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2024-04-17 00:48:52, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_021138 2298 bp mRNA linear PRI 08-JUN-2013
DEFINITION Homo sapiens TNF receptor-associated factor 2 (TRAF2), mRNA.
ACCESSION NM_021138 NM_145718
VERSION NM_021138.3 GI:42544228
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2298)
AUTHORS Fang,D.F., He,K., Wang,J., Mu,R., Tan,B., Jian,Z., Li,H.Y.,
Song,W., Chang,Y., Gong,W.L., Li,W.H. and Wang,G.J.
TITLE RAD23A negatively regulates RIG-I/MDA5 signaling through promoting
TRAF2 polyubiquitination and degradation
JOURNAL Biochem. Biophys. Res. Commun. 431 (4), 686-692 (2013)
PUBMED 23357418
REMARK GeneRIF: RAD23A down-regulated TRAF2 protein level through
ubiquitin-proteasome system.
REFERENCE 2 (bases 1 to 2298)
AUTHORS Yang,H.J., Youn,H., Seong,K.M., Jin,Y.W., Kim,J. and Youn,B.
TITLE Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2
protein mediates radioresistance in non-small cell lung cancer
cells
JOURNAL J. Biol. Chem. 288 (5), 2965-2975 (2013)
PUBMED 23188828
REMARK GeneRIF: A novel radioresistance mechanism through functional
orchestration of rpS3, TRAF2, and NF-kappaB in non-small cell lung
cancer cells, is reported.
REFERENCE 3 (bases 1 to 2298)
AUTHORS Gonzalvez,F., Lawrence,D., Yang,B., Yee,S., Pitti,R., Marsters,S.,
Pham,V.C., Stephan,J.P., Lill,J. and Ashkenazi,A.
TITLE TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8
with a ubiquitin shutoff timer
JOURNAL Mol. Cell 48 (6), 888-899 (2012)
PUBMED 23142077
REMARK GeneRIF: TRAF2 sets a critical barrier for cell-Extrinsic apoptosis
commitment by tagging activated caspase-8 with a K48-ubiquitin
shutoff timer.
REFERENCE 4 (bases 1 to 2298)
AUTHORS He,W., Wang,Q., Xu,J., Xu,X., Padilla,M.T., Ren,G., Gou,X. and
Lin,Y.
TITLE Attenuation of TNFSF10/TRAIL-induced apoptosis by an autophagic
survival pathway involving TRAF2- and RIPK1/RIP1-mediated MAPK8/JNK
activation
JOURNAL Autophagy 8 (12), 1811-1821 (2012)
PUBMED 23051914
REMARK GeneRIF: These results reveal a critical role for the MAPK8
activation pathway through TRAF2 and RIPK1 for TNFSF10-induced
autophagy that blunts apoptosis in cancer cells.
REFERENCE 5 (bases 1 to 2298)
AUTHORS Shen,R.R., Zhou,A.Y., Kim,E., Lim,E., Habelhah,H. and Hahn,W.C.
TITLE IkappaB kinase epsilon phosphorylates TRAF2 to promote mammary
epithelial cell transformation
JOURNAL Mol. Cell. Biol. 32 (23), 4756-4768 (2012)
PUBMED 23007157
REMARK GeneRIF: This work defines TRAF2 phosphorylation to be one key
effector of IKKE-induced mammary epithelial cell transformation.
REFERENCE 6 (bases 1 to 2298)
AUTHORS Hsu,H., Huang,J., Shu,H.B., Baichwal,V. and Goeddel,D.V.
TITLE TNF-dependent recruitment of the protein kinase RIP to the TNF
receptor-1 signaling complex
JOURNAL Immunity 4 (4), 387-396 (1996)
PUBMED 8612133
REFERENCE 7 (bases 1 to 2298)
AUTHORS Lee,S.Y., Park,C.G. and Choi,Y.
TITLE T cell receptor-dependent cell death of T cell hybridomas mediated
by the CD30 cytoplasmic domain in association with tumor necrosis
factor receptor-associated factors
JOURNAL J. Exp. Med. 183 (2), 669-674 (1996)
PUBMED 8627180
REFERENCE 8 (bases 1 to 2298)
AUTHORS Hsu,H., Shu,H.B., Pan,M.G. and Goeddel,D.V.
TITLE TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF
receptor 1 signal transduction pathways
JOURNAL Cell 84 (2), 299-308 (1996)
PUBMED 8565075
REFERENCE 9 (bases 1 to 2298)
AUTHORS Hsu,H., Xiong,J. and Goeddel,D.V.
TITLE The TNF receptor 1-associated protein TRADD signals cell death and
NF-kappa B activation
JOURNAL Cell 81 (4), 495-504 (1995)
PUBMED 7758105
REFERENCE 10 (bases 1 to 2298)
AUTHORS Rothe,M., Wong,S.C., Henzel,W.J. and Goeddel,D.V.
TITLE A novel family of putative signal transducers associated with the
cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
JOURNAL Cell 78 (4), 681-692 (1994)
PUBMED 8069916
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC043492.1 and BC064662.1.
On or before Feb 13, 2004 this sequence version replaced
gi:22027613, gi:22027611.
Summary: The protein encoded by this gene is a member of the TNF
receptor associated factor (TRAF) protein family. TRAF proteins
associate with, and mediate the signal transduction from members of
the TNF receptor superfamily. This protein directly interacts with
TNF receptors, and forms a heterodimeric complex with TRAF1. This
protein is required for TNF-alpha-mediated activation of MAPK8/JNK
and NF-kappaB. The protein complex formed by this protein and TRAF1
interacts with the inhibitor-of-apoptosis proteins (IAPs), and
functions as a mediator of the anti-apoptotic signals from TNF
receptors. The interaction of this protein with TRADD, a TNF
receptor associated apoptotic signal transducer, ensures the
recruitment of IAPs for the direct inhibition of caspase
activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing
ubiquitin ligase activity, can unbiquitinate and induce the
degradation of this protein, and thus potentiate TNF-induced
apoptosis. Multiple alternatively spliced transcript variants have
been found for this gene, but the biological validity of only one
transcript has been determined. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC043492.1, BC033810.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1630 BC043492.1 1-1630
1631-2277 BC064662.1 1626-2272
2278-2298 BC043492.1 2278-2298
FEATURES Location/Qualifiers
source 1..2298
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q34"
gene 1..2298
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/note="TNF receptor-associated factor 2"
/db_xref="GeneID:7186"
/db_xref="HGNC:12032"
/db_xref="HPRD:03538"
/db_xref="MIM:601895"
exon 1..29
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/inference="alignment:Splign:1.39.8"
exon 30..245
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/inference="alignment:Splign:1.39.8"
variation 42
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:376785145"
variation 49
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200264510"
CDS 58..1563
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/note="tumor necrosis factor type 2 receptor associated
protein 3; tumor necrosis factor type 2
receptor-associated protein 3; E3 ubiquitin-protein ligase
TRAF2"
/codon_start=1
/product="TNF receptor-associated factor 2"
/protein_id="NP_066961.2"
/db_xref="GI:22027612"
/db_xref="CCDS:CCDS7013.1"
/db_xref="GeneID:7186"
/db_xref="HGNC:12032"
/db_xref="HPRD:03538"
/db_xref="MIM:601895"
/translation="
MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL
"
misc_feature 61..63
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylalanine; propagated from
UniProtKB/Swiss-Prot (Q12933.2); acetylation site"
misc_feature 76..78
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q12933.2); phosphorylation site"
misc_feature 76..78
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 88..90
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q12933.2); phosphorylation site"
misc_feature 88..90
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 118..120
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/experiment="experimental evidence, no additional details
recorded"
/note="ubiquitination site; modified site"
misc_feature 121..123
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q12933.2); phosphorylation site"
misc_feature 148..150
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/experiment="experimental evidence, no additional details
recorded"
/note="ubiquitination site; modified site"
misc_feature 157..273
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/note="Zinc finger, C3HC4 type (RING finger); Region:
zf-C3HC4; pfam00097"
/db_xref="CDD:200999"
misc_feature 406..408
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine, by PKC; propagated from
UniProtKB/Swiss-Prot (Q12933.2); phosphorylation site"
misc_feature 589..762
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/note="TRAF-type zinc finger; Region: zf-TRAF; pfam02176"
/db_xref="CDD:190233"
misc_feature 904..936
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q12933.2);
Region: Important for interaction with BIRC2 and BIRC3 (By
similarity)"
misc_feature 1057..1548
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/note="Tumor Necrosis Factor Receptor (TNFR) Associated
Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF
molecules serve as adapter proteins that link TNFRs and
downstream kinase cascades resulting in the activation of
transcription factors and the...; Region: MATH_TRAF2;
cd03778"
/db_xref="CDD:58109"
misc_feature order(1060..1062,1069..1071,1093..1095,1099..1101,
1120..1122,1126..1128,1210..1215,1306..1308,1315..1317,
1366..1368)
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/note="trimer interface [polypeptide binding]; other site"
/db_xref="CDD:58109"
misc_feature order(1234..1236,1240..1242,1252..1254,1285..1287,
1396..1401,1414..1416,1420..1425,1453..1461)
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/note="TNFR binding site; other site"
/db_xref="CDD:58109"
misc_feature order(1258..1260,1273..1275,1390..1392,1399..1407,
1414..1419,1423..1425,1456..1461,1477..1479)
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/note="TRADD binding site; other site"
/db_xref="CDD:58109"
variation 65
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:369489108"
variation 67
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="g"
/db_xref="dbSNP:61735540"
variation 72
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199836341"
variation 78
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:373594239"
variation 108
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:147576715"
variation 147
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:149061831"
variation 153
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:144753635"
variation 197
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:376801177"
exon 246..324
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/inference="alignment:Splign:1.39.8"
variation 277
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="g"
/db_xref="dbSNP:151009848"
variation 288
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:187030513"
variation 300
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:148192660"
variation 305
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:370634762"
variation 317
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:11555947"
variation 323
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:200834553"
exon 325..423
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/inference="alignment:Splign:1.39.8"
variation 381
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:371188050"
exon 424..585
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/inference="alignment:Splign:1.39.8"
variation 426
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:140121451"
variation 428
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:376437711"
variation 432
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:369603509"
variation 439
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:373483375"
variation 446
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:145541787"
variation 447
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:35257683"
variation 457
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:142528394"
variation 468
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:146000553"
variation 469
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:138185376"
variation 488
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:377582627"
variation 498
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="t"
/db_xref="dbSNP:199667825"
variation 505
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:373018887"
variation 527
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:149585522"
variation 530
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:144301926"
variation 584
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200775038"
exon 586..660
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/inference="alignment:Splign:1.39.8"
variation 587
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:367860949"
variation 606
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201377057"
variation 627
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:17250428"
variation 628
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:144636458"
variation 653
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:199507094"
exon 661..735
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/inference="alignment:Splign:1.39.8"
variation 673
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369480645"
variation 686
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:372434556"
variation 688
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:147529604"
variation 702
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:140194151"
variation 708
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="c"
/db_xref="dbSNP:145511794"
variation 714
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:34592255"
variation 726
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:149686627"
variation 729
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:199990999"
variation 730
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:377131385"
exon 736..1017
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/inference="alignment:Splign:1.39.8"
variation 806
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:376884527"
variation 844
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:371511079"
variation 846
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:200313379"
variation 847
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:144427288"
variation 848
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201857326"
variation 849
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:148589670"
variation 850
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:369008686"
variation 858
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373833243"
variation 873
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:145264551"
variation 883
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="g"
/db_xref="dbSNP:376467561"
variation 890
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="c"
/db_xref="dbSNP:146501200"
variation 893
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201077633"
variation 954
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:112407582"
variation 980
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:371121908"
variation 981
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:17244166"
exon 1018..1195
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/inference="alignment:Splign:1.39.8"
variation 1059
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:146825488"
variation 1083
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:200115576"
variation 1093
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:141280500"
variation 1140
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:17250560"
variation 1141
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="g"
/replace="t"
/db_xref="dbSNP:374009362"
variation 1179
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201954782"
variation 1182
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:138829625"
exon 1196..1344
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/inference="alignment:Splign:1.39.8"
variation 1221
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="c"
/db_xref="dbSNP:201085972"
variation 1254
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:202188895"
variation 1260
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:189329794"
variation 1314
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201247047"
variation 1315
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:201675834"
variation 1326
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200660050"
exon 1345..2277
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/inference="alignment:Splign:1.39.8"
variation 1384
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373560625"
variation 1404
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:142950766"
variation 1408
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:147459885"
variation 1419
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:201046393"
variation 1440
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:139915243"
variation 1441
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:144092600"
variation 1462
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:144405558"
variation 1479
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="g"
/db_xref="dbSNP:201565826"
variation 1480
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:148765924"
variation 1491
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:370806633"
variation 1509
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:150502565"
variation 1518
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:116933326"
variation 1519
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:142412558"
variation 1540
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:151161910"
variation 1564
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:373269558"
variation 1568
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="g"
/db_xref="dbSNP:185169126"
variation 1573
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:17250680"
variation 1583
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:370864551"
variation 1607
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="g"
/db_xref="dbSNP:111793983"
variation 1610
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:13291315"
variation 1614
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="c"
/db_xref="dbSNP:376712787"
variation 1631
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:7852970"
variation 1635
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:373488491"
variation 1671
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:139025947"
variation 1679
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:190399967"
variation 1762
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:142208697"
variation 1779
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:370337976"
variation 1810
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:146365735"
variation 1811
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:368146215"
variation 2003..2005
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace=""
/replace="ctg"
/db_xref="dbSNP:377713483"
STS 2056..2225
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/standard_name="RH79117"
/db_xref="UniSTS:51861"
variation 2063..2064
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace=""
/replace="gg"
/db_xref="dbSNP:17250694"
variation 2067..2068
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace=""
/replace="gg"
/db_xref="dbSNP:371548088"
variation 2140..2141
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace=""
/replace="ga"
/db_xref="dbSNP:5901110"
variation 2141..2142
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace=""
/replace="ag"
/db_xref="dbSNP:200473034"
variation 2141
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:200761890"
variation 2143
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace=""
/replace="a"
/replace="ag"
/db_xref="dbSNP:3034879"
variation 2158
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:192922611"
variation 2194
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace=""
/replace="a"
/db_xref="dbSNP:5901111"
variation 2238
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:183986463"
polyA_signal 2251..2256
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
variation 2261..2262
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace=""
/replace="a"
/db_xref="dbSNP:17244313"
variation 2262..2263
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace=""
/replace="a"
/db_xref="dbSNP:368036819"
polyA_site 2269
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/experiment="experimental evidence, no additional details
recorded"
polyA_site 2277
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
variation 2278
/gene="TRAF2"
/gene_synonym="MGC:45012; TRAP; TRAP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:3750512"
ORIGIN
cttagttccgggcgcgctgcgaccgttggggctttgttcgcgggggtcacagctctcatggctgcagctagcgtgaccccccctggctccctggagttgctacagcccggcttctccaagaccctcctggggaccaagctggaagccaagtacctgtgctccgcctgcagaaacgtcctccgcaggcccttccaggcgcagtgtggccaccggtactgctccttctgcctggccagcatcctcagctctgggcctcagaactgtgctgcctgtgttcacgagggcatatatgaagaaggcatttctattttagaaagcagttcggccttcccagataatgctgcccgcagggaggtggagagcctgccggccgtctgtcccagtgatggatgcacctggaaggggaccctgaaagaatacgagagctgccacgaaggccgctgcccgctcatgctgaccgaatgtcccgcgtgcaaaggcctggtccgccttggtgaaaaggagcgccacctggagcacgagtgcccggagagaagcctgagctgccggcattgccgggcaccctgctgcggagcagacgtgaaggcgcaccacgaggtctgccccaagttccccttaacttgtgacggctgcggcaagaagaagatcccccgggagaagtttcaggaccacgtcaagacttgtggcaagtgtcgagtcccttgcagattccacgccatcggctgcctcgagacggtagagggtgagaaacagcaggagcacgaggtgcagtggctgcgggagcacctggccatgctactgagctcggtgctggaggcaaagcccctcttgggagaccagagccacgcggggtcagagctcctgcagaggtgcgagagcctggagaagaagacggccacttttgagaacattgtctgcgtcctgaaccgggaggtggagagggtggccatgactgccgaggcctgcagccggcagcaccggctggaccaagacaagattgaagccctgagtagcaaggtgcagcagctggagaggagcattggcctcaaggacctggcgatggctgacttggagcagaaggtcttggagatggaggcatccacctacgatggggtcttcatctggaagatctcagacttcgccaggaagcgccaggaagctgtggctggccgcatacccgccatcttctccccagccttctacaccagcaggtacggctacaagatgtgtctgcgtatctacctgaacggcgacggcaccgggcgaggaacacacctgtccctcttctttgtggtgatgaagggcccgaatgacgccctgctgcggtggcccttcaaccagaaggtgaccttaatgctgctcgaccagaataaccgggagcacgtgattgacgccttcaggcccgacgtgacttcatcctcttttcagaggccagtcaacgacatgaacatcgcaagcggctgccccctcttctgccccgtctccaagatggaggcaaagaattcctacgtgcgggacgatgccatcttcatcaaggccattgtggacctgacagggctctaactgccccctactggtgtctgggggttgggggcagccaggcacagccggctcacggaggggccaccacgctgggccagggtctcactgtacaagtgggcaggggccgcgcttgggcgcttgggagggtgtcggcctgcagccaagttcactgtcacgggggaaggagccaccagccagtcctcagatttcagagactgcggaggggcttggcagacggtcttagccaagggctgtggtggcattggccgagggtcttcgggtgcttcccagcacaagctgcccttgctgtcctgtgcagtgaagggagaggccctgggtgggggacactcagagtgggagcacatcccagcagtgcccatgtagcaggagcacagtggatggccttgtgtccctcgggcatgacaggcagaaacgagggctgctccaggagaagggcctcctgctggccagagcaaggaaggctgagcagcttggttctcccctctggcccctggagagaagggagcattcctagacccctgggtgcttgtctgcacagagctctggtctgtgccaccttggccaggctggctgtgggagagggtctggtcccacgccgcctctgctcagaccactgtgtgggaggtgcacagcacagcctgcgggtaaagtgtgagagcttgccatccagctcacgaagacagagttattaaaccattcaaatctctgtggtcaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7186 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IDA
GeneID:7186 -> Molecular function: GO:0004871 [signal transducer activity] evidence: NAS
GeneID:7186 -> Molecular function: GO:0005164 [tumor necrosis factor receptor binding] evidence: IPI
GeneID:7186 -> Molecular function: GO:0005174 [CD40 receptor binding] evidence: ISS
GeneID:7186 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7186 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:7186 -> Molecular function: GO:0019899 [enzyme binding] evidence: IPI
GeneID:7186 -> Molecular function: GO:0019903 [protein phosphatase binding] evidence: IPI
GeneID:7186 -> Molecular function: GO:0031625 [ubiquitin protein ligase binding] evidence: IPI
GeneID:7186 -> Molecular function: GO:0031996 [thioesterase binding] evidence: IPI
GeneID:7186 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
GeneID:7186 -> Molecular function: GO:0046625 [sphingolipid binding] evidence: IDA
GeneID:7186 -> Biological process: GO:0002726 [positive regulation of T cell cytokine production] evidence: IMP
GeneID:7186 -> Biological process: GO:0006461 [protein complex assembly] evidence: TAS
GeneID:7186 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:7186 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: TAS
GeneID:7186 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:7186 -> Biological process: GO:0007250 [activation of NF-kappaB-inducing kinase activity] evidence: IMP
GeneID:7186 -> Biological process: GO:0030163 [protein catabolic process] evidence: IEA
GeneID:7186 -> Biological process: GO:0032743 [positive regulation of interleukin-2 production] evidence: IMP
GeneID:7186 -> Biological process: GO:0033209 [tumor necrosis factor-mediated signaling pathway] evidence: IDA
GeneID:7186 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: IDA
GeneID:7186 -> Biological process: GO:0043507 [positive regulation of JUN kinase activity] evidence: IDA
GeneID:7186 -> Biological process: GO:0043623 [cellular protein complex assembly] evidence: ISS
GeneID:7186 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
GeneID:7186 -> Biological process: GO:0050870 [positive regulation of T cell activation] evidence: IC
GeneID:7186 -> Biological process: GO:0051023 [regulation of immunoglobulin secretion] evidence: IEA
GeneID:7186 -> Biological process: GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] evidence: IMP
GeneID:7186 -> Biological process: GO:0051092 [positive regulation of NF-kappaB transcription factor activity] evidence: IDA
GeneID:7186 -> Biological process: GO:0051092 [positive regulation of NF-kappaB transcription factor activity] evidence: IMP
GeneID:7186 -> Biological process: GO:0051865 [protein autoubiquitination] evidence: IDA
GeneID:7186 -> Biological process: GO:0051865 [protein autoubiquitination] evidence: TAS
GeneID:7186 -> Biological process: GO:0070207 [protein homotrimerization] evidence: IPI
GeneID:7186 -> Biological process: GO:0070534 [protein K63-linked ubiquitination] evidence: IDA
GeneID:7186 -> Biological process: GO:0090073 [positive regulation of protein homodimerization activity] evidence: IMP
GeneID:7186 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
GeneID:7186 -> Biological process: GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] evidence: IMP
GeneID:7186 -> Biological process: GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand] evidence: TAS
GeneID:7186 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:7186 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:7186 -> Cellular component: GO:0009898 [internal side of plasma membrane] evidence: ISS
GeneID:7186 -> Cellular component: GO:0035631 [CD40 receptor complex] evidence: ISS
by
@meso_cacase at
DBCLS
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