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2024-03-28 17:13:48, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_020826               5184 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens synaptotagmin XIII (SYT13), transcript variant 1,
            mRNA.
ACCESSION   NM_020826
VERSION     NM_020826.2  GI:187936944
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5184)
  AUTHORS   Jahn,J.E., Best,D.H. and Coleman,W.B.
  TITLE     Exogenous expression of synaptotagmin XIII suppresses the
            neoplastic phenotype of a rat liver tumor cell line through
            molecular pathways related to mesenchymal to epithelial transition
  JOURNAL   Exp. Mol. Pathol. 89 (3), 209-216 (2010)
   PUBMED   20840848
  REMARK    GeneRIF: These studies combine to suggest that SYT13 is a liver
            tumor suppressor gene and that its function may be mediated through
            pathways implicated in mesenchymal to epithelial transition
REFERENCE   2  (bases 1 to 5184)
  AUTHORS   Jahn,J.E. and Coleman,W.B.
  TITLE     Re-expression of tumorigenicity after attenuation of human
            synaptotagmin 13 in a suppressed microcell hybrid cell line
  JOURNAL   Int. J. Oncol. 32 (2), 441-449 (2008)
   PUBMED   18202767
  REMARK    GeneRIF: human SYT13 functions as a liver tumor suppressor gene
            that complements a molecular defect in rat liver tumor cells
            resulting in a normalized cellular phenotype in vitro and
            suppression of tumorigenicity in vivo
REFERENCE   3  (bases 1 to 5184)
  AUTHORS   Craxton,M.
  TITLE     Genomic analysis of synaptotagmin genes
  JOURNAL   Genomics 77 (1-2), 43-49 (2001)
   PUBMED   11543631
REFERENCE   4  (bases 1 to 5184)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Characterization of KIAA1427 protein as an atypical synaptotagmin
            (Syt XIII)
  JOURNAL   Biochem. J. 354 (PT 2), 249-257 (2001)
   PUBMED   11171101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP251101.1, AB037848.1,
            AC103681.4 and AL512743.1.
            On May 10, 2008 this sequence version replaced gi:24308232.
            
            Summary: This gene encodes a member of the large synaptotagmin
            protein family. Family members have an extracellular N-terminal
            transmembrane domain and a cytoplasmic C terminus with two tandem
            C2 domains (C2A and C2B). Synaptotogmin family members can form
            homo- and heteromeric complexes with each other. They also have
            different biochemical properties and developmental profiles, and
            patterns of tissue distribution. Synaptotagmins function as
            membrane traffickers in multicellular organisms. Two alternatively
            spliced transcript variants that encode different protein isoforms
            have been described for this gene. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL512743.1, AB037848.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025084 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BP251101.1         1-14
            15-2490             AB037848.1         1-2476
            2491-4884           AC103681.4         39309-41702
            4885-5184           AL512743.1         4809-5108
FEATURES             Location/Qualifiers
     source          1..5184
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p12-p11"
     gene            1..5184
                     /gene="SYT13"
                     /note="synaptotagmin XIII"
                     /db_xref="GeneID:57586"
                     /db_xref="HGNC:14962"
                     /db_xref="HPRD:12128"
                     /db_xref="MIM:607716"
     exon            1..309
                     /gene="SYT13"
                     /inference="alignment:Splign:1.39.8"
     STS             77..1457
                     /gene="SYT13"
                     /db_xref="UniSTS:480820"
     STS             79..1451
                     /gene="SYT13"
                     /db_xref="UniSTS:483650"
     misc_feature    85..87
                     /gene="SYT13"
                     /note="upstream in-frame stop codon"
     CDS             127..1407
                     /gene="SYT13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     synaptotagmin-13; sytXIII"
                     /codon_start=1
                     /product="synaptotagmin-13 isoform 1"
                     /protein_id="NP_065877.1"
                     /db_xref="GI:24308233"
                     /db_xref="CCDS:CCDS31470.1"
                     /db_xref="GeneID:57586"
                     /db_xref="HGNC:14962"
                     /db_xref="HPRD:12128"
                     /db_xref="MIM:607716"
                     /translation="
MVLSVPVIALGATLGTATSILALCGVTCLCRHMHPKKGLLPRDQDPDLEKAKPSLLGSAQQFNVKKSTEPVQPRALLKFPDIYGPRPAVTAPEVINYADYSLRSTEEPTAPASPQPPNDSRLKRQVTEELFILPQNGVVEDVCVMETWNPEKAASWNQAPKLHYCLDYDCQKAELFVTRLEAVTSNHDGGCDCYVQGSVANRTGSVEAQTALKKRQLHTTWEEGLVLPLAEEELPTATLTLTLRTCDRFSRHSVAGELRLGLDGTSVPLGAAQWGELKTSAKEPSAGAGEVLLSISYLPAANRLLVVLIKAKNLHSNQSKELLGKDVSVKVTLKHQARKLKKKQTKRAKHKINPVWNEMIMFELPDDLLQASSVELEVLGQDDSGQSCALGHCSLGLHTSGSERSHWEEMLKNPRRQIAMWHQLHL
"
     misc_feature    145..213
                     /gene="SYT13"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7L8C5.1);
                     transmembrane region"
     misc_feature    604..957
                     /gene="SYT13"
                     /note="C2 domain; Region: C2A_Synaptotagmin-13; cd08677"
                     /db_xref="CDD:176059"
     misc_feature    988..1401
                     /gene="SYT13"
                     /note="C2 domain second repeat present in Synaptotagmin
                     13; Region: C2B_Synaptotagmin-13; cd08407"
                     /db_xref="CDD:176052"
     STS             219..1149
                     /gene="SYT13"
                     /standard_name="Syt13"
                     /db_xref="UniSTS:507260"
     exon            310..535
                     /gene="SYT13"
                     /inference="alignment:Splign:1.39.8"
     exon            536..670
                     /gene="SYT13"
                     /inference="alignment:Splign:1.39.8"
     exon            671..972
                     /gene="SYT13"
                     /inference="alignment:Splign:1.39.8"
     exon            973..1102
                     /gene="SYT13"
                     /inference="alignment:Splign:1.39.8"
     exon            1103..5157
                     /gene="SYT13"
                     /inference="alignment:Splign:1.39.8"
     STS             2449..2623
                     /gene="SYT13"
                     /standard_name="HSC1SF092"
                     /db_xref="UniSTS:76282"
     STS             2498..2623
                     /gene="SYT13"
                     /standard_name="WI-14707"
                     /db_xref="UniSTS:76281"
     variation       3209
                     /gene="SYT13"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:714720"
     variation       3439
                     /gene="SYT13"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3168293"
     variation       3670
                     /gene="SYT13"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3180446"
     variation       3944
                     /gene="SYT13"
                     /replace=""
                     /replace="g"
                     /replace="ggg"
                     /db_xref="dbSNP:5791668"
     STS             4530..4712
                     /gene="SYT13"
                     /standard_name="RH18313"
                     /db_xref="UniSTS:63018"
     variation       4884
                     /gene="SYT13"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8929"
ORIGIN      
gtccccgcccctctggcggcgggagagctgctggctcgcccggatcccgggagctgcctggaggcgggcccggcccggggaaggtgagcggctgcgggacccagcccctcgccgggagcgggcaccatggtgctgtcggtgcctgtgatcgcgctgggcgccacgctgggcacagccaccagcatcctcgcgttgtgcggggtcacctgcctgtgtcggcacatgcaccccaagaaggggctgctgccgcgggaccaggaccccgacctggagaaggcgaagcccagcttgctcgggtctgcacaacagttcaatgttaaaaagtccacggaacctgttcagccccgtgccctcctcaagttcccagacatctatggacccaggccagctgtgacggctccagaggtcatcaactatgcagactattcactgaggtctacggaggagcccactgcacctgccagcccccaacccccgaatgacagtcgcctcaagaggcaggtcacagaggagctgttcatcctccctcagaatggtgtggtggaggatgtctgtgtcatggagacctggaacccagagaaggctgccagttggaaccaggcccccaaactccactactgcctggactatgactgtcagaaggcagaattgtttgtgactcgcctggaagctgtgaccagcaaccacgacggaggctgtgactgctacgtccaagggagtgtggccaataggaccggctctgtggaggctcagacagccctaaagaagcggcagctgcacaccacctgggaggagggcctggtgctccccctggcggaggaggagctccccacagccaccctgacgctgaccttgaggacctgcgaccgcttctcccgtcacagcgtggccggggagctccgcctgggcctggacgggacatctgtgcctctaggggctgcccagtggggcgagctgaagacttcagcgaaggagccatctgcaggagctggagaggtcctactatccatcagctacctcccggctgccaaccgcctcctggtggtgctgattaaagccaagaacctccactctaaccagtccaaggagctcctggggaaggatgtctctgtcaaggtgaccttgaagcaccaggctcggaagctgaagaagaagcagactaaacgagctaagcacaagatcaaccccgtgtggaacgagatgatcatgtttgagctgcctgacgacctgctgcaggcctccagtgtggagctggaagtgctgggccaggacgattcagggcagagctgtgcgcttggccactgcagcctgggcctgcacacctcgggctctgagcgcagccactgggaggagatgctcaaaaaccctcgccggcagattgccatgtggcaccagctgcacctgtaaccagctgcccagctgcctcccttcttggacagccctgacccgtcctctgcaacctcctttctgtgcccctttcctcattctgacacccagaagacagtgacagatgtgtttgcaaggctgggatggctctctcatcatactcttgtttcttagaaataagcaagacagagcaggaaatggaatatgcgggtcacactgaggaatgcattttgctcatctgtgttattgaaggaggtgcttattaaatacagttcctatgcctgttttataggtggggttaggccagatgcagagaaagctaaatgtgggaatcatggatgcaaagaagaatttggctttttgaaaaacaagcatttcaaaaatgatgaaggaagtgaaagtatcctggatcaactcctagagttagagattgcccaggtggaaagaaaccttagccagcgttcaatcaagctcaccatgcagggcagtcacccggcagttctcaaactttagcatgtgaagagtcaccagcagattcctgggctcgcctggagacattcctagtcggtattcctggtcgaagcccaggagccttcctttttaacaagctgatgtagagggtggagcactgtatgtggagaaattccttctacaatattccacacaggtttttggccacagtccttgatggagtcccaaaaccatggtgcagccagttccaatgctggacacctcaaccatcagggtgaaatctggggcctcagctttttaatttaattattttaattcttaatactttaatttgtgcatttcataagccccctgctcttggactgaattttgtgctttttattgaagaattttattgtttttatcttaaaatcagtttctattatccttggggagaccatccctaacaaagtacaggtgggatctcctgtgagtcattggctgggttctgattgctagatgtcacacccaccagcatcaccaaagtgactctgagatagaccggtcccttctcagcgttccagtcacttcaggaggaatttagttattgacttagtctatgacatctggctacatgtaggtagagaagaaagataattttaaaaaggaaatcaggtcttttgcaactgtgcctccctctgtctgttttcacttgaatgggtaaataaccagcagctaggttttgaattcctaccttgttattctaaacagatgtccacattgttaattaaatctaaattatgagccttgctgagtggatacggtacttacacctgaaccaggattcctgggttctgttgttgacattgcccttcagcacctgtttggccagctgtgtaagataggactaatgactaggaagcctaccccaatgaatgatatactagatgaaatagtgttcaaaacctgtaggcactctctggctaaaaacaaactctgaggccaccagcagatcatctttaagctaagttactatttttcacctttttttttagacggagttttgctctttgttgcccaggctggagtgcagtggcacgatctcggctcactgcaacctccgcctcccaagttcaagcgattctcctctctcagcctcctgggtagctgggattacaggtgcccaccaacatgcctggctaatttttgtacttttagtagagatggggtttcaccatgttggccaggctggtcttcaactccagatctcaggtgatctaccctcctcggcctcccaaagtactgggattacaggcctgagccaccgcgcccggcctatttttcactttaatttggcagctgagaatgcccagaaagtgccagaagcatcgtggcatttccagaaccatggattctgcctttggacccctctctattaatattaaaactctgggccttcagatgtcaccctaatccacttccctaagacagaatttctggacaagatgggtaagggcttcattccttcaacaagtcaagtcatacttggcctctccctgagaatctgagcaggagccttataacctgtggtcattattttttctttctgtacagaaatagaaaagcattagaaataacttctaaccatcctctgaaaaaacagaaaaaatatcgaatccctctttcatgagaagtcttttggataattggaaaccttcatcactgaggttggccagcccctgccaagtgttgtgtaggcaaagcacttgttagtggcttcctatgaaatgttttagagatctcttcaccatactggtttcttctctttggttggtgtgggtaaaagaaaacaaaacatttcctataagctgaaagctgaccagcattctcttcttggtaacatctactactccaatctagaaaatttggattctagaccaaaaatcaggaaacatggctccttataaatctgtgcagctgccttatagtaccatcaaaggaatttcaggtgggctgggcggggccccgatcccagaattatcaactccacccatcatcatttggtcatgaagcatcctttcattcttcttcttcttttttttgggggggcggggcgggggagggatctcaaagttttagtcttccagaatccaaattaaaggttgcccctgatgggggccaggttccgccacagaacatcttagatgtcagccttgacctcacttagcagggattacagaaatgagatacattttgaaggagagttgtctgttatgttcactgtattctaagtgcctgggataaagctgtctcatgggtgctccatatatattcatatatatttgttgagtgaattaatgaattaagagtggctggcagagtaggcagaaaaagacactgcaaatggcataaaaattaaagtcctagctgagttctcaatggtaaaggcatcagatgtcttagcagtcaagctagaaattcatgacaatgagtattactatttgcctaatggcaactcattgctctccatgtaaatgtaatcaacagatgaagagaatataattgctctgcttttccactaaaactccatcttagtgaattttaaattatccagagatgtcaaactgccaaataaaaatatttcagtagtctttgcatcagcttaccttgtaccagaaacatttccaatttactatcaaattatagtaactgagcctgtgtgaagtatctcatcattttcgaaaggaacaccttgtgtgatgccagtgagcatttctaaaaagggtgtgaggtagaggtaaaaataaggtgagagaccatttcagaatgcactgttgctcaaaaaggtgatctggttctttcttcagagatttctacggggatagaaaatcgggagtctgccctcattaatctgtgattccacctcttgcaccaaatcaatatctatttgttgagcacttattgattaagaccttgcatatgtctgtccattttgatttgagatacaactttttgtgtgggttgaatgacaaatcactccaaacaaagctgggcacagagaatcagctaggagaccagttattcagggtccatttctcttggatgtaaaggagtcctgggtaaaatgtggctgtaacctaaaccaactagtccttgtgatttgtttctgccctctgtgtttcctgttgtcaaatgctaagtgtgtgttttgcagtcatgaactaaagcacaaaaagatgcatgagacattgtagtcatatgtctggtgtgacactttggagcaaaaaccttgcagtggtaaataaaaaatttccaacagggaaaaaaaaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:57586 -> Biological process: GO:0016192 [vesicle-mediated transport] evidence: IEA
            GeneID:57586 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: IEA
            GeneID:57586 -> Cellular component: GO:0030133 [transport vesicle] evidence: IDA

by @meso_cacase at DBCLS
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