2024-03-28 23:18:40, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_020168 3950 bp mRNA linear PRI 17-JUN-2013 DEFINITION Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 6 (PAK6), transcript variant 1, mRNA. ACCESSION NM_020168 VERSION NM_020168.5 GI:456367257 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3950) AUTHORS Liu,T., Li,Y., Gu,H., Zhu,G., Li,J., Cao,L. and Li,F. TITLE p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2) JOURNAL J. Biol. Chem. 288 (5), 3359-3369 (2013) PUBMED 23132866 REMARK GeneRIF: PAK6 phosphorylates Mdm2 on Thr-158 and Ser-186, which is critical for AR ubiquitin-mediated degradation. REFERENCE 2 (bases 1 to 3950) AUTHORS Shepelev,M.V. and Korobko,I.V. TITLE Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV JOURNAL Biochemistry Mosc. 77 (1), 26-32 (2012) PUBMED 22339630 REFERENCE 3 (bases 1 to 3950) AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K., Gibbs,R.A. and Butte,N.F. TITLE Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population JOURNAL PLoS ONE 7 (12), E51954 (2012) PUBMED 23251661 REFERENCE 4 (bases 1 to 3950) AUTHORS McCarty,S.K., Saji,M., Zhang,X., Jarjoura,D., Fusco,A., Vasko,V.V. and Ringel,M.D. TITLE Group I p21-activated kinases regulate thyroid cancer cell migration and are overexpressed and activated in thyroid cancer invasion JOURNAL Endocr. Relat. Cancer 17 (4), 989-999 (2010) PUBMED 20817787 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 3950) AUTHORS Wells,C.M. and Jones,G.E. TITLE The emerging importance of group II PAKs JOURNAL Biochem. J. 425 (3), 465-473 (2010) PUBMED 20070256 REMARK Review article Publication Status: Online-Only REFERENCE 6 (bases 1 to 3950) AUTHORS Wu,X., Carr,H.S., Dan,I., Ruvolo,P.P. and Frost,J.A. TITLE p21 activated kinase 5 activates Raf-1 and targets it to mitochondria JOURNAL J. Cell. Biochem. 105 (1), 167-175 (2008) PUBMED 18465753 REMARK GeneRIF: PAK5 is a potent regulator of Raf-1 activity and may control Raf-1 dependent signaling at mitochondria REFERENCE 7 (bases 1 to 3950) AUTHORS Kaur,R., Liu,X., Gjoerup,O., Zhang,A., Yuan,X., Balk,S.P., Schneider,M.C. and Lu,M.L. TITLE Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase JOURNAL J. Biol. Chem. 280 (5), 3323-3330 (2005) PUBMED 15550393 REMARK GeneRIF: The activation of PAK6 by both p38 MAP kinase and MKK6 suggests that PAK6 plays a role in the cellular response to stress-related signals. REFERENCE 8 (bases 1 to 3950) AUTHORS Schrantz,N., da Silva Correia,J., Fowler,B., Ge,Q., Sun,Z. and Bokoch,G.M. TITLE Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling JOURNAL J. Biol. Chem. 279 (3), 1922-1931 (2004) PUBMED 14573606 REFERENCE 9 (bases 1 to 3950) AUTHORS Lee,S.R., Ramos,S.M., Ko,A., Masiello,D., Swanson,K.D., Lu,M.L. and Balk,S.P. TITLE AR and ER interaction with a p21-activated kinase (PAK6) JOURNAL Mol. Endocrinol. 16 (1), 85-99 (2002) PUBMED 11773441 REFERENCE 10 (bases 1 to 3950) AUTHORS Yang,F., Li,X., Sharma,M., Zarnegar,M., Lim,B. and Sun,Z. TITLE Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6 JOURNAL J. Biol. Chem. 276 (18), 15345-15353 (2001) PUBMED 11278661 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY128655.1, DA229537.1, AJ236915.1, AK131522.1 and AK026592.1. On Mar 1, 2013 this sequence version replaced gi:191252778. Summary: This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, 3, and 4 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ236915.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025088 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-37 HY128655.1 2-38 38-572 DA229537.1 1-535 573-3072 AJ236915.1 513-3012 3073-3240 AK131522.1 3351-3518 3241-3518 AK131522.1 3529-3806 3519-3950 AK026592.1 1-432 FEATURES Location/Qualifiers source 1..3950 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="15" /map="15q14" gene 1..3950 /gene="PAK6" /gene_synonym="PAK5" /note="p21 protein (Cdc42/Rac)-activated kinase 6" /db_xref="GeneID:56924" /db_xref="HGNC:16061" /db_xref="HPRD:06426" /db_xref="MIM:608110" exon 1..299 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 33 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:141183923" exon 300..382 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 325 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:184060506" variation 368 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:4924439" exon 383..494 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 442 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:11636097" misc_feature 458..460 /gene="PAK6" /gene_synonym="PAK5" /note="upstream in-frame stop codon" exon 495..703 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 496 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:201707008" CDS 500..2545 /gene="PAK6" /gene_synonym="PAK5" /EC_number="2.7.11.1" /note="isoform 1 is encoded by transcript variant 1; p21(CDKN1A)-activated kinase 6; serine/threonine-protein kinase PAK 6" /codon_start=1 /product="serine/threonine-protein kinase PAK 6 isoform 1" /protein_id="NP_064553.1" /db_xref="GI:9910476" /db_xref="CCDS:CCDS10054.1" /db_xref="GeneID:56924" /db_xref="HGNC:16061" /db_xref="HPRD:06426" /db_xref="MIM:608110" /translation="
MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
" misc_feature 527..664 /gene="PAK6" /gene_synonym="PAK5" /note="PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the...; Region: CRIB_PAK_like; cd01093" /db_xref="CDD:29038" misc_feature order(533..535,542..544,551..553,557..559,566..568, 617..619,629..631) /gene="PAK6" /gene_synonym="PAK5" /note="GTPase interaction site [polypeptide binding]; other site" /db_xref="CDD:29038" misc_feature 575..1717 /gene="PAK6" /gene_synonym="PAK5" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q9NQU5.1); Region: Linker" misc_feature 1652..2542 /gene="PAK6" /gene_synonym="PAK5" /note="Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 6; Region: STKc_PAK6; cd06659" /db_xref="CDD:132990" misc_feature 1733..2473 /gene="PAK6" /gene_synonym="PAK5" /note="Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220" /db_xref="CDD:197582" misc_feature order(1736..1750,1760..1762,1799..1801,1805..1807, 1832..1834,1892..1894,1940..1954,1958..1963,1970..1972, 2075..2077,2081..2092,2096..2098,2126..2131,2138..2140, 2177..2191,2195..2197,2276..2278,2303..2311) /gene="PAK6" /gene_synonym="PAK5" /note="active site" /db_xref="CDD:132990" misc_feature order(1736..1750,1760..1762,1799..1801,1805..1807, 1892..1894,1940..1954,1958..1963,1970..1972,2087..2092, 2096..2098,2126..2131) /gene="PAK6" /gene_synonym="PAK5" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:132990" misc_feature order(1745..1750,1832..1834,2075..2077,2081..2089, 2138..2140,2177..2191,2195..2197,2276..2278,2303..2311) /gene="PAK6" /gene_synonym="PAK5" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:132990" misc_feature 2126..2197 /gene="PAK6" /gene_synonym="PAK5" /note="activation loop (A-loop); other site" /db_xref="CDD:132990" misc_feature 2177..2179 /gene="PAK6" /gene_synonym="PAK5" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" /citation=[8] variation 507 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:201346085" variation 525 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:61733786" variation 529 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:139649727" variation 540 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:11544039" variation 541 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:145212795" variation 547 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:371968905" variation 568 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:202083311" variation 577 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:376250193" variation 578 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:149132419" variation 611 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:372639063" variation 612 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:142256590" variation 641 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369235955" variation 649 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:199695379" variation 654 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:146905959" variation 656 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:371738802" variation 659 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:147960311" variation 681 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:376432897" variation 700 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:372069647" exon 704..1357 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 725 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:2412504" variation 748 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:2016902" variation 760 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:138470960" variation 806 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:36081263" variation 820 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:150318570" variation 821 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:137969148" variation 824 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:375852612" variation 828 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:149461942" variation 854 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:370496102" variation 871 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:200035365" variation 872 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:202073596" variation 895 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:375526083" variation 900 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="t" /db_xref="dbSNP:373050572" variation 916 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:376277766" variation 923 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:201017672" variation 931 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:34608644" variation 943 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369750707" variation 944 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:373280531" variation 949 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:138761742" variation 951 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:35593179" variation 962 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:370397655" variation 964 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:141846316" variation 976 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:373870185" variation 977 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:146254732" variation 978 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="g" /db_xref="dbSNP:67578703" variation 1027 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:377362218" variation 1041 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:191280501" variation 1049 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:56349744" variation 1058 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:376068775" variation 1062 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:368829109" variation 1066 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:138937506" variation 1068 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:149315160" variation 1071 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:61732685" variation 1084 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:371505679" variation 1086 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:200417617" variation 1087 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371452582" variation 1092 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:144246288" variation 1094 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:55741128" variation 1113 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:55920845" variation 1119 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:141487285" variation 1121 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:35501648" variation 1128 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:34869667" variation 1129 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:368535824" variation 1131 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:147727470" variation 1133 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:371550083" variation 1135 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:370838549" variation 1143 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:3743135" variation 1163 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:181253186" variation 1177 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:185330250" variation 1195 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:376968689" variation 1204 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:148386599" variation 1210 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:375014773" variation 1223 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:367656601" variation 1244 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371445081" variation 1258 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:374286048" variation 1271 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:143324236" variation 1273 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:201350352" variation 1284 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:61739745" variation 1342 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:202230516" variation 1354 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:373963726" exon 1358..1855 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 1367..1371 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="tcttt" /db_xref="dbSNP:144811359" variation 1371 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:75694545" variation 1374 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:150100570" variation 1377 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371298913" variation 1378 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:138523206" variation 1381 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:141886873" variation 1408 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:146266050" variation 1431 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:374205024" variation 1432 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:149513654" variation 1438 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:371922217" variation 1441 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:200815331" variation 1457 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:200107644" variation 1471 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:367831338" variation 1499 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:143993282" variation 1509 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:3743137" variation 1523 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371395174" variation 1532 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371593698" variation 1545 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:201684963" variation 1556 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369825628" variation 1602 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:142340502" variation 1608 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:202233605" variation 1611 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:377762904" variation 1614 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="t" /db_xref="dbSNP:67864419" variation 1626 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:55806501" variation 1635 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:139850733" variation 1661 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:145336671" variation 1677 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:147750062" variation 1707 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:5021809" variation 1753 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:149826022" variation 1772 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:145812191" variation 1773 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:145647822" variation 1790 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369042481" variation 1792 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:35119729" variation 1835..1836 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="g" /db_xref="dbSNP:35003343" variation 1851 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="a" /db_xref="dbSNP:68158967" variation 1852 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:1006606" exon 1856..1989 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 1868 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:201655600" variation 1887 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:201153660" variation 1888 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:144657412" variation 1922 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:34445577" STS 1948..3074 /gene="PAK6" /gene_synonym="PAK5" /standard_name="D1S3693" /db_xref="UniSTS:474271" variation 1951 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:200429138" variation 1973 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:140245743" variation 1985 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:372547442" exon 1990..2116 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 1993 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:146088177" variation 1999 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:145203209" variation 2000 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:377397005" variation 2108 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:148062077" exon 2117..2242 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 2121 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:373086987" variation 2152 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:199802493" variation 2154 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:113493588" variation 2161 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:201198106" variation 2162 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:141761526" variation 2182 /gene="PAK6" /gene_synonym="PAK5" /replace="g" /replace="t" /db_xref="dbSNP:35644942" exon 2243..2377 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 2263 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:149385124" variation 2280 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:147489955" variation 2321 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:74468066" variation 2332 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:139943572" variation 2335 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:201804704" variation 2340 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:143844489" variation 2341 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:375706027" variation 2362 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:56111625" variation 2372 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:371992889" exon 2378..3938 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 2386 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:201093320" variation 2402 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369819404" variation 2409 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:147232997" variation 2419 /gene="PAK6" /gene_synonym="PAK5" /replace="g" /replace="t" /db_xref="dbSNP:186069684" variation 2449 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:374185464" variation 2507 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:201637258" variation 2520 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:377614111" variation 2560..2561 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="g" /db_xref="dbSNP:373523942" variation 2585 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:370753710" variation 2641 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="t" /db_xref="dbSNP:67409239" variation 2691 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="t" /db_xref="dbSNP:34376657" variation 2897 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:34276379" variation 2935 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="t" /db_xref="dbSNP:2242120" variation 2974 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:192345226" variation 2984 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:36068492" variation 3003 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:34042288" variation 3073 /gene="PAK6" /gene_synonym="PAK5" /replace="g" /replace="t" /db_xref="dbSNP:2242119" variation 3160 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:189289921" variation 3163 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:144984113" variation 3200..3201 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgtgtgt" /db_xref="dbSNP:371193727" variation 3201..3210 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgtgt" /db_xref="dbSNP:113864236" variation 3201..3208 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgt" /db_xref="dbSNP:376406581" variation 3222..3229 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="tgtgtgtg" /db_xref="dbSNP:72058737" variation 3224..3231 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="tgtgtgtg" /db_xref="dbSNP:71898851" variation 3230..3231 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="tgtgtgtg" /db_xref="dbSNP:72216147" variation 3231..3232 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgt" /replace="gtgtgtgtgtgt" /db_xref="dbSNP:67649145" variation 3233..3240 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgt" /db_xref="dbSNP:58716292" variation 3240..3241 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="ac" /replace="acacacacac" /replace="cacacac" /db_xref="dbSNP:67205800" variation 3241..3242 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgtgt" /db_xref="dbSNP:72212801" variation 3288 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:75122003" variation 3312 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371075338" variation 3387 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:183657807" variation 3399 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:111385535" variation 3470 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:187963215" variation 3502 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:55738516" variation 3520 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:116029092" STS 3629..3909 /gene="PAK6" /gene_synonym="PAK5" /standard_name="WI-21468" /db_xref="UniSTS:26519" STS 3670..3821 /gene="PAK6" /gene_synonym="PAK5" /standard_name="RH15701" /db_xref="UniSTS:82077" variation 3690 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:11635121" variation 3691 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:75108621" variation 3734 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:138256759" polyA_signal 3916..3921 /gene="PAK6" /gene_synonym="PAK5" polyA_site 3938 /gene="PAK6" /gene_synonym="PAK5" ORIGIN
gggcaggtaggtggctctgtgttgggtgtggacccacgtgtgtgtgagtgcgagagtgtgtaagccagtgtgtgtgccgtccccctgctggggacagcagctgggtccagcagagagctggctgggggcttgacaggagtttatcctaactgatgctgggtgggcgcaggccctgagatgggcgtcagggagaggggacgccagacacacggcctgagcagggtgaggagcagctgccagccccggcaggcccaggccctgtctgggtgcacaggacagagacacagcaagatgcccagggagtgccgcttcctgggctagagacaagcaccagcctgcagtggagaacgcaggaccccgctgcccagaaggagcagccacggcctgcggaggactggcccagcaaggtcccaggtcttccctctcctcagcgcctaagagagaggcccagtgcgggtgaggagtcgcgaggaagaggcggaaggcgccggaaggcaccatgttccgcaagaaaaagaagaaacgccctgagatctcagcgccacagaacttccagcaccgtgtccacacctccttcgaccccaaagaaggcaagtttgtgggcctccccccacaatggcagaacatcctggacacactgcggcgccccaagcccgtggtggacccttcgcgaatcacacgggtgcagctccagcccatgaagacagtggtgcggggcagcgcgatgcctgtggatggctacatctcggggctgctcaacgacatccagaagttgtcagtcatcagctccaacaccctgcgtggccgcagccccaccagccggcggcgggcacagtccctggggctgctgggggatgagcactgggccaccgacccagacatgtacctccagagcccccagtctgagcgcactgacccccacggcctctacctcagctgcaacgggggcacaccagcaggccacaagcagatgccgtggcccgagccacagagcccacgggtcctgcccaatgggctggctgcaaaggcacagtccctgggccccgccgagtttcagggtgcctcgcagcgctgtctgcagctgggtgcctgcctgcagagctccccaccaggagcctcgccccccacgggcaccaataggcatggaatgaaggctgccaagcatggctctgaggaggcccggccacagtcctgcctggtgggctcagccacaggcaggccaggtggggaaggcagccctagccctaagacccgggagagcagcctgaagcgcaggctattccgaagcatgttcctgtccactgctgccacagcccctccaagcagcagcaagccaggccctccaccacagagcaagcccaactcctctttccgaccgccgcagaaagacaaccccccaagcctggtggccaaggcccagtccttgccctcggaccagccggtggggaccttcagccctctgaccacttcggataccagcagcccccagaagtccctccgcacagccccggccacaggccagcttccaggccggtcttccccagcgggatccccccgcacctggcacgcccagatcagcaccagcaacctgtacctgccccaggaccccacggttgccaagggtgccctggctggtgaggacacaggtgttgtgacacatgagcagttcaaggctgcgctcaggatggtggtggaccagggtgacccccggctgctgctggacagctacgtgaagattggcgagggctccaccggcatcgtctgcttggcccgggagaagcactcgggccgccaggtggccgtcaagatgatggacctcaggaagcagcagcgcagggagctgctcttcaacgaggtggtgatcatgcgggactaccagcacttcaacgtggtggagatgtacaagagctacctggtgggcgaggagctgtgggtgctcatggagttcctgcagggaggagccctcacagacatcgtctcccaagtcaggctgaatgaggagcagattgccactgtgtgtgaggctgtgctgcaggccctggcctacctgcatgctcagggtgtcatccaccgggacatcaagagtgactccatcctgctgaccctcgatggcagggtgaagctctcggacttcggattctgtgctcagatcagcaaagacgtccctaagaggaagtccctggtgggaaccccctactggatggctcctgaagtgatctccaggtctttgtatgccactgaggtggatatctggtctctgggcatcatggtgattgagatggtagatggggagccaccgtacttcagtgactccccagtgcaagccatgaagaggctccgggacagccccccacccaagctgaaaaactctcacaaggtctccccagtgctgcgagacttcctggagcggatgctggtgcgggacccccaagagagagccacagcccaggagctcctagaccaccccttcctgctgcagacagggctacctgagtgcctggtgcccctgatccagctctaccgaaagcagacctccacctgctgagcccaccccaagtatgcctgccacctacgcccacaggcagggcacactgggcagccagcctgccggcaggacttgcctgcctcctcctctcagtattctctccaaagattgaaatgtgaagccccagccccaccctctgcccttcagcctactgggccaggccggacctgccccctcagtgtctctccctcccgagtccccagatggagacccctttctacaggatgaccccttgatatttgcacagggatatttctaagaaacgcagaggccagcgttcctggcctctgcagccaacacagtagaaaaggctgctgtggttttttaaaggcagttgtccactagtgtcctaggccactgcagagggcagactgctggtctccacagatacctgctgttctcagctccagcttcaaacctcgagtctcgagagggccacggggtggtttttatgaccggaatcccgcttcctccctcacgtctgatgtcctgaaggtgcagtcccacctgtacagcccctccccgcccagaactgtgaatggcctgctccaggccatggctgggggcagggagtgaggggacaatttctgagtgaaagagaaagaatggggtcggtggtgaaggtgctctcactttacagaatggagagaacatcgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtaaggggaggaaagccaccttgacagcccaggtccctccaggtcacccacagccagtttcaggaaggctgcccctctctcccactaagttctggcctgaagggacctgctttcttggcctggcttccacctctccactcctgtgtctacctggccagtggagtggtccatgctaagtctaacactcctgggagctcaggaggcttctgagcttctcctgtactgtgcatcgtgagggccagagacaggaatgtaaggattggcaactgtgttacctttcaagtttatctcaataaccaggtcatcagggacccattgttctcttcagaaccctatctgggagagaaggcgaaccacctccgggtttccatcatgtcaaggtcacaggcatccatgtgtgcaaaccatctgccccagctgcctccacagactgctgtctccttgtcctcctcggccctgccccacttcagggctgctgtgagatggaattccaggaaagaacttcaggtgtctggaccctttctatctagataatatttttagattcttctgctccctagtgacctacctgggggcaaagaaattgcaaggacttttttttaagggtcagagttttcaaaacaaaagcatcttccctagaaatttttgtgaattgtttgcacttgtgcctgttttaaattaaattgagtgttcaaagccaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:56924 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA GeneID:56924 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:56924 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: TAS GeneID:56924 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:56924 -> Biological process: GO:0007010 [cytoskeleton organization] evidence: TAS GeneID:56924 -> Cellular component: GO:0005634 [nucleus] evidence: IEA GeneID:56924 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_064553 -> EC 2.7.11.1
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@meso_cacase at
DBCLS
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