LOCUS       NM_021958               2308 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens H2.0-like homeobox (HLX), mRNA.
ACCESSION   NM_021958
VERSION     NM_021958.3  GI:187826632
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2308)
  AUTHORS   Kawahara,M., Pandolfi,A., Bartholdy,B., Barreyro,L., Will,B.,
            Roth,M., Okoye-Okafor,U.C., Todorova,T.I., Figueroa,M.E.,
            Melnick,A., Mitsiades,C.S. and Steidl,U.
  TITLE     H2.0-like homeobox regulates early hematopoiesis and promotes acute
            myeloid leukemia
  JOURNAL   Cancer Cell 22 (2), 194-208 (2012)
   PUBMED   22897850
  REMARK    GeneRIF: This study identifies HLX as a key regulator in immature
            hematopoietic and leukemia cells and as a prognostic marker and
            therapeutic target in acute myeloid leukemia.
REFERENCE   2  (bases 1 to 2308)
  AUTHORS   Morita,M., Watanabe,M., Inoue,N., Inaoka,C., Akamizu,T.,
            Tatsumi,K.I., Hidaka,Y. and Iwatani,Y.
  TITLE     Functional polymorphisms in TBX21 and HLX are associated with
            development and prognosis of Graves' disease
  JOURNAL   Autoimmunity 45 (2), 129-136 (2012)
   PUBMED   22014209
  REMARK    GeneRIF: a functional polymorphism in HLX in combination with the
            TBX21 polymorphism is also associated with the prognosis of Graves'
            disease.
REFERENCE   3  (bases 1 to 2308)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), E51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 2308)
  AUTHORS   Liu,H.Y., Jia,X.Q., Gao,L.X. and Ma,Y.Y.
  TITLE     Hepatocyte growth factor regulates HLX1 gene expression to modulate
            HTR-8/SVneo trophoblast cells
  JOURNAL   Reprod. Biol. Endocrinol. 10, 83 (2012)
   PUBMED   22989111
  REMARK    GeneRIF: Data suggest that HLX1 is downstream mediator of
            hepatocyte growth factor- (HGF-) induced cell survival, cell
            proliferation, and invasive properties of trophoblast cells; thus,
            both HGF and HLX1 appear to be involved in normal placental
            development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2308)
  AUTHORS   Casaca,V.I., Illi,S., Suttner,K., Schleich,I., Ballenberger,N.,
            Klucker,E., Turan,E., von Mutius,E., Kabesch,M. and Schaub,B.
  TITLE     TBX21 and HLX1 polymorphisms influence cytokine secretion at birth
  JOURNAL   PLoS ONE 7 (1), E31069 (2012)
   PUBMED   22303482
  REMARK    GeneRIF: This study investigated the influence of TBX21 and HLX1
            single nucleotide polymorphisms (SNPs), which have previously been
            shown to be associated with asthma, on T(H)1/T(H)2 lineage
            cytokines at birth.
REFERENCE   6  (bases 1 to 2308)
  AUTHORS   Najfeld,V., Menninger,J., Ballard,S.G., Deguchi,Y., Ward,D.C. and
            Kehrl,J.H.
  TITLE     Two diverged human homeobox genes involved in the differentiation
            of human hematopoietic progenitors map to chromosome 1, bands
            q41-42.1
  JOURNAL   Genes Chromosomes Cancer 5 (4), 343-347 (1992)
   PUBMED   1283323
REFERENCE   7  (bases 1 to 2308)
  AUTHORS   Deguchi,Y., Kirschenbaum,A. and Kehrl,J.H.
  TITLE     A diverged homeobox gene is involved in the proliferation and
            lineage commitment of human hematopoietic progenitors and highly
            expressed in acute myelogenous leukemia
  JOURNAL   Blood 79 (11), 2841-2848 (1992)
   PUBMED   1375114
REFERENCE   8  (bases 1 to 2308)
  AUTHORS   Deguchi,Y., Thevenin,C. and Kehrl,J.H.
  TITLE     Stable expression of HB24, a diverged human homeobox gene, in T
            lymphocytes induces genes involved in T cell activation and growth
  JOURNAL   J. Biol. Chem. 267 (12), 8222-8229 (1992)
   PUBMED   1349016
REFERENCE   9  (bases 1 to 2308)
  AUTHORS   Deguchi,Y., Moroney,J.F., Wilson,G.L., Fox,C.H., Winter,H.S. and
            Kehrl,J.H.
  TITLE     Cloning of a human homeobox gene that resembles a diverged
            Drosophila homeobox gene and is expressed in activated lymphocytes
  JOURNAL   New Biol. 3 (4), 353-363 (1991)
   PUBMED   1676597
REFERENCE   10 (bases 1 to 2308)
  AUTHORS   Allen,J.D., Lints,T., Jenkins,N.A., Copeland,N.G., Strasser,A.,
            Harvey,R.P. and Adams,J.M.
  TITLE     Novel murine homeo box gene on chromosome 1 expressed in specific
            hematopoietic lineages and during embryogenesis
  JOURNAL   Genes Dev. 5 (4), 509-520 (1991)
   PUBMED   1672660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA951303.1 and BC033808.1.
            On May 9, 2008 this sequence version replaced gi:19923769.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056326.1, BC007294.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               DA951303.1         1-242
            243-2308            BC033808.1         1-2066
FEATURES             Location/Qualifiers
     source          1..2308
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2308
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /note="H2.0-like homeobox"
                     /db_xref="GeneID:3142"
                     /db_xref="HGNC:4978"
                     /db_xref="HPRD:00875"
                     /db_xref="MIM:142995"
     exon            1..1049
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /inference="alignment:Splign:1.39.8"
     variation       23
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2738752"
     variation       28
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:12730158"
     variation       28
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:11300127"
     variation       29
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148346751"
     variation       47
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:199553841"
     variation       48
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:67420025"
     variation       51..52
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace=""
                     /replace="tc"
                     /db_xref="dbSNP:201919277"
     variation       51
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377063056"
     variation       52
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:35462307"
     variation       52
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2738753"
     variation       59..60
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace=""
                     /replace="cc"
                     /db_xref="dbSNP:78219651"
     variation       59
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace=""
                     /replace="ct"
                     /db_xref="dbSNP:200566716"
     variation       59
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201873114"
     variation       61
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112618703"
     variation       61
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace=""
                     /replace="ct"
                     /replace="t"
                     /db_xref="dbSNP:35700343"
     misc_feature    110..112
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /note="upstream in-frame stop codon"
     variation       189
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:55955117"
     variation       195
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2738754"
     variation       275
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143725741"
     variation       352
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370813784"
     CDS             458..1924
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /note="H2.0-like homeo box-1; H2.0-like homeobox 1;
                     homeobox protein HB24; homeobox protein HLX1; H2.0-like
                     homeo box 1"
                     /codon_start=1
                     /product="H2.0-like homeobox protein"
                     /protein_id="NP_068777.1"
                     /db_xref="GI:11386181"
                     /db_xref="CCDS:CCDS1527.1"
                     /db_xref="GeneID:3142"
                     /db_xref="HGNC:4978"
                     /db_xref="HPRD:00875"
                     /db_xref="MIM:142995"
                     /translation="

MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFPLDPAAVKKPSFCIADILHAGVGDLGAAPEGLAGASAAALTAHLGSVHPHASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAAYHHHHPQQQQQQQQPQQQQPPPPPRAGALQPPASGTRVVPNPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLSGLQPSAGQFFASLDPINEASAILSPLNSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGAPAADGEQDERSPSRSEGEAESESSDSESLDMAPSDTERTEGSERSLHQTTVIKAPVTGALITASSAGSGGSSGGGGNSFSFSSASSLSSSSTSAGCASSLGGGGASELLPATQPTASSAPKSPEPAQGALGCL

"
     misc_feature    1136..1528
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]; Region: COG5576"
                     /db_xref="CDD:35135"
     misc_feature    1295..1462
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(1295..1300,1304..1306,1355..1357,1373..1375,
                     1412..1414,1418..1423,1430..1435,1439..1447,1451..1456)
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(1301..1303,1421..1423,1430..1435,1442..1444)
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     misc_feature    1553..1555
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     variation       477
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377648480"
     variation       602
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201129497"
     variation       697
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370630244"
     variation       744
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375393771"
     variation       749
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374220349"
     variation       757
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182881175"
     variation       800
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370298817"
     variation       803
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:12141189"
     variation       819
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200442482"
     variation       820
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200497987"
     variation       825
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372827556"
     variation       832
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:62621984"
     variation       846
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:113191234"
     variation       858
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201006102"
     variation       886
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368467617"
     variation       891
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371600047"
     variation       908
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:12041280"
     variation       922..923
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:34343224"
     variation       935
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138862723"
     variation       940
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375008910"
     variation       951
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150557175"
     variation       956
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201755479"
     variation       961
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367706334"
     variation       991
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149312492"
     exon            1050..1229
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1050
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:139812768"
     variation       1070
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199775753"
     variation       1085
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373398191"
     variation       1099
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377616408"
     variation       1102
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143406406"
     variation       1130
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370989205"
     variation       1145
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375880001"
     variation       1161
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140376930"
     variation       1162
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:146391223"
     variation       1189
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377719897"
     variation       1202
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:150049769"
     variation       1209
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371382529"
     exon            1230..1414
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1231
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200626100"
     variation       1260
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:371914368"
     variation       1281
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375198616"
     variation       1294
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375247956"
     variation       1313
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369786993"
     variation       1314
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372872181"
     variation       1320
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374839413"
     variation       1363
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187627822"
     exon            1415..2279
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /inference="alignment:Splign:1.39.8"
     variation       1481
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369388837"
     variation       1504
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374105307"
     variation       1524
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2738755"
     variation       1540
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3738182"
     variation       1545
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:141255580"
     variation       1599
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377670231"
     variation       1617
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11578466"
     variation       1629
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199521070"
     variation       1635
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77213368"
     variation       1648
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:144497660"
     variation       1653
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371016648"
     variation       1664
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:180838062"
     variation       1668
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:112404524"
     variation       1669
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375578569"
     variation       1686
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:376040668"
     variation       1697
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370407346"
     variation       1708
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373865414"
     variation       1735
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142918916"
     variation       1833
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368112101"
     variation       1852
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200503375"
     variation       1856
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370523363"
     variation       1876
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200128618"
     variation       1915
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200872584"
     variation       1929
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:376365352"
     variation       1934
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371049169"
     variation       1937
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2738756"
     STS             1958..2060
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /standard_name="SHGC-32821"
                     /db_xref="UniSTS:57997"
     variation       2021
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:186187730"
     variation       2126
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:143347425"
     variation       2145
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75257669"
     variation       2174
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:142138538"
ORIGIN      

aaaactttgggagtttttagagacgagtttttttttttttctattacttttccccccccctaactaacggactattattgttgttgttttaaatttagctcttagggcttagctatttgggttttcttgcggtgtccggctcccgtctccctggctcccccgcccgccctgcggccccagcgcccctcgctctcatccagcccgcgaggagtgcgggcgccgcgccgcctttaaagcgaggccagggagcgaggcggtgaccggccgagatccggccctcgcctcctccctcggtggcgctagggctcccggcctctcttcctcagtgcgggcggagaagcgaaagcggatcgtcctcggctgccgccgccttctccgggactcgcgcgcccctccccgcgcgcccacccacccagtccggctggactgcggcagccgcgcggctcaccccggcaggatgttcgcagccgggctggctcccttctacgcctccaacttcagcctctggtcggccgcttactgctcctcggccggcccaggcggctgctccttccccttggaccccgccgccgtcaaaaagccctccttctgcatcgcagacattctgcacgccggcgtgggggatctgggggcggccccggagggcctggcaggggcctcggccgccgccctcaccgcgcacttgggctcggttcacccgcacgcctctttccaagcggcggccagatccccgcttcgacccaccccagtggtggcgccctccgaagtcccggctggcttcccgcagcggctgtctccgctctcagccgcctaccaccaccatcacccgcaacaacaacagcagcagcaacagccgcagcagcaacagcctccgcctccgccccgggctggcgccctgcagcccccggcctcggggacgcgagtggttccgaacccccaccacagtggctctgccccggccccctccagcaaagacctcaaatttggaattgaccgcattttatctgcagaatttgacccaaaagtcaaagaaggcaacacgctgagagatctcacttccctgctaaccggtgggcggcccgccggggtgcacctctcaggcctgcagccctcggccggccagttcttcgcatctctagatcccattaacgaggcttctgcaatcctgagtcccttaaactcgaacccaagaaattcagttcagcatcagttccaagacacgtttccaggtccctatgctgtgctcacgaaggacaccatgccgcagacgtacaaaaggaagcgttcatggtcgcgcgctgtgttctccaacctgcagaggaaaggcctggagaaaaggtttgagattcagaagtacgtgaccaagccggaccgaaagcagctggcggcgatgctgggcctcacggacgcacaggtgaaggtgtggttccagaaccggcggatgaagtggcggcactccaaggaggcccaggcccaaaaggacaaggacaaggaggctggcgagaagccatcaggtggagccccggctgcggatggcgagcaggacgagaggagccccagccgttctgaaggcgaggctgagagcgagagcagcgactccgagtccctggacatggcccccagcgacacggagcggactgaggggagtgagcgttctctgcaccaaacaacagttattaaggccccggtcactggcgccctcattaccgccagcagtgctgggagtggtgggagcagcggcggcggcggcaatagtttcagcttcagcagcgccagcagtcttagtagcagcagcaccagtgcgggttgcgccagcagccttggcggcggcggcgcctcggagcttctccctgcaacacagcccacagccagcagcgctcccaaaagccccgagccagcccaaggcgcgcttggctgcttatagactgtactagggcggaggggatccgggccttgcgtgcagcctcccaaccatgggctgggttttgtgcttactgtatgttggcgacttggtagggcaggagacgcagcgtggagcctacctcccgacattcacgcttcgccccacgctgctccgactggctgcagcggacactgcccaaagcagaggggagtctcagtgtcctgctagccagccgaacacttctctccggaagcaggctggttcgactgtgaggtgtttgactaaactgtttctctgactcgccccagaggtcgtggctcaaaggcacttaggacgccttaaatttgtaaataaaatgtttactacggtttgtaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:3142 -> Molecular function: GO:0000976 [transcription regulatory region sequence-specific DNA binding] evidence: IEA
            GeneID:3142 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:3142 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IDA
            GeneID:3142 -> Biological process: GO:0001889 [liver development] evidence: IEA
            GeneID:3142 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:3142 -> Biological process: GO:0007275 [multicellular organismal development] evidence: TAS
            GeneID:3142 -> Biological process: GO:0007519 [skeletal muscle tissue development] evidence: IEA
            GeneID:3142 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IEA
            GeneID:3142 -> Biological process: GO:0030154 [cell differentiation] evidence: IEA
            GeneID:3142 -> Biological process: GO:0045627 [positive regulation of T-helper 1 cell differentiation] evidence: IEA
            GeneID:3142 -> Biological process: GO:0045629 [negative regulation of T-helper 2 cell differentiation] evidence: IEA
            GeneID:3142 -> Biological process: GO:0046622 [positive regulation of organ growth] evidence: IEA
            GeneID:3142 -> Biological process: GO:0048484 [enteric nervous system development] evidence: IEA
            GeneID:3142 -> Biological process: GO:0048557 [embryonic digestive tract morphogenesis] evidence: IEA
            GeneID:3142 -> Cellular component: GO:0005634 [nucleus] evidence: IEA