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2024-04-27 04:46:49, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_020532 4871 bp mRNA linear PRI 01-JUL-2013
DEFINITION Homo sapiens reticulon 4 (RTN4), transcript variant 1, mRNA.
ACCESSION NM_020532
VERSION NM_020532.4 GI:47519458
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4871)
AUTHORS Shi,S., Zhou,B., Wang,Y., Chen,Y., Zhang,K., Wang,K., Quan,Y.,
Song,Y., Rao,L. and Zhang,L.
TITLE Genetic variation in RTN4 3'-UTR and susceptibility to cervical
squamous cell carcinoma
JOURNAL DNA Cell Biol. 31 (6), 1088-1094 (2012)
PUBMED 22320844
REMARK GeneRIF: genetic variation in RTN4 3'-UTR contributes to the
susceptibility to CSCC
REFERENCE 2 (bases 1 to 4871)
AUTHORS Li,H., Chen,Y., Zhou,B., Peng,Y., Bai,W. and Rao,L.
TITLE RNT4 3'-UTR insertion/deletion polymorphisms are not associated
with atrial septal defect in Chinese Han population: a brief
communication
JOURNAL DNA Cell Biol. 31 (6), 1121-1124 (2012)
PUBMED 22313113
REMARK GeneRIF: CAA and TATC insertion/deletion polymorphisms of RNT4 gene
may not be a useful marker to predict the susceptibility of ASD in
Chinese Han population
REFERENCE 3 (bases 1 to 4871)
AUTHORS Marucci,G., Di Oto,E., Farnedi,A., Panzacchi,R., Ligorio,C. and
Foschini,M.P.
TITLE Nogo-A: a useful marker for the diagnosis of oligodendroglioma and
for identifying 1p19q codeletion
JOURNAL Hum. Pathol. 43 (3), 374-380 (2012)
PUBMED 21835431
REMARK GeneRIF: Nogo-A is a useful marker for the diagnosis of
oligodendroglioma and for identifying 1p19q codeletion
REFERENCE 4 (bases 1 to 4871)
AUTHORS Haybaeck,J., Llenos,I.C., Dulay,R.J., Bettermann,K., Miller,C.L.,
Walchli,T., Frei,K., Virgintino,D., Rizzi,M. and Weis,S.
TITLE Expression of nogo-a is decreased with increasing gestational age
in the human fetal brain
JOURNAL Dev. Neurosci. 34 (5), 402-416 (2012)
PUBMED 23146900
REMARK GeneRIF: The results demonstrate a significant change in the
expression of Nogo-A during the development of the human brain
REFERENCE 5 (bases 1 to 4871)
AUTHORS Zhang,L., Kuang,X. and Zhang,J.
TITLE Nogo receptor 3, a paralog of Nogo-66 receptor 1 (NgR1), may
function as a NgR1 co-receptor for Nogo-66
JOURNAL J Genet Genomics 38 (11), 515-523 (2011)
PUBMED 22133682
REMARK GeneRIF: Nogo receptor 3, a paralog of NgR1,functions as a NgR1
co-receptor for Nogo-66.
REFERENCE 6 (bases 1 to 4871)
AUTHORS Tagami,S., Eguchi,Y., Kinoshita,M., Takeda,M. and Tsujimoto,Y.
TITLE A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on
endoplasmic reticulum and reduces their anti-apoptotic activity
JOURNAL Oncogene 19 (50), 5736-5746 (2000)
PUBMED 11126360
REFERENCE 7 (bases 1 to 4871)
AUTHORS GrandPre,T., Nakamura,F., Vartanian,T. and Strittmatter,S.M.
TITLE Identification of the Nogo inhibitor of axon regeneration as a
Reticulon protein
JOURNAL Nature 403 (6768), 439-444 (2000)
PUBMED 10667797
REFERENCE 8 (bases 1 to 4871)
AUTHORS Chen,M.S., Huber,A.B., van der Haar,M.E., Frank,M., Schnell,L.,
Spillmann,A.A., Christ,F. and Schwab,M.E.
TITLE Nogo-A is a myelin-associated neurite outgrowth inhibitor and an
antigen for monoclonal antibody IN-1
JOURNAL Nature 403 (6768), 434-439 (2000)
PUBMED 10667796
REFERENCE 9 (bases 1 to 4871)
AUTHORS Prinjha,R., Moore,S.E., Vinson,M., Blake,S., Morrow,R.,
Christie,G., Michalovich,D., Simmons,D.L. and Walsh,F.S.
TITLE Inhibitor of neurite outgrowth in humans
JOURNAL Nature 403 (6768), 383-384 (2000)
PUBMED 10667780
REFERENCE 10 (bases 1 to 4871)
AUTHORS Yang,J., Yu,L., Bi,A.D. and Zhao,S.Y.
TITLE Assignment of the human reticulon 4 gene (RTN4) to chromosome
2p14-->2p13 by radiation hybrid mapping
JOURNAL Cytogenet. Cell Genet. 88 (1-2), 101-102 (2000)
PUBMED 10773680
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AY123246.1, BC016165.1,
AY123250.1, AF125103.1, AF132048.1 and AI671568.1.
This sequence is a reference standard in the RefSeqGene project.
On May 19, 2004 this sequence version replaced gi:28557782.
Summary: This gene belongs to the family of reticulon encoding
genes. Reticulons are associated with the endoplasmic reticulum,
and are involved in neuroendocrine secretion or in membrane
trafficking in neuroendocrine cells. The product of this gene is a
potent neurite outgrowth inhibitor which may also help block the
regeneration of the central nervous system in higher vertebrates.
Alternatively spliced transcript variants derived both from
differential splicing and differential promoter usage and encoding
different isoforms have been identified. [provided by RefSeq, Jul
2008].
Transcript Variant: This variant (1), also known as Nogo-A and
RTN-XL, represents the longest transcript, and encodes the longest
isoform (A).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC150182.1, AB040462.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-51 AY123246.1 1-51
52-911 BC016165.1 1-860
912-4126 AY123250.1 129-3343
4127-4571 AF125103.1 1064-1508
4572-4844 AF132048.1 1407-1679
4845-4871 AI671568.1 1-27 c
FEATURES Location/Qualifiers
source 1..4871
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2p16.3"
gene 1..4871
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/note="reticulon 4"
/db_xref="GeneID:57142"
/db_xref="HGNC:14085"
/db_xref="HPRD:07259"
/db_xref="MIM:604475"
exon 1..854
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/inference="alignment:Splign:1.39.8"
misc_feature 173..175
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/note="upstream in-frame stop codon"
CDS 299..3877
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/note="isoform A is encoded by transcript variant 1;
neuroendocrine-specific protein C homolog; neurite
outgrowth inhibitor; foocen; reticulon 5; My043 protein;
neurite growth inhibitor 220; Human NogoA"
/codon_start=1
/product="reticulon-4 isoform A"
/protein_id="NP_065393.1"
/db_xref="GI:24431935"
/db_xref="CCDS:CCDS42684.1"
/db_xref="GeneID:57142"
/db_xref="HGNC:14085"
/db_xref="HPRD:07259"
/db_xref="MIM:604475"
/translation="
MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEPVIRSSAENMDLKEQPGNTISAGQEDFPSVLLETAASLPSLSPLSAASFKEHEYLGNLSTVLPTEGTLQENVSEASKEVSEKAKTLLIDRDLTEFSELEYSEMGSSFSVSPKAESAVIVANPREEIIVKNKDEEEKLVSNNILHNQQELPTALTKLVKEDEVVSSEKAKDSFNEKRVAVEAPMREEYADFKPFERVWEVKDSKEDSDMLAAGGKIESNLESKVDKKCFADSLEQTNHEKDSESSNDDTSFPSTPEGIKDRSGAYITCAPFNPAATESIATNIFPLLGDPTSENKTDEKKIEEKKAQIVTEKNTSTKTSNPFLVAAQDSETDYVTTDNLTKVTEEVVANMPEGLTPDLVQEACESELNEVTGTKIAYETKMDLVQTSEVMQESLYPAAQLCPSFEESEATPSPVLPDIVMEAPLNSAVPSAGASVIQPSSSPLEASSVNYESIKHEPENPPPYEEAMSVSLKKVSGIKEEIKEPENINAALQETEAPYISIACDLIKETKLSAEPAPDFSDYSEMAKVEQPVPDHSELVEDSSPDSEPVDLFSDDSIPDVPQKQDETVMLVKESLTETSFESMIEYENKEKLSALPPEGGKPYLESFKLSLDNTKDTLLPDEVSTLSKKEKIPLQMEELSTAVYSNDDLFISKEAQIRETETFSDSSPIEIIDEFPTLISSKTDSFSKLAREYTDLEVSHKSEIANAPDGAGSLPCTELPHDLSLKNIQPKVEEKISFSDDFSKNGSATSKVLLLPPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPSAIFSAELSKTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE
"
misc_feature 299..301
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="N-acetylmethionine; propagated from
UniProtKB/Swiss-Prot (Q9NQC3.2); acetylation site"
misc_feature 317..319
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NQC3.2); phosphorylation site"
misc_feature 317..319
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 329..331
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 335..337
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 341..343
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NQC3.2); phosphorylation site"
misc_feature 341..343
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 617..619
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NQC3.2); phosphorylation site"
misc_feature 617..619
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 839..841
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NQC3.2); phosphorylation site"
misc_feature 839..841
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 842..844
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q9NQC3.2); phosphorylation site"
misc_feature 848..850
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 860..862
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 884..886
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2876..2878
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2885..2887
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3311..3823
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/note="Reticulon; Region: Reticulon; pfam02453"
/db_xref="CDD:190314"
misc_feature 3353..3415
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NQC3.2);
transmembrane region"
misc_feature 3608..3610
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q9NQC3.2); acetylation site"
misc_feature 3698..3760
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NQC3.2);
transmembrane region"
exon 855..911
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/inference="alignment:Splign:1.39.8"
exon 912..3311
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/inference="alignment:Splign:1.39.8"
STS 1629..1778
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/standard_name="SGC32447"
/db_xref="UniSTS:27904"
variation 3007
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/replace="c"
/replace="g"
/db_xref="dbSNP:1048202"
exon 3312..3519
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/inference="alignment:Splign:1.39.8"
variation 3493
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/replace="a"
/replace="g"
/db_xref="dbSNP:3916038"
exon 3520..3658
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/inference="alignment:Splign:1.39.8"
exon 3659..3728
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/inference="alignment:Splign:1.39.8"
exon 3729..3775
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/inference="alignment:Splign:1.39.8"
exon 3776..3834
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/inference="alignment:Splign:1.39.8"
exon 3835..4844
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/inference="alignment:Splign:1.39.8"
variation 3908
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/replace="a"
/replace="c"
/db_xref="dbSNP:1801912"
STS 3930..4066
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/standard_name="RH11556"
/db_xref="UniSTS:19351"
variation 3957
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/replace="c"
/replace="t"
/db_xref="dbSNP:1801911"
STS 4042..4220
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/standard_name="D2S1981"
/db_xref="UniSTS:62317"
STS 4125..4194
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/standard_name="SHGC-5636"
/db_xref="UniSTS:3994"
polyA_signal 4144..4149
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
polyA_site 4237
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/experiment="experimental evidence, no additional details
recorded"
STS 4539..4647
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/standard_name="A002P20"
/db_xref="UniSTS:11346"
STS 4662..4804
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
/standard_name="AB049853"
/db_xref="UniSTS:480168"
polyA_signal 4823..4828
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
polyA_site 4844
/gene="RTN4"
/gene_synonym="ASY; Nbla00271; Nbla10545; NI220/250; NOGO;
NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4-A;
RTN4-B1; RTN4-B2; RTN4-C"
ORIGIN
agtccctgccctcccctggggagggtgagtcacgccaaactgggcggagagtccgctggcctcactcctagctcatctgggcggcggcggcaagtggggacagggcgggtggcgcatcaccggcgcggaggcaggaggagcagtctcattgttccgggagccgtcaccacagtaggtccctcggctcagtcggcccagcccctctcagtcctccccaacccccacaaccgcccgcggctctgagacgcggccccggcggcggcggcagcagctgcagcatcatctccaccctccagccatggaagacctggaccagtctcctctggtctcgtcctcggacagcccaccccggccgcagcccgcgttcaagtaccagttcgtgagggagcccgaggacgaggaggaagaagaggaggaggaagaggaggacgaggacgaagacctggaggagctggaggtgctggagaggaagcccgccgccgggctgtccgcggccccagtgcccaccgcccctgccgccggcgcgcccctgatggacttcggaaatgacttcgtgccgccggcgccccggggacccctgccggccgctccccccgtcgccccggagcggcagccgtcttgggacccgagcccggtgtcgtcgaccgtgcccgcgccatccccgctgtctgctgccgcagtctcgccctccaagctccctgaggacgacgagcctccggcccggcctccccctcctcccccggccagcgtgagcccccaggcagagcccgtgtggaccccgccagccccggctcccgccgcgcccccctccaccccggccgcgcccaagcgcaggggctcctcgggctcagtggatgagaccctttttgctcttcctgctgcatctgagcctgtgatacgctcctctgcagaaaatatggacttgaaggagcagccaggtaacactatttcggctggtcaagaggatttcccatctgtcctgcttgaaactgctgcttctcttccttctctgtctcctctctcagccgcttctttcaaagaacatgaataccttggtaatttgtcaacagtattacccactgaaggaacacttcaagaaaatgtcagtgaagcttctaaagaggtctcagagaaggcaaaaactctactcatagatagagatttaacagagttttcagaattagaatactcagaaatgggatcatcgttcagtgtctctccaaaagcagaatctgccgtaatagtagcaaatcctagggaagaaataatcgtgaaaaataaagatgaagaagagaagttagttagtaataacatccttcataatcaacaagagttacctacagctcttactaaattggttaaagaggatgaagttgtgtcttcagaaaaagcaaaagacagttttaatgaaaagagagttgcagtggaagctcctatgagggaggaatatgcagacttcaaaccatttgagcgagtatgggaagtgaaagatagtaaggaagatagtgatatgttggctgctggaggtaaaatcgagagcaacttggaaagtaaagtggataaaaaatgttttgcagatagccttgagcaaactaatcacgaaaaagatagtgagagtagtaatgatgatacttctttccccagtacgccagaaggtataaaggatcgttcaggagcatatatcacatgtgctccctttaacccagcagcaactgagagcattgcaacaaacatttttcctttgttaggagatcctacttcagaaaataagaccgatgaaaaaaaaatagaagaaaagaaggcccaaatagtaacagagaagaatactagcaccaaaacatcaaacccttttcttgtagcagcacaggattctgagacagattatgtcacaacagataatttaacaaaggtgactgaggaagtcgtggcaaacatgcctgaaggcctgactccagatttagtacaggaagcatgtgaaagtgaattgaatgaagttactggtacaaagattgcttatgaaacaaaaatggacttggttcaaacatcagaagttatgcaagagtcactctatcctgcagcacagctttgcccatcatttgaagagtcagaagctactccttcaccagttttgcctgacattgttatggaagcaccattgaattctgcagttcctagtgctggtgcttccgtgatacagcccagctcatcaccattagaagcttcttcagttaattatgaaagcataaaacatgagcctgaaaaccccccaccatatgaagaggccatgagtgtatcactaaaaaaagtatcaggaataaaggaagaaattaaagagcctgaaaatattaatgcagctcttcaagaaacagaagctccttatatatctattgcatgtgatttaattaaagaaacaaagctttctgctgaaccagctccggatttctctgattattcagaaatggcaaaagttgaacagccagtgcctgatcattctgagctagttgaagattcctcacctgattctgaaccagttgacttatttagtgatgattcaatacctgacgttccacaaaaacaagatgaaactgtgatgcttgtgaaagaaagtctcactgagacttcatttgagtcaatgatagaatatgaaaataaggaaaaactcagtgctttgccacctgagggaggaaagccatatttggaatcttttaagctcagtttagataacacaaaagataccctgttacctgatgaagtttcaacattgagcaaaaaggagaaaattcctttgcagatggaggagctcagtactgcagtttattcaaatgatgacttatttatttctaaggaagcacagataagagaaactgaaacgttttcagattcatctccaattgaaattatagatgagttccctacattgatcagttctaaaactgattcattttctaaattagccagggaatatactgacctagaagtatcccacaaaagtgaaattgctaatgccccggatggagctgggtcattgccttgcacagaattgccccatgacctttctttgaagaacatacaacccaaagttgaagagaaaatcagtttctcagatgacttttctaaaaatgggtctgctacatcaaaggtgctcttattgcctccagatgtttctgctttggccactcaagcagagatagagagcatagttaaacccaaagttcttgtgaaagaagctgagaaaaaacttccttccgatacagaaaaagaggacagatcaccatctgctatattttcagcagagctgagtaaaacttcagttgttgacctcctgtactggagagacattaagaagactggagtggtgtttggtgccagcctattcctgctgctttcattgacagtattcagcattgtgagcgtaacagcctacattgccttggccctgctctctgtgaccatcagctttaggatatacaagggtgtgatccaagctatccagaaatcagatgaaggccacccattcagggcatatctggaatctgaagttgctatatctgaggagttggttcagaagtacagtaattctgctcttggtcatgtgaactgcacgataaaggaactcaggcgcctcttcttagttgatgatttagttgattctctgaagtttgcagtgttgatgtgggtatttacctatgttggtgccttgtttaatggtctgacactactgattttggctctcatttcactcttcagtgttcctgttatttatgaacggcatcaggcacagatagatcattatctaggacttgcaaataagaatgttaaagatgctatggctaaaatccaagcaaaaatccctggattgaagcgcaaagctgaatgaaaacgcccaaaataattagtaggagttcatctttaaaggggatattcatttgattatacgggggagggtcagggaagaacgaaccttgacgttgcagtgcagtttcacagatcgttgttagatctttatttttagccatgcactgttgtgaggaaaaattacctgtcttgactgccatgtgttcatcatcttaagtattgtaagctgctatgtatggatttaaaccgtaatcatatctttttcctatctatctgaggcactggtggaataaaaaacctgtatattttactttgttgcagatagtcttgccgcatcttggcaagttgcagagatggtggagctagaaaaaaaaaaaaaaaagcccttttcagtttgtgcactgtgtatggtccgtgtagattgatgcagattttctgaaatgaaatgtttgtttagacgagatcataccggtaaagcaggaatgacaaagcttgcttttctggtatgttctaggtgtattgtgacttttactgttatattaattgccaatataagtaaatatagattatatatgtatagtgtttcacaaagcttagacctttaccttccagccaccccacagtgcttgatatttcagagtcagtcattggttatacatgtgtagttccaaagcacataagctagaagaagaaatatttctaggagcactaccatctgttttcaacatgaaatgccacacacatagaactccaacatcaatttcattgcacagactgactgtagttaattttgtcacagaatctatggactgaatctaatgcttccaaaaatgttgtttgtttgcaaatatcaaacattgttatgcaagaaattattaattacaaaatgaagatttataccattgtggtttaagctgtactgaactaaatctgtggaatgcattgtgaactgtaaaagcaaagtatcaataaagcttatagacttaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:57142 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:57142 -> Biological process: GO:0001525 [angiogenesis] evidence: IEA
GeneID:57142 -> Biological process: GO:0006915 [apoptotic process] evidence: NAS
GeneID:57142 -> Biological process: GO:0007413 [axonal fasciculation] evidence: ISS
GeneID:57142 -> Biological process: GO:0021801 [cerebral cortex radial glia guided migration] evidence: ISS
GeneID:57142 -> Biological process: GO:0030308 [negative regulation of cell growth] evidence: IMP
GeneID:57142 -> Biological process: GO:0030334 [regulation of cell migration] evidence: IDA
GeneID:57142 -> Biological process: GO:0030517 [negative regulation of axon extension] evidence: IDA
GeneID:57142 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: NAS
GeneID:57142 -> Biological process: GO:0048011 [neurotrophin TRK receptor signaling pathway] evidence: TAS
GeneID:57142 -> Biological process: GO:0050770 [regulation of axonogenesis] evidence: TAS
GeneID:57142 -> Biological process: GO:0050771 [negative regulation of axonogenesis] evidence: TAS
GeneID:57142 -> Biological process: GO:0060317 [cardiac epithelial to mesenchymal transition] evidence: IEA
GeneID:57142 -> Biological process: GO:0071786 [endoplasmic reticulum tubular network organization] evidence: IMP
GeneID:57142 -> Biological process: GO:2000172 [regulation of branching morphogenesis of a nerve] evidence: ISS
GeneID:57142 -> Cellular component: GO:0005635 [nuclear envelope] evidence: IDA
GeneID:57142 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: NAS
GeneID:57142 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:57142 -> Cellular component: GO:0030176 [integral to endoplasmic reticulum membrane] evidence: IDA
GeneID:57142 -> Cellular component: GO:0042995 [cell projection] evidence: IEA
GeneID:57142 -> Cellular component: GO:0043025 [neuronal cell body] evidence: IEA
by
@meso_cacase at
DBCLS
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