GGRNA | NM_018953.2

LOCUS       NM_018953               1613 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens homeobox C5 (HOXC5), transcript variant 1, mRNA.
ACCESSION   NM_018953
VERSION     NM_018953.2  GI:24497541
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1613)
  AUTHORS   Estrada,K., Styrkarsdottir,U., Evangelou,E., Hsu,Y.H., Duncan,E.L.,
            Ntzani,E.E., Oei,L., Albagha,O.M., Amin,N., Kemp,J.P., Koller,D.L.,
            Li,G., Liu,C.T., Minster,R.L., Moayyeri,A., Vandenput,L.,
            Willner,D., Xiao,S.M., Yerges-Armstrong,L.M., Zheng,H.F.,
            Alonso,N., Eriksson,J., Kammerer,C.M., Kaptoge,S.K., Leo,P.J.,
            Thorleifsson,G., Wilson,S.G., Wilson,J.F., Aalto,V., Alen,M.,
            Aragaki,A.K., Aspelund,T., Center,J.R., Dailiana,Z., Duggan,D.J.,
            Garcia,M., Garcia-Giralt,N., Giroux,S., Hallmans,G., Hocking,L.J.,
            Husted,L.B., Jameson,K.A., Khusainova,R., Kim,G.S., Kooperberg,C.,
            Koromila,T., Kruk,M., Laaksonen,M., Lacroix,A.Z., Lee,S.H.,
            Leung,P.C., Lewis,J.R., Masi,L., Mencej-Bedrac,S., Nguyen,T.V.,
            Nogues,X., Patel,M.S., Prezelj,J., Rose,L.M., Scollen,S.,
            Siggeirsdottir,K., Smith,A.V., Svensson,O., Trompet,S., Trummer,O.,
            van Schoor,N.M., Woo,J., Zhu,K., Balcells,S., Brandi,M.L.,
            Buckley,B.M., Cheng,S., Christiansen,C., Cooper,C., Dedoussis,G.,
            Ford,I., Frost,M., Goltzman,D., Gonzalez-Macias,J., Kahonen,M.,
            Karlsson,M., Khusnutdinova,E., Koh,J.M., Kollia,P., Langdahl,B.L.,
            Leslie,W.D., Lips,P., Ljunggren,O., Lorenc,R.S., Marc,J.,
            Mellstrom,D., Obermayer-Pietsch,B., Olmos,J.M.,
            Pettersson-Kymmer,U., Reid,D.M., Riancho,J.A., Ridker,P.M.,
            Rousseau,F., Slagboom,P.E., Tang,N.L., Urreizti,R., Van Hul,W.,
            Viikari,J., Zarrabeitia,M.T., Aulchenko,Y.S.,
            Castano-Betancourt,M., Grundberg,E., Herrera,L., Ingvarsson,T.,
            Johannsdottir,H., Kwan,T., Li,R., Luben,R., Medina-Gomez,C.,
            Palsson,S.T., Reppe,S., Rotter,J.I., Sigurdsson,G., van Meurs,J.B.,
            Verlaan,D., Williams,F.M., Wood,A.R., Zhou,Y., Gautvik,K.M.,
            Pastinen,T., Raychaudhuri,S., Cauley,J.A., Chasman,D.I.,
            Clark,G.R., Cummings,S.R., Danoy,P., Dennison,E.M., Eastell,R.,
            Eisman,J.A., Gudnason,V., Hofman,A., Jackson,R.D., Jones,G.,
            Jukema,J.W., Khaw,K.T., Lehtimaki,T., Liu,Y., Lorentzon,M.,
            McCloskey,E., Mitchell,B.D., Nandakumar,K., Nicholson,G.C.,
            Oostra,B.A., Peacock,M., Pols,H.A., Prince,R.L., Raitakari,O.,
            Reid,I.R., Robbins,J., Sambrook,P.N., Sham,P.C., Shuldiner,A.R.,
            Tylavsky,F.A., van Duijn,C.M., Wareham,N.J., Cupples,L.A.,
            Econs,M.J., Evans,D.M., Harris,T.B., Kung,A.W., Psaty,B.M.,
            Reeve,J., Spector,T.D., Streeten,E.A., Zillikens,M.C.,
            Thorsteinsdottir,U., Ohlsson,C., Karasik,D., Richards,J.B.,
            Brown,M.A., Stefansson,K., Uitterlinden,A.G., Ralston,S.H.,
            Ioannidis,J.P., Kiel,D.P. and Rivadeneira,F.
  TITLE     Genome-wide meta-analysis identifies 56 bone mineral density loci
            and reveals 14 loci associated with risk of fracture
  JOURNAL   Nat. Genet. 44 (5), 491-501 (2012)
   PUBMED   22504420
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1613)
  AUTHORS   Gong,L.G., Qiu,G.R., Jiang,H., Xu,X.Y., Zhu,H.Y. and Sun,K.L.
  TITLE     Analysis of single nucleotide polymorphisms and haplotypes in HOXC
            gene cluster within susceptible region 12q13 of simple congenital
            heart disease
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22 (5), 497-501 (2005)
   PUBMED   16215934
  REMARK    GeneRIF: The A17860G located in 3'flanking sequence of HOXC5 gene
            is associated with simple congenital heart disease; the haplotype
            of 3 SNPs may be linked with the susceptible gene of simple CHD.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1613)
  AUTHORS   Kosaki,K., Kosaki,R., Suzuki,T., Yoshihashi,H., Takahashi,T.,
            Sasaki,K., Tomita,M., McGinnis,W. and Matsuo,N.
  TITLE     Complete mutation analysis panel of the 39 human HOX genes
  JOURNAL   Teratology 65 (2), 50-62 (2002)
   PUBMED   11857506
REFERENCE   4  (bases 1 to 1613)
  AUTHORS   Apiou,F., Flagiello,D., Cillo,C., Malfoy,B., Poupon,M.F. and
            Dutrillaux,B.
  TITLE     Fine mapping of human HOX gene clusters
  JOURNAL   Cytogenet. Cell Genet. 73 (1-2), 114-115 (1996)
   PUBMED   8646877
REFERENCE   5  (bases 1 to 1613)
  AUTHORS   Guazzi,S., Lonigro,R., Pintonello,L., Boncinelli,E., Di Lauro,R.
            and Mavilio,F.
  TITLE     The thyroid transcription factor-1 gene is a candidate target for
            regulation by Hox proteins
  JOURNAL   EMBO J. 13 (14), 3339-3347 (1994)
   PUBMED   7913891
REFERENCE   6  (bases 1 to 1613)
  AUTHORS   Arcioni,L., Simeone,A., Guazzi,S., Zappavigna,V., Boncinelli,E. and
            Mavilio,F.
  TITLE     The upstream region of the human homeobox gene HOX3D is a target
            for regulation by retinoic acid and HOX homeoproteins
  JOURNAL   EMBO J. 11 (1), 265-277 (1992)
   PUBMED   1346761
REFERENCE   7  (bases 1 to 1613)
  AUTHORS   Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
            Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
  TITLE     The human HOX gene family
  JOURNAL   Nucleic Acids Res. 17 (24), 10385-10402 (1989)
   PUBMED   2574852
REFERENCE   8  (bases 1 to 1613)
  AUTHORS   Boncinelli,E., Acampora,D., Pannese,M., D'Esposito,M., Somma,R.,
            Gaudino,G., Stornaiuolo,A., Cafiero,M., Faiella,A. and Simeone,A.
  TITLE     Organization of human class I homeobox genes
  JOURNAL   Genome 31 (2), 745-756 (1989)
   PUBMED   2576652
REFERENCE   9  (bases 1 to 1613)
  AUTHORS   Simeone,A., Pannese,M., Acampora,D., D'Esposito,M. and
            Boncinelli,E.
  TITLE     At least three human homeoboxes on chromosome 12 belong to the same
            transcription unit
  JOURNAL   Nucleic Acids Res. 16 (12), 5379-5390 (1988)
   PUBMED   2898768
REFERENCE   10 (bases 1 to 1613)
  AUTHORS   Rabin,M., Ferguson-Smith,A., Hart,C.P. and Ruddle,F.H.
  TITLE     Cognate homeo-box loci mapped on homologous human and mouse
            chromosomes
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 83 (23), 9104-9108 (1986)
   PUBMED   2878432
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X61755.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Nov 3, 2002 this sequence version replaced gi:11321637.
            
            Summary: This gene belongs to the homeobox family of genes. The
            homeobox genes encode a highly conserved family of transcription
            factors that play an important role in morphogenesis in all
            multicellular organisms. Mammals possess four similar homeobox gene
            clusters, HOXA, HOXB, HOXC and HOXD, which are located on different
            chromosomes and consist of 9 to 11 genes arranged in tandem. This
            gene, HOXC5, is one of several homeobox HOXC genes located in a
            cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6,
            share a 5' non-coding exon. Transcripts may include the shared exon
            spliced to the gene-specific exons, or they may include only the
            gene-specific exons. Two alternatively spliced variants have been
            described for HOXC5. The transcript variant which includes the
            shared exon apparently doesn't encode a protein. The protein-coding
            transcript variant contains gene-specific exons only. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and is protein coding.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN309383.1, CN309384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..1613
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /note="homeobox C5"
                     /db_xref="GeneID:3222"
                     /db_xref="HGNC:5127"
                     /db_xref="HPRD:00859"
                     /db_xref="MIM:142973"
     exon            1..529
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    34..36
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /note="upstream in-frame stop codon"
     variation       72
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373282368"
     CDS             76..744
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /note="homeo box C5; homeobox protein CP11; homeobox
                     protein Hox-3D"
                     /codon_start=1
                     /product="homeobox protein Hox-C5"
                     /protein_id="NP_061826.1"
                     /db_xref="GI:11321638"
                     /db_xref="CCDS:CCDS8872.1"
                     /db_xref="GeneID:3222"
                     /db_xref="HGNC:5127"
                     /db_xref="HPRD:00859"
                     /db_xref="MIM:142973"
                     /translation="

MSSYVANSFYKQSPNIPAYNMQTCGNYGSASEVQASRYCYGGLDLSITFPPPAPSNSLHGVDMAANPRAHPDRPACSAAAAPGHAPGRDEAAPLNPGMYSQKAARPALEERAKSSGEIKEEQAQTGQPAGLSQPPAPPQIYPWMTKLHMSHETDGKRSRTSYTRYQTLELEKEFHFNRYLTRRRRIEIANNLCLNERQIKIWFQNRRMKWKKDSKMKSKEAL

"
     misc_feature    493..510
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00444.1);
                     Region: Antp-type hexapeptide"
     misc_feature    541..696
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(541..555,559..561,610..612,628..630,667..669,
                     673..678,685..690,694..696)
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(547..549,556..558,676..678,685..690)
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       81
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201414819"
     variation       108
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:35606176"
     variation       161
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200385207"
     variation       167
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199703080"
     variation       207
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:151147734"
     variation       221
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200351551"
     variation       255
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:139064806"
     variation       277
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200703154"
     variation       280
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369572312"
     variation       312
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34720266"
     variation       317
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2071448"
     variation       341
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146874223"
     variation       383
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373127865"
     variation       393
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376224435"
     variation       416
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200190925"
     variation       449
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140687506"
     variation       481
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201107649"
     STS             497..578
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /standard_name="Hoxc5"
                     /db_xref="UniSTS:536662"
     variation       529
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202063227"
     exon            530..1613
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /inference="alignment:Splign:1.39.8"
     variation       533
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145794998"
     variation       537
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:145300322"
     variation       545
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:149168463"
     variation       561
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376228055"
     variation       589
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:376926310"
     variation       622
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370344965"
     variation       735
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143274247"
     variation       781
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371365110"
     variation       832
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:113264704"
     variation       839
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4016778"
     variation       972
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:58994757"
     variation       1000
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2071450"
     variation       1111
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149895718"
     variation       1151
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373936762"
     variation       1168
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:61921796"
     variation       1215
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61921797"
     variation       1272
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:145357528"
     STS             1326..1427
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /standard_name="D12S1961"
                     /db_xref="UniSTS:9524"
     variation       1337..1339
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace=""
                     /replace="aca"
                     /db_xref="dbSNP:377514653"
     variation       1351
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191530738"
     variation       1384
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:184371311"
     variation       1445
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:188058463"
     variation       1457
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:140104713"
     variation       1473
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192290087"
     variation       1506
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:185833901"
     polyA_signal    1591..1596
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
     polyA_site      1613
                     /gene="HOXC5"
                     /gene_synonym="CP11; HOX3; HOX3D"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN

acccctcaacttcaaagagtcacaaatcacccttaatcaaaaagggtgcagaaatttttttgggccctccccgccatgagctcctacgtagccaattcattctataagcagagccccaatatccctgcctataacatgcaaacttgtgggaactatggatcggcctcagaggtgcaggcatccaggtactgctacggcggattggacttaagcatcactttcccaccgcctgcgccttccaactctctccacggggtagacatggctgccaacccccgggctcaccccgaccgccccgcctgcagcgccgcggccgctccgggacacgctccgggcagagacgaagcggctcctctgaaccccgggatgtacagtcagaaggcggctcgcccggcgctggaggagcgagctaagagcagtggggagatcaaagaggagcaggcgcagacagggcagcccgccggactgagccagccaccggccccgccacagatttacccgtggatgaccaaactgcacatgagccacgagacggacggcaagcggtcccgaaccagttacacgcgctaccagactctggaactcgagaaagaattccactttaaccgctacctcactcgccgcaggcgcatagagatcgccaacaacttgtgtctcaatgagagacagatcaagatctggttccagaaccgcaggatgaagtggaagaaagattccaaaatgaaaagcaaagaggctctttagaggcagcgggggaggcccgcagagcgcgcccctagccggttcctgtccctgcgcctttccttttcgcctttcctctctatatttcgggtcgggggcaggtgctggagcactgggctcccgggccccacagacaaaagcgcttttccttggcattccgcatccctaccgacccagggttcccgcggggctgtcggcgctgccccatctcccctcagctcggctcagctcggtacccggggcccagggcaagctccgcaggacttccccggagggctgcggcgtacaggctggcgcagaacgaaccttggcctgggccgtatctccggctcccagcctcagcgcggccctcccgagttaaggtgggcccggcccgcgccacaggaccctcgccggaccctctaacctcgccctctcctttgttcccggctggacgggttagacagccaaaggctggcgagagtctggccctagactcggggtgcttccttgtagcgactaaactagattttcacttatgaatgatttgcatatgaaaggagagcatcggcctagggcccccacagttgctctatgctttccaaaccttatctccacaacctcttccccccaaaacccgggaacctccccagcctgcgcctgctgcatgccctctcaggccggcagccccagcctgctagctagctcaactagtggggtttcctggcactggaccccagcaagtggtcctagaggccctttgctgtcccatagtccctgccacgaatttctgtgccctcctgacccattgctgttgtccaactatttattgactctgggtccttcctgaaactatattttgtcatatcaaataaagagagaacaggactaaa

//

Annotations: