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2024-04-20 17:48:29, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_019855 1845 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens calcium binding protein 5 (CABP5), mRNA.
ACCESSION NM_019855
VERSION NM_019855.4 GI:329755246
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1845)
AUTHORS McCue,H.V., Burgoyne,R.D. and Haynes,L.P.
TITLE Membrane targeting of the EF-hand containing calcium-sensing
proteins CaBP7 and CaBP8
JOURNAL Biochem. Biophys. Res. Commun. 380 (4), 825-831 (2009)
PUBMED 19338761
REFERENCE 2 (bases 1 to 1845)
AUTHORS Haeseleer,F., Imanishi,Y., Sokal,I., Filipek,S. and Palczewski,K.
TITLE Calcium-binding proteins: intracellular sensors from the calmodulin
superfamily
JOURNAL Biochem. Biophys. Res. Commun. 290 (2), 615-623 (2002)
PUBMED 11785943
REMARK Review article
REFERENCE 3 (bases 1 to 1845)
AUTHORS Haeseleer,F., Sokal,I., Verlinde,C.L., Erdjument-Bromage,H.,
Tempst,P., Pronin,A.N., Benovic,J.L., Fariss,R.N. and Palczewski,K.
TITLE Five members of a novel Ca(2+)-binding protein (CABP) subfamily
with similarity to calmodulin
JOURNAL J. Biol. Chem. 275 (2), 1247-1260 (2000)
PUBMED 10625670
REFERENCE 4 (bases 1 to 1845)
AUTHORS Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
White,O. et al.
TITLE Initial assessment of human gene diversity and expression patterns
based upon 83 million nucleotides of cDNA sequence
JOURNAL Nature 377 (6547 SUPPL), 3-174 (1995)
PUBMED 7566098
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AA318398.1, AF169159.1,
AC010458.6, AC010330.7 and BU734136.1.
On Apr 22, 2011 this sequence version replaced gi:21536280.
Summary: The product of this gene belongs to a subfamily of calcium
binding proteins, which share similarity to calmodulin. Calcium
binding proteins are an important component of calcium mediated
cellular signal transduction. Expression of this gene is
retina-specific. The mouse homolog of this protein has been shown
to express in the inner nuclear layer of the retina, suggested its
role in neuronal functioning. The specific function of this gene is
unknown. [provided by RefSeq, Oct 2009].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: AF169159.1, BC126135.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-154 AA318398.1 1-154
155-369 AF169159.1 148-362
370-370 AC010458.6 90225-90225
371-855 AF169159.1 364-848
856-1375 AC010330.7 9305-9824
1376-1845 BU734136.1 1-470 c
FEATURES Location/Qualifiers
source 1..1845
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.33"
gene 1..1845
/gene="CABP5"
/gene_synonym="CABP3"
/note="calcium binding protein 5"
/db_xref="GeneID:56344"
/db_xref="HGNC:13714"
/db_xref="HPRD:09537"
/db_xref="MIM:607315"
exon 1..195
/gene="CABP5"
/gene_synonym="CABP3"
/inference="alignment:Splign:1.39.8"
STS 41..985
/gene="CABP5"
/gene_synonym="CABP3"
/db_xref="UniSTS:480632"
STS 91..696
/gene="CABP5"
/gene_synonym="CABP3"
/db_xref="UniSTS:482104"
STS 93..923
/gene="CABP5"
/gene_synonym="CABP3"
/db_xref="UniSTS:486262"
CDS 133..654
/gene="CABP5"
/gene_synonym="CABP3"
/note="calcium-binding protein 3"
/codon_start=1
/product="calcium-binding protein 5"
/protein_id="NP_062829.1"
/db_xref="GI:11067753"
/db_xref="CCDS:CCDS12709.1"
/db_xref="GeneID:56344"
/db_xref="HGNC:13714"
/db_xref="HPRD:09537"
/db_xref="MIM:607315"
/translation="
MQFPMGPACIFLRKGIAEKQRERPLGQDEIEELREAFLEFDKDRDGFISCKDLGNLMRTMGYMPTEMELIELGQQIRMNLGGRVDFDDFVELMTPKLLAETAGMIGVQEMRDAFKEFDTNGDGEITLVELQQAMQRLLGERLTPREISEVVREADVNGDGTVDFEEFVKMMSR
"
misc_feature 205..645
/gene="CABP5"
/gene_synonym="CABP3"
/note="calmodulin; Provisional; Region: PTZ00184"
/db_xref="CDD:185504"
misc_feature 226..414
/gene="CABP5"
/gene_synonym="CABP3"
/note="EF-hand, calcium binding motif; A diverse
superfamily of calcium sensors and calcium signal
modulators; most examples in this alignment model have 2
active canonical EF hands. Ca2+ binding induces a
conformational change in the EF-hand motif, leading to...;
Region: EFh; cd00051"
/db_xref="CDD:28933"
misc_feature order(253..255,259..261,265..267,286..288,361..363,
367..369,373..375,394..396)
/gene="CABP5"
/gene_synonym="CABP3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28933"
misc_feature 457..648
/gene="CABP5"
/gene_synonym="CABP3"
/note="EF-hand, calcium binding motif; A diverse
superfamily of calcium sensors and calcium signal
modulators; most examples in this alignment model have 2
active canonical EF hands. Ca2+ binding induces a
conformational change in the EF-hand motif, leading to...;
Region: EFh; cd00051"
/db_xref="CDD:28933"
misc_feature order(484..486,490..492,496..498,517..519,595..597,
601..603,607..609,628..630)
/gene="CABP5"
/gene_synonym="CABP3"
/note="Ca2+ binding site [ion binding]; other site"
/db_xref="CDD:28933"
exon 196..226
/gene="CABP5"
/gene_synonym="CABP3"
/inference="alignment:Splign:1.39.8"
exon 227..370
/gene="CABP5"
/gene_synonym="CABP3"
/inference="alignment:Splign:1.39.8"
exon 371..480
/gene="CABP5"
/gene_synonym="CABP3"
/inference="alignment:Splign:1.39.8"
exon 481..628
/gene="CABP5"
/gene_synonym="CABP3"
/inference="alignment:Splign:1.39.8"
variation 515
/gene="CABP5"
/gene_synonym="CABP3"
/replace="c"
/replace="t"
/db_xref="dbSNP:3745746"
variation 587
/gene="CABP5"
/gene_synonym="CABP3"
/replace="a"
/replace="g"
/db_xref="dbSNP:3745747"
exon 629..1828
/gene="CABP5"
/gene_synonym="CABP3"
/inference="alignment:Splign:1.39.8"
variation 741
/gene="CABP5"
/gene_synonym="CABP3"
/replace="c"
/replace="g"
/db_xref="dbSNP:1171097"
STS 1116..1220
/gene="CABP5"
/gene_synonym="CABP3"
/standard_name="SHGC-30732"
/db_xref="UniSTS:46411"
polyA_signal 1799..1804
/gene="CABP5"
/gene_synonym="CABP3"
polyA_signal 1811..1816
/gene="CABP5"
/gene_synonym="CABP3"
polyA_site 1828
/gene="CABP5"
/gene_synonym="CABP3"
ORIGIN
ggagaagccaagagaggcaggaagaggtggcaaaggagtgctggagaagataaggaggctgagctccgacagggagcagggaggaggggccatcttgagactggtgccctgcgagctccaccccacccctccatgcagttccccatgggccccgcctgcatcttcttgaggaaaggcattgctgagaaacagcgggaaagaccactgggacaagatgagattgaagagctgcgggaagcatttcttgagttcgataaggaccgagatgggttcatctcttgtaaggatctggggaatctcatgaggacgatgggttacatgcccacggagatggaactgattgagctcggccagcaaatccgcatgaacctgggtggccgtgtagactttgatgactttgtggagctgatgacccccaaattgcttgcagaaacagctgggatgatcggtgtccaggagatgcgggatgccttcaaggagtttgacacgaatggagatggggagatcaccctggtggagctacagcaggccatgcagagactcctgggggagcggctcaccccccgggagatctctgaggttgtccgggaggctgatgttaatggagacggcacagttgactttgaagagtttgtgaagatgatgtctcgctgaggaggtcctggaagctccagaccctctccacctggtcaacatggagcaagcgcttgtggagaaccaaagcccaaaagccccagatccccttaaagcagagagggagggcaggcgggagggagggcattggcatgcggcgctgtgcatggggtgagacccagagcggtatctttgccaggatgggggcgtctgcagaactagattaagaaggaagagtctgtggatggaaataggaagcgtgggagggtccagttgccacccccaaaaattccaatgattcttgacatcttttcacttcacgtagtcctaagtccctgtgacctgccagagtctcttccccagcttccccttgggtgaaaatagtctcttctcctgttgggtatcaaaaggttcagaacgtagtctctactcttcccctgcctgcatcaactgttgcaaatcccgtttctctctcccggtaaggggacaaattatactttattcaggtgatggttacatgaacagcccagacttcaccactacgcaatatatccatgtaacaaaaccgcacttgtactccctaaatctatagaaatacaaaatgaaataaaaaggatgcaaatcagtcacagagctggaaacagagttgttgttgaggctgggcttggaaatggctcgtgcaagtggcattcaaagtcaactccttccttttcctgatttcctggaagcactgtctggtttctctctctctctctctctctctctctctctctctctctgtctgtctgtctctgtctcccctcccacatcccttcctttgtgtaagatactcaggggactgaattaaaccacaaatctggattatcaaggtttagagctagctgatccttggggaattaatcccctgaaaaaatgtcatcatgcaaagagagagatgacaggatcccccaaatccccagttcagccaggttgttgcaaagtctttcctagaagcctcctacctccgcgctggtctgtcctggaccacccagaggctgtgtctctgttagatgggtcgtctgttccgtccctcacgtcctgacatcgatctgtgccatgaaacagaaaagagagattcctcctgacctccgcccaaagcaagacactccagcaatgcaaaggttaaaataaaagtcaaaataaagaattaacttcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:56344 -> Molecular function: GO:0005509 [calcium ion binding] evidence: NAS
GeneID:56344 -> Biological process: GO:0007165 [signal transduction] evidence: NAS
GeneID:56344 -> Cellular component: GO:0005575 [cellular_component] evidence: ND
GeneID:56344 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:56344 -> Cellular component: GO:0005829 [cytosol] evidence: IDA
GeneID:56344 -> Cellular component: GO:0015630 [microtubule cytoskeleton] evidence: IDA
by
@meso_cacase at
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