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2024-04-25 10:13:16, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_021797 1414 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens chitinase, acidic (CHIA), transcript variant 2, mRNA.
ACCESSION NM_021797
VERSION NM_021797.3 GI:384367978
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1414)
AUTHORS Di Rosa,M., De Gregorio,C., Malaguarnera,G., Tuttobene,M.,
Biazzo,F. and Malaguarnera,L.
TITLE Evaluation of AMCase and CHIT-1 expression in monocyte macrophages
lineage
JOURNAL Mol. Cell. Biochem. 374 (1-2), 73-80 (2013)
PUBMED 23129258
REMARK GeneRIF: results showed that the expression of AMCase and CHIT-1
were differently modulated in monocyte macrophages at different
stage of maturation. The behavior of these two active chitinase
suggests that in the immune response their role is complementary.
REFERENCE 2 (bases 1 to 1414)
AUTHORS Aminuddin,F., Akhabir,L., Stefanowicz,D., Pare,P.D., Connett,J.E.,
Anthonisen,N.R., Fahy,J.V., Seibold,M.A., Burchard,E.G., Eng,C.,
Gulsvik,A., Bakke,P., Cho,M.H., Litonjua,A., Lomas,D.A.,
Anderson,W.H., Beaty,T.H., Crapo,J.D., Silverman,E.K. and
Sandford,A.J.
TITLE Genetic association between human chitinases and lung function in
COPD
JOURNAL Hum. Genet. 131 (7), 1105-1114 (2012)
PUBMED 22200767
REMARK GeneRIF: study demonstrated genetic associations between chitinase
gene variants and lung function level and rate of decline in
chronic obstructive pulmonary disease patients from the Lung Health
Study; also functional effect of the rs3818822 polymorphism on
AMCase levels and activity was demonstrated
REFERENCE 3 (bases 1 to 1414)
AUTHORS Birben,E., Sackesen,C., Kazani,S., Tincer,G., Karaaslan,C.,
Durgunsu,B., Gursel,I., Wechsler,M.E., Israel,E. and Kalayci,O.
TITLE The effects of an insertion in the 5'UTR of the AMCase on gene
expression and pulmonary functions
JOURNAL Respir Med 105 (8), 1160-1169 (2011)
PUBMED 21511453
REMARK GeneRIF: A ten base pair insertion in the second exon in the 5'UTR
region of the AMCase gene may modify the gene expression and thus
may affect the severity of asthma.
REFERENCE 4 (bases 1 to 1414)
AUTHORS Gu,Z., Cao,Z. and Jin,M.
TITLE Expression and role of acidic mammalian chitinase and eotaxin-3 in
chronic rhinosinusitis with nasal polyps
JOURNAL J Otolaryngol Head Neck Surg 40 (1), 64-69 (2011)
PUBMED 21303604
REMARK GeneRIF: AMCase and eotaxin-3 may be important mediators in the
pathogenesis of nasal polyps. The increased AMCase and eotaxin-3
might lead to nasal polyp formation and growth.
REFERENCE 5 (bases 1 to 1414)
AUTHORS Park,S.K., Heo,K.W., Hur,D.Y. and Yang,Y.I.
TITLE Chitinolytic activity in nasal polyps
JOURNAL Am J Rhinol Allergy 25 (1), 12-14 (2011)
PUBMED 21711963
REMARK GeneRIF: increased chitinolytic activity in nasal polyps
REFERENCE 6 (bases 1 to 1414)
AUTHORS Chou,Y.T., Yao,S., Czerwinski,R., Fleming,M., Krykbaev,R., Xuan,D.,
Zhou,H., Brooks,J., Fitz,L., Strand,J., Presman,E., Lin,L.,
Aulabaugh,A. and Huang,X.
TITLE Kinetic characterization of recombinant human acidic mammalian
chitinase
JOURNAL Biochemistry 45 (14), 4444-4454 (2006)
PUBMED 16584180
REMARK GeneRIF: human AMCase has only one pH optimum for k(cat)/K(m)
between pH 4 and 5. Steady state kinetics shows that human AMCase
has 'low' intrinsic transglycosidase activity, which leads to the
observation of apparent substrate inhibition.
REFERENCE 7 (bases 1 to 1414)
AUTHORS Zhu,Z., Zheng,T., Homer,R.J., Kim,Y.K., Chen,N.Y., Cohn,L.,
Hamid,Q. and Elias,J.A.
TITLE Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13
pathway activation
JOURNAL Science 304 (5677), 1678-1682 (2004)
PUBMED 15192232
REMARK GeneRIF: expressed in exaggerated quantities in human asthma
REFERENCE 8 (bases 1 to 1414)
AUTHORS Goto,M., Fujimoto,W., Nio,J., Iwanaga,T. and Kawasaki,T.
TITLE Immunohistochemical demonstration of acidic mammalian chitinase in
the mouse salivary gland and gastric mucosa
JOURNAL Arch. Oral Biol. 48 (10), 701-707 (2003)
PUBMED 12971947
REFERENCE 9 (bases 1 to 1414)
AUTHORS Boot,R.G., Blommaart,E.F., Swart,E., Ghauharali-van der Vlugt,K.,
Bijl,N., Moe,C., Place,A. and Aerts,J.M.
TITLE Identification of a novel acidic mammalian chitinase distinct from
chitotriosidase
JOURNAL J. Biol. Chem. 276 (9), 6770-6778 (2001)
PUBMED 11085997
REFERENCE 10 (bases 1 to 1414)
AUTHORS Saito,A., Ozaki,K., Fujiwara,T., Nakamura,Y. and Tanigami,A.
TITLE Isolation and mapping of a human lung-specific gene, TSA1902,
encoding a novel chitinase family member
JOURNAL Gene 239 (2), 325-331 (1999)
PUBMED 10548734
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK290702.1, AB025008.1 and
BC036339.1.
On Apr 14, 2012 this sequence version replaced gi:42542397.
Summary: The protein encoded by this gene degrades chitin, which is
found in the cell wall of most fungi as well as in arthropods and
some nematodes. The encoded protein can also stimulate interleukin
13 expression, and variations in this gene can lead to asthma
susceptibility. Several transcript variants encoding a few
different isoforms have been found for this gene. [provided by
RefSeq, Apr 2012].
Transcript Variant: This variant (2) lacks exons in the 5' coding
region and initiates translation at a downstream AUG compared to
variant 4. The encoded isoform (a, also known as TSA1902-L) has a
shorter N-terminus and lacks a signal peptide compared to isoform
c. Variants 2, 5, and 7 all encode the same isoform (a).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB025008.1 [ECO:0000332]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-10 AK290702.1 1-10
11-145 AB025008.1 1-135
146-1414 BC036339.1 84-1352
FEATURES Location/Qualifiers
source 1..1414
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p13.2"
gene 1..1414
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/note="chitinase, acidic"
/db_xref="GeneID:27159"
/db_xref="HGNC:17432"
/db_xref="MIM:606080"
exon 1..99
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 16..18
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="ct"
/db_xref="dbSNP:34698010"
variation 16..17
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="ct"
/db_xref="dbSNP:374234404"
variation 22
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:116488064"
variation 44
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:12026825"
variation 72
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:149411814"
variation 75
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:146385552"
variation 88
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:139768111"
STS 95..1351
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/db_xref="UniSTS:486602"
variation 97
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:142723581"
exon 100..156
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 103
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:368828123"
variation 110
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:143910053"
variation 139
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:147282128"
variation 146
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:3818822"
variation 156
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:201556508"
exon 157..322
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
CDS 167..1273
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/EC_number="3.2.1.14"
/note="isoform a is encoded by transcript variant 2;
acidic mammalian chitinase; lung-specific protein TSA1902"
/codon_start=1
/product="acidic mammalian chitinase isoform a"
/protein_id="NP_068569.2"
/db_xref="GI:42542398"
/db_xref="CCDS:CCDS832.1"
/db_xref="GeneID:27159"
/db_xref="HGNC:17432"
/db_xref="MIM:606080"
/translation="
MVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
"
misc_feature <167..1003
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/note="The GH18 (glycosyl hydrolase, family 18) type II
chitinases hydrolyze chitin, an abundant polymer of
beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a
major component of the cell wall of fungi and the
exoskeleton of arthropods. Chitinases have...; Region:
GH18_chitinase-like; cl10447"
/db_xref="CDD:209141"
misc_feature <167..937
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/note="Glyco_18 domain; Region: Glyco_18; smart00636"
/db_xref="CDD:197811"
misc_feature order(248..250,254..256,260..262,476..481,641..643,
920..922)
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/note="active site"
/db_xref="CDD:119349"
misc_feature 1127..1270
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/note="Chitin-binding domain type 2; Region: ChtBD2;
smart00494"
/db_xref="CDD:197759"
variation 189
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:146209261"
variation 193
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:150698600"
variation 210
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:377228357"
variation 216
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:61756687"
variation 220
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:41282498"
variation 221
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:369223512"
variation 225
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:140031055"
variation 229
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:200273853"
variation 241
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:140252614"
variation 260
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="g"
/db_xref="dbSNP:144029730"
variation 275
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:188294966"
variation 279
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:142253415"
variation 285
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:373203725"
variation 316
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:146460083"
variation 318
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:199990081"
exon 323..447
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 329
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:139158262"
variation 344
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:199860140"
variation 347
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:143586120"
variation 357
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:144679403"
variation 359
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="t"
/db_xref="dbSNP:116430435"
variation 364
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:200617710"
variation 384
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:377181497"
variation 407
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:369860168"
variation 422
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:199874052"
variation 437
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="c"
/db_xref="dbSNP:150563512"
exon 448..571
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 454
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:140904700"
variation 466
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:368843945"
variation 478
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:148384495"
variation 479
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:200134913"
variation 535
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:369614927"
variation 537
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:376497990"
variation 542
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:147103194"
variation 547
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:143960572"
variation 556
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:139759326"
variation 557
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:142137716"
variation 563
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:151297358"
exon 572..757
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 595
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:114510939"
variation 599
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="t"
/db_xref="dbSNP:181434663"
variation 626
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:367730751"
variation 653
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:78293817"
variation 658
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:139093708"
variation 667
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:143107428"
variation 669
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:371506503"
variation 674
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:143732960"
variation 690
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:150309903"
variation 705
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:61748620"
variation 715
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:61748619"
variation 725
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:79500525"
variation 731
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:139420194"
variation 733
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:201390788"
variation 744
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:150840174"
variation 755
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:201266629"
exon 758..877
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 765
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:142736771"
variation 792
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:139812869"
variation 798..799
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="tgcccctcaggaag"
/db_xref="dbSNP:151326722"
variation 800
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:200566957"
variation 802..803
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="cctcaggaagtgcc"
/db_xref="dbSNP:375881947"
variation 816
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace=""
/replace="cctcaggaagtgcc"
/db_xref="dbSNP:74706064"
variation 835
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:144546962"
variation 836
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:375947945"
variation 838
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:17027410"
variation 839
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:190772785"
variation 841
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:144182515"
variation 850
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:370020615"
variation 856
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:182916944"
variation 857
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:2275253"
variation 864
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:189146821"
variation 868
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:200092579"
variation 872
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:374270214"
exon 878..1019
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 903
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:2275254"
variation 910
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:151038298"
variation 911
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:201691527"
variation 912
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:374315938"
variation 914
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:142800191"
variation 924
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:373985805"
variation 939
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:141843885"
variation 955
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:76395847"
variation 971
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:36011905"
variation 985
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:368203516"
variation 993
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:143969273"
variation 998
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:147768976"
variation 1003
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:2820092"
variation 1004
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:371701062"
variation 1007
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:12094378"
exon 1020..1373
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/inference="alignment:Splign:1.39.8"
variation 1027
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:372590829"
variation 1034
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:140459744"
variation 1048
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:199879175"
variation 1057
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:377085074"
variation 1060
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:150421495"
variation 1062
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:145023911"
variation 1063
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="t"
/db_xref="dbSNP:187769579"
variation 1074
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:144623576"
variation 1082
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:199811046"
variation 1083
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:141747675"
variation 1088
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:138227985"
variation 1108
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:376164222"
variation 1114
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:35242709"
variation 1118
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:149869566"
variation 1137
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:2256721"
variation 1150
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:369442393"
variation 1157
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="c"
/db_xref="dbSNP:368010768"
variation 1158
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:143551303"
variation 1160
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:138073907"
variation 1179
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:201456008"
variation 1183
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:368211379"
variation 1219
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="g"
/db_xref="dbSNP:145057685"
variation 1228
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:140461957"
variation 1229
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:142653250"
variation 1268
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:146040153"
variation 1290
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="a"
/replace="g"
/db_xref="dbSNP:373720681"
variation 1295
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:139802202"
variation 1307
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="c"
/replace="t"
/db_xref="dbSNP:372826781"
variation 1312
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
/replace="g"
/replace="t"
/db_xref="dbSNP:141163072"
polyA_signal 1349..1354
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
polyA_site 1373
/gene="CHIA"
/gene_synonym="AMCASE; CHIT2; TSA1902"
ORIGIN
aaagcttcatgaaacctcctcgtctgtgcacgaacaggtggccgactctggagcccaggctgttgctttccagtctggtggtgaatcctccatagtctggaacagccagctgaaaactctcctggccattggaggctggaacttcgggactgcccctttcactgccatggtttctactcctgagaaccgccagactttcatcacctcagtcatcaaattcctgcgccagtatgagtttgacgggctggactttgactgggagtaccctggctctcgtgggagccctcctcaggacaagcatctcttcactgtcctggtgcaggaaatgcgtgaagcttttgagcaggaggccaagcagatcaacaagcccaggctgatggtcactgctgcagtagctgctggcatctccaatatccagtctggctatgagatcccccaactgtcacagtacctggactacatccatgtcatgacctacgacctccatggctcctgggagggctacactggagagaacagccccctctacaaatacccgactgacaccggcagcaacgcctacctcaatgtggattatgtcatgaactactggaaggacaatggagcaccagctgagaagctcatcgttggattccctacctatggacacaacttcatcctgagcaacccctccaacactggaattggtgcccccacctctggtgctggtcctgctgggccctatgccaaggagtctgggatctgggcttactacgagatctgtaccttcctgaaaaatggagccactcagggatgggatgcccctcaggaagtgccttatgcctatcagggcaatgtgtgggttggctatgacaacatcaagagcttcgatattaaggctcaatggcttaagcacaacaaatttggaggcgccatggtctgggccattgatctggatgacttcactggcactttctgcaaccagggcaagtttcccctaatctccaccctgaagaaggccctcggcctgcagagtgcaagttgcacggctccagctcagcccattgagccaataactgctgctcccagtggcagcgggaacgggagcgggagtagcagctctggaggcagctcgggaggcagtggattctgtgctgtcagagccaacggcctctaccccgtggcaaataacagaaatgccttctggcactgcgtgaatggagtcacgtaccagcagaactgccaggccgggcttgtcttcgacaccagctgtgattgctgcaactgggcataaacctgacctggtctatattccctagagttccagtctcttttgcttaggacatgttgcccctacctaaagtcctgcaataaaatcagcagtcaaaacatgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:27159 -> Molecular function: GO:0003796 [lysozyme activity] evidence: NAS
GeneID:27159 -> Molecular function: GO:0004568 [chitinase activity] evidence: IDA
GeneID:27159 -> Molecular function: GO:0004568 [chitinase activity] evidence: NAS
GeneID:27159 -> Molecular function: GO:0008061 [chitin binding] evidence: TAS
GeneID:27159 -> Molecular function: GO:0019900 [kinase binding] evidence: IPI
GeneID:27159 -> Molecular function: GO:0030246 [carbohydrate binding] evidence: NAS
GeneID:27159 -> Biological process: GO:0000272 [polysaccharide catabolic process] evidence: IEA
GeneID:27159 -> Biological process: GO:0001101 [response to acid] evidence: TAS
GeneID:27159 -> Biological process: GO:0002532 [production of molecular mediator involved in inflammatory response] evidence: IDA
GeneID:27159 -> Biological process: GO:0006030 [chitin metabolic process] evidence: NAS
GeneID:27159 -> Biological process: GO:0006032 [chitin catabolic process] evidence: IDA
GeneID:27159 -> Biological process: GO:0006032 [chitin catabolic process] evidence: NAS
GeneID:27159 -> Biological process: GO:0006037 [cell wall chitin metabolic process] evidence: TAS
GeneID:27159 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:27159 -> Biological process: GO:0006955 [immune response] evidence: NAS
GeneID:27159 -> Biological process: GO:0007586 [digestion] evidence: NAS
GeneID:27159 -> Biological process: GO:0009620 [response to fungus] evidence: TAS
GeneID:27159 -> Biological process: GO:0090197 [positive regulation of chemokine secretion] evidence: IDA
GeneID:27159 -> Cellular component: GO:0005615 [extracellular space] evidence: IC
GeneID:27159 -> Cellular component: GO:0005615 [extracellular space] evidence: IDA
GeneID:27159 -> Cellular component: GO:0005737 [cytoplasm] evidence: ISS
GeneID:27159 -> Cellular component: GO:0005737 [cytoplasm] evidence: NAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_068569 -> EC 3.2.1.14
by
@meso_cacase at
DBCLS
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