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2024-04-26 13:17:53, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_020341 4777 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 7 (PAK7),
transcript variant 1, mRNA.
ACCESSION NM_020341
VERSION NM_020341.3 GI:191252790
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4777)
AUTHORS Gu,J., Li,K., Li,M., Wu,X., Zhang,L., Ding,Q., Wu,W., Yang,J.,
Mu,J., Wen,H., Ding,Q., Lu,J., Hao,Y., Chen,L., Zhang,W., Li,S. and
Liu,Y.
TITLE A role for p21-activated kinase 7 in the development of gastric
cancer
JOURNAL FEBS J. 280 (1), 46-55 (2013)
PUBMED 23106939
REMARK GeneRIF: PAK7 is a new hallmark of gastric cancer, PAK7 may
contribute to gain of tumor growth potential, acting by affecting
the expression of cell cycle regulators.
REFERENCE 2 (bases 1 to 4777)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 3 (bases 1 to 4777)
AUTHORS Wong,L.E., Reynolds,A.B., Dissanayaka,N.T. and Minden,A.
TITLE p120-catenin is a binding partner and substrate for Group B Pak
kinases
JOURNAL J. Cell. Biochem. 110 (5), 1244-1254 (2010)
PUBMED 20564219
REMARK GeneRIF: Data show that both Pak5 and constitutively active Pak4,
the founding member of the Group B Paks, directly phosphorylate
p120 in vitro.
REFERENCE 4 (bases 1 to 4777)
AUTHORS Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
TITLE Genetic variants in nuclear-encoded mitochondrial genes influence
AIDS progression
JOURNAL PLoS ONE 5 (9), E12862 (2010)
PUBMED 20877624
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 4777)
AUTHORS Gong,W., An,Z., Wang,Y., Pan,X., Fang,W., Jiang,B. and Zhang,H.
TITLE P21-activated kinase 5 is overexpressed during colorectal cancer
progression and regulates colorectal carcinoma cell adhesion and
migration
JOURNAL Int. J. Cancer 125 (3), 548-555 (2009)
PUBMED 19415746
REMARK GeneRIF: Study demonstrated that PAK5 expression increased
significantly with malignant progression of CRC (colorectal
cancer), and that PAK5 might promote CRC metastasis by regulating
CRC cell adhesion and migration.
REFERENCE 6 (bases 1 to 4777)
AUTHORS Cau,J., Faure,S., Comps,M., Delsert,C. and Morin,N.
TITLE A novel p21-activated kinase binds the actin and microtubule
networks and induces microtubule stabilization
JOURNAL J. Cell Biol. 155 (6), 1029-1042 (2001)
PUBMED 11733543
REFERENCE 7 (bases 1 to 4777)
AUTHORS Tan,Y., Demeter,M.R., Ruan,H. and Comb,M.J.
TITLE BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and
cell survival
JOURNAL J. Biol. Chem. 275 (33), 25865-25869 (2000)
PUBMED 10837486
REFERENCE 8 (bases 1 to 4777)
AUTHORS Lizcano,J.M., Morrice,N. and Cohen,P.
TITLE Regulation of BAD by cAMP-dependent protein kinase is mediated via
phosphorylation of a novel site, Ser155
JOURNAL Biochem. J. 349 (PT 2), 547-557 (2000)
PUBMED 10880354
REFERENCE 9 (bases 1 to 4777)
AUTHORS Scheid,M.P., Schubert,K.M. and Duronio,V.
TITLE Regulation of bad phosphorylation and association with Bcl-x(L) by
the MAPK/Erk kinase
JOURNAL J. Biol. Chem. 274 (43), 31108-31113 (1999)
PUBMED 10521512
REFERENCE 10 (bases 1 to 4777)
AUTHORS del Peso,L., Gonzalez-Garcia,M., Page,C., Herrera,R. and Nunez,G.
TITLE Interleukin-3-induced phosphorylation of BAD through the protein
kinase Akt
JOURNAL Science 278 (5338), 687-689 (1997)
PUBMED 9381178
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK315820.1, AB033090.1 and
AB040812.1.
On Jun 21, 2008 this sequence version replaced gi:29826330.
Summary: The protein encoded by this gene is a member of the PAK
family of Ser/Thr protein kinases. PAK family members are known to
be effectors of Rac/Cdc42 GTPases, which have been implicated in
the regulation of cytoskeletal dynamics, proliferation, and cell
survival signaling. This kinase contains a CDC42/Rac1 interactive
binding (CRIB) motif, and has been shown to bind CDC42 in the
presence of GTP. This kinase is predominantly expressed in brain.
It is capable of promoting neurite outgrowth, and thus may play a
role in neurite development. This kinase is associated with
microtubule networks and induces microtubule stabilization. The
subcellular localization of this kinase is tightly regulated during
cell cycle progression. Alternatively spliced transcript variants
encoding the same protein have been described. [provided by RefSeq,
Jul 2008].
Transcript Variant: This variant (1) represents the longer
transcript. This variant and variant 2 encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB033090.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025082, ERS025084 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-125 AK315820.1 2-126
126-3077 AB033090.1 128-3079
3078-4777 AB040812.1 2913-4612
FEATURES Location/Qualifiers
source 1..4777
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="20"
/map="20p12"
gene 1..4777
/gene="PAK7"
/gene_synonym="PAK5"
/note="p21 protein (Cdc42/Rac)-activated kinase 7"
/db_xref="GeneID:57144"
/db_xref="HGNC:15916"
/db_xref="HPRD:06423"
/db_xref="MIM:608038"
exon 1..278
/gene="PAK7"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
variation 102
/gene="PAK7"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:2294900"
exon 279..384
/gene="PAK7"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
exon 385..534
/gene="PAK7"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
misc_feature 441..443
/gene="PAK7"
/gene_synonym="PAK5"
/note="upstream in-frame stop codon"
exon 535..749
/gene="PAK7"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
CDS 546..2705
/gene="PAK7"
/gene_synonym="PAK5"
/EC_number="2.7.11.1"
/note="protein kinase PAK5; p21(CDKN1A)-activated kinase
7; serine/threonine-protein kinase PAK7;
p21CDKN1A-activated kinase 7; PAK-5; PAK-7; p21-activated
kinase 5; p21-activated kinase 7"
/codon_start=1
/product="serine/threonine-protein kinase PAK 7"
/protein_id="NP_065074.1"
/db_xref="GI:24308191"
/db_xref="CCDS:CCDS13107.1"
/db_xref="GeneID:57144"
/db_xref="HGNC:15916"
/db_xref="HPRD:06423"
/db_xref="MIM:608038"
/translation="
MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCITPIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHAEENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEAYYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTAGTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQSQSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH
"
misc_feature 570..710
/gene="PAK7"
/gene_synonym="PAK5"
/note="PAK (p21 activated kinase) Binding Domain (PBD),
binds Cdc42p- and/or Rho-like small GTPases; also known as
the Cdc42/Rac interactive binding (CRIB) motif; has been
shown to inhibit transcriptional activation and cell
transformation mediated by the...; Region: CRIB_PAK_like;
cd01093"
/db_xref="CDD:29038"
misc_feature order(576..578,585..587,594..596,600..602,609..611,
660..662,672..674)
/gene="PAK7"
/gene_synonym="PAK5"
/note="GTPase interaction site [polypeptide binding];
other site"
/db_xref="CDD:29038"
misc_feature 618..1889
/gene="PAK7"
/gene_synonym="PAK5"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9P286.1);
Region: Linker"
misc_feature 1830..2684
/gene="PAK7"
/gene_synonym="PAK5"
/note="Catalytic domain of the Protein Serine/Threonine
Kinase, Group II p21-activated kinase; Region:
STKc_PAK_II; cd06648"
/db_xref="CDD:132979"
misc_feature 1905..2645
/gene="PAK7"
/gene_synonym="PAK5"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature order(1908..1922,1932..1934,1971..1973,1977..1979,
2004..2006,2064..2066,2112..2126,2130..2135,2142..2144,
2247..2249,2253..2264,2268..2270,2298..2303,2310..2312,
2349..2363,2367..2369,2448..2450,2475..2483)
/gene="PAK7"
/gene_synonym="PAK5"
/note="active site"
/db_xref="CDD:132979"
misc_feature order(1908..1922,1932..1934,1971..1973,1977..1979,
2064..2066,2112..2126,2130..2135,2142..2144,2259..2264,
2268..2270,2298..2303)
/gene="PAK7"
/gene_synonym="PAK5"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:132979"
misc_feature order(1917..1922,2004..2006,2247..2249,2253..2261,
2310..2312,2349..2363,2367..2369,2448..2450,2475..2483)
/gene="PAK7"
/gene_synonym="PAK5"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:132979"
misc_feature 2262..2264
/gene="PAK7"
/gene_synonym="PAK5"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:06423"
misc_feature 2298..2369
/gene="PAK7"
/gene_synonym="PAK5"
/note="activation loop (A-loop); other site"
/db_xref="CDD:132979"
exon 750..1535
/gene="PAK7"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
exon 1536..2027
/gene="PAK7"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
exon 2028..2161
/gene="PAK7"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
exon 2162..2288
/gene="PAK7"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
exon 2289..2414
/gene="PAK7"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
exon 2415..2549
/gene="PAK7"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
exon 2550..4777
/gene="PAK7"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
STS 2789..3039
/gene="PAK7"
/gene_synonym="PAK5"
/standard_name="D20S723"
/db_xref="UniSTS:61938"
variation 3062
/gene="PAK7"
/gene_synonym="PAK5"
/replace="a"
/replace="c"
/db_xref="dbSNP:200193192"
variation 3347
/gene="PAK7"
/gene_synonym="PAK5"
/replace="a"
/replace="c"
/db_xref="dbSNP:3185693"
STS 4335..4488
/gene="PAK7"
/gene_synonym="PAK5"
/standard_name="D20S958"
/db_xref="UniSTS:28056"
STS 4375..4499
/gene="PAK7"
/gene_synonym="PAK5"
/standard_name="WI-15350"
/db_xref="UniSTS:7266"
variation 4422
/gene="PAK7"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:1045762"
STS 4581..4710
/gene="PAK7"
/gene_synonym="PAK5"
/standard_name="RH25698"
/db_xref="UniSTS:92158"
STS 4600..4752
/gene="PAK7"
/gene_synonym="PAK5"
/standard_name="RH12132"
/db_xref="UniSTS:22204"
polyA_signal 4754..4759
/gene="PAK7"
/gene_synonym="PAK5"
polyA_signal 4760..4765
/gene="PAK7"
/gene_synonym="PAK5"
polyA_site 4777
/gene="PAK7"
/gene_synonym="PAK5"
ORIGIN
aaaacccggagcagctgcgtacgctcatggacagtcctccgaggggcgaagccgggcagctgggcatgctcagtagctgggggaggtttgggtggagagtagaaagctgtggctctgcctctcaccccctcccgctggcccccgccccccttgcccctacccagccagtagtagttccccagcgtgcgcccggggagaccgggaacatggcgctgggagcgctgtagcagctgagaaggggctgaggcaccgccgcttcgctgacagccggccaccagatgttcatgcattctagagaaagtggaaaacttagaagcctaattaatgactgtcttctggacctctgagaccatgtttctagtgttttccgtggaatattatcagaaatacactgtggtgaaatgcttccacctcttgctaaaatgaacactgaggaaaaatgaagaagactgacaagcaccagcgaaaagttgcagaatagaaatagccacactcctctggagtctttaattcatccacagccatcatataaaggttttggcatcatgtttgggaagaaaaagaaaaagattgaaatatctggcccgtccaactttgaacacagggttcatactgggtttgatccacaagagcagaagtttaccggccttccccagcagtggcacagcctgttagcagatacggccaacaggccaaagcctatggtggacccttcatgcatcacacccatccagctggctcctatgaagacaatcgttagaggaaacaaaccctgcaaggaaacctccatcaacggcctgctagaggattttgacaacatctcggtgactcgctccaactccctaaggaaagaaagcccacccaccccagatcagggagcctccagccacggtccaggccacgcggaagaaaatggcttcatcaccttctcccagtattccagcgaatccgatactactgctgactacacgaccgaaaagtacagggagaagagtctctatggagatgatctggatccgtattatagaggcagccacgcagccaagcaaaatgggcacgtaatgaaaatgaagcacggggaggcctactattctgaggtgaagcctttgaaatccgattttgccagattttctgccgattatcactcacatttggactcactgagcaaaccaagtgaatacagtgacctcaagtgggagtatcagagagcctcgagtagctcccctctggattattcattccaattcacaccttctagaactgcagggaccagcgggtgctccaaggagagcctggcgtacagtgaaagtgaatggggacccagcctggatgactatgacaggaggccaaagtcttcgtacctgaatcagacaagccctcagcccaccatgcggcagaggtccaggtcaggctcgggactccaggaaccgatgatgccatttggagcaagtgcatttaaaacccatccccaaggacactcctacaactcctacacctaccctcgcttgtccgagcccacaatgtgcattccaaaggtggattacgatcgagcacagatggtcctcagccctccactgtcagggtctgacacctaccccaggggccctgccaaactacctcaaagtcaaagcaaatcgggctattcctcaagcagtcaccagtacccgtctgggtaccacaaagccaccttgtaccatcacccctccctgcagagcagttcgcagtacatctccacggcttcctacctgagctccctcagcctctcatccagcacctacccgccgcccagctggggctcctcctccgaccagcagccctccagggtgtcccatgaacagtttcgggcggccctgcagctggtggtcagcccaggagaccccagggaatacttggccaactttatcaaaatcggggaaggctcaaccggcatcgtatgcatcgccaccgagaaacacacagggaaacaagttgcagtgaagaaaatggacctccggaagcaacagagacgagaactgcttttcaatgaggtcgtgatcatgcgggattaccaccatgacaatgtggttgacatgtacagcagctaccttgtcggcgatgagctctgggtggtcatggagtttctagaaggtggtgccttgacagacattgtgactcacaccagaatgaatgaagaacagatagctactgtctgcctgtcagttctgagagctctctcctaccttcataaccaaggagtgattcacagggacataaaaagtgactccatcctcctgacaagcgatggccggataaagttgtctgattttggtttctgtgctcaagtttccaaagaggtgccgaagaggaaatcattggttggcactccctactggatggcccctgaggtgatttctaggctaccttatgggacagaggtggacatctggtccctcgggatcatggtgatagaaatgattgatggcgagcccccctacttcaatgagcctcccctccaggcgatgcggaggatccgggacagtttacctccaagagtgaaggacctacacaaggtttcttcagtgctccggggattcctagacttgatgttggtgagggagccctctcagagagcaacagcccaggaactcctcggacatccattcttaaaactagcaggtccaccgtcttgcatcgtccccctcatgagacaatacaggcatcactgagcagaggattcgtgtaggtggcaaagctagatgaggacatgagaataattcaggagaacaaaaggaaacacagaacatgcaaaaggcctgtgcattctagaccagccaattggtgggacagcgtgatgaccggcagggttcaacagaccagggcatcttcttgtgtcttaaacaggcatctctccactgacagccggtgtggtcacttggagcacggctttaataagtcattattatatttttcagcccttcatccagcaaatcagaaggactcagtacaaactccgttatgatatatcctagccacatgcagggtaacatgtaggattttctatattgaaagaatacttttctggcaaaaaaaaaaaaaaaagaaagaaaggaaaacaaaaagcacttttttcttaatggtagcagtataatgtattttgcaacgaatttgtaatttttctgtacgatagttttgataatttatagtactttgatgtcatgtagccattgtatcagttgaagtaatacttgtttactagaggagtttgaacaaagcctttcctacttttttatccctttaagagaaccaatgattctttaggaactttgaatactgaatgactctcaatcaccgtcagctttagtaaaatctctttcttatcctaacaagtgtcttatttggtggaagaagaattaagagtgatggtgatggtgtgcacgtttcattaatccaaccaaaaataatgaaataaaatttgagccacagtataccactccttgggataaagttaaatatttttaaagatcacattttccatgaacgcctctagtagcaaaccattcttttgcacaccacaatgtttccctcagtgccctttctcaaatgggtacaatgttcccttgtggccaaatttccctcccagggagcaatttcagtgctaggatcattggattcagttcccaaaatagaatgtttcagtgagaccatgagaattccaggctcacaaagggagaggagagaacagggcaagacgtttggtttcatttgtcaccatttttaaaactctgtatgctagcacaccaaactcttgtctatatttacctttgtaccacagtattaatcgctattgttcatgtatcgtgctggaagtctgaactgactctagaggatgaattagcaagagggtattttaccaggtatgatctgacttcagttgtgcccatgttataatgtgtttccgacataggagagtcgtgctgctgtctagatcttcttgaatgttgataaaaatgaatgactactacaatacattttgtgttgcttgttggatgaatttgcatgttaactgtaggccaatatagatttgcctttaaaactctggaagagctacatagtcatcattagtttctattaattatgcatcagacaaaagccatttgttaccaaactgggaaaacagaggcttttcttaactatttcacatactgtaacaaatatgaatttaaatttgtgatagcgctctggttgctctaagcataattaagaatttttgtaattaataggttgctaattatttatcactgctaaaaaggaaaaaaggcataaaatgaccttctactgattagattttcagttttctttcaaactggaaatgcctccataaatatgatctatgattttgcttcataaaacagcaaatcaatgttttatgtaaaatattaaagcattaatataaatatgtgagaataaaaacaatctaaatccagaaaatggcagtcctaaatgttcatgagacagattgtattaatttaaccaggactatgtagaagtagaaagaaaagaaaaagaaaatcttttttaaaccagaataaacattaaaaactattgcagaaaatagtggattttggattccaaacattttcgacagtgtaatggaaatttttctgtaattttcttaccatcgggtattttttaaagtattcattgagtttaccaaaagttactgtagcttaaaaggttttgtgagcactaactattggcagaaactgcatttgcaaataaaaataaatgtttgcctttt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:57144 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA
GeneID:57144 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:57144 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:57144 -> Biological process: GO:0007010 [cytoskeleton organization] evidence: TAS
GeneID:57144 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:57144 -> Biological process: GO:0008283 [cell proliferation] evidence: TAS
GeneID:57144 -> Biological process: GO:0016049 [cell growth] evidence: TAS
GeneID:57144 -> Biological process: GO:0016477 [cell migration] evidence: TAS
GeneID:57144 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
GeneID:57144 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:57144 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_065074 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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