneID:63967 -> Biological process: GO:0032147 [activation of protein kinase activity] evidence: IDA
GeneID:63967 -> Biological process: GO:0033314 [mitotic DNA replication checkpoint] evidence: IMP
GeneID:63967 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
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