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2024-03-28 19:45:23, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_020524               3213 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens pre-B-cell leukemia homeobox interacting protein 1
            (PBXIP1), mRNA.
ACCESSION   NM_020524
VERSION     NM_020524.2  GI:19923829
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3213)
  AUTHORS   Manavathi,B., Lo,D., Bugide,S., Dey,O., Imren,S., Weiss,M.J. and
            Humphries,R.K.
  TITLE     Functional regulation of pre-B-cell leukemia homeobox interacting
            protein 1 (PBXIP1/HPIP) in erythroid differentiation
  JOURNAL   J. Biol. Chem. 287 (8), 5600-5614 (2012)
   PUBMED   22187427
  REMARK    GeneRIF: HPIP is a target of GATA1 and CTCF in erythroid cells and
            plays an important role in erythroid differentiation by modulating
            the PI3K/AKT pathway
REFERENCE   2  (bases 1 to 3213)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat. Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   3  (bases 1 to 3213)
  AUTHORS   Manavathi,B., Acconcia,F., Rayala,S.K. and Kumar,R.
  TITLE     An inherent role of microtubule network in the action of nuclear
            receptor
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 103 (43), 15981-15986 (2006)
   PUBMED   17043237
REFERENCE   4  (bases 1 to 3213)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   5  (bases 1 to 3213)
  AUTHORS   Abramovich,C., Chavez,E.A., Lansdorp,P.M. and Humphries,R.K.
  TITLE     Functional characterization of multiple domains involved in the
            subcellular localization of the hematopoietic Pbx interacting
            protein (HPIP)
  JOURNAL   Oncogene 21 (44), 6766-6771 (2002)
   PUBMED   12360403
REFERENCE   6  (bases 1 to 3213)
  AUTHORS   Abramovich,C., Shen,W.F., Pineault,N., Imren,S., Montpetit,B.,
            Largman,C. and Humphries,R.K.
  TITLE     Functional cloning and characterization of a novel nonhomeodomain
            protein that inhibits the binding of PBX1-HOX complexes to DNA
  JOURNAL   J. Biol. Chem. 275 (34), 26172-26177 (2000)
   PUBMED   10825160
REFERENCE   7  (bases 1 to 3213)
  AUTHORS   Epplen,C. and Epplen,J.T.
  TITLE     Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of
            human lymphocytes
  JOURNAL   Hum. Genet. 93 (1), 35-41 (1994)
   PUBMED   7505766
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC016852.1.
            On Apr 4, 2002 this sequence version replaced gi:10092622.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016852.1, AF221521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025098 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3213
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..3213
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /note="pre-B-cell leukemia homeobox interacting protein 1"
                     /db_xref="GeneID:57326"
                     /db_xref="HGNC:21199"
                     /db_xref="HPRD:17823"
     exon            1..23
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:1.39.8"
     exon            24..110
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:1.39.8"
     CDS             60..2255
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /note="pre-B-cell leukemia transcription factor
                     interacting protein 1; hematopoietic PBX-interacting
                     protein"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription
                     factor-interacting protein 1"
                     /protein_id="NP_065385.2"
                     /db_xref="GI:19923830"
                     /db_xref="CCDS:CCDS1074.1"
                     /db_xref="GeneID:57326"
                     /db_xref="HGNC:21199"
                     /db_xref="HPRD:17823"
                     /translation="
MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEGTLFQTESPQSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKAAWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALVLLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQGLEADCVRGPDGVCLSGGRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSVQQDLERSLQDASRGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKEKWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRKSGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFGTELAPVRQQELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDEVDDFEDFIFSHFFGDKALKKRSGKKDKHSQSPRAAGPREGHSHSHHHHHRG
"
     misc_feature    186..188
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q96AQ6.1); phosphorylation site"
     misc_feature    186..188
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    192..194
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    495..497
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q96AQ6.1); phosphorylation site"
     misc_feature    495..497
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    498..500
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q96AQ6.1); phosphorylation site"
     misc_feature    498..500
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    501..503
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q96AQ6.1); phosphorylation site"
     misc_feature    501..503
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    513..515
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine; propagated from
                     UniProtKB/Swiss-Prot (Q96AQ6.1); phosphorylation site"
     misc_feature    513..515
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    <735..>875
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /note="PEP-CTERM family integral membrane protein; Region:
                     PEP_integral; TIGR02921"
                     /db_xref="CDD:131967"
     misc_feature    1512..1574
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AQ6.1);
                     Region: Nuclear localization signal (Potential)"
     misc_feature    2142..2219
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96AQ6.1);
                     Region: Nuclear localization signal (Potential)"
     exon            111..237
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:1.39.8"
     exon            238..302
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:1.39.8"
     exon            303..468
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:1.39.8"
     exon            469..702
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:1.39.8"
     exon            703..726
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:1.39.8"
     exon            727..797
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:1.39.8"
     exon            798..929
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:1.39.8"
     exon            930..2161
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:1.39.8"
     variation       1941
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:11559159"
     variation       2096
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3211037"
     exon            2162..3199
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:1.39.8"
     STS             2298..3000
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /standard_name="PBXIP1_8075"
                     /db_xref="UniSTS:467817"
     STS             2641..2799
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /standard_name="RH15903"
                     /db_xref="UniSTS:64483"
     variation       2751
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200074029"
     STS             2982..3127
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /standard_name="A002B11"
                     /db_xref="UniSTS:5238"
     STS             3034..3143
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /standard_name="Cda0tg01"
                     /db_xref="UniSTS:44653"
     variation       3153
                     /gene="PBXIP1"
                     /gene_synonym="HPIP"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:9236"
ORIGIN      
gaccgaagcaagagctggttcaggtggcagccacagcagcctcagggacctcagcaactatggcctcctgcccagactctgataatagctgggtgcttgctggctccgagagcctgccagtggagacactgggcccggcatccaggatggacccagaatctgagagagccctgcaggcccctcacagcccctccaagacagatgggaaagaattagctgggaccatggatggagaagggacgctcttccagactgaaagccctcagtctggcagcattctaacagaggagactgaggtcaagggcaccctggaaggtgatgtttgtggtgtggagcctcctggcccaggagacacagtagtccagggagacctgcaggagaccaccgtggtgacaggcctgggaccagacacacaggacctggaaggccagagccctccacagagcctgccttcaacccccaaagcagcttggatcagggaggagggccgctgctccagcagtgacgatgacaccgacgtggacatggagggtctgcggagacggcggggccgggaggccggcccacctcagcccatggtgcccctggctgtggagaaccaggctgggggtgagggtgcaggcggggagctgggcatctccctcaacatgtgcctccttggggccctggttctgcttggcctgggggtcctcctcttctcaggtggcctctcagagtctgagactgggcccatggaggaagtggagcggcaggtcctcccagaccccgaggtgctggaagctgtgggggacaggcaggatgggctaagggaacagctgcaggccccagtgcctcctgacagtgtccccagcctgcaaaacatgggtcttctgctggacaagctggccaaggagaaccaggacatccggctgctgcaggcccagctgcaggcccaaaaggaagagcttcagagcctgatgcaccagcccaaagggctagaggaggagaatgcccagctccggggggctctgcagcagggcgaagccttccagcgggctctggagtcagagctgcagcagctgcgggcccggctccaggggctggaggccgactgtgtccggggcccagatggggtgtgcctcagtgggggtagaggcccacagggtgacaaggccatcagggagcaaggccccagggagcaggagccagaactcagcttcctgaagcagaaggaacagctggaggctgaggcacaggcattaaggcaagagttagagaggcagcgacggctgctggggtctgtacagcaggatctggagaggagcttgcaggatgccagccgcggggacccagctcatgctggcttggctgagctgggccacagattggcccagaaactgcagggcctggagaactggggccaggaccctggggtctctgccaatgcctcaaaggcctggcaccagaagtcccacttccagaattctagggagtggagtggaaaggaaaagtggtgggatgggcagagagaccggaaggctgagcactggaaacataagaaggaagaatctggccgggaaaggaagaagaactggggaggtcaggaggacagggagccagcaggaaggtggaaggagggcaggccaagggtggaggagtcggggagcaagaaggagggcaagcgacagggcccgaaggaacccccaaggaaaagtggtagcttccactcctctggagaaaagcagaagcaacctcggtggagggaagggactaaggacagccatgaccccctgccatcctgggcagagctgttgaggcccaagtaccgggcaccccagggctgctcaggtgtggacgagtgtgcccggcaggagggcctgactttctttggcacagagctagccccagtgcggcaacaggagctggcctctctgctaagaacatacttggcacggctgccctgggctgggcagctgaccaaggagctacccctctcacctgctttctttggtgaggatggcatcttccgtcatgaccgcctccgcttccgggattttgtggatgccctggaggacagcttggaggaggtggctgtgcaacagacaggtgatgatgatgaagtagatgactttgaggacttcatcttcagccacttctttggagacaaagcactgaagaagaggtcagggaagaaggacaagcactcacagagcccaagagctgcggggcccagggaggggcacagccatagccaccaccaccaccaccggggctgacaccctgccccacagggaatggccttggcctggcccagcccaagatcccagcgttatctaactcctggagggtggactctgtcctggcttgtttggtgtcctcagatatctttcacacagtagagcaaaatcaccagccctgcactgatgtcactttatgtagaaaaaggccttagctggacctgcgttgccgtctatgcaaatgcatgcaaatactccaggccctgggatgtgggcttgtgttttgtcactgtgaagggggagatgggagaggagcctgttttggggtggggtctggggaaggcaatctgattctgaagctaaagagctttcatcctcttgagtgtatgtccccatagtgggccccttgacccacatgctgaccggtgccttgggatttgactagagttgctggctcgaggcccagcacgaggacttaccctggggttttgttaggtttggaagcagctgtccctagggggtgaagtcccccccctttttttttttacccctgcttctcccacggcttcacctccctatgtgaactgtagactcagatcccaataaagtgctgttgcagctatgatgctaggtggtttctaagcacaggggacaccccacaccccctgcctgaatggatgggtccatcccaggcactggtacttgcccccttgttctgtatccccctttgcccttgccttgcccttccaacaaaccctaggcccttgagaagctgatacttctccttttgctcacagctgccttggccccacccctgggagatgtagcaaattgagtgtgggttttggagtctgagcctcaggctcaaatccaggccaagtgatcttgggcaagttaatctctgggaactttgggtttcttatcctcaaaaaaggcgatggaagggctggggaagtgattaaataaaagcaacgcaagaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:57326 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: NAS
            GeneID:57326 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:57326 -> Biological process: GO:0007275 [multicellular organismal development] evidence: NAS
            GeneID:57326 -> Biological process: GO:0030154 [cell differentiation] evidence: NAS
            GeneID:57326 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: NAS
            GeneID:57326 -> Cellular component: GO:0005634 [nucleus] evidence: NAS
            GeneID:57326 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:57326 -> Cellular component: GO:0005829 [cytosol] evidence: NAS
            GeneID:57326 -> Cellular component: GO:0005874 [microtubule] evidence: IEA
            GeneID:57326 -> Cellular component: GO:0043231 [intracellular membrane-bounded organelle] evidence: IDA

by @meso_cacase at DBCLS
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