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2024-04-24 02:48:58, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_021137 3822 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens tumor necrosis factor, alpha-induced protein 1
(endothelial) (TNFAIP1), mRNA.
ACCESSION NM_021137
VERSION NM_021137.4 GI:221316727
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3822)
AUTHORS Hu,X., Yan,F., Wang,F., Yang,Z., Xiao,L., Li,L., Xiang,S., Zhou,J.,
Ding,X. and Zhang,J.
TITLE TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10
proteins and inhibit the transcriptional activities of NF-kappaB
and AP-1
JOURNAL Mol. Biol. Rep. 39 (11), 9911-9919 (2012)
PUBMED 22810651
REMARK GeneRIF: TNFAIP1 inhibited the transcriptional activities of
nuclear factor kappa B (NF-kappaB) and activating protein-1
reporters
REFERENCE 2 (bases 1 to 3822)
AUTHORS Yang,L., Liu,N., Hu,X., Zhang,W., Wang,T., Li,H., Zhang,B.,
Xiang,S., Zhou,J. and Zhang,J.
TITLE CK2 phosphorylates TNFAIP1 to affect its subcellular localization
and interaction with PCNA
JOURNAL Mol. Biol. Rep. 37 (6), 2967-2973 (2010)
PUBMED 19851886
REMARK GeneRIF: CK2 could phosphorylate TNFAIP1 in vitro and in vivo,
which facilitated the distribution of TNFAIP1 in nucleus and
enhanced its interaction with PCNA.
REFERENCE 3 (bases 1 to 3822)
AUTHORS Grinchuk,O.V., Motakis,E. and Kuznetsov,V.A.
TITLE Complex sense-antisense architecture of TNFAIP1/POLDIP2 on 17q11.2
represents a novel transcriptional structural-functional gene
module involved in breast cancer progression
JOURNAL BMC Genomics 11 (SUPPL 1), S9 (2010)
PUBMED 20158880
REMARK GeneRIF: suggest that the TNFAIP1/POLDIP2 complex sense-antisense
architecture represents a clinically significant transcriptional
structural-functional gene module associated with amplification of
the genomic region on 17q11.2 in breast cancer.
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 3822)
AUTHORS Kim,D.M., Chung,K.S., Choi,S.J., Jung,Y.J., Park,S.K., Han,G.H.,
Ha,J.S., Song,K.B., Choi,N.S., Kim,H.M., Won,M. and Seo,Y.S.
TITLE RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa
cells
JOURNAL Int. J. Cancer 125 (11), 2520-2527 (2009)
PUBMED 19637314
REFERENCE 5 (bases 1 to 3822)
AUTHORS Chen,Y., Yang,Z., Meng,M., Zhao,Y., Dong,N., Yan,H., Liu,L.,
Ding,M., Peng,H.B. and Shao,F.
TITLE Cullin mediates degradation of RhoA through evolutionarily
conserved BTB adaptors to control actin cytoskeleton structure and
cell movement
JOURNAL Mol. Cell 35 (6), 841-855 (2009)
PUBMED 19782033
REMARK Erratum:[Mol Cell. 2011 Dec 23;44(6):1005]
REFERENCE 6 (bases 1 to 3822)
AUTHORS Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
TITLE Protein-protein interaction panel using mouse full-length cDNAs
JOURNAL Genome Res. 11 (10), 1758-1765 (2001)
PUBMED 11591653
REFERENCE 7 (bases 1 to 3822)
AUTHORS Pandey,A., Shao,H., Marks,R.M., Polverini,P.J. and Dixit,V.M.
TITLE Role of B61, the ligand for the Eck receptor tyrosine kinase, in
TNF-alpha-induced angiogenesis
JOURNAL Science 268 (5210), 567-569 (1995)
PUBMED 7536959
REFERENCE 8 (bases 1 to 3822)
AUTHORS Wolf,F.W., Marks,R.M., Sarma,V., Byers,M.G., Katz,R.W., Shows,T.B.
and Dixit,V.M.
TITLE Characterization of a novel tumor necrosis factor-alpha-induced
endothelial primary response gene
JOURNAL J. Biol. Chem. 267 (2), 1317-1326 (1992)
PUBMED 1370465
REFERENCE 9 (bases 1 to 3822)
AUTHORS Holzman,L.B., Marks,R.M. and Dixit,V.M.
TITLE A novel immediate-early response gene of endothelium is induced by
cytokines and encodes a secreted protein
JOURNAL Mol. Cell. Biol. 10 (11), 5830-5838 (1990)
PUBMED 2233719
REFERENCE 10 (bases 1 to 3822)
AUTHORS Dixit,V.M., Green,S., Sarma,V., Holzman,L.B., Wolf,F.W.,
O'Rourke,K., Ward,P.A., Prochownik,E.V. and Marks,R.M.
TITLE Tumor necrosis factor-alpha induction of novel gene products in
human endothelial cells including a macrophage-specific chemotaxin
JOURNAL J. Biol. Chem. 265 (5), 2973-2978 (1990)
PUBMED 2406243
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB093553.1 and BC003694.2.
On Jan 24, 2009 this sequence version replaced gi:26051238.
Summary: This gene was identified as a gene whose expression can be
induced by the tumor necrosis factor alpha (TNF) in umbilical vein
endothelial cells. Studies of a similar gene in mouse suggest that
the expression of this gene is developmentally regulated in a
tissue-specific manner. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC003694.2, M80783.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-238 DB093553.1 1-238
239-1721 BC003694.2 1-1483
1722-2135 BC003694.2 1485-1898
2136-3822 BC003694.2 1900-3586
FEATURES Location/Qualifiers
source 1..3822
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17q22-q23"
gene 1..3822
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/note="tumor necrosis factor, alpha-induced protein 1
(endothelial)"
/db_xref="GeneID:7126"
/db_xref="HGNC:11894"
/db_xref="HPRD:01856"
/db_xref="MIM:191161"
exon 1..335
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/inference="alignment:Splign:1.39.8"
variation 26
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:73271168"
variation 91
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:185140023"
exon 336..654
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/inference="alignment:Splign:1.39.8"
misc_feature 339..341
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/note="upstream in-frame stop codon"
variation 385
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:183329838"
variation 423
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376989015"
variation 431
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="g"
/replace="t"
/db_xref="dbSNP:145146981"
CDS 450..1400
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/note="BTB/POZ domain-containing protein TNFAIP1"
/codon_start=1
/product="BTB/POZ domain-containing adapter for
CUL3-mediated RhoA degradation protein 2"
/protein_id="NP_066960.1"
/db_xref="GI:10863937"
/db_xref="CCDS:CCDS11227.1"
/db_xref="GeneID:7126"
/db_xref="HGNC:11894"
/db_xref="HPRD:01856"
/db_xref="MIM:191161"
/translation="
MSGDTCLCPASGAKPKLSGFKGGGLGNKYVQLNVGGSLYYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTITLPQNRQEIKELMAEAKYYLIQGLVNMCQSALQDKKDSYQPVCNIPIITSLKEEERLIESSTKPVVKLLYNRSNNKYSYTSNSDDHLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNVLLYETPRVPDNSLLEATSRSRSQASPSEDEETFELRDRVRRIHVKRYSTYDDRQLGHQSTHRD
"
misc_feature 537..809
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/note="K+ channel tetramerisation domain; Region: K_tetra;
pfam02214"
/db_xref="CDD:202161"
misc_feature 1281..1283
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q13829.1); phosphorylation site"
misc_feature 1281..1283
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1287..1289
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by CK2; propagated from
UniProtKB/Swiss-Prot (Q13829.1); phosphorylation site"
variation 459
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="g"
/replace="t"
/db_xref="dbSNP:375008673"
variation 487
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375110401"
variation 490
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="c"
/db_xref="dbSNP:143447631"
variation 549
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="g"
/replace="t"
/db_xref="dbSNP:201290313"
variation 579
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:188075311"
variation 580
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369478186"
variation 594
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:140317871"
variation 608
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376658401"
variation 642
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="t"
/db_xref="dbSNP:144048032"
exon 655..824
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/inference="alignment:Splign:1.39.8"
variation 687
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="t"
/db_xref="dbSNP:150955614"
variation 691
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:377434381"
variation 742
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="g"
/db_xref="dbSNP:140747015"
variation 773
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:371064789"
variation 783
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="c"
/db_xref="dbSNP:11550488"
exon 825..914
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/inference="alignment:Splign:1.39.8"
exon 915..967
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/inference="alignment:Splign:1.39.8"
variation 917
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:150081648"
variation 935
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:371221886"
exon 968..1163
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/inference="alignment:Splign:1.39.8"
variation 1009
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:112815924"
variation 1022
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="g"
/db_xref="dbSNP:201236663"
variation 1025..1026
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace=""
/replace="g"
/db_xref="dbSNP:11392068"
variation 1031
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:77434228"
variation 1037
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:373345460"
variation 1067
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3093722"
variation 1070
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376181760"
variation 1098
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="g"
/db_xref="dbSNP:138622447"
variation 1100
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="c"
/db_xref="dbSNP:3093686"
variation 1136
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373460853"
variation 1142
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2234119"
variation 1145
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376735584"
exon 1164..3809
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/inference="alignment:Splign:1.39.8"
variation 1189
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="t"
/db_xref="dbSNP:202073255"
STS 1197..2103
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/standard_name="TNFAIP1__5106"
/db_xref="UniSTS:466517"
variation 1230
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:370053669"
variation 1232
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:201646341"
variation 1264
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:373733645"
variation 1269
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:200262864"
variation 1303
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370500931"
variation 1306
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:374888514"
variation 1308
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="g"
/replace="t"
/db_xref="dbSNP:372504132"
variation 1315
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:2234121"
variation 1316
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:147106718"
variation 1329
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:375777138"
variation 1358
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:138477954"
variation 1388
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:145418568"
variation 1393
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376548251"
variation 1397
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="g"
/db_xref="dbSNP:181116793"
STS 1405..1620
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/standard_name="SHGC-31509"
/db_xref="UniSTS:9128"
variation 1425
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:368989668"
variation 1539
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="g"
/db_xref="dbSNP:373244085"
variation 1600
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:115170044"
variation 1614
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:185848165"
variation 1719..1720
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:66977965"
variation 1719..1720
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace=""
/replace="g"
/db_xref="dbSNP:5819840"
variation 1722
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="g"
/db_xref="dbSNP:75080325"
variation 1732
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="g"
/replace="t"
/db_xref="dbSNP:11550487"
variation 1747
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:189051124"
variation 1794
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:181687343"
variation 1795
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3093695"
variation 1798
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:11550489"
variation 1834
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:116332866"
STS 1916..2058
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/standard_name="RH64867"
/db_xref="UniSTS:89583"
variation 1961
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="t"
/db_xref="dbSNP:186389870"
variation 1974
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="c"
/db_xref="dbSNP:374010963"
variation 2039
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3093696"
variation 2134..2135
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace=""
/replace="c"
/db_xref="dbSNP:11394711"
variation 2195..2196
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace=""
/replace="g"
/db_xref="dbSNP:370362972"
variation 2289
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:376089557"
variation 2403
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:75945208"
variation 2431
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:149766082"
variation 2449
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:370619251"
variation 2515
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:376791645"
variation 2517
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:192143673"
variation 2530
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="g"
/db_xref="dbSNP:3093697"
variation 2545
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:369437455"
variation 2573
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:3093698"
variation 2674
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="g"
/replace="t"
/db_xref="dbSNP:117117462"
variation 2684
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:3093699"
variation 2814
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:78433288"
variation 2823
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3093700"
variation 2873
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3093701"
variation 2876
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3093702"
variation 2913
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:373050881"
variation 2948
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:183965660"
variation 2956
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:3093703"
variation 3010
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:141105720"
variation 3029
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="g"
/db_xref="dbSNP:144787950"
variation 3077
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:80173960"
variation 3090
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="t"
/db_xref="dbSNP:3093704"
variation 3112
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:185901624"
variation 3138
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:3093705"
variation 3169
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:3093706"
variation 3206
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:140301828"
variation 3248
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:190822575"
variation 3547
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:182494703"
variation 3605
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="g"
/replace="t"
/db_xref="dbSNP:187185696"
variation 3608
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:60150286"
variation 3630..3634
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace=""
/replace="acaac"
/db_xref="dbSNP:375960000"
variation 3633..3637
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace=""
/replace="acaca"
/db_xref="dbSNP:3093707"
variation 3633..3634
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace=""
/replace="tgtgt"
/db_xref="dbSNP:200568692"
variation 3665
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:3093708"
variation 3667
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:3093709"
variation 3738..3739
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace=""
/replace="tg"
/db_xref="dbSNP:150639318"
variation 3756
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:143481279"
polyA_signal 3788..3793
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
variation 3795
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:148004236"
variation 3800
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
/replace=""
/replace="t"
/db_xref="dbSNP:71662303"
polyA_site 3809
/gene="TNFAIP1"
/gene_synonym="B12; B61; BTBD34; EDP1; hBACURD2"
ORIGIN
agagcctgctgggaaacagaggcccgaggggaggcccggcctacaagacccagaagccttagcgccggcaaggcggccagaagtagctctgctctctccgcgaagaccctcgggggattccgcctccaccctttcccggatagagcgctatgcatgcagggacttgtagtctcaggctccccagccggctgggctgggcagcactccgggcggagtcgacgagcgcaggatgtgagctcacagcttgggactgctgaggggcaggcggctgcaggctaggggcggctcggagtccgctggccacccagctgagaggagaggcgcccccggggacgcactgagattatgaggctctggcctccactggccactcactcgtgaccctttccaccacggcggagccttccaagcctacctcctgccgtgtggtgatctacctgcagcgggagatgtcgggggacacctgcctgtgcccagcctcaggggccaagcccaagctcagtggcttcaagggaggagggttgggcaacaagtatgtccagctcaacgtgggcggctctctgtactacaccactgtgcgggccctgacccgccacgacaccatgctcaaggccatgttcagtgggcgcatggaggtgctgaccgacaaagaaggctggatcctcatagaccgttgtggaaagcactttggcaccattttgaattacctccgagatgacaccatcaccctccctcagaaccggcaagaaatcaaggaattgatggctgaagcaaagtattacctcatccaggggctggtgaatatgtgccagagtgccctgcaggacaagaaggactcctaccagcctgtgtgcaacatccccatcatcacatccctaaaggaggaggagcggctcatcgaatcctccaccaagcccgtggtgaagctgctgtacaacagaagcaacaacaagtattcctacaccagcaactctgacgaccacctgctgaaaaacatcgagctgtttgacaagctctccctgcgcttcaacggccgcgtgctcttcatcaaggatgtcattggtgacgagatctgctgctggtccttttatggccagggccgtaagctggcagaggtgtgctgtacctccatcgtgtatgccacggagaagaagcagaccaaggtggaattcccagaggcccgaatctatgaggagacactcaacgtcctactctatgagactccccgcgtccccgacaactccttgttggaggccacaagccgtagccgcagccaggcttcccccagtgaagatgaggagacctttgaactgcgggaccgtgtccgccgcatccacgtcaagcgctacagcacttacgatgaccggcagctcggccaccagtctacccatcgcgactgaccagaccctcagggagtcagggcacgggaggccctatctcccatcctgtggaacccgccccattggccaccccatgctgctgctgcctgggtctctgctctagcacccagaggcatgacaggccctgctcagaggtcagagggtctgggcagaggagggaccacattcccctgccttgcccctgagcacttctggagactgcgtcctgtcctatctgctcaccatcacccttcctgcccgacggagctgcttctgctccctggggcatatggactgacccacctcctgctgagaaccttcccctaggccctgtgcagaaggctactgccccttaggcctcagctgggggaaaggcagttctggtgctgtagaggccctggtgcagaaagtgggacgtcttttttcctaaggtgtttaagcacaggcttgataagtttggtttttaaaaaataatctaggaaatgaataattctaaatctagtaatgaggaaactgagcatttcttttgccctccagggtgccaagaccctacatatgacagaacccttggcccttctccatgcctgtgggatctgtttctttaaagcactttgtactgttattcaggaggttgataatctccttgacccatgtctttctaccctaatccccacttccctgcagaatcaatctgagggaggggataaagaggaagcaataaaaaaaaaacatccgacagagcagctctggctttgcagcctggccagcagctcagagtgcaccgaggagggaaggatggctaagctgggaccggcagtcctcacagggtgcctgtgagaaaggacattttacccccacatcatagtcacatcactgactcctaggtctagcacgactgctctttgtgattctcttgagtacccttggcttccagccatgctgtcctcacatacggtaaagccaaagagctgtcacatgggccagaaacatgagccacggcaggaagaccgtggagcccgtgggcactgcatggtgttggctggcatgcccatcagctgaggacagcaaactcccagcagcccctacagaggtggcacatgcttggccacacatctactccctgcccacaccatctatgctcttggttggtgctggctgggatggcggttctgcccagtggtgtctctgagcgcgggatgacaggagcaaccgaagcaccctgaaggccttcactccttgttgggtaactcagccatggagatgccaagcactagccaggaggtgagttcctctttagggctttggttttcattcctttttgtttggcttggccaaaccagaattcagcttatctgaattattttccaaaggaatgctgtcagggagggactgttctgccagcctaacaaagcaacgtagccacgtatagtacccactttctgctctttggagagaacacaggttatcaagttcatctctcttgactactcttatgatagctgatgccacagagcctatgggcaaatgccagacccagggttagacacaaggacctgaagtgacatgacggcgggacaggggaaatgtgactttctaattaggcattttatgttagtcacagtcttgaatgtataaacagcactaagactctcaggtcaggtaccttggtgatcagctactagttcttccagccctcattgaggtaacaagataaagacaaatccacttctttggccaaattcaggctttggctttatgactttcccacagagactggaatgcgtcagcctgagaccactggcctattttctcagctgccctcttgaggtcctttaacactcaaattcccagctccccactgaggtgttgtgatgcttgccttttgacctccccatcccctttagtccctgcttactactttgacattcacatcctcagtgtctcagtcttttttgccgagaaagcacagtagtctgggactgggcatttatcttctctgactgaaaatctctccttggtcttaaggaaaatactaacattgaactcactgacatgatcttagcttctttaatcagactttgtgacttaaaagtttgggggttttctttgaaagtttccagccctattcagaaagcaactcttggctgtgtgcatttttcaactccaagcagcccaggggtaagtaaacaaagtatggatgaaggtcagattttcttgtcagtttctgagaaacctggcagcctgctgttaacaacacaggccagtattgggttttattgaatttggtatgtgaccaaggtcggcctaaaggatggcgcaggtcctgggcaggaaagaatttttcctttatcacataactgtaatatttggttgctcagcataagtgatggaagcaaacactaatttctaataaaattgtgttaaactcaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7126 -> Molecular function: GO:0004842 [ubiquitin-protein ligase activity] evidence: IDA
GeneID:7126 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7126 -> Molecular function: GO:0017049 [GTP-Rho binding] evidence: IDA
GeneID:7126 -> Molecular function: GO:0019904 [protein domain specific binding] evidence: IEA
GeneID:7126 -> Biological process: GO:0006260 [DNA replication] evidence: ISS
GeneID:7126 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:7126 -> Biological process: GO:0006955 [immune response] evidence: IEP
GeneID:7126 -> Biological process: GO:0009790 [embryo development] evidence: ISS
GeneID:7126 -> Biological process: GO:0016477 [cell migration] evidence: IMP
GeneID:7126 -> Biological process: GO:0016567 [protein ubiquitination] evidence: IDA
GeneID:7126 -> Biological process: GO:0035024 [negative regulation of Rho protein signal transduction] evidence: IMP
GeneID:7126 -> Biological process: GO:0043149 [stress fiber assembly] evidence: IMP
GeneID:7126 -> Biological process: GO:0043161 [proteasomal ubiquitin-dependent protein catabolic process] evidence: IDA
GeneID:7126 -> Biological process: GO:0045740 [positive regulation of DNA replication] evidence: IEA
GeneID:7126 -> Biological process: GO:0051260 [protein homooligomerization] evidence: IEA
GeneID:7126 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:7126 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:7126 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:7126 -> Cellular component: GO:0005768 [endosome] evidence: IDA
GeneID:7126 -> Cellular component: GO:0031463 [Cul3-RING ubiquitin ligase complex] evidence: IDA
by
@meso_cacase at
DBCLS
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