Home |
Help |
Advanced search
2024-04-25 23:25:50, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_022037 4620 bp mRNA linear PRI 20-APR-2013
DEFINITION Homo sapiens TIA1 cytotoxic granule-associated RNA binding protein
(TIA1), transcript variant 1, mRNA.
ACCESSION NM_022037
VERSION NM_022037.2 GI:188219592
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4620)
AUTHORS Bauer,W.J., Heath,J., Jenkins,J.L. and Kielkopf,C.L.
TITLE Three RNA recognition motifs participate in RNA recognition and
structural organization by the pro-apoptotic factor TIA-1
JOURNAL J. Mol. Biol. 415 (4), 727-740 (2012)
PUBMED 22154808
REMARK GeneRIF: Three RNA recognition motifs participate in RNA
recognition and structural organization by the pro-apoptotic factor
TIA-1.
REFERENCE 2 (bases 1 to 4620)
AUTHORS Aroca,A., Diaz-Quintana,A. and Diaz-Moreno,I.
TITLE A structural insight into the C-terminal RNA recognition motifs of
T-cell intracellular antigen-1 protein
JOURNAL FEBS Lett. 585 (19), 2958-2964 (2011)
PUBMED 21846467
REMARK GeneRIF: Results characterise the C-terminal RRM2 and RRM3 domains
of T-cell intracellular antigen-1 protein.
REFERENCE 3 (bases 1 to 4620)
AUTHORS Izquierdo,J.M., Alcalde,J., Carrascoso,I., Reyes,R. and Ludena,M.D.
TITLE Knockdown of T-cell intracellular antigens triggers cell
proliferation, invasion and tumour growth
JOURNAL Biochem. J. 435 (2), 337-344 (2011)
PUBMED 21284605
REMARK GeneRIF: A role for TIA proteins as growth/tumour-suppressor genes.
REFERENCE 4 (bases 1 to 4620)
AUTHORS McDonald,K.K., Aulas,A., Destroismaisons,L., Pickles,S., Beleac,E.,
Camu,W., Rouleau,G.A. and Vande Velde,C.
TITLE TAR DNA-binding protein 43 (TDP-43) regulates stress granule
dynamics via differential regulation of G3BP and TIA-1
JOURNAL Hum. Mol. Genet. 20 (7), 1400-1410 (2011)
PUBMED 21257637
REMARK GeneRIF: TAR DNA-binding protein 43 (TDP-43) regulates stress
granule dynamics via differential regulation of G3BP and TIA-1.
REFERENCE 5 (bases 1 to 4620)
AUTHORS Singh,N.N., Seo,J., Ottesen,E.W., Shishimorova,M., Bhattacharya,D.
and Singh,R.N.
TITLE TIA1 prevents skipping of a critical exon associated with spinal
muscular atrophy
JOURNAL Mol. Cell. Biol. 31 (5), 935-954 (2011)
PUBMED 21189287
REMARK GeneRIF: TIA1 and TIAR proteins are intron-associated positive
regulators of SMN2 exon 7 splicing.
REFERENCE 6 (bases 1 to 4620)
AUTHORS Dember,L.M., Kim,N.D., Liu,K.Q. and Anderson,P.
TITLE Individual RNA recognition motifs of TIA-1 and TIAR have different
RNA binding specificities
JOURNAL J. Biol. Chem. 271 (5), 2783-2788 (1996)
PUBMED 8576255
REFERENCE 7 (bases 1 to 4620)
AUTHORS Tian,Q., Taupin,J., Elledge,S., Robertson,M. and Anderson,P.
TITLE Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1
during Fas-mediated apoptosis
JOURNAL J. Exp. Med. 182 (3), 865-874 (1995)
PUBMED 7544399
REFERENCE 8 (bases 1 to 4620)
AUTHORS Kawakami,A., Tian,Q., Streuli,M., Poe,M., Edelhoff,S.,
Disteche,C.M. and Anderson,P.
TITLE Intron-exon organization and chromosomal localization of the human
TIA-1 gene
JOURNAL J. Immunol. 152 (10), 4937-4945 (1994)
PUBMED 8176212
REFERENCE 9 (bases 1 to 4620)
AUTHORS Tian,Q., Streuli,M., Saito,H., Schlossman,S.F. and Anderson,P.
TITLE A polyadenylate binding protein localized to the granules of
cytolytic lymphocytes induces DNA fragmentation in target cells
JOURNAL Cell 67 (3), 629-639 (1991)
PUBMED 1934064
REFERENCE 10 (bases 1 to 4620)
AUTHORS Anderson,P., Nagler-Anderson,C., O'Brien,C., Levine,H., Watkins,S.,
Slayter,H.S., Blue,M.L. and Schlossman,S.F.
TITLE A monoclonal antibody reactive with a 15-kDa cytoplasmic
granule-associated protein defines a subpopulation of CD8+ T
lymphocytes
JOURNAL J. Immunol. 144 (2), 574-582 (1990)
PUBMED 2104899
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB136383.1, CN295707.1,
DR157578.1 and AC016700.8.
On May 15, 2008 this sequence version replaced gi:11863160.
Summary: The product encoded by this gene is a member of a
RNA-binding protein family and possesses nucleolytic activity
against cytotoxic lymphocyte (CTL) target cells. It has been
suggested that this protein may be involved in the induction of
apoptosis as it preferentially recognizes poly(A) homopolymers and
induces DNA fragmentation in CTL targets. The major
granule-associated species is a 15-kDa protein that is thought to
be derived from the carboxyl terminus of the 40-kDa product by
proteolytic processing. Alternative splicing resulting in different
isoforms of this gene product has been described in the literature.
[provided by RefSeq, Jul 2008].
Transcript Variant: This variant (1) is missing exon 5, which is
included in transcript variant 2, resulting in the shorter isoform
(1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M77142.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-91 DB136383.1 12-102
92-797 CN295707.1 8-713
798-1388 DR157578.1 170-760
1389-4620 AC016700.8 125791-129022 c
FEATURES Location/Qualifiers
source 1..4620
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p13"
gene 1..4620
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/note="TIA1 cytotoxic granule-associated RNA binding
protein"
/db_xref="GeneID:7072"
/db_xref="HGNC:11802"
/db_xref="MIM:603518"
exon 1..243
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/inference="alignment:Splign:1.39.8"
misc_feature 101..103
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/note="upstream in-frame stop codon"
variation 146
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/replace="c"
/replace="t"
/db_xref="dbSNP:11547900"
CDS 218..1345
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/note="isoform 1 is encoded by transcript variant 1;
p40-TIA-1 (containing p15-TIA-1); T-cell-restricted
intracellular antigen-1; nucleolysin TIA-1 isoform p40"
/codon_start=1
/product="nucleolysin TIA-1 isoform p40 isoform 1"
/protein_id="NP_071320.2"
/db_xref="GI:188219593"
/db_xref="CCDS:CCDS1900.1"
/db_xref="GeneID:7072"
/db_xref="HGNC:11802"
/db_xref="MIM:603518"
/translation="
MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPQPYGQWGQWYGNAQQIGQYMPNGWQVPAYGMYGQAWNQQGFNQTQSSAPWMGPNYGVQPPQGQNGSMLPNQPSGYRVAGYETQ
"
misc_feature 239..457
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/note="RRM (RNA recognition motif), also known as RBD (RNA
binding domain) or RNP (ribonucleoprotein domain), is a
highly abundant domain in eukaryotes found in proteins
involved in post-transcriptional gene expression processes
including mRNA and rRNA...; Region: RRM; cd00590"
/db_xref="CDD:100104"
misc_feature order(245..247,359..361,365..367)
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/note="RNA/DNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:100104"
misc_feature 449..457
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/note="RRM dimerization site [polypeptide binding]; other
site"
/db_xref="CDD:100104"
misc_feature 506..727
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/note="RRM (RNA recognition motif), also known as RBD (RNA
binding domain) or RNP (ribonucleoprotein domain), is a
highly abundant domain in eukaryotes found in proteins
involved in post-transcriptional gene expression processes
including mRNA and rRNA...; Region: RRM; cd00590"
/db_xref="CDD:100104"
misc_feature order(509..511,629..631,635..637)
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/note="RNA/DNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:100104"
misc_feature 719..727
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/note="RRM dimerization site [polypeptide binding]; other
site"
/db_xref="CDD:100104"
misc_feature 827..1033
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/note="RRM (RNA recognition motif), also known as RBD (RNA
binding domain) or RNP (ribonucleoprotein domain), is a
highly abundant domain in eukaryotes found in proteins
involved in post-transcriptional gene expression processes
including mRNA and rRNA...; Region: RRM; cd00590"
/db_xref="CDD:100104"
misc_feature order(833..835,935..937,941..943)
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/note="RNA/DNA binding site [nucleotide binding]; other
site"
/db_xref="CDD:100104"
misc_feature 1025..1033
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/note="RRM dimerization site [polypeptide binding]; other
site"
/db_xref="CDD:100104"
exon 244..340
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/inference="alignment:Splign:1.39.8"
exon 341..439
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/inference="alignment:Splign:1.39.8"
exon 440..494
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/inference="alignment:Splign:1.39.8"
exon 495..582
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/inference="alignment:Splign:1.39.8"
exon 583..658
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/inference="alignment:Splign:1.39.8"
exon 659..767
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/inference="alignment:Splign:1.39.8"
STS 671..857
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/standard_name="RH48876"
/db_xref="UniSTS:48595"
exon 768..863
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/inference="alignment:Splign:1.39.8"
exon 864..948
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/inference="alignment:Splign:1.39.8"
exon 949..1072
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/inference="alignment:Splign:1.39.8"
exon 1073..1218
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/inference="alignment:Splign:1.39.8"
variation 1205
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/replace="a"
/replace="c"
/db_xref="dbSNP:1804521"
exon 1219..4620
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/inference="alignment:Splign:1.39.8"
STS 1747..1947
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/standard_name="RH81041"
/db_xref="UniSTS:86501"
variation 1792
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/replace="a"
/replace="g"
/db_xref="dbSNP:1545357"
variation 1860
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/replace="g"
/replace="t"
/db_xref="dbSNP:1059359"
variation 1963
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/replace="a"
/replace="t"
/db_xref="dbSNP:3207592"
polyA_site 2384
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
STS 2473..2604
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/standard_name="RH47301"
/db_xref="UniSTS:12500"
polyA_signal 3310..3315
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
polyA_site 3335
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
polyA_signal 3384..3389
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
polyA_site 3408
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
STS 3712..3842
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/standard_name="WI-11889"
/db_xref="UniSTS:3530"
polyA_signal 3834..3839
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
polyA_site 3860
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
variation 4378
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/replace="a"
/replace="g"
/db_xref="dbSNP:1059408"
STS 4380..4483
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/standard_name="SHGC-64100"
/db_xref="UniSTS:34519"
STS 4457..4589
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
/standard_name="SHGC-32459"
/db_xref="UniSTS:15067"
polyA_signal 4591..4596
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
polyA_site 4620
/gene="TIA1"
/gene_synonym="TIA-1; WDM"
ORIGIN
gctcctaggctcccggctcgccgccatcttgtattggggtttcattgttcccgctgggccgggcggtttagtgtaattgccgccggaggaggaggcggagtaacctctggtcagccgagaaaccccactatcctgtagccataaccgcttaaacgatttgggaggtagtgaagggcagggagctggacctggaggcgccgccgcgacagcagcagccatggaggacgagatgcccaagactctatacgtcggtaacctttccagagatgtgacagaagctctaattctgcaactctttagccagattggaccttgtaaaaactgcaaaatgattatggatacagctggaaatgatccctattgttttgtggagtttcatgagcatcgtcatgcagctgcagcattagctgctatgaatggacggaagataatgggtaaggaagtcaaagtgaattgggcaacaacccctagcagtcaaaagaaagatacaagcaatcatttccatgtctttgttggtgatctcagcccagaaattacaactgaagatataaaagctgcttttgcaccatttggaagaatatcagatgcccgagtggtaaaagacatggcaacaggaaagtctaagggatatggctttgtctcctttttcaacaaatgggatgctgaaaacgccattcaacagatgggtggccagtggcttggtggaagacaaatcagaactaactgggcaacccgaaagcctcccgctccaaagagtacatatgagtcaaataccaaacagctatcatatgatgaggttgtaaatcagtctagtccaagcaactgtactgtatactgtggaggtgttacttctgggctaacagaacaactaatgcgtcagactttttcaccatttggacaaataatggaaattcgagtctttccagataaaggatattcatttgttcggttcaattcccatgaaagtgcagcacatgcaattgtttctgttaatggtactaccattgaaggtcatgttgtgaaatgctattggggcaaagaaactcttgatatgataaatcccgtgcaacagcagaatcaaattggatatccccaaccttatggccagtggggccagtggtatggaaatgcacaacaaattggccagtatatgcctaatggttggcaagttcctgcatatggaatgtatggccaggcatggaaccagcaaggatttaatcagacacagtcttctgcaccatggatgggaccaaattatggagtgcaaccgcctcaagggcaaaatggcagcatgttgcccaatcagccttctgggtatcgagtggcagggtatgaaacccagtgaataaggactccagaatctaaagccagtggcttgaggctacagggagtgtagtaaagccgttgtttacttaaagatttatcaaatcagtcagtgcaaatgtcagatacaatgtatttatttaaaagattcatttttaatcatgaaattacttatcatccacattgttttaaaaagaaacaagatgctggatgtctgccaatttttgccttcattaccttttttgataaagtttctcagatccttgtttcaaacacaaatgcagggattgctgccactttttaactattaagaggcagaaaattgcacaatattgaacttttttccactgaagtagtgtgcagttctagtttgcattcctgatatgatttaaaacatgtaatataaagatgttaaaaaaaaaaaccaaaactgtgcagagtctagaagttgtttgtcatcttcagcttgtgcacaattctgttttaggttaaaaaaaggcattgtttgagctgtcccatctccactgttatccctttggggttttttaatataaattattagtttacatcatttttgtatctacatcttttttcacaaatttgtcttgccttattaaagttctgtaaaatatacttaaatggaaaaaatgatgttcatttagattgaaaacttttctcagatggattgataattgcattcatcttgtgttttatatgagaaggtgcctcaagaatttcctgttggatttgtttaaaaggatttttatctttcgtgataaactttgctgtgtaccaggaactataaaaacaaaaacttgttactaaagaaaatatctgaaatgtgataagttcttatgccatgttaatttcatgtgtcaacttcaacatttacatgtattatttcattatgtaaaatgttttagcaatttaatattttgcacagttagcaaactttgtatgtcatttccttcaaggcatcatgcagagttgacatgagatttataaggttttaagttgtttgcatgtgaaaatcaaatacatactttggtagtctttgaatacaaagtcatctgctcttgtttttcaagaattttgagacacaaagttgtatgtaaaggaatatattaatttgccgttttctaggtagatttgctcaaaaagagtgaatcaacttaatatgtacaaatgatagctgtgaaactgtagaatatctttgtgtcaggcttggagttcattgtgacctccaaattttgcctgaaggaccagctgggcaaagcatcttttaaatgttcagaggccaaaagataaacaaaaaaaaaaccttaaaatcctacctctttaaacagccttcagataagagaatcctcagtgcaatcattattttgattcgtttggtacctgttttcctggagttcccgattttattattttggggtggctccaagcattaagaggtttaatctttgatggcattgttctagttttgaaatttctagtatatttcagagtctcttagaagacttgtgtgggaagtttcactttgttttcagtgaagatcacaaacctccttcttcctttactcaagaggaaaggtcccagtatacatatttgaatggttgatggttttcaagaccttcagggagctccctgcattttacctagaaacagaaaaggcccgcaaaatcttaagtttcctggcctgcatttcccgggtaggggcaaatgactccaagctggtctctaagccaatacccttataaaccagagcccaggaaagacagctcgagtgtataattctctggagctcaattctatgcagttgtgctgatatttcattaagtcactgtgtatttttaagtgttgatacattaaaagtcgctttatggaagatgagtaaattttttaaatacttggaaattttatttccttgttaacttctacagatcagggcatgcaaccaaaagcagcttaaatgaaatattttaaaataaaatatcaggaagctatttttagatttcttctggcttatgtttctactttaggaccctcattgttctcttattaaaaaaaattatttcctgtgcatctcatggactgcagggtaaattatttgggcataaataatttaaatagttttctttcattttgactatctccagtaataacagtttttattatccagcatattggcttattgcacaaatcttaaaatgtacattgactactttctgagaagaaagtggtatcagtactcatgatgaaaaggttactactgaacaaattcacatttcaggaacacctctatctttggtttaaatcttactcttagtttttccgtctaaaaatcatactggtattagtatcaggtaaggaaattaaagtttttaaaatggtttcattctctgcaatatgcaaaatttagattttactttctggtactgtaaagaacctgaagtgatttacacttaatgggtgattaatccagtattctttaccctgaatgtttggatattaaagttcctttatgttttctataacctgtgggatcttcttgcagtgattattgtgtgtgagattttttttctttttggtctatccatattgttatattcactcaggtattttttttttaatcttattccagaatcagtggtttatattgggttactgtttaacaccaaatggaattggcattctgcagatttaattaattatgaaaccagggtctcattttccttgctgatacttgttgaaaatgagattcacattctagtctttattttcctcctgttttgtccctgtgcttgtacatcttccttttatttgtgtgttatagttctattccatttgagaaggcagttggtaagaactagattgcatgtacaaagacaggtttactaagtgctgtacagtggtcctgaggttacagttgaattagaaaaacgaaatgtacttacaggaaataagaaagcaaacctttcaaatgagagtgatgatttctttaaaaaaaatcagtttttttctctcaaataatgttctttatttcacgaaatcgtcaatcttaagcatgagcagggataaacaactcctagaaggaactcaattcattcttcctggattttctctgttgttaaatcacaaaaatgatagtccccaatcgtttctttataggaggttattacatttcattacagtcactgcattttgactgttgtgtttagaatttgaatgtacatccaaaatgatgagtttcaatttaagagccttaataaaatgtgtgagtgtgtctcaattgaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7072 -> Molecular function: GO:0000166 [nucleotide binding] evidence: IEA
GeneID:7072 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7072 -> Molecular function: GO:0008143 [poly(A) RNA binding] evidence: TAS
GeneID:7072 -> Molecular function: GO:0017091 [AU-rich element binding] evidence: IEA
GeneID:7072 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:7072 -> Biological process: GO:0006917 [induction of apoptosis] evidence: TAS
GeneID:7072 -> Biological process: GO:0017148 [negative regulation of translation] evidence: IEA
GeneID:7072 -> Biological process: GO:0042036 [negative regulation of cytokine biosynthetic process] evidence: IEA
GeneID:7072 -> Biological process: GO:0048024 [regulation of mRNA splicing, via spliceosome] evidence: IDA
GeneID:7072 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:7072 -> Cellular component: GO:0010494 [cytoplasmic stress granule] evidence: IEA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.