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2024-03-29 21:22:14, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_021111               4427 bp    mRNA    linear   PRI 24-JUN-2013
DEFINITION  Homo sapiens reversion-inducing-cysteine-rich protein with kazal
            motifs (RECK), mRNA.
ACCESSION   NM_021111
VERSION     NM_021111.2  GI:207029343
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4427)
  AUTHORS   Chiang,C.H., Hou,M.F. and Hung,W.C.
  TITLE     Up-regulation of miR-182 by beta-catenin in breast cancer increases
            tumorigenicity and invasiveness by targeting the matrix
            metalloproteinase inhibitor RECK
  JOURNAL   Biochim. Biophys. Acta 1830 (4), 3067-3076 (2013)
   PUBMED   23333633
  REMARK    GeneRIF: inverse association between miR-182 and RECK was
            demonstrated in breast tumor tissues
REFERENCE   2  (bases 1 to 4427)
  AUTHORS   Xin,C., Buhe,B., Hongting,L., Chuanmin,Y., Xiwei,H., Hong,Z.,
            Lulu,H., Qian,D. and Renjie,W.
  TITLE     MicroRNA-15a promotes neuroblastoma migration by targeting
            reversion-inducing cysteine-rich protein with Kazal motifs (RECK)
            and regulating matrix metalloproteinase-9 expression
  JOURNAL   FEBS J. 280 (3), 855-866 (2013)
   PUBMED   23176145
  REMARK    GeneRIF: Findings indicate thet the miR-15a-RECK-matrix
            metalloproteinase-9 axis in neuroblastoma (NB) progression,
            especially in NB migration and invasion.
REFERENCE   3  (bases 1 to 4427)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet. 9 (1), E1003225 (2013)
   PUBMED   23382691
REFERENCE   4  (bases 1 to 4427)
  AUTHORS   Shen,B., Chen,J., Zheng,M.Q., Xu,X.Y., Wei,D. and Feng,J.F.
  TITLE     [Expression and significance of HER-2/neu mRNA and RECK mRNA in
            breast carcinoma tissue]
  JOURNAL   Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 26 (4), 279-281
            (2012)
   PUBMED   23189844
  REMARK    GeneRIF: The level of HER-2/neu mRNA was higher and RECK mRNA was
            lower in breast carcinoma than homologous paraneoplastic breast
            tissue.
REFERENCE   5  (bases 1 to 4427)
  AUTHORS   Hirata,H., Ueno,K., Shahryari,V., Tanaka,Y., Tabatabai,Z.L.,
            Hinoda,Y. and Dahiya,R.
  TITLE     Oncogenic miRNA-182-5p targets Smad4 and RECK in human bladder
            cancer
  JOURNAL   PLoS ONE 7 (11), E51056 (2012)
   PUBMED   23226455
  REMARK    GeneRIF: miR-182-5p plays an important role as an oncogene by
            knocking down RECK and Smad4, resulting in activation of the
            Wnt-beta-catenin signaling pathway in bladder cancer.
REFERENCE   6  (bases 1 to 4427)
  AUTHORS   Masui,T., Doi,R., Koshiba,T., Fujimoto,K., Tsuji,S., Nakajima,S.,
            Koizumi,M., Toyoda,E., Tulachan,S., Ito,D., Kami,K., Mori,T.,
            Wada,M., Noda,M. and Imamura,M.
  TITLE     RECK expression in pancreatic cancer: its correlation with lower
            invasiveness and better prognosis
  JOURNAL   Clin. Cancer Res. 9 (5), 1779-1784 (2003)
   PUBMED   12738734
  REMARK    GeneRIF: High RECK protein is associated with invasiveness of
            pancreatic cancer by MMP-2 activation
REFERENCE   7  (bases 1 to 4427)
  AUTHORS   Eisenberg,I., Hochner,H., Sadeh,M., Argov,Z. and
            Mitrani-Rosenbaum,S.
  TITLE     Establishment of the genomic structure and identification of
            thirteen single-nucleotide polymorphisms in the human RECK gene
  JOURNAL   Cytogenet. Genome Res. 97 (1-2), 58-61 (2002)
   PUBMED   12438739
  REMARK    GeneRIF: Four SNPs were identified in the coding region of the gene
            (exons 1, 9, 13 and 15), and the remaining nine in introns 5, 8,
            10, 12, 15 and 17.
REFERENCE   8  (bases 1 to 4427)
  AUTHORS   Oh,J., Takahashi,R., Kondo,S., Mizoguchi,A., Adachi,E.,
            Sasahara,R.M., Nishimura,S., Imamura,Y., Kitayama,H.,
            Alexander,D.B., Ide,C., Horan,T.P., Arakawa,T., Yoshida,H.,
            Nishikawa,S., Itoh,Y., Seiki,M., Itohara,S., Takahashi,C. and
            Noda,M.
  TITLE     The membrane-anchored MMP inhibitor RECK is a key regulator of
            extracellular matrix integrity and angiogenesis
  JOURNAL   Cell 107 (6), 789-800 (2001)
   PUBMED   11747814
REFERENCE   9  (bases 1 to 4427)
  AUTHORS   Takahashi,C., Sheng,Z., Horan,T.P., Kitayama,H., Maki,M.,
            Hitomi,K., Kitaura,Y., Takai,S., Sasahara,R.M., Horimoto,A.,
            Ikawa,Y., Ratzkin,B.J., Arakawa,T. and Noda,M.
  TITLE     Regulation of matrix metalloproteinase-9 and inhibition of tumor
            invasion by the membrane-anchored glycoprotein RECK
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 95 (22), 13221-13226 (1998)
   PUBMED   9789069
REFERENCE   10 (bases 1 to 4427)
  AUTHORS   Gerstein,M.
  TITLE     Measurement of the effectiveness of transitive sequence comparison,
            through a third 'intermediate' sequence
  JOURNAL   Bioinformatics 14 (8), 707-714 (1998)
   PUBMED   9789096
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292653.1, D50406.1 and
            BC050306.1.
            On Sep 27, 2008 this sequence version replaced gi:11863155.
            
            Summary: The protein encoded by this gene is a cysteine-rich,
            extracellular protein with protease inhibitor-like domains whose
            expression is suppressed strongly in many tumors and cells
            transformed by various kinds of oncogenes. In normal cells, this
            membrane-anchored glycoprotein may serve as a negative regulator
            for matrix metalloproteinase-9, a key enzyme involved in tumor
            invasion and metastasis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292653.1, D50406.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AK292653.1         1-6
            7-4117              D50406.1           30-4140
            4118-4427           BC050306.1         4244-4553
FEATURES             Location/Qualifiers
     source          1..4427
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..4427
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /note="reversion-inducing-cysteine-rich protein with kazal
                     motifs"
                     /db_xref="GeneID:8434"
                     /db_xref="HGNC:11345"
                     /db_xref="HPRD:05567"
                     /db_xref="MIM:605227"
     exon            1..186
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       17..18
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace=""
                     /replace="ta"
                     /db_xref="dbSNP:373891869"
     variation       24
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:143148105"
     variation       51
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368806096"
     variation       64
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147477093"
     CDS             87..3002
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /note="suppression of tumorigenicity 5
                     (reversion-inducing-cysteine-rich protein with kazal
                     motifs); membrane-anchored glycoprotein (metastasis and
                     invasion); suppression of tumorigenicity 15
                     (reversion-inducing-cysteine-rich protein with kazal
                     motifs); reversion-inducing cysteine-rich protein with
                     Kazal motifs; suppressor of tumorigenicity 15 protein"
                     /codon_start=1
                     /product="reversion-inducing cysteine-rich protein with
                     Kazal motifs precursor"
                     /protein_id="NP_066934.1"
                     /db_xref="GI:11863156"
                     /db_xref="CCDS:CCDS6597.1"
                     /db_xref="GeneID:8434"
                     /db_xref="HGNC:11345"
                     /db_xref="HPRD:05567"
                     /db_xref="MIM:605227"
                     /translation="
MATVRASLRGALLLLLAVAGVAEVAGGLAPGSAGALCCNHSKDNQMCRDVCEQIFSSKSESRLKHLLQRAPDYCPETMVEIWNCMNSSLPGVFKKSDGWVGLGCCELAIALECRQACKQASSKNDISKVCRKEYENALFSCISRNEMGSVCCSYAGHHTNCREYCQAIFRTDSSPGPSQIKAVENYCASISPQLIHCVNNYTQSYPMRNPTDSLYCCDRAEDHACQNACKRILMSKKTEMEIVDGLIEGCKTQPLPQDPLWQCFLESSQSVHPGVTVHPPPSTGLDGAKLHCCSKANTSTCRELCTKLYSMSWGNTQSWQEFDRFCEYNPVEVSMLTCLADVREPCQLGCRNLTYCTNFNNRPTELFRSCNAQSDQGAMNDMKLWEKGSIKMPFINIPVLDIKKCQPEMWKAIACSLQIKPCHSKSRGSIICKSDCVEILKKCGDQNKFPEDHTAESICELLSPTDDLKNCIPLDTYLRPSTLGNIVEEVTHPCNPNPCPANELCEVNRKGCPSGDPCLPYFCVQGCKLGEASDFIVRQGTLIQVPSSAGEVGCYKICSCGQSGLLENCMEMHCIDLQKSCIVGGKRKSHGTSFSIDCNVCSCFAGNLVCSTRLCLSEHSSEDDRRTFTGLPCNCADQFVPVCGQNGRTYPSACIARCVGLQDHQFEFGSCMSKDPCNPNPCQKNQRCIPKPQVCLTTFDKFGCSQYECVPRQLACDQVQDPVCDTDHMEHNNLCTLYQRGKSLSYKGPCQPFCRATEPVCGHNGETYSSVCAAYSDRVAVDYYGDCQAVGVLSEHSSVAECASVKCPSLLAAGCKPIIPPGACCPLCAGMLRVLFDKEKLDTIAKVTNKKPITVLEILQKIRMHVSVPQCDVFGYFSIESEIVILIIPVDHYPKALQIEACNKEAEKIESLINSDSPTLASHVPLSALIISQVQVSSSVPSAGVRARPSCHSLLLPLSLGLALHLLWTYN
"
     sig_peptide     87..164
                     /gene="RECK"
                     /gene_synonym="ST15"
     mat_peptide     165..2999
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /product="reversion-inducing cysteine-rich protein with
                     Kazal motifs"
     misc_feature    195..1100
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O95980.1);
                     Region: 5 X Knot repeats"
     variation       124
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17855037"
     variation       135
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139893051"
     variation       141
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:17855036"
     variation       156
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201017437"
     variation       175
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373799395"
     exon            187..245
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       194
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147362697"
     variation       227
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373725096"
     variation       230
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:58611653"
     exon            246..320
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       271
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374518021"
     exon            321..357
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     exon            358..443
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       384
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371801859"
     variation       426
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200440946"
     variation       427
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374243748"
     exon            444..491
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     exon            492..525
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     exon            526..723
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       553
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201791836"
     variation       571
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372609725"
     variation       594
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1046658"
     variation       595
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375748786"
     variation       612
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200516550"
     variation       647
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371411958"
     variation       649
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373443775"
     variation       695
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374632258"
     variation       697
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140078883"
     variation       705
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144022766"
     variation       718
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144381566"
     variation       719
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377258060"
     exon            724..991
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       800
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148788190"
     variation       864
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147873679"
     variation       868
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142469900"
     variation       896
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200048340"
     variation       909
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:16932912"
     variation       923
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201898968"
     variation       935
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201258733"
     variation       941
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139106894"
     variation       963
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370216203"
     variation       978
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376825824"
     exon            992..1171
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       1009
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372625092"
     variation       1080
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376008783"
     variation       1088
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3736884"
     variation       1090
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372033961"
     variation       1114
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374907660"
     variation       1143
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372176214"
     exon            1172..1384
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       1215
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139919356"
     variation       1218
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:4430169"
     variation       1232
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144037912"
     variation       1323
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146471055"
     variation       1365
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189825349"
     exon            1385..1521
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       1395
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199723720"
     variation       1408
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140988213"
     variation       1412
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:71508012"
     variation       1472
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143337188"
     variation       1479
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:145575211"
     variation       1509
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148890313"
     exon            1522..1662
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       1560
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:146554287"
     variation       1578
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78749972"
     variation       1646
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11788747"
     exon            1663..1851
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       1671
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:148296262"
     variation       1699
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202116020"
     variation       1744
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141592531"
     variation       1751
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41277085"
     variation       1763
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138423971"
     variation       1830
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199710956"
     variation       1833
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375477269"
     variation       1850
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:112938194"
     exon            1852..1974
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       1872
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201016307"
     variation       1880
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199987061"
     variation       1884
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371492299"
     variation       1944
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150659859"
     variation       1961
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:10972727"
     variation       1962
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149420244"
     exon            1975..2146
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       1979
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:144862936"
     variation       1988
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376678481"
     variation       2029
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139092872"
     variation       2036
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:144005841"
     variation       2049
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369196726"
     variation       2094
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:369829569"
     variation       2106
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374527319"
     variation       2141
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145965365"
     exon            2147..2339
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       2190
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:139849271"
     variation       2223
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370905430"
     variation       2228
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:183480403"
     variation       2229
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142114378"
     variation       2231
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:151184551"
     variation       2334
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140337764"
     exon            2340..2550
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       2343
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:149956466"
     variation       2348
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147648443"
     variation       2364
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141528795"
     variation       2391
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372053108"
     variation       2413
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150265796"
     variation       2414
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147027096"
     variation       2421
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371483607"
     variation       2429
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369985868"
     variation       2430
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138317907"
     variation       2437
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199917585"
     variation       2453
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374500095"
     variation       2480
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200760523"
     variation       2486
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142383795"
     variation       2491
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143294934"
     variation       2501
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377608152"
     variation       2512
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:148349008"
     variation       2537
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141548175"
     variation       2540
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369729608"
     variation       2547
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373692210"
     exon            2551..2624
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       2591
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373948774"
     variation       2600
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:150899620"
     exon            2625..2780
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       2635
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371744677"
     variation       2639
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:138496550"
     variation       2663
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201184262"
     variation       2674
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375728854"
     variation       2676
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:139573143"
     variation       2704
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143080722"
     variation       2742
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145922032"
     variation       2744
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139816613"
     variation       2778
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:189943108"
     exon            2781..4412
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /inference="alignment:Splign:1.39.8"
     variation       2877
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372729870"
     variation       2883
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:149268263"
     variation       2915
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56680169"
     variation       2916
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192974126"
     variation       2930
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148449362"
     variation       2955
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142634835"
     variation       2957
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147618963"
     variation       2977
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:140581680"
     variation       2986
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374233309"
     variation       2996
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:376167480"
     variation       3011
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111613206"
     variation       3028
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199717555"
     variation       3042
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369357445"
     variation       3089
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:7042392"
     variation       3177
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:75612573"
     variation       3368
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:7026399"
     variation       3439
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:72729497"
     variation       3472
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:188686266"
     variation       3515
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:193004377"
     variation       3615
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74725990"
     variation       3720
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184771768"
     variation       3759
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:115985599"
     variation       3849
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188011114"
     variation       3852
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371106795"
     variation       3893..3895
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace=""
                     /replace="ttc"
                     /db_xref="dbSNP:3070848"
     variation       3897..3899
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace=""
                     /replace="aag"
                     /db_xref="dbSNP:5897628"
     variation       4010..4013
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace=""
                     /replace="ctga"
                     /db_xref="dbSNP:10523829"
     variation       4100..4101
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:201199618"
     variation       4129..4130
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace=""
                     /replace="ca"
                     /db_xref="dbSNP:150780340"
     STS             4226..4372
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /standard_name="RH70038"
                     /db_xref="UniSTS:66152"
     variation       4248
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191216848"
     variation       4349
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201902123"
     variation       4362
                     /gene="RECK"
                     /gene_synonym="ST15"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:183723576"
     polyA_signal    4388..4393
                     /gene="RECK"
                     /gene_synonym="ST15"
     polyA_site      4412
                     /gene="RECK"
                     /gene_synonym="ST15"
ORIGIN      
gcgcgagcggcggcggtagcggcggcagcggctgcggccaagctgggtccgagcatcccgcggctctggagccgcccggcccggacatggcgaccgtccgggcctctctgcgaggtgcgctgctccttctgctggccgtggcgggggtcgcggaggtggcagggggcctggctccgggcagtgcgggtgcattgtgttgtaatcattcaaaggataaccaaatgtgccgtgatgtatgtgaacagattttctcctcaaaaagtgaatcccgactaaaacatctgttgcagcgagccccagattattgcccagagacaatggttgaaatttggaattgtatgaattcatctttgccaggtgtgtttaagaagtctgatggctgggttggcttaggctgctgtgaactggctattgccttggagtgtcgacaggcatgcaagcaggcatcttcaaagaatgatatttccaaagtttgcagaaaagaatatgagaatgctcttttcagttgcattagcagaaatgaaatgggctcggtttgttgcagttatgcaggtcatcacacaaactgccgagaatactgtcaagccatttttcgaacagactcttctcctggtccatctcagataaaagcagtggaaaattattgcgcctctattagtccacaattaatacattgtgtgaacaattatactcaatcttatccaatgaggaacccaacggatagtttatattgctgtgacagagctgaagaccatgcttgccaaaatgcctgcaagagaatcctgatgtccaagaaaacggaaatggagattgttgatggtctcatcgagggttgtaagacccagcccttgcctcaagatcctctttggcaatgttttcttgaaagctcacaatctgttcaccctggagtcactgtacaccctcctccctctacaggcctcgatggggctaaattgcattgttgttctaaagcaaacacttcaacatgtagggaactctgcactaaactttacagcatgagctggggcaatacacagagttggcaagagtttgatcgcttttgtgaatataatccagtggaagtgtccatgttgacctgtttagcggatgtccgggaaccttgccagttgggctgtagaaaccttacttactgtactaattttaacaacaggccaacagaacttttcaggagttgtaatgcacagtcagatcaaggagccatgaatgacatgaagttgtgggagaaaggaagcataaagatgccatttatcaatatacctgttcttgatattaaaaagtgccagccagagatgtggaaagcaatagcttgttcactgcagattaaaccttgtcatagtaaatctcggggaagtattatttgcaaatcagattgtgtggagattcttaaaaaatgtggagaccagaacaaattccctgaagaccacacagctgaaagtatttgtgagcttctgtcacctacagatgatctgaagaattgtatacctttggatacatacctcaggccaagtactttaggtaacattgtagaagaagtgactcatccctgtaacccaaatccttgccctgccaatgagctctgtgaagtaaaccgaaaaggatgtccatctggagatccctgtcttccatacttttgtgttcaaggttgcaaactgggagaagcttctgatttcattgtccgtcaagggacactaatccaggtgccatcatctgcaggggaagttggttgttataaaatctgttcatgtggacaaagtggactcttagaaaactgtatggaaatgcactgtatagacctccagaagtcttgtattgttggaggaaaaagaaaaagtcatggaacatcctttagtattgactgcaatgtctgttcttgttttgctggcaatttggtgtgctctacccgcctttgcctcagtgagcacagttcagaagatgaccgtcgtaccttcacaggtctgccctgtaactgtgcagatcagtttgtccctgtatgtgggcagaatgggcgcacttaccccagtgcctgcattgctcgctgtgtgggcctccaagaccatcagtttgagtttggatcatgcatgtcaaaggatccatgtaatcctaatccctgccaaaaaaaccaaaggtgcatacccaaaccacaggtctgcctgacgacttttgataaatttggatgtagccagtatgagtgtgtaccaagacagctcgcgtgtgaccaggtccaagatcctgtttgtgacacagaccacatggagcacaacaatctctgcactttataccaaagaggaaaaagcctctcttacaaaggtccctgccagcccttttgcagagcaaccgagcccgtatgtgggcacaatggtgagacctacagcagtgtgtgtgctgcctactcggatcgcgtggcagtcgattactatggggactgccaggccgtcggagtcctctcagagcacagctccgtcgccgagtgtgcttctgtcaagtgtccttcgctcttggcagctggatgcaaacccatcatcccaccgggtgcttgttgcccattatgtgctgggatgttaagagttttatttgacaaagaaaaactggatactattgctaaggtaacaaataaaaagccaataacagttctggaaatacttcagaaaatccgcatgcacgtgtctgtcccacagtgtgatgtgtttggatacttcagcattgaatcagaaattgtgatcctgatcattcccgtcgatcactatccaaaagctctgcagattgaagcctgcaataaagaagcagagaagattgagtcccttatcaactctgacagcccgactttggcgtcccatgtccctctctctgccctcatcatttcccaggtacaggtctccagcagtgtgccatcggccggtgtcagggccaggccttcttgccactccctcctccttcccctcagcttgggccttgccttgcacttgctctggacatataactgactgcccacggaaagtgcagaatgctcctccacctcactctcctgccttgaaaaagacattcaggactgctggtttgtagttgaatattggccaaggaaaggcacatgtcacctctattcgccacacagtatttttttttttaatccgccaatattagtaggatttttgttttgtttttacaaatgttaaaatgtgttgttccaaatactaatgaaaacagaatgtctcttcctggtagaccactgccatatgatttacatttcctcaccataagggtcccccactctaaagcaaatttatcgctgggaaatgagatgaccactttttagaaagataattcactgtactatcaggttcacaaacttcatttcagagttctttttgaagtatttaaggttcccgttgcatttgttttgtttacagataattacctactctggctagaagctaggggtcccagtgaagagccactgccattaaagaatatgaaacatagataaaacatctttgaaattatgtaaattatgtaaattatcaggcaaatttgcattaaattacagaaatttaattcagaaccccaactactgtgttatgcaaaagcaagctgattaaatgacactcatataattatatgttgtaagcaacaggctcactggtcacggatttgtgtctgtgacttttgtgaaagggagaagtgacattgcatcaaagcatcttgcattatgcaatttttatattaaccagatatatattcatcggtattcatccaagttaaatgtagagtttttaaacatcaatctttaaaccaattgctgctacttatataattgccaaaaagtgaaataatgtgtagttcatgtaaataatacattatatttctattttattatgaagaaggtgaatagccatatttgtaaaatgacaatcatgtgtgttaacccagtgctttccattcgtgaaaacacatttgctttttgtgatatgcacaatgtagataagtgttctgtctgactttcttttttgatatagaagtataaagaattgtggtttatatatttaaaagtgtcaagctgagtattaaaatgtatgcatgttgtctaagaaattgaatactttgaatgtgtttcacagtttgaaataagctatttgatgtaatacttcttgtgtgtatgcacatgaacttagattttacatgaagtattttttcagtattatatgtaccctctgaaatacatagggatatgcgtattataccaaaatgttgctgaaaaatgggcacttaaagctttcagaatatgtcagtgctgatgtagcatgcttgttgcaattgccttttttctgtataaatgtctttaatgcaatatactggaaagcttttctattttaataaaaataatttttatatgatcaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:8434 -> Molecular function: GO:0004866 [endopeptidase inhibitor activity] evidence: IDA
            GeneID:8434 -> Molecular function: GO:0004867 [serine-type endopeptidase inhibitor activity] evidence: IEA
            GeneID:8434 -> Molecular function: GO:0008191 [metalloendopeptidase inhibitor activity] evidence: TAS
            GeneID:8434 -> Biological process: GO:0001955 [blood vessel maturation] evidence: IEA
            GeneID:8434 -> Biological process: GO:0007566 [embryo implantation] evidence: IEA
            GeneID:8434 -> Biological process: GO:0030198 [extracellular matrix organization] evidence: IEA
            GeneID:8434 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
            GeneID:8434 -> Cellular component: GO:0016020 [membrane] evidence: TAS
            GeneID:8434 -> Cellular component: GO:0031225 [anchored to membrane] evidence: IEA

by @meso_cacase at DBCLS
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